Conserved Protein Domain Family
FSIP2

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pfam15783: FSIP2 (This model is not part of the current CDD release)
Fibrous sheath-interacting protein 2
FSIP2, fibrous sheath-interacting protein 2, is the C-terminal portion of a family of proteins found in mammals. The function is not known but the domain appears to be repeated up to 10 times in some members.
Statistics
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PSSM-Id: 522015
Aligned: 15 rows
Threshold Bit Score: 1485.77
Created: 17-Feb-2025
Updated: 25-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5CZC0        5901 SSDKIPSIDKTLVNKVVHSSVCNILNDYGSQDSIWKNINSNGENLARRLTSAVINEIFQRQVNLIFCDEVSVSACLPLES 5980 human
6_pfamImport     1 SSEKIPSVDKTFVNKVVHSSVCNILKEYKSQDSICKNINSDGENLARQLSSAVINEIFQHQLNLIFCDDIPVSACLPLES 80  
XP_051705327  5912 FLDKMLSIDKTLVNKVVHSSICNILKEYKSQDSICKNINSNGEDLAKKLTSAVINEIFQHQLNLKTCDNVPVSACLPLES 5991
A2ARZ3        5998 ALEKIPSIEKSIVNKIVHSCVCNIFKECKSQESICENINSNGENLAKRLTSTVINEIFQHQLNLIFSDEVPASACVPLES 6077 house mouse
2_pfamImport     1 SLHRMPSIEKSVVNKIVHSCVCNVLKECTSQESVCKNINSNGENLAKRLTSTVISEIFQHQLNLMFSDEIPASACVPLES 80  
1_pfamImport     1 FLDRIPAIDKTLVNKVVHSSVCNILKEYRSQDSLCQNIKSNKGNLARKLTSTVINEIFQQKLNLEPSDEVPSSACLPLEC 80  
4_pfamImport     1 FIANMPSISKSLVNKVVHSSICNILLEYGSQGSICGDINSNGNKLARRLASAVIEEIFQHQLDFLLCDVAPSSVYLPLES 80  
5_pfamImport     1 LMAKMPSTYKTLVNKVVHSSVGNILQEHRSQSSICEIINSNGENLARRLSKAVLDEMFQHQANLLTYDEVPPSICLPLES 80  
XP_038320735  5821 SMANIPSSDKRLVNKIVHSSICNILREYRSQDSIYKDINSNGENLARKLANAVIEESFQHQLNLLLYDDVPAAACLPLES 5900
10_pfamImport    1 FMAKIPSIDKMLVNKVVHSSICNILQDYRSQDSICEDINFNVEKLAKRLANAVIEEILQYQLNLLLYDEVSDSKCLPLES 80  
Q5CZC0        5981 KDVVKKVQKLAQTASKECQTSSPYTIILPHKFLENVISALFSKIFSTISST--KTKEPEDNLSTELNFLQMKLVSAVATE 6058 human
6_pfamImport    81 KDVFKKVQRVAKTASKECQTSSPYTIMLPHKFLENVISALLSKFFSRISST--KAKHFGSYLFTELDVLHMKLVSTVAAH 158 
XP_051705327  5992 RDICKKVQKVAQTASKECQTSSPYTIILSYKFLEDVIAALLSKIFSTISNTspKVKASEGSILTELDFLQMKLLNTVAIG 6071
A2ARZ3        6078 KDVEQKVQNVVQTVSKECQTASPYTVQLPYKFLEDVTSGLLAKVFSKLSNV--KTKLTPENVLTQLDFLQSNLVKTIAAE 6155 house mouse
2_pfamImport    81 KDVEKKVQKAVETASKECQTSSPYTIKLPFKFLDDVISALLAKVFSKLSNV--KTKISQQTPLTQLDFLQMKLVNTVAAE 158 
1_pfamImport    81 KDIVKKVQKVVQTASKECQTFSPYAILLPRDFLQTMISALLHKVFSVAPKT--KAVTSEGGWLTELDFLQMKLLGTIMTE 158 
4_pfamImport    81 KEVIKKLQKVTETACKECQTSLPHTIMLPHKFLENIISSLLSKIFSTVANT--ETEIFENNSYTELDFLQMKLVSTIMTQ 158 
5_pfamImport    81 RELIKKVQKVRQTACKECQTSWPYTIILPHGFLDSMVSCLLSKMWSIVATT--TTEISEDGLFTELDFFQMKLVSTIKKE 158 
XP_038320735  5901 KEVMKKVHKGIQTACKECQTSSPYTIMLPHEFLESIISSLLSKIFSTVARA--KTETSEDNLHTELDFLQMKFVSTIMTE 5978
10_pfamImport   81 TKVMKKVHKVAQTACKECQTSSPYTIMLPYEFLERIISSLLSRIFSTVANA--KTEMSEDNLYTELDFLQMKLASTVKTE 158 
Q5CZC0        6059 ISQDKYMTIQYVETLQSDDDEIIQLVVQSVYNNLLPQFGSQEIIQNCVTSGCKILSENIVDLVLREVASNQLQSYFCGEL 6138 human
6_pfamImport   159 ISKNEDMTIQYVEPLQSNDDEIIQLVAQSIYNNLLPQFGSEEIIQNCVTSGCKILSETIVDLVLQEVASNQMQNYFCGDL 238 
XP_051705327  6072 ISKSEDINIQYVESLHPNDDEIIQLIVQSIYNNLLPQFGSQEIIQNCVISGCRILSETLVDLIIQEIAGNQLQKYFCGEL 6151
A2ARZ3        6156 ISKNEDLIIQYVESLHPNDDEVIQLVVQTIYNNLLPQFGSQEILQKCIISGCKLLSKTIVDLVLREVTGNQLQNYFGGEL 6235 house mouse
2_pfamImport   159 IAKNEDMIIQYVESLHPNDDEIIQLVVQTIYNNLLPQFGTQETIQNCIASGCRLLSKTIVDLVLREVAGNQLQNYFGGEL 238 
1_pfamImport   159 ISKDKDISIQYVESLHPNDDEVIQLVALSIYGNLLSQFGSQEMIRNCAASGCRILSETIVELVLREVSGNQLQSYFSGEL 238 
4_pfamImport   159 IAKDKDMIIQYVDSLHPNDDEIIQLVAQTIYNNLL-QFASQEIIQNCVIQGCRILSETIVSLVVREVAGNQLQNYFSEML 237 
5_pfamImport   159 MSKDKHVSVKYVESLHPNDEEIIQLVAQTIYNNLLQQFGSQESIKKGVTSGCRRLLETTVDLVVREVAGNQLQTYFSGEL 238 
XP_038320735  5979 ISKDKDMIVQYVQSLHPNDDEIIQLVVQTIYNNLLPQFGSQESIQNCASSGCKILSETIVNLVVQEVAGNQLQNYFSGEL 6058
10_pfamImport  159 ISKDEDMIIQYVKSLHPNDDEIIQLVVQTVYNNLLPQFGSQENIRKCISSGCKILSEAIVNLVVQEVTGNQLQNYFSGEL 238 
Q5CZC0        6139 TPHQCVEVENIVEKILKDVFQTTDVPLPKPSHADKLSYNIIEEIAVKFLSKLLSIFPKVHKERTKSLETDMQKITSKVLN 6218 human
6_pfamImport   239 TPNQCAEVERVVENILKEVIRTPNVPPRESSHAHKLSYNIVEEIAVKFLSKLLSVFPNVHKERGKSPETEMQKISSKILN 318 
XP_051705327  6152 STYQYSEVDSIVENILKDVIQTTGVPPPEPSQV-KLSYNIIEEIAVKFLSKLLSVFPKEQKERTTPRETEVQRIISKILK 6230
A2ARZ3        6236 TPIQCAEVDNVVENILTNVVLTTP---SQPSGPRKLSYNIIETIAVKFLSKLLSVFPKGHPERTKSQETEMRKITSKILH 6312 house mouse
2_pfamImport   239 TPYQCAEVDNVVENILTNVALTTS---PQPPHPRKLSYHVIEAISVKFLSKLLSVFPTVHTVKTKSPETEMQKISSKILK 315 
1_pfamImport   239 TPRQCEEVDSIIENILKDAIRSADTPRPHPAPAHRLPYNVIEEIAVQFLSKLLSVFPNVDKKRNKSLETEMQNIMSKILT 318 
4_pfamImport   238 SPHQCTAVDSVAGNILQNVIQNTEVVQPQPSYTYKLPFNIIEEIAVNFLSKLLSMFPKADKEQNNSLNPEMQKITSKILN 317 
5_pfamImport   239 TPYQCTEIDSVVENILKDIIETTENLQSQPPQAYKLPFDIIEEIAVKFLTKLLSMFPKVYKEPNKSLNSEMQKITSKILN 318 
XP_038320735  6059 TPHQCTEIDSVVENILKDVIQTTEVPQPQPSQAYKLPFPIIEEIAVNFLSKLLSMFPKADKKQNNSLNAEMQTIISKILS 6138
10_pfamImport  239 TPLQCTEIDSTIENILRGIIQTNEVPQPQPSWAYKLPFNIIEEIAVKFLSRLLSMFPKADKEQNNSLNTEMQKISSKILS 318 
Q5CZC0        6219 SVQEFISKSKIKLVPPTKESPTVPVADNATIENIVNSIYTSVLKHSGSYTSVFKDLMGKSNVLSDTIGFLMVNAISNSEF 6298 human
6_pfamImport   319 SVQEFISKSKIKLVAAGKEPPTVPLADNAVIDKVVNSVYTSVLKHSGSLASVFKDLMSQSNALSDIIGFLMVKEISNSKF 398 
XP_051705327  6231 SIQEFISKSKIKLIQPAKEFPTVPLADNASIEKVVNAVYTNILNHSGSYTSIFKDLMGNSNVLSDIIGFLMVREISNSEF 6310
A2ARZ3        6313 SIQEFISKSKIKVVQPVKESEAVPSADKAAIEKVVNSVYTNLLKHCGSPTSAFEDLMRKSDVISDIIGFSMVKEISNSEF 6392 house mouse
2_pfamImport   316 SIQECMSKSKIKVVKPAKELEPEPLADDATIEKVANSVYANLLKHSGSPASVFEDLMGKNNVLPDIIGSLMVKEISNSEF 395 
1_pfamImport   319 SLQEFISKSKIQLVPPAKALATVPSSDNETIKQVVNSVYTRVLKHSGSHTSIFKDLKGKSSALSDIIGFLMVKEISNSKF 398 
4_pfamImport   318 SLQEYISKSQIKVVPQAKENTTISSADSATIEKVVSSVYNSVLKHSGSHTSVFKDLMGQSNVLADIIGFLMVKEISNSEL 397 
5_pfamImport   319 SFQEYMSKCHIKVVLQATGSFTVSLADSALIEKVVTSVYNSVLKHSGSHMSVYKDLMGKSNVLSDIIGFLMVREICNSEF 398 
XP_038320735  6139 SFQEYLSKSQITVVPQAKESPTVSLADSTTIEKVVTSVYNSVLKHSGSHISVYKDLMSKSNVLSDIIGFLMVKEISNSEF 6218
10_pfamImport  319 SFQQYISKSHITVVPRVKESSTVSLTDSATIEKIVTSVYSTVLKHCGSHISVYKDLMGKSNVLSDIIGFLMVKEISNSEF 398 
Q5CZC0        6299 QPQVEEEVSNSELVLEAVKIMEKVIKIIDELKSKEKSSSRKGLTLDAKLLEEVLALFLAKLIRLPSSSSKDEKNLSKTEL 6378 human
6_pfamImport   399 QPQEEEDVSSTELVLEAVKIMEKVVKIIDKFNFQEKASCRKDSTLDARFLEETLALLLAKLVKLPGTSIEDEKNLPQPEL 478 
XP_051705327  6311 QPQIEKEVSSTELVLEAVKVMEKVIKITDEFKFQDKSSSQKFSMLDGKFLEEILALLSAKLVRTPSASSKDTSDMSQPKL 6390
A2ARZ3        6393 QPQAEEELSSSELALEAVKIMEKVVKIIDELKSQEKPASITDVMLDSRVLEEALALFLAKLVKTPGPASKDTTSLTKPEL 6472 house mouse
2_pfamImport   396 QAQAEEELSSSEIALEAVKIMEKVVKIIDELKSKEKSSSIKDLILDSRVLEEALALFLAKLVKKPGPESKDTDNLTKPEL 475 
1_pfamImport   399 QPQGGEEVSSSELGLEAVKIMEKVVKIV-ELKSQDRSSSKKGSMLDATCLEEALALFLAKLVKLPSASSKDAKNLSKPEL 477 
4_pfamImport   398 QPQMEEEASSSELLLEAVIILDKVTKIIDDLKLKEKPASRKGSVLDAMFLEETLALFLAKLAKLPCASNRDAKTLSKPEL 477 
5_pfamImport   399 HPQLEGKTSTTELVLEAAKILEKVVKGIDDPKLKEKASSRKDAVVDAMFLEEILALFLARIVKSASASNEDTTN-STPEI 477 
XP_038320735  6219 HPQV-EEASSSELVLEAAKIMEKVVKIIDDLKSKKKPSTRKETVLNARFLEETLALFLAKLVKVPWASSRDVKNLSKSEV 6297
10_pfamImport  399 HPQEQEETSSSELVLEAVKIMEKVAKIIDDLKSKKKPPTEKEAVLDARFLEEILALFLAKLAKLPSASSKDAENLSKPEL 478 
Q5CZC0        6379 NKIASQLSKLVTAEISRSSISLI-ASDPEEHCLNPENTERIYQVVDSVYSNILQQSGTNKEFYYDIKDTNTAFPKKVASL 6457 human
6_pfamImport   479 NKIASQLTKSVTAEISKSNISLV-ADDSKKQVLNTENIEKISHVVDSVYSDVLQQSGTPKELYYDIRDSNTVFPKKVASL 557 
XP_051705327  6391 NKIASQLTKSVTAEISRSNINLTnPANPGKHFSNPENTEMVSQVVNSVYSNVLQYSGTNKEIY-NVKDTKILLPDKVASL 6469
A2ARZ3        6473 NKIASQLTKSVTAEISKSNISLV-ESNHEEQSLDPENIEVISQVVESVYSNVVKQSGTENELS-DIKGTKKAFPKKVASL 6550 house mouse
2_pfamImport   476 NKIASQLTKSVTAEISRSNISLV-DSDPEEQPLDPENIEKISQVIDSVYSNIIKQSGDDNELY-DMKGTKKLFPKKVASL 553 
1_pfamImport   478 NKIASQLTKSVSAEISKSNISLV-AADPEGQLLNPESVEMISQIIDSIYSNVLIQSGTYKDLYYDIKGTNRVFPQKVANL 556 
4_pfamImport   478 NKIASQLTKSVTAEISKNNISIV-ATNPEEHHLTPENMEMISQVVDSVYNHVLQQSGTHEDLYHDMKGTNRFFPQKVASL 556 
5_pfamImport   478 HKVTSQLTKSVTAEISKKNISVI-AANPEEYFLNPERIEVTSQVADSVYNHVLQQFGTHEELYSRMTGTN-FFPNKVASL 555 
XP_038320735  6298 KKIASRLTKCVTAEISRNNINVV-STDPEETFLSPESIEIISQMVDSVYNQVLQQSGTHEELYYNMKGTNNVFPKEIASL 6376
10_pfamImport  479 NKIASQLTKSMTAEISRKNISIV-AANPEEYFLNPESIEIISQMVDSVYNCVLQQSGTHEELYHDMKDTNHIFPKEVASL 557 
Q5CZC0        6458 IIDGVSSFPLDTIN--STISNADLSGELDVNRIVQKAQEHAFNVIPELEQEKLDQNLSEEESPIKIVPHVGKKPVKIDPK 6535 human
6_pfamImport   558 IVDKVSGFSSDTSS--SKQLTADNSRKLDVNRIVRKARSHSENTVSDTDKEESDQESPEEEFSAEIVPHVGKRAIKVDPR 635 
XP_051705327  6470 IIDEVLNFPLSTDS--TKSADSGLFGDLDLNRIVEKAQVHAVKMMPDLHK-ESDQYFYEEEFPIKIVPHVGKKPIKIDPN 6546
A2ARZ3        6551 IVDGVSSVPSCRVI--TESSYTAAHGDLDTNRIIEKAQKHAALMSSDSDKDS--KKELEDEFPVRIVPHVRNKPLRIDPN 6626 house mouse
2_pfamImport   554 IVNGVSNVPSCRVI--TKSSDAGVFGDLDTNRIIEKAQKHAARMNSDSDKEL--DDVVEDELPVRIIPHIGNKPLKIDPN 629 
1_pfamImport   557 IIDGVSSVTLDTDTdcSKDSHADHFGDLDVNRIVQKAQEHAFKMNADTKNGA---EEWGEETQIKIVPHIGNKPIKIDPG 633 
4_pfamImport   557 ITSKISNYPLETTG--SKTSSADLFGDLNVDRIVEKAHEHAVKMEPQLEEEMLHGELIG--LPTCILPYRGKQPITIGPD 632 
5_pfamImport   556 IISEVLNCPLETMC--SRNSSSNLFGDLDIGRIIQRLNKHAIKIEPRLEQEELDQDLIEEELPVKIIPHRGKRPININPH 633 
XP_038320735  6377 LISKVSSCSLETVS--PKDSQADLFSDLDIDQIVKKVHEYAVKSQPELEQKELDQDVSEEELPIKIVPHRGKQPINIDPD 6454
10_pfamImport  558 IIRKVSSCPLAMIS--SGDPCANLFGDLDIDRIVEKVHEHAIKIEPGLEQKGLDQGLRQEELSVRIIPHLGKEPINIDPD 635 
Q5CZC0        6536 IISEHLAVISIKTQPLEKLKQECLKRTGHSIAELRRASISGRNYSl-GSPDLEKRKTERRTSLDKTGRLDVKPLEAVARN 6614 human
6_pfamImport   636 IVSEHLAVISVKTQPLEKLKMECLRNTGHSIAELRRASITGRNYS--DTSYTGERKRERRTSLDRTGRLDVKPLEAVCRN 713 
XP_051705327  6547 IVSEHLAVISVKTKPLEKIKMECIKRTGHSIAELRKASLNGRSYSslDSYTVGNKKKERRISLNMTGRLDVKPLEAVCRN 6626
A2ARZ3        6627 IVSDHLAVISMKTQPLETLQMDCLKRTGCSIAELRRNSIRGIGPSstDVSEMGTRQKERRISLDRTGRLDVKPLEAVGRN 6706 house mouse
2_pfamImport   630 IIAEHLAVISMKTQPLETLKMDCLKRTGYSIAELRRASISGKGHSstEVCEMGTRQKERRISLDRTGRLDVKPLEAVGRN 709 
1_pfamImport   634 ILSQHLAVISVKTEPLEKLQMECLRNTGHSIAEVRRASMQGRSYScaDTSNEEKLKKERRTSLNRTGRLDMKPLEAVGRN 713 
4_pfamImport   633 TVAEHLGVISIKTQPLEKLKIECLERTGHSIEELRRAAVSGRSYIv-NTPGTGQRQKEGRVSLDKSGRLDVKPFEPATRN 711 
5_pfamImport   634 IVAEHLGVISIKTHTIEKMQKDCLAGTGYNIETLRKGAIYGRSYSi-DSPAAEQR-RDRRASLDTKGRLNVKPFEVSSRN 711 
XP_038320735  6455 IVAEHLGVLSIKTQPLEKLQLECLTRTGYSIEALRRMSVSGRSHSv-DISDAGKRKQKKRVSLDEVGRLNLRPLEAASRN 6533
10_pfamImport  636 IVAEHLGVISIKTQSLKKLQTECLTRTGHSIETLRRASINGKRYSt-EITAAGNRKKEKRISLDQMGRLNVKPLEASSRN 714 
Q5CZC0        6615 SFQNIRKPDITKVELLKDVQSKNDLIVRLVAHDIDQVYLENYIKEERDSDEDEVVLTQTFAkEEGIkv-feDQVKEVKKP 6693 human
6_pfamImport   714 SFQNIRKPDISKVELLKDVQSKKDLIIRLVAHDIDQANMEDYIEEEVNSEEEEVILGEVFAqDQFI-----NHVKKVNKP 788 
XP_051705327  6627 SFQNVRKPDITKVELLKDVHCKRDLITRLVAHDIDHGDSESTTGEVI-SDEDEIVLGEVIGqEECIrelseCQVKEVMKT 6705
A2ARZ3        6707 SFQNVRRPDITRVELLKDINNKTDLIIRLVAHDIGRKESDSSLSEGMVSDEEEVVLGEVVG-DQCLrkisgGRVQQVKKS 6785 house mouse
2_pfamImport   710 SFQNVRRPDITRVELLKDIHNKKDLIVRLVAHDISKNDLEGSFREDMVSDEEEIVLGEVAG-HQCLgeisgDHVGEVLKP 788 
1_pfamImport   714 SFQNLRKPDISKVELLKDVQNKQDLLIRLVVHDIEGE-SESHMGEEATTDDYEFVLREDIReESCel--ceDEATE---- 786 
4_pfamImport   712 SFPNLRKPDITRVALLKDVKDKKDLIIRLSAHDIDHKSTGNKIEKDLISDEDEAVLQEVVK-GECFeglveDQVKEDMKP 790 
5_pfamImport   712 SFQNLIKPDITKVELLKDVRKKKDLIIRLVAHDIDQEEPESKIEDSYSSDEDEVVLQDCIK-RDFFegl--feVKEDMRP 788 
XP_038320735  6534 SFQNLIKPDITKVELLKDVHSKKDLIIRLVTHDIGQEVSENKVEEGLTSNEDEVVLQNVVK-EELPedlfdDQAKEEIKP 6612
10_pfamImport  715 SFQSLIKPDITKVELLKDVQSKKDLIIRLITH-ISQENLENK-EESLASDEDEVVLQEVIKeEEFPespleDQVKEDMNL 792 
Q5CZC0        6694 IQSKL-SPKSTLSTSSLKKFLSLSKCCQtTASANIESTEAISNQVIESKETHVKRAVAELDMATPKtMPETASSSWEEKP 6772 human
6_pfamImport   789 VESKV-SPKSTPSTSSLKKFLSLSKCCH-ISSENIESIEPVSNQIIESNETNVKRAVAELDMSTAK-MTPDTVSSWEKKP 865 
XP_051705327  6706 PASKAaSPKTTVSTGSLKRFLALSKCCQpTYSANIESIEAISNLRIESNESQVKRAVAKLDMATTK-ILTETNTSREKKL 6784
A2ARZ3        6786 AESHVvSSKTATSTSNLKRFLALSKCCQpTSGENIESIEESGIQIMDPNKAYVKRAAAELDMPSCKsLAEETTSRDKLQY 6865 house mouse
2_pfamImport   789 SETQVvSPKTTTSTSSLRKFLALSKCCHpTSGEHIESIEATGNQTMEPSKTHVKRAVAELDMPSSKiLAEGPSSSDKLQY 868 
1_pfamImport   787 --------------------------------ADTESPEATGKPPGGPTGREVKWPTAELDQPTRSsILAVTNSFWGNEP 834 
4_pfamImport   791 RASAAtSPKPITSMSSLKKRLSLGKYCp-KSTPTPKSVTTHSTQLTESAETQMKSILSGRDRTTSQsSTGTASTHWEKNT 869 
5_pfamImport   789 TASRLaYCKARRNKSSMRNFLSSSDSWHqNSSVSTKSTEPSPPQSPEPGETKIRRIFSGFNVATTKsTINTDSSFEGERT 868 
XP_038320735  6613 IMGTVaLHKPLISKRNLKKFLSLGKCCHrRSTVTTTNTEASPTLWTESEETQ-QRLVSNTDVTTSKsPTGTDSSFWERKT 6691
10_pfamImport  793 TTSTVaHPKPPISKCSLKKFLSVGKC-QpKSSVTII-PEVSPAKQTEYEQTL--RSVSSIDVTTSKcLTVTNSP-WEKKT 867 
Q5CZC0        6773 QC 6774 human
6_pfamImport   866 QH 867 
XP_051705327  6785 QC 6786
A2ARZ3        6866 KE 6867 house mouse
2_pfamImport   869 KL 870 
1_pfamImport   835 QC 836 
4_pfamImport   870 QP 871 
5_pfamImport   869 PF 870 
XP_038320735  6692 QL 6693
10_pfamImport  868 QL 869 
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