7DVQ


Conserved Protein Domain Family
SCNM1_acidic
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pfam15805: SCNM1_acidic (This model is not part of the current CDD release)
Acidic C-terminal region of sodium channel modifier 1 SCNM1
SCNM1_acidic is the C-terminal acidic region of eukaryotic sodium channel modifier protein 1. Deletion of this region affects the splicing and normal activity of the sodium channel Nav1.6 from gene Scn8a. SCNM1 sits within the U1C subfamily of RNA binding proteins that is commonly found in RNA-processing proteins, suggesting that SCNM1 is involved in splicing activities. SCNM1 and LUC7L2 associate with the mammalian spliceosomal subunit U1 snRNP.
Links
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Statistics
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PSSM-Id: 522034
Aligned: 12 rows
Threshold Bit Score: 65.8651
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7DVQ_v       183 SPTRRRALDHYLTLRSSGWIPDGRGRWVKDENVEFDSDEEEPPDLP 228 human
XP_023187132 182 TAQRRREMEHYLKLKSDGWVQDRKGQWVKDENVEFDSDEEEPAPLV 227
2_pfamImport   1 TPQRRREMEHYLKLKSNGWLQDGNGQWVKDNNVEFDSDEETPPSFA 46 
Q2YDS5       198 TEQRRRELDHYLKLKSSGWLQDRSGKWVKDENVEFDSDEEEPTLLP 243 zebrafish
5_pfamImport   1 SAERLRILRHHLHLRSQGWLQDAAGNWLKDENAEFDSDEEEPPPLP 46 
XP_011603538 193 SAQRRRELEHYLHLKSRGWLQDGSGRWTKDEDVEFDSDEEEPPPLP 238
XP_011410368 165 VVTSSNINSDYNRLRSSGWLPLSDGTWIKDPQVEFDSSSDDETSDE 210
EDO46534     342 SPSKKLRAEYLVRMRQQGWIMGNDGKWRRDQDAEFDSDEEEPPHPP 387
XP_002432255 213 SSKNRQDVNYHLKLFESGWIQDSNGKWIKDPNVEFDSDEEEPPKFF 258
XP_015192205 218 AAQRRQEMEHYLRLKSSGWLQDRSGNWVKDENVEFDSDEDQPPTLS 263
XP_002107820 206 HTTGNPLTTRYIQLRSLGWRLDANGNWFKDENVEFESDEEEPEPLF 251 Trichoplax adhaerens
XP_005996543 225 APEKRKLMEHYLRLKSSGWIQDGAGKWVKDENVEFDSDEDEPPTLQ 270 coelacanth
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