Conserved Protein Domain Family
DUF4704

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pfam15787: DUF4704 (This model is not part of the current CDD release)
Neurobeachin/BDCP, DUF4704 alpha solenoid region
This domain of unknown function is found in eukaryotes on neurobeachin and BEACH domain-containing proteins (BDCPs). Mutations in this proteins are associated with Lipopolysaccharide-responsive and beige-like anchor (LRBA) deficiency. According to structure prediction is adopts an alpha-helical solenoid structure.
Statistics
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PSSM-Id: 522019
Aligned: 16 rows
Threshold Bit Score: 390.119
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002683233 1373 DIHQAMLNSRILNGTQLCVTHNAKDIIGCLGGIKVLFPLFLQMDRLSHTDQVISE-------KADPFLVNTLFSLIIDLL 1445
5_pfamImport    1 TADKHCCEATVMAGTQLCSRRLFQHIIYCVGGVSVFFPLLNQFDSITEKSKSEQEecsmlksILRERLAAEVIELIASVL 80  
XP_004345297  507 WFSAESSGAILLNGSRTVVTHSYHHALESIGGIQTLFPLVSQFDHADQPRD--GAlgi--vyEPDPAYSLTLLSLFAETL 582 
A8XSV3        546 TYFVQIPHAVMKEGVEVITTHSIHKSLQSVGGIQILLPLFAQIDLPSSHD---NT--------IDGDVCQTLLSLISLLL 614  Caenorhabditi...
EFJ20988      568 QSDAVSHEATIMSGTQLCYRCLVQNNIHCVGGITVFFPLLTRFRHAGKDFDGSVT-------DADDYYLADVIELLTAVA 640 
2_pfamImport    1 ALDKNSFEATVMLGTQLCSRRLLQQIIYCVGGVSVFFPLFSQSDRYENVESGKLEhtl-ltpITKERLTAEVIELIASVL 79  
XP_002886711  692 LQERLAFEADIMVGTQLCSRRLLQQIIYCVGGISVFFPLITQSDRCESEALKEETsa----mPLKERMTAEVIELIASVL 767 
XP_020427426 1545 NIGGDRNYDATLVAINPCVSRDIKDIIYCLGGIKVLFPLIPQLNQTLADPQLDST--------SSSKLTIQVLGLFKDML 1616
XP_025881949 1303 sADRSTFEATIMGGTKLCSRHLPQDIIYCVGGVSVFFPLFSC--NAVTDGEQSCHt-----sVINGKLRAEVIELVASVL 1375 Japanese rice
KAF8356627    640 AHYVQIAHAVMKGGVEVIRTHSLQSSLQSVGGMQMLLPLFDQLDAEVEE----GDg------EEAIDLCATLLSIVTRLL 709  Pristionchus ...
XP_002683233 1446 SAHNDNLEDMARCRGFLVISFLLKQISPQHLTRNTVALIPSLLSCAKD--------HSVLYSDIVNYLVFNFRLWIYTDV 1517
5_pfamImport   81 DDNLANQQQMHLLSGFSILGFLLQSVPPRQLTLETVSALKRMLTVVGNsg-----mSKILLPDSISRIFLNAHIWIYTDY 155 
XP_004345297  583 AASTTSQSQLDQHRGFTVLAHLLDDVLPTNMSRQVLEVLLQLAQSLRKaaetnslaAQSLFRDLFDQVLFRFNLWICSDV 662 
A8XSV3        615 SSSQSSQQQLFHSKGFLIISSCLQEASPSHLSMKVLEQIIHIAKFLLRcp-----aGGPLLKHLFDYILFNPKLWIRARP 689  Caenorhabditi...
EFJ20988      641 TKNYVNQKVLHSTGGLGLLGYLLQFVSIKQLSVKVITALNNLLCVLSEtad--nalSDLLVRETVLKVYLNPSAWIYAPY 718 
2_pfamImport   80 DENSANQHQMHLLSGFSILGFLLQSVPPVQLNLETLSALKHMFNVVAScg-----lSELLVKDAISSVFLNPLIWVYTVY 154 
XP_002886711  768 DENPANQQQMHLLSGFPILGFLLQSIQPKQLNLETLSSLKHLFNVISSsg-----fAEQLVEDAISSIFLNPHIWLHAAY 842 
XP_020427426 1617 RGSEANQEEMLRCNGLAVLSYLLQTIPPENLTLGALNIFKDMSNQI----------SEPSLVEEVYSLLLDFRLWIKTRF 1686
XP_025881949 1376 DANVSNQQQMYLLSGLSIMGFLLQSATPKLLNIETLSALKYMFDVLRNcg-----mSKVLLKDAILQIYLNPQIWVHSSY 1450 Japanese rice
KAF8356627    710 ECSYTFQQQFVHARGVLIIAHALQKSDPRHLTVEVVQCIASLARLCNSaa-----sGPVLLRHLLDHILFNPKLWIMADP 784  Pristionchus ...
XP_002683233 1518 EVQKLLFQQLLDISNEKKDNFTKIREILgvqKLLDLMRWFYWYERa------------------------------KSNS 1567
5_pfamImport  156 VVQRELYMFLVQYFDKDSHLLTSLCRLP---RIIDIIRQFYWDKS-------------------------------KGRS 201 
XP_004345297  663 AVQKRLLGVLASDLVRTESV--NVRSLIgvqRLMDLISNFFWLPDpataaaaaaisatteppasraepapdnedetQSPT 740 
A8XSV3        690 EVQVHLYQYLATDFLANNNFSQMLRRVPtviEMCHTLKHFYWLALp------------------------------QTVS 739  Caenorhabditi...
EFJ20988      719 VIQRELFLSLINFLENRK--YDNVCGVS---RFLDMLHQFYWD---------------------------------KPKH 760 
2_pfamImport  155 KVQRELYMFLIQQFDNDPRLLKSLCRLP---RVIDIIRQFYW-GNa------------------------------KSRS 200 
XP_002886711  843 NVQRELYMFLIQQLDNDPRLLGSLCRLP---RVIDIVWNFYWESEry---------------------------ckGSKP 892 
XP_020427426 1687 EVQKSLMVMIKQIIFDK---HDQVKDIItvqVMLDIMANFYWYEFa------------------------------ESSA 1733
XP_025881949 1451 EVQRDLYMFLLKYFETDGRFLPLLCGLP---RIIDIVCQYYSEYV-------------------------------DCRC 1496 Japanese rice
KAF8356627    785 AVQIQFYSYLSLDFMANSKFPEHIKRVAtviEMCHTLKHYYYVVAa------------------------------RYPS 834  Pristionchus ...
XP_002683233 1568 TESEYQLGTekicnpatgavlgQRP---SQENIYEIRQKLTKLLKCLTSKSaeivivnnderlttttgtvlttatsISYP 1644
5_pfamImport  202 AFGSKPLLHpvtg-----eiigMRP---SRQEVQKLRLLLLSLAEMTLRQH-------------------------ISAS 248 
XP_004345297  741 GAARYQLAGqpvlhpvtkravaQRP---NTSDIVELRMIVLTIIKQLVLDGs-----------------------gITAD 794 
A8XSV3        740 DYTVE-----------------ERPenfATAEIVSIRSAILTFINRIIISSnspd-----------------eeekARDQ 785  Caenorhabditi...
EFJ20988      761 RKMSKTVGTr------------DRP---RQEELSQLRILILSLAETAIRNH-------------------------MSLS 800 
2_pfamImport  201 AIGSKPLLHpitk-----qvigERP---SKEEIRKIRLLLLSLGEMSVRQN-------------------------IAAS 247 
XP_002886711  893 LMHPARTIE-------------ERP---SRDEIHKIRLLLLSLGEMSLRQN-------------------------ISSG 931 
XP_020427426 1734 ILTSKDILQ-------------KRP---NQSDITDLRQVIFEIIRQLLRNP--------------------------TTS 1771
XP_025881949 1497 AVGSKSLLRtgnk-----qvvgDRP---KIEEICKLRLLLLSLAEMSLKLQ-------------------------VCLA 1543 Japanese rice
KAF8356627    835 DWIPE-----------------QRSktlSTENIITIRGSLLGLINKLILLGipdkea--------------ivpspMRDQ 883  Pristionchus ...
XP_002683233 1645 ELEAIINLL---ADCNDNMQYSDVVIFVLELLLSPD--GVVIAdMLANMKAYQVFVQLLYTHHEPTRLNILKCIGQMLIL 1719
5_pfamImport  249 DVKSLIAFF---EKSEDMVCIEDVLHMIIRATSQKSllTSFLE-QVSLHGGYQIFLNLLHRDLEPVRLQGLQFLGKLLVG 324 
XP_004345297  795 ELSAILNYIvanLSINQEWHVIDAVELILTLMCDHP--EPILG-LFEQQNGIQVALSLLSAKSVPVRGFGLKILGKLLSW 871 
A8XSV3        786 EIHTLLNLL---ATVREDDNLYDVLALVTRLLAEHP--AIMIP-AIDKNKALGIIFNLLAAPNELIRIPALKILGFFLSR 859  Caenorhabditi...
EFJ20988      801 DAKSLISFI---DRNDDLICVEEVLQMLLGLLGEPIflSSFLE-CVHSLGGIHIFLNLLSRRQEVIRLLALHVLGSLFLA 876 
2_pfamImport  248 DIKALVAFF---ETSQDMACIEDVLHMVIRAVSQKSllASFLE-QVNLIGGCHIFVNLLQREFEPVRLLGLQFLGRLLVG 323 
XP_002886711  932 DVKALTAFF---ETCQDVACIEDVLHMVIRAISQTSvlVSFLE-QVNLIGGCHIFVDLLQRDYEPIRLLSLQFLGRLLYD 1007
XP_020427426 1772 DVAAIARYT---IYTMDKTQVIEMIEFLIDLLSKSSf-QQFFD-ELEKIGSTDIFLTLMSNKDEAVRGAALQLISKLHLT 1846
XP_025881949 1544 DIRALASLF---ERNQDVACVEDILKMIIRALSEGPvlSSFLE-HVNCLGGCCIFINLLKRESEPVRLLGLQLVGKLMAG 1619 Japanese rice
KAF8356627    884 EIHVLLNLV---STVHENDNLYDVLALVNRLLCDYP--QLLIP-ALDRDHAIGMIFSLLAKPSPLIRIPALKLLGHFLAR 957  Pristionchus ...
XP_002683233 1720 NPKLRQR--------------------VFAETSYGFS-TITNILTIFN--ITIQTYGVLRDIFLGCISLNqrdiL---EF 1773
5_pfamImport  325 LPLEKKGprlfnlavgrskslsesnrrVNPGSQTLFS-AISDRLFMFP--PTDSLYATLFDVLLGGASPK----Q---VL 394 
XP_004345297  872 LPTKRAD--------------------KLIQQHQLFS-LISTTLSMYSteLDKTTYNALFEIMLNQVTKQ----L---VP 923 
A8XSV3        860 STLKRKT--------------------ESMGSQNLFS-LIGERLLSHKrtISLPTYNVLLEVLVEQMTPT----F---TY 911  Caenorhabditi...
EFJ20988      877 IPVERKSiwlfgigg-----nkgqgdtVISRQKDLVWsIIKERLLQFP--FTDSLRVTLFDLLLGAAIPK----Q---VR 942 
2_pfamImport  324 LPSEKKGpkffnlavgrsrsasesqrkISLRMQPIFF-AMSDRLFRFS--LTDNLCATLFDVLLGGASPK----Q---VL 393 
XP_002886711 1008 VPSERKGpkffnlavgrtkslsqghkkIGARTQPIFL-AMSDRLFQYP--QTDNLRATLFDVLLGGASPK----Q---VL 1077
XP_020427426 1847 SHANNQTvsnnk----------ltlkkKVKSIFQDSI-IIARSLHLFP--LTEYTYRYLMAFALGFNVEPvnfnI---TM 1910
XP_025881949 1620 IPSEKKGaklftlpigqsrplsdnsknEITAASHLFFyTISERLFKFP--LSYNLCAAFFNVLLGGTSPI----KvlqEY 1693 Japanese rice
KAF8356627    958 STMKRKT--------------------EAVGANNALA-LLSDRLAMHTphLAMPIYSVLFEILTEKMTPQ----Q---MY 1009 Pristionchus ...
XP_002683233 1774 DGFEQTEQS-----------YKVQ--AVLQPIFRLLVNTQPn-----vKHHILQNFKIVLKSNRA-KDCLLQQVgWQEWL 1834
5_pfamImport  395 QKHNQPEKQknkknshndtgSHFVipQILVLIFKFLSCCKDis----tREKILSDLLDLLETNHSnIEALMENA-WSSWL 469 
XP_004345297  924 DRFVSRDAT-----------SRIAhpGVLRTLFDLVTHDSSsagtttlFRL-LGDLVMLLSHEPDnRRIFLAFPnWQNWF 991 
A8XSV3        912 AAHQPAQPD-----------WKFEnpHLLKVIAHVISQCEEteslvqiKKCFLIDIINLCRESKEnRRTILQMSvWQDWL 980  Caenorhabditi...
EFJ20988      943 ENDFETSISagnpa-htatfPEFFlpQVLGVLLKFVEASDDwt----sRQDVLKDILALIQTNPAnCGVLLQEPgWQDWL 1017
2_pfamImport  394 QKHSHVDKHrsk-----assSHFFlpQILVLIFRFLSGCGDas----aRLKIMTDLLDLLDSNPSnIEALMEYA-WNAWL 463 
XP_002886711 1078 QKHNQVDKHrsk-----psnSHFFlpQIFVFIFEFLSGCKDgl----aRMKIISDILDLLDSNPMnVEALMEFG-WSAWL 1147
XP_020427426 1911 TLEDLMADH-----------VNIVfpEIIGAILKLLPTAESii----lRQLILQNIKVLMGNNAAnRTSLLQIDkWPEHL 1975
XP_025881949 1694 SQSEQSKNKscst----shlVPFFlpQILVCIFRYLQSCQDss----aRIRILSELIGLLDSNPTnIEALMEHS-WNYWL 1764 Japanese rice
KAF8356627   1010 TDHMPPPKD-----------SRFEnpSLLKVISQLLINSDDsqeamtvRKTFLIDLITMCKDSREnRRTILQMSvWQEWL 1078 Pristionchus ...
XP_002683233 1835 LNIICVSGI----------------------------------------------------------------------- 1843
5_pfamImport  470 LTSASLEVI----------------------------------------------------------------------- 478 
XP_004345297  992 VTFLKSVTRvqdcgfsahhlvnpaaahssvlvvsgnrqsaapasarpasptpppadpssssdaslpptptppgaaaaaqs 1071
A8XSV3        981 IGLAYVFHT----------------------------------------------------------------------- 989  Caenorhabditi...
EFJ20988     1018 FAVFSSASS----------------------------------------------------------------------- 1026
2_pfamImport  464 TASMRLDVL----------------------------------------------------------------------- 472 
XP_002886711 1148 TASMKLDVI----------------------------------------------------------------------- 1156
XP_020427426 1976 FSVLNDAEI----------------------------------------------------------------------- 1984
XP_025881949 1765 ETSTKLDVL----------------------------------------------------------------------- 1773 Japanese rice
KAF8356627   1079 IQLAYVYPL----------------------------------------------------------------------- 1087 Pristionchus ...
XP_002683233 1844 ---SDASipsdvgqsaQfELCKDIVIELIAILLYHSLKTVKKGWRD----------IEDTICQVIL 1896
5_pfamImport  479 ---RNYKtktqvqvanSkISEEILVRKLYVVVLFHNLCLVKGGWQQ----------LEETWTFLVL 531 
XP_004345297 1072 fsgSAAPaaivasaaqEnLQCAELICTLFRVLLCHALKNEREGYQV----------WVDTIAVFKH 1127
A8XSV3        990 ---SESQ-----------NEVSELVWEAFSILLHHALRHEYGGWRV----------WVDTLAIAHS 1031 Caenorhabditis briggsae
EFJ20988     1027 ---RKQKedq---dskRwADEVLLIRKIFCALQVHAVFNTKGGWRQvermtvyvlkYTEQVCCSHK 1086
2_pfamImport  473 ---KIYKvesriqsdtE-INEQNLVRNLFCVVLCHYTLSVKGGWQH----------LEETVNVLVM 524 
XP_002886711 1157 ---KDYRsellnhddlA-LNEQHFVRGLFCVVLCHYILSVKGGWQQ----------LEETVNFILL 1208
XP_020427426 1985 ---KNDQ---------QySNVTDLIIDIMKILSIHSL-TEAKGYKT----------LEQILATLRP 2027
XP_025881949 1774 ---KEYSlvskgeldnVeIDEVILVRKLYALVLAYYLSAVKGGWHQ----------LEDTVNYFLL 1826 Japanese rice
KAF8356627   1088 ---DEAQ-----------SEICELVYDLFNILLHHAIRHEYGGWRV----------WVDTLAIAHS 1129 Pristionchus pacificus
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