Conserved Protein Domain Family
DUF4690
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pfam15756: DUF4690 (This model is not part of the current CDD release)
Small Novel Rich in Cartilage
This family of proteins is found in eukaryotes and include SNORC, a cartilage specific small membrane proteoglycan that plays a role in the regulation of chondrocyte maturation and postnatal endochondral ossification. There are two conserved sequence motifs: LGPGAI and LRKF.
Links
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Statistics
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PSSM-Id: 521998
Aligned: 7 rows
Threshold Bit Score: 96.4326
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EOA94168       9 EYPQGPVPTLWNEPPELPSGAGPFDaATTTARLSDATAfppYTSELEPEDTTHLHRLDTGdGSLGPGAIGAIVIASLLGT 88 
2_pfamImport   1 ETAADPAPTPQSESQETCSGGGSYD-VTTRDPPHDLTD---NTFTFEYEDTTHSQPMDRG-GVLGPGAIAAIVIAVILGA 75 
NP_996778     26 DVPQEPVPTLWNEPAELPSGEGPVE-STSPGREPVDTGppaPTVAPGPEDSTAQERLDQGgGSLGPGAIAAIVIAALLAT 104
Q9CXL7        26 EGPQEPDPTLWNEPIELPSGEGPLE-STSHNQEFAVSGppfPTSAPAPEDSTPPARVDQDgGSLGPGAIAAIVIAALLAT 104 house mouse
XP_016847623  25 EYPQGPFPTLWNDPPELPSGGGPLE-TTPSPRFSDSPGfppYTSDYEPEDTTHLHQLDNGnGSLGPGAIGAIVIAALLGT 103
XP_003438183  27 DTVSDTAPAT-RDNQDTVSGDEPPSdTTTK--PPYLTD---PPSTIDYDDATEV--FNEEeGAMGPGAITAIVIAVFLGA 98 
XP_021326975  29 ETVADSSPTFQKD--DTVSGDGSFD-VTTK--AQELIE---STVIADYEDSTHIITLEEE-VVLGPGAIAAIVIAVFLGA 99  zebrafish

EOA94168      89 SVLVALVVITLRKFSaS 105
2_pfamImport  76 SVLIALVVITLKRFT-T 91 
NP_996778    105 CVVLALVVVALRKFSaS 121
Q9CXL7       105 CVVLALVVVALRKFSaS 121 house mouse
XP_016847623 104 SVIVALIVITLRKFSaS 120
XP_003438183  99 SVLLALIVITLRKFTaS 115
XP_021326975 100 SVLLALIVITLRKFTaS 116 zebrafish
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