Conserved Protein Domain Family
GPS2_interact
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pfam15784: GPS2_interact (This model is not part of the current CDD release)
G-protein pathway suppressor 2-interacting domain
GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.
Links
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Statistics
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PSSM-Id: 522016
Aligned: 7 rows
Threshold Bit Score: 103.477
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_015793204   11 YYPGVEAISPALPS-EESQPDYSstfRTSKDELLQNIDKIDREISQTETQISELKERKKQLELKAVSRDSVKDVRENVDN 89  
EFN66084      133 YTPQTEAISPTLPE-PNTQEDAL---RSTKDELLQQIGKVDREIAKRENQLNMLRKRIKELEEAANKPLEATGLKRNIEE 208 
3_pfamImport    1 YNPQVEAISPTLPT-DAAALQEDanfRSTKDDLLHGISKVDREITKTELQISKLKKKQQELEQAAKKPAIKQEEEEIPQP 79  
KAI2568667     62 LTGKLEPVSPPSPP-HTDPELELvppRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKP---PEPEKPVSP 137 
NP_001007033  140 SIGKIEPISPVSPV-PMEADLDLvpsRLSKEELIQNMDRVDREITMVEQQISKLRKKQQQLEEEAAKP---QEPERTISP 215 
NP_001193583  141 LTGKLEPVSPPSPP-HTDPELELvppRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKP---PEPEKPVSP 216  human
XP_063125776  150 FGGKHEAPSSPLAGqPCGDDQNAspsKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKP---PEPEKPVSP 226  Norway rat

XP_015793204   90 S-SETRQLSIAQH 101 
EFN66084      209 QsQQPKHQSLAQK 221 
3_pfamImport   80 K-----HHSPAQK 87  
KAI2568667    138 PpIESKHRSLVQI 150 
NP_001007033  216 PpSEAKHRSLVQI 228 
NP_001193583  217 PpIESKHRSLVQI 229  human
XP_063125776  227 PpVEQKHRSIVQI 239  Norway rat
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