Conserved Protein Domain Family
GREB1_N
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pfam15782: GREB1_N (This model is not part of the current CDD release)
GREB1 N-terminal domain
GREB1 (gene regulated by estrogen in breast cancer 1) was first identified as an estrogen-regulated gene expressed in breast cancer. Its exact function is not known but its expression is regulated by the coordinated binding of estrogen-receptors to distal sites interacting with Pol II to activate gene transcription from core promoters located at a considerable distance from the greb1 gene. It acts as a regulator of hormone-dependent cancer growth in breast, ovarian and prostate cancers. This entry represents a N-terminal domain whose function is not yet known. Structure predictions suggest that it may have an alpha-beta fold.
Links
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Statistics
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PSSM-Id: 522014
Aligned: 6 rows
Threshold Bit Score: 294.846
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_012818910   58 NDDEEDDedDGSGSSSPPLSYQSKPPPEGCCTTDGFCQAGKDLRLSSLSTDYFDVPPGFLLVGVKSPSLPDHILVCAVDK 137 
XP_020555377   52 ENDDEDDe-DGSESNSPPIPYQMKPPPEGCCTADGFCQAGKDLRLSSLASDTLDVPAGFMLVGVKSPSLPDNLLVCAVDH 130 
XP_035126591   85 EMEDDEDdeEMSDSNSPPIPYSQKPAPEGSCTTDGFCQAGKDLRLVSLCMEQIDIPAGFLLVGAKSPNLPEHILVCAVDK 164 
B8JKP6         78 nsvedmddeddsdtssPPLPYLQGPPPDGCCTVDGFCQAGKDLRLVSMATESIEVPAGFELVGAKSPSIPEHILVCAVDK 157  zebrafish
XP_029702287   55 EVDDDDE--DASEDTSPHIPYQMKPPPEGCCTTEGFCQAGRDLRLSSLALDTFDVPPGFLLVGVKSHTLPEDLLVCTVDC 132  torafugu
NP_683701      59 neeeeeegeggletNGPPNPFQLHPLPEGCCTTDGFCQAGKDLRLVSISNEPMDVPAGFLLVGVKSPSLPDHLLVCAVDK 138  human

XP_012818910  138 RFLPDDNGCNALLGFSGNCVGCGEKGFRYFTEFSNHINLKLATQPKKQKHLKYYLIRNAQGNLTKGAIISWKG 210 
XP_020555377  131 RFLPDERGRNALLGFSGNCMGCGEKGFRYFTEFSNHINLKLSTQPKKQKHLKYHLYRNKQGILVKGAPICWRV 203 
XP_035126591  165 RFLPDDNGKNALLGFSGNCIGCGERGFRYFTEFSNHINLKLTTQPKKQKHLKYYLVRSSQGVLSKGPLICWke 237 
B8JKP6        158 RFLPDENGKNALLGFSGNCVGCGEKGFRYFTEFSNHINLKLSTQPKKQKHLKYYLVKNSQGALCKGALICWKd 230  zebrafish
XP_029702287  133 RFLPDERGHDALLGFSGNCVGCGEKGFRYFTDFANHINLKLSTQPKKQKHLKYLLYRNNQSVLVKGAPICWRG 205  torafugu
NP_683701     139 RFLPDDNGHNALLGFSGNCVGCGKKGFCYFTEFSNHINLKLTTQPKKQKHLKYYLVRNAQGTLTKGPLICWKG 211  human
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