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Protein glycosylation ligase PglL_A is a pilin glycosylation ligase domain found in Gram negative bacteria. PglL protein O-oligosaccharyltransferases differ from the wider Wzy_C family, pfam04932, which contains both WaaL O-antigen ligases, in its substrate-specificity. PglL O-oligosaccharyltransferases (O-OTase) transfer oligosaccharide to serine or threonine in a protein. A further indication that the genes identified are PglL rather than WaaL homologues is that they are not located within lipopolysaccharide biosynthetic loci. The specific pilin glycosylation ligases are a subset of the more general bacterial protein o-oligosaccharyltransferases. |
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