Conserved Protein Domain Family
MRNIP

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pfam15749: MRNIP (This model is not part of the current CDD release)
MRN-interacting protein
This family is found in eukaryotes. Family members include MRN complex-interacting protein (MRNIP), which plays a role in preventing the accumulation of damaged DNA in cells. It associates with the MRE11-RAD50-NBS1 (MRN) damage-sensing complex and is rapidly recruited to sites of DNA damage. Phosphorylation of a serine promotes nuclear localization of MRNIP.
Statistics
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PSSM-Id: 521994
Aligned: 23 rows
Threshold Bit Score: 75.106
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBN74166      10 ALRCFSCQCF-QVNQRTK-SGKWKCRMCGEGQSIVKVWGrGGHAKDVRGLVMALNAAAGGGEDLNNvlrnnvggfgpqSQ 87 
EFJ12587       6 ALRCYACKMF-QVKPRKKsSSKWCCSVCNEKQSVTKVYGsSGAAKKIRELVQTLNYSPLAQEQDHFepndvgdlttqeNG 84 
XP_002674783   6 IFQCFNCTAF-SINQVTK-NRKWKCKLCGSQQSIRKVFAnSNQPKDLRPIVQELNMKRGEIEQEVLe-----------AR 72 
XP_004357399   6 LLQCYSCHTF-QINQKTK-VSKFQCKICNEKQSVKKIYAiSNQPKDLRPLVQKYNLEGGLKREEADkhkveqfeinqqQD 83 
XP_020435422   6 LIQCFSCSMF-QVKQKAK-VNTFKCVICSEKQSIKKIFGiSYQAKDLRELVKKYNLEAGQRKERq------------eQQ 71 
XP_003283081   1 --------MY-QVHQLNK-KKAFNCKICNEKQSYQKIYGqSYQAKDLTQLVKKYNMEKHNKPKPISi----------qDD 60 
Q55D89         6 LVQCYSCTMF-QVSQKKK-KKDFQCKICNEKQSIRKVYGiSFMGKDLTTLVKKYNIEKKSNPPKPIkhnefeddededED 83  Dictyostelium d...
XP_004994640   8 YVFC--CRLFpRLHQTKK----WKCKLCGEAQSVRKIFF-KGTGKDCRTRVQALNLRRGEMESISAeta-------meRD 73 
Q7PFR8         7 VVRCFQCLKY-QVDIVKK-ANKWACKMCGAKQSLAREYF-RGTGQDCRSMVQQLSVRHLEMDQREAevaelvlqnkiqLP 83  Anopheles gambi...
XP_650306      7 LLQCFSCKMF-QVHIKKK-TKKFECKVCGAKQSYKHIFGiSKQAKDLRQICGEYNEKRIIEEEQHIekq------vkqKQ 78  Entamoeba histo...
CBN74166      88 SRRHKQDGRNSSDRIGNQDGDraystvdraalqhtvgpaqpgLYGRNSSW 137
EFJ12587      85 QSEVGEKNvh-------------------------------gYETKPSKW 103
XP_002674783  73 QLEEENEEQIVEKKPIYKQAS-------------------------ASKW 97 
XP_004357399  84 DQHQHQQQANYFDDDDSEQNHqdefeqlqqq-qqtergsmkrKQQPQSSW 132
XP_020435422  72 QQDDYDDNFDFNLENESNNHSdslninnn------nstkstpQPQPPPSW 115
XP_003283081  61 HDNNNNNNNNNNNNNNNNNNNnnnnnnn--------sqslkqNTKPRTNW 102
Q55D89        84 EVNNNNNNNNNEDDNENDKNNnnennrnq------qqqqqqqQSSQPNKW 127 Dictyostelium discoideum AX4
XP_004994640  74 YTEYEAEEGDAMDSWHAEYGDsidnpsp-------tthapefQTPKQSKW 116
Q7PFR8        84 QPTQLDPAMLRNGTNESTNTT----------------------SKGPSKW 111 Anopheles gambiae str. PEST
XP_650306     79 KQKEEDKVLDIKEEEKINKGE-------------------------ESIW 103 Entamoeba histolytica HM-1:IMSS
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