Conserved Protein Domain Family
SVIP
?
pfam15811: SVIP (This model is not part of the current CDD release)
Small VCP/p97-interacting protein
SVIP, small VCP/p97-interacting protein, is a family of proteins found in eukaryotes. SVIP was identified by yeast two-hybrid screening to be an interactive partner of VCP/p97. Mammalian VCP/p97 and its yeast counterpart Cdc48p participate in the formation of organelles, including the endoplasmic reticulum (ER), Golgi apparatus, and nuclear envelope. Over-expression of SVIP caused the formation of large vacuoles that seemed to be derived from the ER. The family has two putative coiled-coil regions and contains proteins of approximately 80 amino acids in length.
Links
?
Statistics
?
PSSM-Id: 522040
Aligned: 51 rows
Threshold Bit Score: 28.0406
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_003687453  42 GSKLSdANTDSNQKN---IS---PQEAARLAAQKRFDDNIEKETKTELGKKLASERSKSQKTHVMEQIEK 105
XP_002027745   2 GVCLS-CCGNSAEEAnlmPSpeeRRQQQLDAAEKRRQENESRGIKNPENLRRQQQKALEQERREREADRQ 70 
XP_016836797   2 GNLLD-CCKGSSSYEditPDrdtIRQQQAEAAERRLAEQEKRGIGNVNAVKRQQKLAEEREKRENEAGNL 70 
XP_011260860   2 GNCCAfCYKESSSYEdltPDretIRRKQAEAAEKRIAEQQQRGIKDIESVKRQQRRALELEKREQEAAAS 71 
NP_001289555   2 GMCLP-CLSGAEDDVvvtPDpetRRKQLAEAAEKRQKETTYRGIKDPEALERKKKKQEESEKQTMSSAPS 70 
XP_006011746   2 GLCLP-CLGGAAEDVvetPDpemRRKQLAEAAEKRQREASNRGIKNPHSVEQKKKKQEEMEKHAMDSTTA 70 
NP_001289121   2 GLCMP-CMGGAVKDVvetPDpeiKRRQLAEAAEKRQMEASSRGIKNIYSVEQKKKKQEEIEKRMAASGPG 70 
Q3UZP4         2 GLCFP-CPAESAPPS---PSpeeKREKLAEAAERRQKEAATRGILDIQSVEAKKKKKEQLEKQMATSGPP 67  house mouse
XP_018672979   2 GSLFS-CCLGNDYET---PDpevRRQQMLEAAERRKQEYENRGLKDPEGVKAKQRKREAAEKSQEQIGSN 67 
XP_007497244   2 GLCLP-CLGDRPPAS---PDleeRRLKLAEAAERRQRESSTRGILNAHSVEAKKRKKEQMEKQMSARSTS 67  gray short-tailed opossum
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap