Conserved Protein Domain Family
IHO1

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pfam15771: IHO1 (This model is not part of the current CDD release)
Interactor of HORMAD1 protein 1
Interactor of HORMAD1 protein 1 (IHO1, previously known as coiled-coil domain-containing protein 36 or DUF4700) is required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. It is thought to function, in collaboration with SPO11-auxiliary proteins MEI4 and REC114, through the formation of DSB-promoting recombinosomes on chromatin at the onset of meiosis.
Statistics
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PSSM-Id: 522006
Aligned: 14 rows
Threshold Bit Score: 780.534
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGW08946      48 SITKPSNW-NSNQTDCSSPSDSQFLFGSQFCPENSESLSASLDIGAYSRHPKQTQQNSVDNEPSIFTKYQTKPQLFGGDT 126
2_pfamImport   1 GAIKSSNW-NNNQTDYSSLSDSQFLFGSQFCPENSETLSAPLDIGTHLRHPKQSQQNSLDSEPSIFTKYQTKPQLFGGDR 79 
Q6PDM4        19 GITKPSNW-NNNQTDCS-LSDSQFLFGSQFCPENSETLLPSLDAGACLRHPKQTQQNSVDSEPSIFIKYQAKPQLLGGDT 96  house mouse
XP_001055346  19 GLTKPSNW-NSNQTDCSSLSDSQFLFGSQFCPENSETLLPPLDAGTYLRYPKQTQQNSVDNEPSIFTKYQAKPQLFGGDT 97 
3_pfamImport   1 GTAKSSNWnNNNQTDYSALSDSQFLFGSQFCPENSETLSAPLDLGAHLRHPKQLHQNSLDSEPSIFTKYQTKPQLFGGEA 80 
EHB14801      19 GTTKSSHW-NNNQTDYSALSDSQFLFGSQFCPENSETLSAPLDLGAHLRHSKQLQQNSVDSEPSIFTKYQTKPQLFGGET 97 
XP_017199304  19 GNTKASVS-NNNQTDYSSLSDSQFLFGSQFCPENSETLSAPLDFGAHLRQQKQSQQNSLDSEPSIFTKYQTKPQLFGGNA 97 
XP_005222900  19 GATKSSNW-NNNQTDYSSLSDSQFLFGSQFCPEGSQTLSTPVDSEVHLRHPKQSQQNSLDSEPSIFTKYQTKPQLLGGDP 97 
XP_023603522  19 GTTKSSNW-ANNPGDYSSLSDSQFLFGSQFCPESSETLSAPLDVGVHLRDPKPLQKGSLDNEPSIFTKYQTKPQLFEEDI 97 
XP_004760731  19 GTTKSSSW-NNNQADYSSLSDSQFLFGSQFCPESSETLSAPLD-GVHVRHPKQSQQNSLDSEPSIFTKYQTKPPLFGADA 96 
EGW08946     127 KDEGLFSLPLPVGKSKGLLKQFEEKKRRATDKCDSEMLYNFVSHFQEVIHKLQTSVEKSEENLSSRSQSILDSLETVAKT 206
2_pfamImport  80 TDGGLFPPPLSVGKSKGLLEQFEEKKKLAKDKCDSETLCSFISRVRESIHRLQTSVEKSEEHLSSRSQTILDSLETVAKT 159
Q6PDM4        97 KDESLFSLPLPVGKSKGLSKQFEEKKRRATDQSDSETLHSFVSHFPEVINKLQTSVEKTEENLSSRSQSILDSVETIAKT 176 house mouse
XP_001055346  98 KGEGLFSLPLPVGKPKGLSKQFEEKKRRATDQSDSETLHNFVSHFPEVIHKLQTAVEKSEEHLSSRSQSILDSVETIAKT 177
3_pfamImport  81 KDGGLFSLPLPVGKPKCLLKQFEEKNKKAKDKCDSETLYNFVSQVRESIQRLQTSVEESEERLSSRSQSVLDCLETVAKT 160
EHB14801      98 KDRGLFSLPLPVGKSKCLLKQFEEKNKTAKDKCDSESLYNFLSQVRENIQRLQTSVDKSEEHLTSRSQSILDSLETVAKT 177
XP_017199304  98 KDGDLFPLPLPVGKSKGLLEQFEEKKKTAKDKCDSETLYNFVSNVRESIHKLQTSVEKSEEHLTIRSQSILDSLETVAKT 177
XP_005222900  98 KDGGLFPLPLSLGKPKGLLEQFEEKKKSAKDKCDSETLYNFISHIKESIHKLQTSVEESEEHLSSRSQSILDSLETVAKT 177
XP_023603522  98 NDGGLFPLPLPVGKSKGLLEQFEEKKKIAKDKCDSETLYSFISHVRESIHKLQTSVEKSEEHLSSRSQSILDSLETVAKT 177
XP_004760731  97 NDRGLFPPPLSVGKAKGLLEQFEEKKKRAKDKCDSETLYNLISHIRESIHRLQTSVEKSEEHLSSRSQSILDGLETLAKT 176
EGW08946     207 FQESAQVQRDLIFDAMRDKGNMEQAILELQRSSETRQAEFMEMKSNLKNLEVLVTQQSKDFQQLCEKLGQLNVPGVLEEL 286
2_pfamImport 160 LQETSKAQSDLVLEAVQDKGSTEQTILEMQKRFEARQAEFIEMKSNLKHLEVLVAQQNKEFQKLCEHLVQLNVPSVLADL 239
Q6PDM4       177 FQETARVQHDLMVESVRDKGSMEQAILEIQRTCAARQAEFMEMKSTLKNLEVLVVEQTKNLQQFCDNLSQLIVPGILEEL 256 house mouse
XP_001055346 178 FQETARVQHDLMVEAVKDKGSVEQAVLEIQRACAARQAEFMEMKSTLKNLEVLVVQQSKDFQQFCDNLGQLIVPSVLGEL 257
3_pfamImport 161 LQETARAQSDMRFEAIQEKGSAGQAILEMQKKFEAKQTEFIEMKSSLERLEVLVVQQSKDFKQLCEQLGQLYVPDILAEL 240
EHB14801     178 LQETARVQSDLRFEAIQEKGNAEQAILEMQKKFEARQTEFIEMKSSLKHLEVLVAQQNKDFQQLCEHLGQLHMPDVLEEL 257
XP_017199304 178 LQETARTQSDLVFEAVQEKGNTEQAILELQKKFEAKQAEILEMKSNLKHLEVLVAQQSKDFQQLCEQLGQLNVPSVLAEL 257
XP_005222900 178 WQETAKAQSGLMLEIVQDKGNVDQAILELQKRLEARQAEFTEMKSDLKHLEVLVIQQSKDFQQLCEHLGQLNMPSVLAEL 257
XP_023603522 178 LQETARAQRDLVLETAQDKGRVEQAVLELRREFQARQAEIVEMKSGLKHLEAVATQQSNYVQQLCEQLARLDVPGTLAEL 257
XP_004760731 177 LQETVRAQSDLVLETVHDKGNMEQVIFEIQKRFEARQAEFIEMRSDLKHLEALVAQQSKDFQQLCEQLGQLNVASVLAEL 256
EGW08946     287 KKL-SAPRLVGHLKDSTSQTSPALAQSLHFTGQEKCTSE------AQVSP-----TGSSQRPREFGVWDEGAESGVFQK- 353
2_pfamImport 240 KKFiSAPRVHEHVKDSASQTSPAPAQSLNFTRQEKSASEgpvmwqAQLLPaawnpSVGSLWPRESGVWGKGGKSDILQEe 319
Q6PDM4       257 KKFtSVPQVAGHLKDSTSQTSPSLTQSLHFTRQEKHPSEepatwqAQEAPag-npSTSSQRPGECGVWDEGAESGVFQK- 334 house mouse
XP_001055346 258 KKFtSVPQVVGHLKDSASQTSPSLTQSHHYPRQEPYPSEepatwqGQEPPag-nsSRGSQRPTEFGVWDEGAESDVFQK- 335
3_pfamImport 241 KRLlLAPRVLDHKKDNASQTSPPLAQSLRFINQKKLPLEepvigqTQAAPaarnpKAGSLMPEEFGVWA-----DYFQEk 315
EHB14801     258 KRLiSAPQVPRHVKDSASQTSPSLAQSLSFIKQSKLTCEepvawqIQAAPaagncSAGFLRPGEFGVWGKQAKSDSLQEk 337
XP_017199304 258 KRWiSVPQVPRHVRDSTSQTSPLLARNLSFTGQEQYALEdpvpwqAQGLPgagnpSRGSSQPGKFDVWGEGAKNGAPQEe 337
XP_005222900 258 KRLtSIALTPKHVKDSASQTSPPLAQSLSFPRQDKYTSEkpvtwqAQALPaacslSVGSPRPREFAVWGEGSKRDALQEe 337
XP_023603522 258 KSFlAGPRAPTHVRDSTSQTSPPRAQSLSPAPQAq----------AQALPar-dlRMGALRPGESDVWGEGAKRAALPEe 326
XP_004760731 257 KRLiSDPRVAGHVKDSTSQTSPPLAQSLHFTRQGRYASEeavlwpAQAPAavrtrSMGSLQPGEFGVCGERAESGALQEe 336
EGW08946     354 AALLTDEPHRGNEHVKNNAMQTYYKNWVITTRSLTNH-CASLPSQKADHDEDLVADEASQL------DLNKFESRVKNAC 426
2_pfamImport 320 ATLPAAGLSKGNKHVQDKEVQTNSEHCVLTKIERKNH-GLSILGHKVPGNRDLVSQGASRLvs---lDLNNFAASTENSC 395
Q6PDM4       335 AALPTDGLHRGDGHVKNKTVPTYCKNWVMTTRSVSNH-FSNLPSQRAGNGQGLMAQGASQR------DVSKFEARVKNAC 407 house mouse
XP_001055346 336 ATLPTDRPHRGSEHVKGKAVQTYCKNWVMTSRSLSNH-FS-VPDQKAGSEQDLTAPGASQL------DCES-EARVEGIC 406
3_pfamImport 316 AALPASEPCKGNGQVQDKAVQTNCQD---TAGSPKNHvGPGIPGHQVHADGDLASQRDTQFts---lDLNNTANSIQSAC 389
EHB14801     338 AALPAVEPCKGNEQVKDKEMQTNCQDLAVTKTSPKNH-GSSIPDHKACADRDLVSQGGSQLis---lDLNDVTNSIQNVC 413
XP_017199304 338 AALPGAQPREGNGCAKDQAMQPHSNNQGVSKSHPENP-GSHIPGYRIPGDRDQVSQGASQLis---lDLNTFATSIENAY 413
XP_005222900 338 AVQPAVGTGKRNRQIKGRAVKTNCQN-SVTKTGSENC-GSAILGHKVPKDRDPVFQGDSQLisrgykDLNNSATSIKNTS 415
XP_023603522 327 ----AVGEGKRSRGVRDKAVQTSLKSQLLPKTSSENC-----------GGRKLVAQGALRLls---lDVNNFVTS----- 383
XP_004760731 337 AMRQAAGTSRSNRRVKDRAVQTNRRNWTGPKTSSENH-GAGSPGPEVLGGKDWVSPGASRLlp---lDSNKFAASIKNTC 412
EGW08946     427 PQIEAQNMCSSDLFEQ-SATEQK-DRTRGKERKGKKQHPRKSQRGRLLARKQEQTPRKACAFVSRHCRTQTSVSSPQGSI 504
2_pfamImport 396 QEYHAKDVFSCDPRGQsLITEPK-GRTVERGKKGKQWQPRKAHKGRLLARKREQTPSKTCAVLSKNQSPQPPVSVPKRPS 474
Q6PDM4       408 PEYGPQSMCSFDSLEQ-SATEQK-GRPCRKRRRGKKQQPQRSKRGGLLDRKQGQTSKAACAFIARHHCPQSPVCDPQGPL 485 house mouse
XP_001055346 407 PTYEAQSKCALDSFEQ-SAAEQKrGRTCRKRRRGKKPQPRRAKRGRLLARVQKQTSGEACAITAERPCPQSSVCSSQGPL 485
3_pfamImport 390 PEYHSQGIVLCDSCEQ-LATEQK-GKSAETAKKGKKRQPMKARRDRHLPRKPAQTPRKTCAPNTKYQRPQSPVSSKQRPP 467
EHB14801     414 PEYQAQSIFFCDPCQQ-LVTEQK-GKTVERGRKSKKQQPRKAHRGRVPARKREQTPSKTRAFNPKYQSTLSPVSGPGRPP 491
XP_017199304 414 PKHQTKSMSSSDPCEQ-VVTEQK-GRAIESRGKGMRQQTRRACRGRPIARKQEQAPSETHALKSKYQSPQPPVSVPQSGP 491
XP_005222900 416 QKWQAKGAFSCHPCEQrLVTEQK-GVTVERGKKDK-QQPRKAPRRRSLRRKQEQMPSKTCVSNSKY--PRPPVSSPQSSP 491
XP_023603522 384 PKCQTKGVFSRDPCEQrLVTGEH-RR--------RGRPPRSTHRGRPPTRRQEQPRSTACAFSSRC--PQPPGPGSQGSP 452
XP_004760731 413 PKCQAAGVSPCDPREQrLVTAQK-SRPVERGRKGRKQAPRKSQRGRLRARKQEQAPSKTCAVIPKY--PQPPVSGPQSPP 489
EGW08946     505 IC------------WRAPRIAMKSARPILGRIVRTNKTARATPGSIQQSTQCSSPVCESL--SSSSQEDQQINWFSDLS- 569
2_pfamImport 475 LEqqepl--qqplrLLRSRSPAKPAGPTLGGAVMPGKTAKAVQGRLLQLRRLPSQDNGLL--SSSSQGDHQMSWFSNLN- 549
Q6PDM4       486 IC------------WLTPRSSTKSTCHILGGTGETSQTARAAQGNLVQHSQRSST-------DSSSQGDQQINWFSDLS- 545 house mouse
XP_001055346 486 IC------------WPPLRSSTKSACHILGGRGETSMTAGAVQGSLLKSSQHSST-------DSSSQEDQQINWFSDIS- 545
3_pfamImport 468 ALc-----------VQTPRSSPKSDCPTPGGRVKPRKTARAVRGGTLQLTMCPSKRSRFL--SSSFQGDHQMSWFSSLN- 533
EHB14801     492 TGqqell--aqalcLQGPRSSPKSVCPALGRRVKPSKTARAVRGGALQFTTCSSKGNRLLpkESSFQRDHQMSWFSDLN- 568
XP_017199304 492 LGqqepl--thvlpLQGVRSPSKPVHPVLRGTVMPTKTARAARGNCLQFNRSSSQDNSLL--SGSSQGDHQMSWFSDLS- 566
XP_005222900 492 WGqqetl--aqplqLWGPRSPTNLVCSAQGGTVMPSKTTRAEQGNLVQCSGHSSQDNSLL--FPSFQGDHKMSWFSDLNd 567
XP_023603522 453 PEqqepraqplcrgFQG-RNPTQ---PARGGALRP-RMAQAAPRALPQLSGHSPQDSSQR--SDSSQGDPQMSWFSDLN- 524
XP_004760731 490 LEqqkpr--aqplhLWGPNSPTKPVSAILGGRVMRTKAVRAAQGDLLELSGLSSQDNSLL--ATSSQGDHQMSWFSDLN- 564
EGW08946     570 -LENPEPPLCKKGGKNLLCDPDFDSSDD 596
2_pfamImport 550 -LRSSESPLCKEPGKNLLYDLAFDSSDD 576
Q6PDM4       546 -LENLEPPQCKKGGTNLLCDPDFDSSDD 572 house mouse
XP_001055346 546 -LENLEPPLCKKGGKNLLSDPDFDSSDD 572
3_pfamImport 534 -PEGSENALCKEAEKNLLYHLHFDSSDD 560
EHB14801     569 -LENSEPAQCKEAGKNLLYHLGFDSSDD 595
XP_017199304 567 -LGRSEPPLRKEPGKHFLYDLGFDSSDD 593
XP_005222900 568 lNPRAESLQSQESGKNILYDLGFDSSDD 595
XP_023603522 525 -PESPQAPQPRQPGKAVFYHLGFDSSDE 551
XP_004760731 565 -LGSSDPPVCKEPGKSMLYDLGFDSSDD 591
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