Conserved Protein Domain Family
CTSRT
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pfam15729: CTSRT 
Cation channel sperm-associated targeting subunit tau
Cation channel sperm-associated targeting subunit tau (CTSRT, also known as Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 and C2 calcium-dependent domain-containing protein 6) has been identified in mice as an auxiliary component of the CatSper complex, which is involved in sperm cell hyperactivation. Sperm cell hyperactivation is required for sperm motility, essential late in the preparation of sperm fertilisation. This protein is key for CatSper flagellar targeting and trafficking into the quadrilinear nanodomains as it links the channel-carrying vesicles ans motor proteins in elongating flagella.
Links
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Statistics
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PSSM-Id: 495307
Aligned: 6 rows
Threshold Bit Score: 261.674
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001019534  145 LIPFGDVVGCLAIHIKSCRQFTQRFIAQ-QHFNLFMRISVNHIVKCTKIRHLKAVN-----NEKNLVLKFDEV--KYFSV 216 
2_pfamImport    1 LVPFGDVVGCLAIHIKNCRYFTPKIILKpYYTNLFIRITINNVVKCTKMYTLLSKG-----NEKNINCKFNAFfnTHFDI 75  
NP_001071527  102 LVPFGDVVGCLAIHIRNCKHFTPKIISQ-HYSNLFIRISINNVVKCTKTCSLLSQN-----TEKDFMITFDEV--KYFSV 173 
1_pfamImport    1 LVPFGDVAGCLAIHVKNCSHFTPKIDVQ-HKNNFFIRISINNIVKYTKLCSLLPQNipfviNERKTLIKFDEV--KYFSV 77  
Q53TS8        100 LVPFGDVVGCLGIHIKNCRHFMPKISLQ-HYANLFIRISINKAVKCTKMCSLLSKN-----DEKNTVIKFDEV--KYFSV 171  human
PNJ73602      100 LVPFGDVVGCLGIHIKNCRHFTPKISVQ-HFANLFIRISINKAAKCTKMCSLLSKN-----NEKNTVIKFDEV--KYFSV 171 

NP_001019534  217 QVPRRQDDERNYIYLELMQdAGDSEKLPYPLGNAESHLYEVIQKGCFTEVMQMMRRNTPICRVEVEFMFSYG 288 
2_pfamImport   76 EVPRRPDDARNNIYLELME-YEDTEKYPVFLGSVQVHLYEVIQKGCFTEEFQILNKNTFVCRVQVEFMFSYG 146 
NP_001071527  174 QVPRRQDDEKNNIRLELMQ-HDNTKKYLLLLGSVQVHLYEVIQKGCFTGELQVLNKNTFICRVEVEFMFSYG 244 
1_pfamImport   78 QVPRRQNDARNNIYLDLMQ-FDNKEKH-ILLGRVQVHLYEVIQKGCFTEEFQMLNENTFICRMEVDFMFSYG 147 
Q53TS8        172 QVPRRYDDKRNNILLELIQ-YDNREKRAFLLGSVQIHLYEVIQKGCFIEEVQVLHGNIFVCRLEVEFMFSYG 242  human
PNJ73602      172 QVPRRYDDERNNILLELIQ-YDNREKRAFLLGSVQIHLYEVIQKGCFIEEVQVLHRNIFVCRLEVEFMFSYG 242
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