Conserved Protein Domain Family
UNC80_N

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pfam15778: UNC80_N (This model is not part of the current CDD release)
UNC80 N-terminal
UNC80 is a family of proteins found in eukaryotes. This entry represents the N-terminal domain. NALCN and UNC80 form a complex in mouse brain, both being tyrosine-phosphorylated; this phosphorylation can be inhibited by PP1. NALCN as the cation channel activated by substance P receptor, and the coupling from receptor to channel is facilitated by UNC80 and Src kinases rather than by a G-protein.
Statistics
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PSSM-Id: 522012
Aligned: 12 rows
Threshold Bit Score: 296.604
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAI16431       16 RGIPLPIQTFLWRQTSAFLRPKLGKQYEASCV----------------SFERVLVENKLHGLSPALSEAIQSISRWELVQ 79  
XP_009016662   16 NSIPIPIQTFLWRQTSPFIRQKLAKLCESSAL----------------SFERVIVQNILHGLSPSLCEAIQSISRWKFVC 79  
EFP00800       42 DSVPLPIQTFLWRQTNPFLGDKIGKLHEASCV----------------TFERVVVQNILHGLSPSLSNALASVSRWKLVR 105 
EEC01341       16 LAVPLPIQTFLWRQTSPFIRPKIGKTHDASAM----------------SFEKVLVQNIQFGLSPSLTVAIKSIRRWRLVR 79  
6_pfamImport    1 ESIPLPIQTFLWRQTSPFIRPKFGKQQDALAMeqre---------ackSFEKVLVQNIQFGLSPSLTDAIKSISRWKLVQ 71  
EDS38925       18 LGVPVPVQTFLWQQIAPFIRPKLGKLHEASCM----------------SFEKSLVQNMFYGLSPSLEAALKSIPRWRLVQ 81  
XP_002426261   21 QALPLPIQIFLWRQISPFIRPKLGKLHEASCM----------------SFEKILVQNIQYGLSPSLTDAVSSVPRWRLIQ 84  
2_pfamImport    1 HPLPIPVQMFLWRHIRPFIRAKLGKLHEASCT----------------CLERVLVQNLHNDLTPSLSQILGNVPRWRLIQ 64  
5_pfamImport    1 --VPIPIQIFLWQQTSPFTRPKLGKLHEASCMelke---------ackAFEKVLVQNLQFGLSISLTDAIKSIPRWRLVQ 69  
XP_046453317   20 DIVPLHIQTFLWRQTSSFLRPKIGKMHEASCIemke---------ackSLEKILVQNIRVGLSPNFTEAIRSISRWKFVQ 90   common water ...
XP_026696027   18 dRTPLPIQSFLWRQTdPFLRRKIGKLYEASCA----------------SFEHILVDNKLQGLPPSLSGAIGSITRWQLID 81   vase tunicate
NP_001263023   51 LGLPVSVQTFLWRQIAPFIRPKLGKLHESTCLfcqhapghheskeackSFEKVLVQNIQFGLSPPLTKGLGVIPRWRLLQ 130  fruit fly
AAI16431       80 AALPHVLHCTATLLSNRNKlgHQDKLGVAETKLLHTLHWMLLEAPQDCNNdqfggtdrgsswggsssafihqienqgspg 159 
XP_009016662   80 ASFPHVIHCCASILLKRLEtnPEAKFSTSDIKLLYTLHWIILDAAGECED------------------------------ 129 
EFP00800      106 AALPHVIQCCGSLLSANSG---EKKLPTSLQKILYILHWMLIDSSAECIEst---------------------------- 154 
EEC01341       80 AALPHVMHCCAALLHARKEs-CLEKLGSAETKLLYTLHWILLDAAEECSDa----------------------------- 129 
6_pfamImport   72 ASLPHVMHCCSALLYNRKNs-NLDKLGAAETKLLYTLHWIVLDAAEECADa----------------------------- 121 
EDS38925       82 AALPHVMHCAGALLHNRVK--DLQALGAVETKMLYTLHWILLFAAEECADd----------------------------- 130 
XP_002426261   85 AAFPHVMHCTATLLQNRKDt-NMQNLGATESKMLYTLHWILLTAAEECADa----------------------------- 134 
2_pfamImport   65 AALPYVLHATASLLHNKKD---FQSLGTMETTLLYILHWILLDSAEECSEn----------------------------- 112 
5_pfamImport   70 AAFPHILHCTSSLLHNRKDt-NLQNLGTSESKLLYILHWIILDAAEECAEa----------------------------- 119 
XP_046453317   91 SSLPHVMLCTAQLIERKDTn-NLQNVGTAASKLLYTLHWTLLDAAEECADa----------------------------- 140  common water ...
XP_026696027   82 ICLPHVMHCAAIFLINRNKlgQADKLGVPGTKLLHTLHWIFLESQKACSAggk--------------------------- 134  vase tunicate
NP_001263023  131 GALPHVMHACAALLYNRVK--DMQAIGPVETKLLYTMQWILLYAAEECADdegge------------------------- 183  fruit fly
AAI16431      160 qpcrssshDEEENNRRK---TFQNSMATVELFVFLFAPLVHRIKESDL--TFRLASGLVIWQPMWEHRQPEVSGFTALVK 234 
XP_009016662  130 --------NEPKKSFKTvkcSYLHSLDTIQLFVFLLIPLVSSLTRSDFd-NLKLENGLRLWEPLWHYQQPNVYCFSTPVK 200 
EFP00800      155 -------sTKEDPNPTQsrtQGLFNISTIQLFIYLIAPLADIITEEEVvdNIRLESGLKIWQAIWQFRQPDIWCFSAPVK 227 
EEC01341      130 --------EHAGG---PdpaRYVFPISVIQVFVYLFAPLIPFLKQSDFvgSFRLENG-----PLWEFRHPSVPCFTAPVQ 193 
6_pfamImport  122 --------EIEQGIN-RpidHYLLPITTIELFVYLFSPLISYLKNSDFltSFRLENGHKLWGPLFDYQHPDIPSFVAQVK 192 
EDS38925      131 --------DLEANKDVKrhqSYLFSIPTISLFVYLFAPIAHLLKESDFq-NIRLENGLKMWQGMWEYRAPNASCFIAPVK 201 
XP_002426261  135 --------DHENGIFQSspfYYLFSIPAITLFIYLFAPIYHHLKESDFq-TYRLENGLKMWQALWDYKHPDIPCFTAHVK 205 
2_pfamImport  113 --------DMDP----SnpfFYLFPIPTMTLFVYLFAPLFNHLKDIDFktNLRLENGLKIWSAMYECRHPEATCFTAHCR 180 
5_pfamImport  120 --------DYEKGIYQAspfYYLFSIPCITLFVYLLAPLCHQVKEGDLq-TFRLENGVKLWHPLWEYRHPDARCFTALCK 190 
XP_046453317  141 --------DREAGIAPRepfPYIFPLTCIQEFVYLFAPLRHLLKEADLq-NFRLENGLKIWPALWDYRHPNAQCFTAPVR 211  common water ...
XP_026696027  135 ------cgEE----------QYSVTFGNVQLFIYLFAPIINNIRETDL--VFRLDSGQLIWRSMWSYEQPNIPAFSRIIp 196  vase tunicate
NP_001263023  184 ---dlglgDA-AEPKSKsidQYLFSVPTITLFVYLFAPIIHHLKESDFq-NFRLENGIKLWQGMWDNRAPGAPCFTAPVK 258  fruit fly
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