Conserved Protein Domain Family
DCAF17

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pfam15802: DCAF17 (This model is not part of the current CDD release)
DDB1- and CUL4-associated factor 17
DCAF17, DDB1- and CUL4-associated factor 17, is a family of proteins found in eukaryotes. It may function as a substrate-receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Mutations in the human protein, otherwise known as C2orf37, are responsible for Woodhouse-Sakati Syndrome. Woodhouse-Sakati Syndrome is a rare autosomal recessive multi-systemic disorder characterised by hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome.
Statistics
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PSSM-Id: 522032
Aligned: 13 rows
Threshold Bit Score: 517.698
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007253568  80 SYESGRIY---FENYRNCY--SSLTAEPQVLYELPRRSKAEKIEDSLLCQCPLEK----VLSQASQQKPFLLALTANNWL 150
1_pfamImport   1 MYENCKLY---FENYQHCY--SCVHAEPQILYKLPTRSKQEKIEDTLMCHSPVEK----SLSSPSDHKPSLLALTANNWL 71 
A8WHR0        73 SYESGRIY---FDNYRCCY--SSLLPEPELLYELPRTPKTEKIEDALLCQCPLEN----VLPNASEQKSCLLTLTANNWL 143 zebrafish
XP_015214453  83 DYEHGKIY---FENYRSCY--SSIPPKPQCLYELPNCSKSQKIEDALICQCPLDR----TLPSPSDRNPCLLALNASNWL 153
EDO48714      53 GFDCGHLF---LDKFRTSF--ST-NGKPKELYRMQPLRSSEKVESAVVFESPLDQqsfvSTVETKGFKSCVIGVTANGFL 126
XP_009031969  56 FYDNLIVFnnkLQKYSNIFskTCMKGI-KIKFKSISSSKYGKIEDCLFSQCPVED----VSYLESLEQPHFYVISQNNWF 130
XP_012826782  83 NYAKGRIY---FDNFRCCF--NSATPVPQQMYEMPRCSKLEKIEDALLCECPLGE----SLPHPSDYTPSLLAVTGQNWL 153
XP_008117078  76 TYQSGKIY---LENYRYCL--SSITPEPRIIYQMPACPKSEKIEDVLLLECPVGE----VLPNPSDYKPSLVVLTAHNWL 146
XP_011488071  61 TYESGKVY---FENYQNCY--SCIQAEPHSLYKMPKRSKHEKIQDALLCQSPLDT----TLPSASDHTPSLLALTANNWL 131
XP_005799456  61 MYDSGRIY---FDNYQNCY--SCVHDQPQNLYKFPKKSKQQKIEDALLCQSPLDK----TLSSPSEHKPCLLALTADNWL 131
Q5H9S7        60 AYERGRIY---FDNYRRCV--SSVASEPRKLYEMPKCSKSEKIEDALLWECPVGD----ILPNSSDYKSSLIALTAHNWL 130 human
XP_064419765  59 VYERGRIY---FDNYQCCF--SCANSSPKLLYKMPKCSKMEKIEDALLSECPVGE----LLPSLLDYKSSLITVTANNWL 129 coelacanth
XP_011608112  61 MYESGKIY---FENYLNCY--SCVHSVPQVLYKLPQRSKLEKFEDALLCQSPLGD----VLSNPSDHKPSLLALTANGWL 131 torafugu
XP_007253568 151 YCLSADTGETLQKVYLSSHFKF-RSLDWDISQETFYVKSVHRKQTAIARQ-AGTD----NVLMHLAIFTVFPLQVVGLLE 224
1_pfamImport  72 IRLSAETGEELQRVYLSPNYKF-RYLGWDVSQETFYVKSVQNKETPLARQ-AGITq---NTVMHIAIFHVFPLDVIGIME 146
A8WHR0       144 YLLSADTGETLQRVYLSSRFKFsRSLGWDSSQETFYVKSVQCKQTALERQ-AGVDn---NILMRVAAFQVFPLQLVGMLE 219 zebrafish
XP_015214453 154 YCYSAMTGEQLEKVYLSPRYKF-RYLCWDVPQETLCIKSVQNKQTSIARQ-TGPGq---DTLMCLAVFRVLPLELLGMLE 228
EDO48714     127 FRQDVDTGKRLQTVFLSRTIKF-KNIFWESDLTRLVIKSVHSK--PLPRViSGNNphvnNVLLHLALFDVAPLKFVALIP 203
XP_009031969 131 LRINCHTCTVDKELYMTDLCKF-KLIMWDVQEERLYLSATISEGg--------------KKTFVFALFSVWPLRFQGVFS 195
XP_012826782 154 LRISADTGEILEKIYLGSYRKF-RYINWDVPQETLVLKSIQTKSATVSQEdEGNTr---AVLFYLAVFSVFPLSLVGILE 229
XP_008117078 147 LRLSATTGEILEKVYLAAHCKF-RYLSWDTPQDVMVVKSIQQKHPGAARQ-AGVQq---SVLFVLAVFRVLPLSFIGMLE 221
XP_011488071 132 YRISSNTGKELQRVYLSPRFQF-RYLGWDVSQETFYIKSLQKKETPLERQ-AGISq---STVMHLAVFHVFPLQIVGILE 206
XP_005799456 132 CRISAETGKELQRIYLSPKYKY-RYLAWNVPQETFYIKSVQNKETPLARQ-AGISq---NVVMHMAIFHVFPLQIVGILE 206
Q5H9S7       131 LRISATTGKILEKIYLAPYCKF-RYLSWDTPQEVIAVKSAQNRGSAVARQ-AGIQq---HVLLYLAVFRVLPFSLVGILE 205 human
XP_064419765 130 FRVSVNTGEVLEKVFLSSLYRF-RYVTWDVPQESLVVKSAQNRQRAMVAQeAGVVq---SGVLCLAVFRVLPLSLIGMLE 205 coelacanth
XP_011608112 132 YRLSAETGEELQKVYLSPNIKF-RYLGWDVSQETVYIKSVQNKETSLERQ-AGITq---NTVMHLAIFHVFPLQIVGILE 206 torafugu
XP_007253568 225 ISKKVFGKSVVDVLLSQGVLAVSHSSKCVKLYSLEYIVKK-FrtteLVLGQQCDLY----------------GAKgTVGE 287
1_pfamImport 147 INKKVFGNGVIGADLVQGVLALYYSNKSVKMYSFEHIVQR-K----VTLGKQSPLL----------------GGK-TVGD 204
A8WHR0       220 INKKVFGKTAVDVLLSQGVLAVSHSSKLVRLYSFEYIVNK-FrteeLILGQQCELN----------------NARgIVGD 282 zebrafish
XP_015214453 229 ISRRVFGNNVVDVMLSQGILAISHSTGMVKLYSFENIVEK-FmikkLTLGEKCEWN----------------GIQgSVGE 291
EDO48714     204 IERSLFGSTITDATSSMGILFVMHRSGLIQLYSTQEIIDK-Ysq-iTDLGKPYTINtsacsnptseyhanniDGTgIVGS 281
XP_009031969 196 LSSKSFGFDMKEALLSENMLLVTSSDAMVRIF-----------------GLDCEFY------------------SkPVNN 240
XP_012826782 230 ITKHIFGSTVTDAMISHGMLIVMHSVGLVRLYSFERITEQ-FmkqkHVVGQVCSWK----------------GETgTIGD 292
XP_008117078 222 LDKKFFGNSMTDASMSDSMLIVTHSTGLVRLYSFQTISEQ-FmlqrVDLGQEYNWN----------------GKIgIVGK 284
XP_011488071 207 INKKVFGSGVTDVVLSQGVLAVSHSNKSVRLYSFVHIIQK-YltekLTLGQQSALL----------------EGK-TVGD 268
XP_005799456 207 INKKGFGSGVTDVVLSQGVLAVSYSNKSVKLYSFEHVVQR-ClieeLTLGQQSPLL----------------GHR-TVGD 268
Q5H9S7       206 INKKIFGN-VTDATLSHGILIVMYSSGLVRLYSFQTIAEQ-FmqqkLDLGCACRWG----------------GTTgTVGE 267 human
XP_064419765 206 INKNVFGNHVIDATISHGILIVMYRMGLVRLYNFQWITET-YtskkVMLGQKCQWN----------------GTTgIVGD 268 coelacanth
XP_011608112 207 INKRVFGNGVTDVVVSQGAIVVSYSNKSVKLYSFEHILQRhLte-rLILGKQSSLL----------------EGK-TVGD 268 torafugu
XP_007253568 288 VPY-GIPVNIQIKECPPVLFEMSYLDNGIQIGGHPWHYIYTPNHKKHKGTHHICSIRDGTLAKNGVQDMKCDSLEADWIF 366
1_pfamImport 205 APF-GIPLNIQITDCPPVLFKVSCAENSVQIGGNPWHYIYTPPRKKDEGTYHICSLKDGTMATNGVQEMDSYSLENDGIF 283
A8WHR0       283 APY-GVPVNICIHECPPVLFEMTYFENGVQIGGHPWHYIYTPNHKRHRGTHHVCSITDGALAKNGVQDMKCDSLEVDWIF 361 zebrafish
XP_015214453 292 SPL-GIPFNIQITDSPTLMFEVSCLESGFQIGGHPWHYIYTPRSKKHKGTYHICSLKDGQLAKNGIQDMNCCSLESDWIY 370
EDO48714     282 HPF-GIPVNVHMVSKPTLLLEVSSHQHSLSFGGFPWHFVVSPP--RQSSVFHVYSIKEKELVGNGIIKSDVLSVEPDQAY 358
XP_009031969 241 LKFeSLPVIPSIENYCRLLFEVPAPWDFFTVGGMPWHYIVFSS--FSQSQFSVQCLRTRTVAKDGKLNIKNALLDPDKCF 318
XP_012826782 293 FPF-GIPCNIKPTESLPFLFEVSCLENAFQVGGHPWHYIITPNKKKEKGTYHIRSLDDHSLAKNGIRDMSCCSLEPDWIH 371
XP_008117078 285 YPF-GIPYNIKITGAPDLLFEVSSLESTFQIGGFPWHYIITPNKKSQKGIFHVCSLKDHTLAKNGVQEMKCCSLEPDWIT 363
XP_011488071 269 APF-GIPVNIQIPDCPPVLFEVSCSNNGVQIGGFPWHYIYTPPHKTHRGTHHICSLQDHSMAINGIQNMNCCALESDGIF 347
XP_005799456 269 VPF-GIPVNIQITEPPPLLFEAF-SHNGIQIGGFPWHYIYTPPHKKHRGTHYISALKDSTLAKNGIQNMNCCSLESDVIF 346
Q5H9S7       268 APF-GIPCNIKITDMPPLLFEVSSLENAFQIGGHPWHYIVTPNKKKQKGVFHICALKDNSLAKNGIQEMDCCSLESDWIY 346 human
XP_064419765 269 TPF-GIPCNITVTDTPPLLFEVPCLENAFQIGGYPWHYIITPNKKKQKGTYHICSLENNTLAENGIQDMKCCSLECDWIY 347 coelacanth
XP_011608112 269 FPF-GIPRNIHITDCPPLLFEVLCSNNSVQIGGYPWHFIYTPPQKNHRGTHHVCSLKDCSLAINGVQSMSCNSLESDAMS 347 torafugu
XP_007253568 367 FHPDDSGRIIHAGPstinvlkiiegkevdtnye----vihdfsiitsrdrsatskVTVTSSGRTVKRRFQQLD---DDPE 439
1_pfamImport 284 FHPDDSGRIIHVGPpi-------------------------------------sqVTVTSSGRTVKRRFQQLD---DDPS 323
A8WHR0       362 FHPDDSGRIIHAGPstinilkimaetgcdwky-----eiitdfsitaardsnasqVIVTSSGRTVKRRFQMLD---DDPA 433 zebrafish
XP_015214453 371 FHPGDSGRIIHVGPskvnvlkiaetqenllqfe----viqeysieahrenkadslVTVTASGRTVRRRLHQLD---DDPE 443
EDO48714     359 FHADHSGRLLHICPhsirflklktlgdlgvgqlvldtcfsistrdnqsnrstkgqTSYTSSGRLVKCVSSDGY---HDPE 435
XP_009031969 319 FYPDSSGKIVKVSNdsvelynlksdgydkfnnp---tcsvellymldyseekrpvVTHTSSGRAIKKR--TFPgaiSENF 393
XP_012826782 372 FHPDASERIIHVGPdqirvlrlkelqndsyrhq----vcedfailatrdkevnkpVTVTASGRLVKKRFAQLD---DDPE 444
XP_008117078 364 FHPDSSGRILHVGPnlikvlklkevegntelqk----vtedfiiqasrenniensITVTSSGRIVKNRFNSLD---DDPE 436
XP_011488071 348 FHPDDSGRIIHVGPttikvlkilgeinsslps-----evvedfsmathrnaptpeVTVTSSGRTVKRRFHQLD---DDPG 419
XP_005799456 347 FHPADSGRVIHIGPntinvlkviselnsplps-----evledysltthrshpsprVTVTSSGRTVRSRFQQLD---DDPM 418
Q5H9S7       347 FHPDASGRIIHVGPnqvkvlklteiennssqhq---isedfvilanrenhknenvLTVTASGRVVKKSFNLLD---DDPE 420 human
XP_064419765 348 FHPDDSGRVVHVGPnqinvlrlketpetdhqhq----vtedfvilakreakllhsVTVTASGRVVKKRFEQLD---DEPE 420 coelacanth
XP_011608112 348 FHPDDSGRMIHVGPtiinvlklvsdlnndmqsr----vvkdfsmathrssnptqqVTVTSSGRTVKRRFHQLD---DDPD 420 torafugu
XP_007253568 440 QETFKMAKYEDELDLLAIVdVSpTAEDVGQASVRLYDNKSGGLMKRITLNEPWDVTYSHEVYLDRDTVIHIEQeRNNSFC 519
1_pfamImport 324 QKTFRMVEYEDELDLLAIV-VTnGEEGEGRACIQLHDNQTGQLLRTIDLIETWDETNKNEVFFDKDTIVHIEQ-KNAKFC 401
A8WHR0       434 QETFRMVKYEDELDLLAVVdIT-HAEDEGQARLRLHDNKTGALMKRVPLEEPWDVTYSHEVYFDRDTIIHTVQeKNNSFC 512 zebrafish
XP_015214453 444 QETFQCVEYEDELDLLAVVsVT-QTESEGKAHVGIYDNWSGVLMKSVPLVESWDVTYGHQFFFDCDTIIHIEQeKNHKFC 522
EDO48714     436 YDSIQDLDYEDELDLVAVL----SSRDCSSGYIGLYDNQTGVLVKEITL-DNWDDESEHSIMMERDLIVHICRtPFKKFS 510
XP_009031969 394 HSKVQLVICEIDMDIIGV--VTlSRCSSNVAAITFYEIDTGNYITKLEFAEAWDVNAEHDVKLDLDILYHYIK-TNSKHV 470
XP_012826782 445 QETFKIVVYEDELDLLTVVaVT-QTEAEGKAHVALHCNDTGKLLKNIVLLESWDVTHSHAVFFDRDTLIHIEErPNRNFS 523
XP_008117078 437 KETFQIVDYEDELNLLSIAaVT-QIGSDGSARLDLRCNERGTRLKSIPFVESWDVTYSHEVYFDRNVVLHIEQkPNRTFS 515
XP_011488071 420 QEAFRMVEYEDELDLLAVV-MTdGVEEEGRAHVLLHDNQTGRLLRKIDLVESWDETYQHQLFFDKDTIVHIEQ-KNSNFC 497
XP_005799456 419 QETFRLLEYEDELDLLAIA-VTnGEGEEGRAHVQLHDNQTGRLQRKIDLDEPWDETYPHELFFDRDTIVHIEQ-KGSQFC 496
Q5H9S7       421 QETFKIVDYEDELDLLSVVaVT-QIDAEGKAHLDFHCNEYGTLLKSIPLVESWDVTYSHEVYFDRDLVLHIEQkPNRVFS 499 human
XP_064419765 421 QETFKIVDYEDELDLLAVVaVT-QTESEGRAHIDLYNNQTGTLVKTVPLVEYWDVTYSHRIFFDRETVVHIEQkPNRIFC 499 coelacanth
XP_011608112 421 QETFRMVEYEDELDLLAAV-VTdGNEGEGRAHIQLYDNQSGQLLRNVALSESWDE------------Tfphelfldkdti 487 torafugu
XP_007253568 520 CHVYKM 525
1_pfamImport 402 YTDICS 407
A8WHR0       513 CHVYKM 518 zebrafish
XP_015214453 523 CHVYKM 528
EDO48714     511 CTLYRL 516
XP_009031969 471 LIVYRL 476
XP_012826782 524 CYVYKM 529
XP_008117078 516 CYVYHM 521
XP_011488071 498 CHVYKL 503
XP_005799456 497 CYVYKL 502
Q5H9S7       500 CYVYQM 505 human
XP_064419765 500 CYVYKM 505 coelacanth
XP_011608112 488 vhieqk 493 torafugu
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