7B93,7B0N,6QC6


Conserved Protein Domain Family
MWFE
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pfam15879: MWFE (This model is not part of the current CDD release)
NADH-ubiquinone oxidoreductase MWFE subunit
MWFE is a short subunit of NADH-ubiquinone oxidoreductase found in eukaryotes. It is necessary for the activity of NADH-ubiquinone oxidoreductase complex I in mitochondria. This subunit is essential for the assembly and function of the enzyme. MWFE is found to be phosphorylated, eg in rat heart mitochondria. The short family includes much of a signal peptide.
Links
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Statistics
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PSSM-Id: 522073
Aligned: 74 rows
Threshold Bit Score: 53.3104
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7B93_a         2 WFEILPGLAI-MGVCLVIPGVSTAYIHKFTN-GGKEKRVARVQYQWYLMERDRRISG 56  house mouse
Q7PP66         2 WFEILPSFGI-ITAVLSVPGFALYGLHKLTL-DNAYRRNTDERWDRIMYTRDMRLTG 56  Anopheles gambiae str. PEST
XP_002004532   2 WFEILPSAAI-ITVALSVPIYAMYGLQKLTL-GNAYRRNMDERFDRVMYQRDFRLTN 56 
8_pfamImport   1 WYEILPAAGI-ICAAMTFPSVFNYYFHKFIYsGNPYRRGISPVFNKDLYLRDTRLSN 56 
2_pfamImport   1 WYEALPSAVI-VYVLLNIPDRINSLSNKLVY-NNVYRRDISQPWLQRYYARDWELTG 55 
KAF8385774    46 WFEQFYSGMI-TMAWVAGACYMSYPFNKWDV-GRHYRRDYCTPARVALSQRDHRLTG 100
XP_025160685   2 WYEMLPPLFL-IGLIPVAPQYWSAFVNQLIL-GNPMRRNMTKVWDRHMFTRDGRIDG 56 
EFX76075       2 WYEAMTSLLL-TTVFVGLPYGIIPLVHKLANnGNAFSRLQNSTHQRFLYRRDTRLTG 57 
EFA10746       2 WYEIIPSFLI-ITVAVAAPHYLAGPFNWLLC-GHFYRRSMMDKHEALQYLRDRRLSD 56 
KAL1229236     2 WYRAIPACLLtVVTGYTIPFYVSYIFNKLDV-KRPNRRHRYHFWTTYLLRRDEHLSG 57  Trichinella pseudospiralis
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