7PW4


Conserved Protein Domain Family
SMG1

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pfam15785: SMG1 (This model is not part of the current CDD release)
Serine/threonine-protein kinase smg-1
SMG1 is a family of eukaryotic proteins. In humans this family acts as an mRNA-surveillance protein. In C.elegans, SMG1, a phosphatidylinositol kinase-related protein kinase, is a key regulator of growth. Loss of SMG1 leads to hyperactive responses to injury and subsequent growth that continues out of control. It has an antagonistic role to mTOR signalling in these worms and possibly also in higher eukaryotes.
Statistics
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PSSM-Id: 522017
Aligned: 7 rows
Threshold Bit Score: 810.28
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7PW4_A        627 MWALSPTVFALLSKNLMIVHSDLAVHFPAIQYAVLYTLYSHCTRHDHFISSSLSssspsLFDGAVI-STVTTATKKHFSI 705  human
XP_001963716  557 MYACKPSILELLLTNCRAQDLALWSRYPSTHQAIINLLVVHCQANHNFRTNSSL-----LRDQEQPlSENTSPTANNFAT 631 
XP_002067384  603 MYACKPSILELLIRNCRADDLALWSRYPGTYEAILNLLATHCQANHNFRTTSSL-----LRDGNIQnPEHTSPTAQSFET 677 
1_pfamImport    1 MWALQPSIFELLSTKL---DPTIIKMNDPLRFSLMFLLYSHCKKHNNFVASSRLvtagrTSEKSQQnVEINSHKSGNLVK 77  
C5J7W8        622 MWALSPTVFALLSQNLVIVHSDLAVHHPAVQYAVLYTLYSHCTRHDHFISSSLSssspsLFDGAVI-STVTTATKRHFST 700  zebrafish
XP_414907     630 MWALSPTVFALLSKNLMIVHGDIAVHFPAVQYAVLYTLYSHCSRHDHFISSSLSssspsLFDGAVI-STVTTATKKHFSI 708 
Q70PP2        571 MYACKPSILELLLTNCRAHELKFWSKYPAAQQAIFGLLVVHCQANHNFRTNSSL-----LRDQELS-AENTSPTANSFAS 644  fruit fly
7PW4_A        706 ILNLLGILLKKD-NLNQDTRKLLMTWALeaaVLMRKSETYAP-LFSLPSFHKFCKGLLANTLVEDvniCLQACSSLHALS 783  human
XP_001963716  632 ILRFLAAVLENAgLLNPQNLRQLLQWLQ---VLLNECRDRCDlLLDQEQFLSICRSLVTTACKWS---PQESAACIQIVL 705 
XP_002067384  678 IIGFLARNLEHSlQLTQQNLKLLLRWTH---SLLDECRERAStLLEQPDFMSICRSVAQIATKWG---LLEAAACIQSVL 751 
1_pfamImport   78 ILNIFEKYLKR--NVNVDCKLLVLKWIYe-lLMHADSASYLNiILLSPEMINIVRSLIYVALKRNeilLFDGIAQILNIV 154 
C5J7W8        701 LLNLLGMLLSKD-HLNPEARRLLLTWSLevaLMMKKSETYAP-LFSLPSFLKFCKGLLANSLNEDttiCLQACNSLQVLS 778  zebrafish
XP_414907     709 ILNLLGLLLKKD-NLTQDTRKLLMTWALevaVLMKKSETYAP-LFSLPSFHKFCKGLLANTLLEDvniCLQACSSLHALS 786 
Q70PP2        645 ILRFLDSVLGQAhQLAPQNLRVLLQWIQ---MLLRECREKIDlLMEQENFRGICRNIAATASKLV---PLESAACIQTVL 718  fruit fly
7PW4_A        784 SSLP------DDLLQRCVDVCRVQLV-HSGTRIRQAFGKLLKSIPLDVVLS-----------------NNNHTEIQEIsl 839  human
XP_001963716  706 DYGPekqehlLELLTLYRDMALQQLQ-VLSPNGHTPFSQIYAKLPLRITLTggdtpipgmssrrvcvwQQRMSQCSAV-- 782 
XP_002067384  752 GYGLts--qqDPLLLLYRDAALQQIKwILASNQLTVFAQIYAQLPLHVTLFaggvps-----priclwQQKISQCSSV-- 822 
1_pfamImport  155 LGNPtfcqskPLIVVDILDLCLSCIN-LTEHDISKQFYALIHKISLITVLQnvsicslknkskfnkkiNQMMSShmrrk- 232 
C5J7W8        779 SSLT------MELLQRCVDVCRVQLV-HSAVRVRQAFGKLLRSVPMHVALS-----------------AHSHSEIKEIsl 834  zebrafish
XP_414907     787 SSLP------DDLLQRCVDVCRVQLV-HSGARVRQTFGKLLKSIPLDVVLS-----------------NRNHTEIQEIsl 842 
Q70PP2        719 DYGLerlekyPKLLILYRDTALQQLQ-MLSTNYHAPYFQIYAQLPLHLTLTggessmpgmasrrvsvwQQRISQYSAV-- 795  fruit fly
7PW4_A        840 alrshmskapsntfHPQDFSDVISFILYGNs-hRTGKDNWLERLFYSCQRLDKRDQS--TIPRNLLKTDAVLWQWAIWEA 916  human
XP_001963716  783 --------------RDSVFRDFFERLQHPE---QQPLTNSLRDLFVRSCQVAPQDERqeKLSQCTRRCQRLATAWMQFEA 845 
XP_002067384  823 --------------RDTVFREFFEHLQQSE---QQQLNQSLRDLFVRSCQISAMDERqeMLSHCIRRCQRLAAAWMQFEA 885 
1_pfamImport  233 ---------avvtlKTEYFKNYMCEMIEPNtnnNDSTTHWLLDVVNSCSFDIDSGET--ELLSHAQHCRVFLYFWINWEA 301 
C5J7W8        835 airrhmskvpsntfHPQDFSDLIGFILYGTv-hRGGKEPWLERLYHSCQRLEKKDSA--MVPRALLKTEAVLWQWAVWEA 911  zebrafish
XP_414907     843 airshmskapsntfHPQDFSDVISFILYGSt-hRTGKDNWLERLFYSCQRLDKRDQP--TIPRNLLKTDAVLWQWAVWEA 919 
Q70PP2        796 --------------RDNVFRDFFDRVQKPE---QDSLIHCLRELFVRSCQVAPQDERqmNLSQCTKRCQRLAIAWLQFEA 858  fruit fly
7PW4_A        917 AQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQDVSQWTT-----ADNDEGHGNNQLRLVLLLQYLENLEKLMY 991  human
XP_001963716  846 ARYCVDQRLRTTLGKPQETFLGFEAIIMRHARQLSGCGKEEERAALd----TLTLEELSNMQSNLVLMLGFLDALEKLIY 921 
XP_002067384  886 ARYCVDQKLRTTLGKPQDTFLGFEAIIMRHARMLSGCAKEAERIDPd----GLSLMQLSNMQMNLNMLLGFLDALEKLIY 961 
1_pfamImport  302 ANFCVINRLRTPFGKPNSTFRAIEGGIKMWARD--------SISALndetkVKHTEGKLNNLRYTRNLVAFIECLEKSVC 373 
C5J7W8        912 AQFTVLSKLRTPLGRAQDTFQTIEGMIRSLAAHSLNTEQELSQWSG-----GESDEGHHTNQLRLALLLQFLENLEKLMY 986  zebrafish
XP_414907     920 AQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQDVSQWTT-----ADNDEGHSSNQLRLVLLLQYLENLEKLMY 994 
Q70PP2        859 ARYCVDQRLRTTVGKPQETFLGFEAIIMRHARLLSGCAKEIERSALd----DLSLEELLSMQSNLSLLLGFLDALEKLIY 934  fruit fly
7PW4_A        992 NAYEGCANALTSPPKVIRTFFYTNRQTCQDWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTem-ktTSLSQGNELEVTIM 1070 human
XP_001963716  922 NAAEGSAFALRPPEKPVAAFFRLNNPTCQSWFNRIRIGVVIIAVHVQQPELVIRYAQKILL-----TQKAQDATYSQAIV 996 
XP_002067384  962 NAAEGTAFALRAPEKPVSAFFRLNNPTCQSWFNRIRIGVVIIAMHSQQPELVIRYAQQILV-----TQNPQDCSFSQAIV 1036
1_pfamImport  374 NAIDGTATALPTAQKPVRHFFHTNRNTCYEWNSTIRSAMLAVALNSGLSSSAIRHGQYLVHhl-tkQSEFPVKEFILAII 452 
C5J7W8        987 NAYEGCASALTAPPKGIRTFFYTNRQTCQDWLTRIRLALMRVGLLSGQPAVTVRHGFDLLTei--kNSSTQGPEMEVPVT 1064 zebrafish
XP_414907     995 NAYEGCANALTSPPKVIRTFFYTNRQTCQDWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTemktnNSLSQGNELEVTIM 1074
Q70PP2        935 NAAEGSAFALRPPEKQVAAFFRLNNPTCQSWFNRIRIGVVIIAMHVQQPELVIRYAQQILV-----NSKTQDPTYSQAIV 1009 fruit fly
7PW4_A       1071 MVVEALCELHCPEAIQGIAVWSSSIVG-KNLLWINSVAQQAEGRFEKASVEYQEHLCAMTGVdCCISSFDKSvltlanag 1149 human
XP_001963716  997 YLAWAWVCCQESDSLRGLYLWARSKSS-KSFQWLQCAADQAGGRKDAALAGYRSLLNETEEQpPELDTHTRQ-------- 1067
XP_002067384 1037 YLAWAWICCQEADSLRGLYLWARCKVSgKTFQWLHCAADQAAGRKETALSGYSQILAEDD---AELEPHTRQ-------- 1105
1_pfamImport  453 QLAWAYSKLKESDCIRGLYVWSKEVAH-LKLPFLNILADQASGKFEEAAESYMNLLTTnsdqiiiylkgggg-------- 523 
C5J7W8       1065 MLVEALCELRCPEAIQGLAAWSLANTG-KSMGWLSSVALQAEGKFEKAALEYQEQLCAVTGMdCSIKVFDRSllkltgtn 1143 zebrafish
XP_414907    1075 MLVEALCELHCPEAIQGIAVWSSAVVG-KSLTWINSVAQQAEGRFEKATAEYQEHLCAMTGVdCCISGFDKTvlklansn 1153
Q70PP2       1010 YMAWSLVSCQEADSLRGLRLWARGKSC-KSYKWLKYAADQAAGKRESALAGYRTILAEKELQ-SELEPHTRQ-------- 1079 fruit fly
7PW4_A       1150 rnsaspkhslng-esrktvlskptdsspevinYLGNKACECYISIADWAAVQEWQNSIHDLKKS-TSSTSLNLKADF--- 1224 human
XP_001963716 1068 --------------------------------FVVAQMMQCLQDTGQWSQLVELKQRQLTRPED-SERNPFLQQSNVevs 1114
XP_002067384 1106 --------------------------------FVIAQKMQCLQDLGRWSRLVELKQKHLNRPED-SELNPFLQRSNVevs 1152
1_pfamImport  524 ------------------sinniegplevlqkFIIEQLKECYMSICDWKPLMDWSQNEENLIPSiAKDKYFWQNRYVs-a 584 
C5J7W8       1144 tsspkhtssge---grktvllkssecspevlnFLANKACECYVALSDWESVQEWQASMMNLKKN-SSSSSVNLKTDF--- 1216 zebrafish
XP_414907    1154 svnnaspkhslngetrktvltkpsdcspevinYLGNKACECYISIADWSAVQEWQNMVHDLKKS-TSNTSINLKADF--- 1229
Q70PP2       1080 --------------------------------FVVSQMMQCLQDLGQWSQLVELKQQQMTRPED-RELNPFLQRSNVevn 1126 fruit fly
7PW4_A       1225 NYIKSLSSFESGKF 1238 human
XP_001963716 1115 ALERLLAKSEEQSA 1128
XP_002067384 1153 ALEKLLAKSEELSS 1166
1_pfamImport  585 NDLQIVNDVEEGNY 598 
C5J7W8       1217 NYIRSMSRFEEGDF 1230 zebrafish
XP_414907    1230 NYIKSLSSFESGEL 1243
Q70PP2       1127 ALERLLAKSEESCS 1140 fruit fly
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