Conserved Protein Domain Family
CCDC106

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pfam15794: CCDC106 (This model is not part of the current CDD release)
Coiled-coil domain-containing protein 106
CCDC106, coiled-coil domain-containing protein 106, is a family of eukaryote proteins. Yeast two-hybrid screening has identified CCDC106 as a p53-interacting partner. CCDC106 is a negative regulator of p53 and may be involved in tumourigenesis in some cancers by promoting the degradation of p53 protein and inhibiting its transactivity.
Statistics
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PSSM-Id: 522025
Aligned: 7 rows
Threshold Bit Score: 193.125
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011479210  82 FILVSNLRAHLYVSLEKNSWLQKRIEELEEERNFLRCQLNRFIVSMSPeatewcgDA----------------------- 138
4_pfamImport   1 MLTITKLQCLLESKQERINFLEKQVEDLQQDRKFLRSQIENLTSAKSI-------TE----------------------- 50 
XP_002664363 234 QLSLEQAKKTIEIQKEKILHLQEKVDFLMDDRNYLRSRLEDAL------------RL----------------------- 278
3_pfamImport   1 CCAMDGAEDKNLCASEKLEWQKKRIEELEGERDFLRSQLSSL-------------------------------------- 42 
NP_001357400  20 LALMNSVKTQLHMALERNSWLQKRIEDLEEERDFLRCQLDKFISSARMe-----aED----------------------- 71 
XP_029694684  71 YMVITNLRTQLQISLEKNSWLQKRIEDLEEERDFLRCQLDRFIFSTKSh-----gQEpgqsqysngyeprrftwrarred 145 torafugu
XP_006005150  81 QMFMTNLRNQLNLTLEKNSWLQKRIEDLEEERDFLRCQLDKFISSTKSda---vsEY----------------------- 134 coelacanth
XP_011479210 139 ---QRAVKVQPNCS---------PSPpspmttrsgmtlkrlqdSGPRTRR------------------NISvpvkqefhi 188
4_pfamImport  51 ---DSKPGKSLYSE---------SKPr----------------KRSRTAS------------------SSS--------- 75 
XP_002664363 279 ---RCETVSSPALT---------ASSs---------------tIVTSQKN------------------QST--------- 304
3_pfamImport  43 ---TKQPKDEPFND---------PFS-----------------SKASENS------------------DSS--------- 66 
NP_001357400  72 ---HCRMKPGPRRM---------EGD-----------------SRGGAGG------------------EAS--------- 95 
XP_029694684 146 erpAEQQKSNSQHFssrpfiqrrPGP-----------------PTMTPPKshvpsqltsqlvsinalfNSA--------- 199 torafugu
XP_006005150 135 ---ESRMKQNLR------------------------------------NG------------------NIS--------- 148 coelacanth
XP_011479210 189 kedkyytedeyveeEE-----------------------EEEAEEEEEDSSVEKG------------------------- 220
4_pfamImport  76 --------------SF-----------------------SNDSGSDISLTTVSSG------------------------- 93 
XP_002664363 305 --------------DT-----------------------SSDSSESTDSSDSEPT------------------------- 322
3_pfamImport  67 --------------SA-----------------------SSSVSSVWSSSSSSP-------------------------- 83 
NP_001357400  96 --------------DP-----------------------ESAASSLSGASEEGSA------------------------- 113
XP_029694684 200 ---------------QsqsllqghghgasaggggggsgqRSSMSEMSGHGSVGPAeplslvgesgeyleqdayldeeeli 264 torafugu
XP_006005150 149 --------------DD-----------------------EDGLGTQSPSSDAGCS------------------------- 166 coelacanth
XP_011479210 221 ---------SKKKGRARNAGEPRmkmRRIFRItHGRERQRVKDPDGVLIRYKKILTTYQRVRSMSRAFQIHGVDRNTMAS 291
4_pfamImport  94 ---------TSNDGKKKRHHKDK---RRGKKA-KDYSRKRATGVQYVIHRYKQVLSAFNKKKSMSGAFRHYGIDRNTIAN 160
XP_002664363 323 ---------AKKKKKGKK--SKR---QKKSKT-KMIDIKRVRTPEDSINRYNKVLQLVRDGLSKAEAYNKVKIDRNTIVK 387
3_pfamImport  84 ---------KKRKEKYKKKHSRA---KKPKK--EQKKFRQLQTPNDIVQRYKSLLKTFPKTKTMTKGFRKHGLDRNTVVS 149
NP_001357400 114 ---------SERRRQKQKGGASR---RRFGKP-KARERQRVKDADGVLCRYKKILGTFQKLKSMSRAFEHHRVDRNTVAL 180
XP_029694684 265 sgedvlsdvTINSNRPPVKR------RRLYR--APRERQRVKDAAGVLLRYKKILLTYQRLKNMSKAFQIHGVDRNTVAS 336 torafugu
XP_006005150 167 ---------ELDRKKLRGRGARG---KQPLRV-KVRDRQRVKDAEDVLCRYKKILTSFQKLKSMSRAFEYHGVDRNTVAL 233 coelacanth
XP_011479210 292 TSPIAELLLVAPEKVSEVGEFEASKEKLLDYARRCYKTM--DEETHAKVQSMKKTHKLLPISY 352
4_pfamImport 161 TAPIAELHLAAKEMLQVVGLFHPREETLVKYAQKCAVVIenDENLSRKIEQMKATGELLPITA 223
XP_002664363 388 QAPIAELATANPTEFKSLRATFKKGESVKKFANLCLTRCl-AQSNMEIIKQLKESNALLDIFK 449
3_pfamImport 150 TSSVGELAIAVPNVYQELLSNRPS-----------------SDEVKNKIESMKAAGTLLPIRR 195
NP_001357400 181 TTPIAELLIVAPEKLAEVGEFDPSKERLLEYSRRCFLAL--DDETLKKVQALKKSKLLLPITY 241
XP_029694684 337 TTPIAELLLVAPEKVAEVGEFDPSKEKLLDYARRCYTAL--DEETLSRVQALKKNNLLLPISY 397 torafugu
XP_006005150 234 TTPIAELLIVAPEKVAEIGEFDSSKERLLEYSKRCFMAL--DEETLMKVQALKRNKLLLPISY 294 coelacanth
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