Conserved Protein Domain Family
LRIF1

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pfam15741: LRIF1 (This model is not part of the current CDD release)
Ligand-dependent nuclear receptor-interacting factor 1
This family of proteins interacts with the retinoic acid receptor RARalpha and inhibit it's ligand-dependent transcriptional activation.
Statistics
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PSSM-Id: 521988
Aligned: 8 rows
Threshold Bit Score: 882.64
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_016159738   1 MYRVIQTTGPDGKNLLKLLPISKTSGSFMPLVQPPAMPNNSNANVSSPVHLTFKTQLGNTTAPSSVKIPIFQPPNPGRII 80 
NP_001120957  26 MYQVVPTIGTDGKKLLQLLPIPKSSGNLIPVVQSPVMSHGLKGNTEKPVQVTFQTQISSSSTSASVQLPVLQPANTTKYF 105
Q5T3J3        28 MYQVVQTIGSDGKNLLQLLPIPKSSGNLIPLVQSSVMSDALKGNTGKPVQVTFQTQISSSSTSASVQLPIFQPASSSNYF 107 human
XP_031823120  28 MYQVVQTTGLDGKNLLKLLPIPNSPGNLLPLVQSSVTSDTSKGNISNPVHVTIQTQLASTPTTASIQFPVFQATNSGNYF 107
XP_007485183  28 MYQVVQTTGLDGKNLLKLLPIPNSSGNLMPLVQSSVTSDTSNGNISNPVHVTIQTQLASSPANASIQFPVFQTTNSGNYI 107
XP_007664971  16 MYQVVQTSGLDGKNLLKLLPISNSPGNPMPLVSSSVTTDSSKANLASPVHVTFQTQLNSLSTGPSIQFPVFQPVTAGKYI 95 
XP_005987651  27 LYQVVQITDANGKNILKLIPASKISRSVAPTIPSSSITKGSEVNMLTPVTLQLQT---TAMNSISSEVSDFHHPTK-KLF 102
XP_027300844  27 MYRVVQTTGPDGKNLLKLLPISKSSGNFVPIVQSSAMSNNPKGNISSPVHLTFKTQLANTTAPSSVKIPVFQSPNPAKII 106
XP_016159738  81 LTRTLDKQESARAGSEKESLIP-SEAASAQSSCM---AVDGVSL-QNIAItSSSHQSSMTCMVVNTKPLPVTVKSPVLPS 155
NP_001120957 106 LTGTIDTSGKDRVTSMGTGNFT-PPISNTQNHGV---KIHRLTR-QTFTI-PPSTQNDSSYFIVNTPSLPANVNSSTLPS 179
Q5T3J3       108 LTRTVDTSEKGRVTSVGTGNFS-SSVSKVQSHGV---KIDGLTM-QTFAV-PPSTQKDSSFIVVNTQSLPVTVKSPVLPS 181 human
XP_031823120 108 LSATVDKSENARVASVGKESL--ASASTAQSNSM---KVERLAL-QKIAVsPSTTQGDTTYMLVNAKNLPVTVKSPVLPY 181
XP_007485183 108 LSRAVDKSENVRVASVGKESLT-SSCSTVQNNAM---KVERLAL-QKIAVsPATPQSDTTYMLVNTKNLPVTVKSPVLPY 182
XP_007664971  96 LTRTLDPPENVRTTSAESKSLP-SKVAAAANAPTppgAADRLSLpQNAIVsPPSTQGDTTYMLVNPKNLPVMVKSPGLPS 174
XP_005987651 103 VTRPVDPKEILGVTHGPTVVTSgSPISLTKNAAL---TVANPSS-QRLLA-SSSNSKDKMYMLISSKHLPGTVKSVALPS 177
XP_027300844 107 LTRTSDKQESVRAGSETESLTA-KSAANIQSSCV---SVDRLSL-QNIAVtSSSNQSNSAYMFVNTKNLPATMKSPVLPS 181
XP_016159738 156 GHHLQIPADAEVKSVPASLLPPSIQQKILAAAATNVSGGADSTKTP-MVIYMSPVNTVKTsqVLPKHLQSFCPKP--AAe 232
NP_001120957 180 GPPLTIPAHAEVKPVLASPLPPLVQQKILGTVTTSTSGTVEASQIP-AVFYVSPVNSVKI--IVDKKTQNIYHKP--VT- 253
Q5T3J3       182 GHHLQIPAHAEVKSVPASSLPPSVQQKILATATTSTSGMVEASQMP-TVIYVSPVNTVKN--VVTKNFQNIYPKP--VTe 256 human
XP_031823120 182 GHHLQIPANAEVKSLPASSLPPPIQQKILAAAATNTSGTAEASKIP-TVIYVSPVNTVKS--VVPKTFKNICPKPpnPTe 258
XP_007485183 183 GHHLQIPANAEVKSVPASSLPPPIQQKILAAAATNTSGTTEASKVP-TVIYVSPVNTVKS--VVSKTYKNICPKPpnPTe 259
XP_007664971 175 GHHLQIPAHAEVKSVPASSLPPAIQQKILAAAAPGPSGSTEAAKTP-TVIYVSPVNTVKT--VVSKCWQAICPKPs-PPe 250
XP_005987651 178 GQHIRIPADAQVKSLAASSFSPAIQEKILVTAATNISGTNEANKTPaSVIYVSPVNTVKT--VVTKPLPVISPKPvvKPs 255
XP_027300844 182 DHHLQIPADAEVKSVPASFLPPAIQQKILAAAATNVSGGADSTKIP-TVIYVSPVNAVKT--VLPKRLQTICPKA--ATd 256
XP_016159738 233 vsktliVTTAQKG-S---GSSPEPVTSEGQQCQQTPMKWIVQETAPLSAACLIPVKSSNNVASKILKTL-SDTKNVE--- 304
NP_001120957 254 ------FSTSQIP-P---NVATKTQLNSGQHPQAAPVNLIFQEYLQPGIPCLVPVKSSNNVPSKVFNTF-VDRKTLG--- 319
Q5T3J3       257 iakpviLNTTQIP-K---NVATETQLKGGQHSQAAPVKWIFQDNLQPFTPSLVPVKSSNNVASKILKTF-VDRKNLG--- 328 human
XP_031823120 259 aakpmiLNTSQTPvK---NPAADVTNNEGQQSRDTPMKWVVKENPQ-CSPCLVPVKSSNNMASKILKTL-MDMKNVE--- 330
XP_007485183 260 paksmvLNTSQTSvK---NPGTDVSNNEGQQSRDAPMKWVVRENPQ-STPCLVPVKSSNNMASKILKTL-MDMKNVE--- 331
XP_007664971 251 askaviLTGPPTPaK---GAAPDVGAKASPPAQGTPMKWVVQRNPQCSSPCLVPVKSSNNVASKILKTL-ADMKNVQ--- 323
XP_005987651 256 tsltriTEAYEMEnRfttGMIASPALPTSNNIAQSPMKWVVQENPQFSAPCLVPVKSSTNAASQILKSLaADLQHVEqpl 335
XP_027300844 257 vsktliMTATQMA-----NCSSETVKSDDQKCQQTPMKWIVQESPQLSSPCLIPVKSSNNVATKILKTL-SDMKNVE--- 327
XP_016159738 305 VNPANILPPCSNGPGGNQTKITPLKENALVMYNGKVyLLTKRGSDVLSA-----QAEKQT--------SSSADGLLkKET 371
NP_001120957 320 DNTVGTPLLSTNSSSRTQSISVPIKDDGLIMFNGKV-LLNKKGTYGLPS-----KIDQQN--------SVSSDIPL-KDS 384
Q5T3J3       329 DNTINMPPLSTIDPSGTRSKNMPIKDNALVMFNGKVyLLAKKGTDVLPS-----QIDQQN--------SVSPDTPVrKDT 395 human
XP_031823120 331 TSSLNMPPLCSGTSGGTQAKITPIKDNALVMFNGKVyLLAKKGSEVLPS-----QTDQQN--------SVASDASPrKDM 397
XP_007485183 332 TGSLNMSSLCSSTSSGTQAKITPIKDNALVMFNGKVyLLAKKGSEVLPS-----QTDQQN--------SAAPDASPrKDT 398
XP_007664971 324 STSAGILPLCSGGSAGSQSKITPIKDNALVMFNGKVyLLAKRGSEVLVP-----QVEPQSppssssspSSSSDIMSrKDP 398
XP_005987651 336 STNAAMPLLSTNSPESPSVKSAAAKKNALVMCNGKVyFMAKQGPEVGTTspkqnQSKDQA--------TCSQSNEVqNLQ 407
XP_027300844 328 VNSANILPLCSSGPGGSQTKITPFKDNALVMYSGKVyLLTKRGSDVLSA-----HVDKQA--------SSSSDASLkKET 394
XP_016159738 372 PKQIDSTKVNKITSKVVNLVLSK-SKgvvLSQKDPKPCTVSKNSSPVA--LRNDLKSTPAAPLVSG---ANQQDPTVIQR 445
NP_001120957 385 SQVVSSSLVTEISREVLSSVLVK-SK---SFQLKTKSLSNSQPAPMAHikPEKSEKVERPSFSVTSphtTNQSTHCLKQS 460
Q5T3J3       396 LQTVSSSPVTEISREVVNIVLAK-SK---SSQMETKSLSNTQLASMANlrAEKN-KVEKPSPSTTNp-hMNQSSNYLKQS 469 human
XP_031823120 398 SQTPNSNSVTKITNEVVNIVLAK-NKt--IPQKETKLISDTQLASEPVpsLEKNNKVECTSLSAQSpqhVTQPL-CLEQC 473
XP_007485183 399 SQISNSSS---ITNEVVNIVLAK-NKt--APQKETKLLSDTQLASEPApnLEKNNKVECASLSALNpqhAKQPISHVEQC 472
XP_007664971 399 PQLADSS-VSKITSEVVNIVLAKrNNslaTPQKDTKEGGEGQLDSESA--TEKKPRAGSALLSTPRphkVNTPIGQGEQG 475
XP_005987651 408 ARTLDSVAISKIS-KAVRAVLSK-NMgskLPQIN---LPRSEKSVQTT--LKRHVKTE-ACQEFPStkkENQRVLHVK-- 477
XP_027300844 395 SKLIASTEVTKITNKVVNLVLSK-SKgmvLSQKDSKMGANAKVSPSAG--LRSDLKSAPAALVTPS---VKQRSSTVIQG 468
XP_016159738 446 QS--LPFTKSVScSGVIPVPAVGMQENVwq---------nGKDMSHS----PKAAGAvl-pqAKQECAVGEDWPKIPCEK 509
NP_001120957 461 KI--VFINPVFS-DGFRTGQNTPRKENL------------IQNIRSS----VDAATV-----TSQQCVFRDQEPQTQYEM 516
Q5T3J3       470 KT--LFTNPIFP-VGFSTGHNAPRKVTAviyarkgsvlqsIEKISSS----VDATTV-----TSQQCVFRDQEPKIHNEM 537 human
XP_031823120 474 KT--APIKLNLP-DVVSPAQNAKKETSVsh---------tKEK--SS----SDDTTT-----TSKHCVYTDQEPKNQGEM 530
XP_007485183 473 NT--VPIKLNLP-DVISPVQNAIKETSInh---------tKEA--GS----ADDPTI-----TSQHCVPTHQEPKNQGEM 529
XP_007664971 476 KTaaLPREPSLP-RGVGTDANAILERDGgs---------sKEKFSSP----ADPATV-----SSHRCTFTDQKPKIQGAM 536
XP_005987651 478 -----PQNEELQ------------RENGdlsnf--svskeREEILNTipknISLMSSelygrTGDMQQHSDVNPS--SDT 536
XP_027300844 469 KS--LPLTMSIS-SGATPITAVGTQENVcq---------gGKEMIHS----PRAASAvl-pqSKQECAFSEDWQKVQHEK 531
XP_016159738 510 MDSPGKVIQIKHQEHPHW---------RQYLELRKKFGLFKEERVYLMRIPLRAFCEnpeERVCSSDSLERKNDSCssss 580
NP_001120957 517 ASILKKDIQERSNKKYSQgnhtkasylKNDAEFKKIFGLTKDLRVCLTRIPDHLSST---KSFDSFNNLMKSSSYK---- 589
Q5T3J3       538 ASTSDKGAQGRNDKKDSQgrsnkalhlKSDAEFKKIFGLTKDLRVCLTRIPDHLTSG---EGFDSFSSLVKSGTYK---- 610 human
XP_031823120 531 AFVLETYTHSRSQRESCP---------KEYAELRKNFGITKDLRVRLTRIPLFDSTS-----LYSPTSLTNNISSK---- 592
XP_007485183 530 ALVLETHFQSRSQKESCR---------REYAELRKKFGITKDLKVNLTRILAFDST----TSLYSPSSLTNSVSSK---- 592
XP_007664971 537 APAPEGEAPAGREPKTCR---------KQEAELRKKFGLVRDLRVRLTRIPVFRDAE---ERKSPPGGLENHHSFQ---- 600
XP_005987651 537 MFSSVKETLGRSKEKGLYn--------ESDDQLRKKFGLNADVRVHLNKIPIQSFSVv-sKKHASPSAVTEMEDPS---- 603
XP_027300844 532 MDSQGKINQIKHQEKPHW---------KQYLELRRKFGLTKEERVYLKRIPLITSSEkpdERVCSSNNLKTRNDSCvsss 602
XP_016159738 581 lDVEIRSHhqg----cvEEKKiivdleEDLIRKRKINSSPLLDSGKRR-----RTSIKPATSPS--LEITSSTSSAL--A 647
NP_001120957 590 -DANVVMK---------EEKK------QSFSKKRNAKPMKKMDYTKRR-----KIENASDMVMNvmNGTDVANSQLLssI 648
Q5T3J3       611 -ETEFMVK---------EGERk----qQNFDKKRKAKTNKKMDHIKKR-----KTENAYNAIIN--GEANVTGSQLLssI 669 human
XP_031823120 593 -ESKIIVDlts----ekEEESqeltvqQDLDKKRKAKTVMKVDSTKKK-----KSGNDVNSSMD--TGTDHTIPQVLnsT 660
XP_007485183 593 -ESEIIVDltt----gnDEESqelilqQDLDKKRKAKTVIMEDNTKKK-----KSGNDGSTSGL--IGTDSTSPQILnsI 660
XP_007664971 601 -EAKFRVEptg----gkEEPNkketveQDLDKKRKAK-VQKTTSAKRR-----KPGPDCPVSPN--PHGNSPRPQRQpsG 667
XP_005987651 604 -GMEFMTKldspmtkniEGNEvkikseQGSARKRKSADAEIVGQAKKRpntfeNSSNRDSESPC--STSSGPNSKRFssK 680
XP_027300844 603 lDVTITNQhqe----cvTEEKiiv-dleDTSKKRKIKSSSVSDSGKRR-----KTSVKSTTSSN--SEDAGPSSILLnrS 670
XP_016159738 648 ISPPAASpQPSVPPGSATGSQGRDSEQDVLPWHSDTAHPGISvlVTSEEDTSVLEGSFRDDAFPVAPPDLDETIRDEKIK 727
NP_001120957 649 LPISDIA-QHNIITSHSTTREDKRTETEHCCHEKQEKGTLSS--STSFEQSNYFNKNYTEDIFPVTPPELEETIRDEKIR 725
Q5T3J3       670 LPTSDVS-QHNILTSHSKTRQEKRTEMEYYTHEKQEKGTLNS--NAAYEQSHFFNKNYTEDIFPVTPPELEETIRDEKIR 746 human
XP_031823120 661 LPNSALLpQSNNLTGCMKSHQENSPELELHAPGGLDRGTRSPasVSFEQDPPDSQDCYIDESFPTTLPELDETIRDEKIK 740
XP_007485183 661 SPDSALSlHSSNLIGYTKFSEENSSELELPNQDGLDRSTDSPasASFEQDPPDSQDCYIDDSFPTTLPELDETIRDEKIK 740
XP_007664971 668 GARSAESrEAGHPVT-TSPVQETSSEPEACSPNNLPSSTWSPacALFEPDLPICQGAFTEDTFPSTPPELDETIRDEKIK 746
XP_005987651 681 LVKTQERfPANSEADSKVLFLEQKSEESSNSNSAVEKENMNSilGTSAEPEKHHGEICTGDFFPVEPLDSDITPGDEKIR 760
XP_027300844 671 ASPPPVLlQQSISTDFVISPVGRDSEQETCSQNSDVIDSHIPvlVSCEDHTSVFEGSFRDDAFPLTPPDLDETIRDEKIK 750
XP_016159738 728 RLKQLLREREAALEEMRREMQQ 749
NP_001120957 726 RLKQILREKEAALEELRKKMHQ 747
Q5T3J3       747 RLKQVLREKEAALEEMRKKMHQ 768 human
XP_031823120 741 RLKQLLKEREAALEEIRKKMQQ 762
XP_007485183 741 RLKQLLKEREAALEEIRKKMQQ 762
XP_007664971 747 RLKQLLREREAALEEMRKKMHQ 768
XP_005987651 761 KLKELLREREAALEEIRKKMFY 782
XP_027300844 751 RLKQLLREREAALEEMRRKMQQ 772
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