Conserved Protein Domain Family
DUF4686

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pfam15742: DUF4686 (This model is not part of the current CDD release)
Domain of unknown function (DUF4686)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 498 and 775 amino acids in length. There is a conserved DLK sequence motif.
Statistics
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PSSM-Id: 521989
Aligned: 17 rows
Threshold Bit Score: 258.1
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_016815844   181 PSSGEKLKYNQQGEVQQLHQNLHRLQILCNSAENELRYERGQNLDLKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSS 260 
1_pfamImport     1 AKSQDALLQQKGEECRQIRQDAQRTQSLFTSAERELRYEREKNLDLKKHNALLDQEKLRVCAELKQAQARLTQLEQSSAS 80  
12_pfamImport    1 LSSGEKQKYQQQEDVQQLRQNLHRLQILCSSAEKELRYERGKNLDLKQHNSLLQEESIKIKIELKQAQQKLLDGTKMCSS 80  
13_pfamImport    1 PSSGEKLKYQQQEEVQQLHQNLHRLQTLCSSAEKELRYERGKNSDLKQHNSLLQEESIKIKIELKQAQEKLLDSSKMCCS 80  
6_pfamImport     1 IDKRLRYQ-HQGEEMQKLQQNLQRVQTLCSSAERELQFERTKSFDLKQHNNLLQEENIKIKAELKQAQKKLLDSTKMCSS 79  
10_pfamImport    1 IKSQDSVLKQKTEEAKQMKQDLQRAQSLFTSAEKELRYEKEKNLDLKRHNTLLDQEKLKLSAELKQVQTKLVQMEQKVTG 80  
8_pfamImport     1 IKSQDSVLSQKAEEAKQMKQDLQRAQSLFTSAERELRYEKEKNMDLKRHNALLDQEKLKISAELKQAQLKLVQVEQKVSS 80  
XP_005162190   731 VKAQDSLLQQKGEENKQLKQDLQRTQHLFTSAERELRYEREKNLDLKRHIALLDQEKVKLCAELKQAQAKVAQHEGNAAG 810  zebrafish
XP_064424006   871 VKSQESLLRQQTEEVQQFRQDLHRVQNLFSSAERELRYERDKNLDLKKHIALLQQENTKVNAEIKQILSKFSDQEQTSIG 950  coelacanth
XP_028920727  1046 PPSGEASPQQQREELQQLRQDFLRIQNLCSSAERELRYERGKSSDLKQHNALLQQENTKVKAELKQVQLKLSESTKMYSS 1125 platypus
XP_016815844   261 LTAECKHCQQKIKELELEVLKHTQSIKSQNNLQEKLAQEKSKVADAEEK---ILDLQRKLEHA-HKVCLTDTCISEKQQL 336 
1_pfamImport    81 LGGELERVQQRARELELEMARGCQSRQAQHSLEEELCSERARLLAADKKkrqVLELQQQLKSAlHQLRLEETRASEADRL 160 
12_pfamImport   81 LTAEWKHGQQKIRELELEVLKQDQSIKSQDNLKEKLAQEKSKVADAEEK---ILVLQQKLEHA-HKVCLTDTCISGKKQL 156 
13_pfamImport   81 LTAEWKHCQQKIRELELEVLKQAQSIKSQNNLQEMLAQEKSKVADAEDK---ILDLQQKLEHA-QKVNLTDTCILEKKQL 156 
6_pfamImport    80 ITANWESSQQKVRDLEQEILKQSKNIQSQNSLYEKLAQEKTRVAHAEKM---VLELQKKLEVA-SESC-TEACILDKKQL 154 
10_pfamImport   81 QAAECEHQQQKIRQLELELARSSTNRSATTSLQGDLQAERARLIAADKK---VLELQQQLKSVqHQLRVEEARAGETNRL 157 
8_pfamImport    81 QTAEIECQQQKIRELELELARTSTNHRASSSLQEDLQAERARLIAADKK---VLELQQQLKNVqHQLRVEEARASESSRL 157 
XP_005162190   811 QVAELERLQQRARDLELEMARSSQNRQTNSSLMDELNSQRSRVIAADKK---VVELQQQLKNAlHQLRLEEARSGETSKL 887  zebrafish
XP_064424006   951 HRVELDRSQLKVKELEIEVAKLRQTTKLNKSLQEKLADERSRAIDADKKv---LELQQQLNAAqHQLHLLETRVQEKELL 1027 coelacanth
XP_028920727  1126 LTGKWEHCQQNIKELELEVRKQTEKTQSQNDLEEQLSQEKARFADAEKM---RLELQQNLKDSlQKFSRVEV---EKNQL 1199 platypus
XP_016815844   337 EEKIKEATENEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQ-LENEKRK-YD 414 
1_pfamImport   161 HRESKDMAQTLGALRAKLQEEQLQRKRLEQREEELQQQARSLREREASLTRATSELGLRLQQQEARLGV-QQAEHSAaEE 239 
12_pfamImport  157 EERIKEALENEAKTKQLYQEEQQKRKLLDQNVNELQKQVRILQDKGNQLEITTSQQQSRIQQQEAQLQKyLENKKEK-SD 235 
13_pfamImport  157 EERIKEAIENEAKIKQQYQEEQQKRKLLDQNMNELQKQVKILQEKESLLEMTSSQQQIKLQQQKAQLKE-LENEKRK-SD 234 
6_pfamImport   155 EEAIKEARKNETKLKMQYQEEQQKRKLLDQSVDELQQHIQYLHAKEALMEQSNSKQQFKIQQQEVQLQI-LEDEKKL-SD 232 
10_pfamImport  158 ERESRDLSDALSSLRAQQQEEHITRKLLEQREEELQQQVRSLRHKEASLTRTNAELSHRVQQLDTRLSV-LEAELSNaRE 236 
8_pfamImport   158 ERDSRDLSDNLSALRAQQQEQHIARKLLEQREEELQQQVRSLRLKEASLSRTNTELSHRVQQLDIRLSI-SETELSK-TR 235 
XP_005162190   888 ERDTRDMSDNLSALRAHLQEEQLQRKLLEQKDEELQQHVRSLRAKEASLVRTNLEISHRVQELETRLQV-MESELNTaRE 966  zebrafish
XP_064424006  1028 EEEVREGKENVARLRGRLQEEQLQRKLLDQNVEDLQQQIKSLRGREASISQTNTELQLRLQQRETQLQV-LENEQVTaAD 1106 coelacanth
XP_028920727  1200 MGKMKEARENEEKLKQHYQEEQQQRKFLDQTIQTLQQQIQFLRDRETLLEQTVVQQQLKIKEHQALLQE-LEDEKKI-SD 1277 platypus
XP_016815844   415 EHV----KSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDE 490 
1_pfamImport   240 EHRht-qKANQNLAEQLLSCQQESERLQEELQQVLQQLDLQVRKYDEKQAQHKAKLRKAKQVFVKETSERDGRIQQLEND 318 
12_pfamImport  236 EHL----KSNGELSEKLSKLQQEKEALCKEYAQLLKQMDAHMRDFNEKHHHHKVKLGRVKNLLLQEVELREKRIEHLENE 311 
13_pfamImport  235 EHL----KSNQELSKKLSVLQQEKEALCEQNEHLLKQFDLHVRNYHQKHQYYKVKLHAVKDRLVDEVELRDEKIKQLENE 310 
6_pfamImport   233 EQV----KNNQELTEKISVLQQEKDSLRDEYRQFLNQLDVHMRNYNEKHNHHKAKLRKAKERLTNEVEQRDERIKQLENE 308 
10_pfamImport  237 EAKds-qASRQKLQEELLASQQDCKGLQDELQQVLLQLDVHVRKYNEKQSQHKTKLRQAKQVFLKATEQRDSTIQKLEND 315 
8_pfamImport   236 EEVkesqKSSQKVQEELLVSQQECERLQAELQQVLLQLDANIRKYNEKQTQNKTKLRQAKQVFLKTTAQRDSTIQKLEND 315 
XP_005162190   967 EQRsg-qKSCHRLEEQLLSAQHESERLQEELKLVVQQLDTNVRRYNEKQSQQKTKLRRAKQIFMKTVSQHEQRIQQLEND 1045 zebrafish
XP_064424006  1107 EHQyn-qRTSQKLSVQLSSCQLETDRLQEELQLVLQQLDTHIRKYNEKQTRHKAKLRRAKEVFEQEIKLRDAKNKQLESE 1185 coelacanth
XP_028920727  1278 EHLhc-qKNRQKLSEQLSALQQEKETQHEKYSEFLNQFDAHVRKYNEKQLHLKAKVRRAKESFVHEVRQRDDTIKQLEHE 1356 platypus
XP_016815844   491 IGILQHKIEKEKAIQDQITAQNDTLLLEKRKLQEQVIEQEQLIHSNKWTISSIQSRVLYMDKENKQLQENSLRL 564 
1_pfamImport   319 LALAHSLAEKEQDWIKKVTEENEKLLLEKRHLLKKLSEEEEVGHMNMRTTSTIQHRVNFLEGENRQLQDRTLQL 392 
12_pfamImport  312 VRILQHQVEKEKAFQDKIIAQNDILLLEKRNLLEKLTEKEELIKSNKGVTSSVQNKVLLLDKENKHLQETSL-W 384 
13_pfamImport  311 VGALRQQIEKEKAFQHQIATQNDTLLLEKRKLLEQVTEQELLIDSNKWRMSSVQNRVLFLDEENKQLQKNCLRL 384 
6_pfamImport   309 IEEMQRLMEKEKEFQDQVTTQNENLLIEKRRLLERLTEQDETIQGNKWMISSVQNRVLFLDEENKLLQENSLRL 382 
10_pfamImport  316 LELASMLSQKDKERIQLVMEVNEKLLEEKRELVQKIIEAEEMGSKAMKTASTVQYRVNLLEVENKQLQDETLKL 389 
8_pfamImport   316 LALANSLSFKEKERIQTVVAENEKLLEDKRELLRRISEAEEMGSKGMRTASTVQHRVNILEVENRQLHERTMKL 389 
XP_005162190  1046 LALATSLSEKEKDWIRTVTEENEQLLLERRELLQRISEAEEMGNNGLRTATTTQQRVKFLEMENKQLQEKTLTL 1119 zebrafish
XP_064424006  1186 IAITKSLSEKEQAWIKKLTTENEQLLLEKRELLQQINEQEEVGRTNNRTISTVQHKMHFLEEENRQLQDRTLKL 1259 coelacanth
XP_028920727  1357 IEIMRKQLEKGEEFHSQIIAKNETLLRENWKLLDELSVQEEVAKDSKLIITSIQNRVFFLDEENKRLQEGTLRL 1430 platypus
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