Conserved Protein Domain Family
Brme1

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pfam15710: Brme1 
Break repair meiotic recombinase recruitment factor 1
Brme1 (also known as Meiok21) is a component of meiotic recombination bridges involved in meiotic double-strand break repair. The C-terminal domain of Brme1 physically interacts with the N-terminal domain of HSF2BP. BRME1 facilitates the loading of RAD51 and DMC1 recombinases onto DSBs (DNA double-strand breaks) through interaction with MEILB2/HSF2BP and replacing ssDNA binding proteins. Brme1 is highly expressed in mice testes and fetal ovaries. Knockout of Brme1 results in male mice infertility.
Statistics
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PSSM-Id: 495291
Aligned: 15 rows
Threshold Bit Score: 727.424
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_020850485  88 MPKRRRPQIS-GDENHLLKFKKIPRIRDTYMK-PENSGMGGYFNLEDSE----IAAVTKQDGEERSQADIRSVDERTDDP 161
XP_021589581   1 MSKRKKLRTS-GEGVRPPKPPKNPRLGPSKGG-PESPDSGHLHHPEESEdssgPAAFPELTGEEPRGAVSSSPHEETGAA 78 
XP_023580535  13 LNNDQSMR---GERVYSLKLPKKPRLGDSDRA-PQSPELGRLPAPEESEgkvgSIPPAEHSEEEPRPAAPSSPDEETEVP 88 
4_pfamImport   1 MSKRKKLRTP-GEGIRPPKPPKHPRLGDPDGD-PQSFQFGPLGHPEESKgssgPVPSTEQSGEESGHEASSSPDKEAGAP 78 
5_pfamImport   1 MSKRKKLRTSgREGLHLRKLPKNPRIEDSDGAtSQSSLLDCLHHPEESEggsgLTPSAEQSGEEPGQAASSSPDNEADAP 80 
XP_021564906   1 MSKRKKPRAS-GEGIHPLKPPKNSRLGDSDRT-PQSCELGCLHHPEESGgklgPALFAEHSREEPGQAIASFPGEETGAP 78 
3_pfamImport   1 MSKRKKLRTS-GEGIRPAKPPKNPRLGDSDGG-PQSSKSDHLRHLEEPEgklgPASSIQHSREEPGQAVPSSPDEETGAP 78 
2_pfamImport   1 MPKRKKLGTS-GEGICPSKPLKNPRLEDSDGD-LQSSTLGCLHHPEVLEgklgPVPSTQQHGEEPGKAVSSSPNKETGAP 78 
Q0VDD7         1 MTKRKKLRTS-GEGLCPPKPLKNPRLGDFYGD-PQSSMLGCLHHPEEPEgklgPVPSTQQHGEEPGKAVSSSPDEETGSP 78  human
EHB14456       1 MSKRKKLRTA-GQGIHPPKPPKNPRPGDSNGG-SRSSKLGTLQHPNESEdistPTTPTELSGQEPGPAVSSFSEETAAA- 77 
XP_020850485 162 TNERRQTRKDPVPFSFSQNSEMKFVPVFAQSKKSLTQKPERKEKAARSSNTKQIMFPESNHQKAENVQFDESLVAAIWED 241
XP_021589581  79 SRLLRQPEKEPTPLPPSQNSVGRFVPQFAKPRKTGTRKAETREEDAENGAVSSDTLPVPSAQQAGSLLLPESLGLALQEA 158
XP_023580535  89 SRLLGEPEKDPTPFPLSQNSVGKFVPQFAKPRKTVTRKAERREEVIGCEAFNLETLQEPSAPQVGSQQLHALPGLAFTEE 168
4_pfamImport  79 SRSLSQPEKEPIPFPPSQNSDRRFVPQFAKPRKAVTRLAATREEDLGSGAFSLETPPEPSAQQAGSQSWQESPELTILEA 158
5_pfamImport  81 SRLLGQPEKEPAPLPPSQNSVGKFVPQFAKPRKTVTRQAERREERLGMGVFSSGTLPEPSAQQTRSQPQEESPGLAPQEA 160
XP_021564906  79 SSLLGQPEEEPAPLPASQNSIGRFVPQFAKPRKTVARKAERQEEDLQCGAFSPETLPKPSAQQAGSQPLEGYLGLTLQEA 158
3_pfamImport  79 CRLLRPPE-EPPALPPSQNSVGRFVPQFSNPRKTVARKAETREEDLGSGAFSLETPPEPSAWQAGSRQREESLGLTVQEG 157
2_pfamImport  79 CRLLHQPEKEPASLPPSQNSVGRFVPQFAKSRKTVPRTGGMKDEDLGSGPFSPETLPESSAQQAGCQLLAETLGLPLQEA 158
Q0VDD7        79 CRLLRQPEKEPAPLPPSQNSFGRFVPQFAKSRKTVTRKEEMKDEDRGSGAFSLETIAESSAQSPGCQLLVETLGVPLQEA 158 human
EHB14456      78 -SLLEQLEKEASFFPDSQTSLGRFVPQFAKPGKIVTRKAKTMEEDTERRAVSLEALPNPSAP----WQLEGSLG------ 146
XP_020850485 242 RELEDQKQKGFLITemdsvgggrvllfqEQDSQSPLKPTDGSYYIAAGTFnnapQEMGSITTMQERTNKEHLSGGMTNTL 321
XP_021589581 159 RGPGEQTQADSPST--------------EQSGQNLEISVPGRGDSQPLFS----PEVGTGPSHPERASQNRLLEQSNSVM 220
XP_023580535 169 GGLKDQAQATVTCP--------------EQHSQLPPKPVPGTGASLPVMSpdgsPSWGAVPSASERASQEHPSEPGTR-- 232
4_pfamImport 159 WEPGDQTQTDGTHS--------------EHSVQNAVTPVSSRGDSQPEVSndisSEWGMVPLVSESASQDCLLKQGTNLP 224
5_pfamImport 161 RDLGHQTQADGTCT--------------KPSGLSPMTPGPSDADPQPSVStntsPELGTVPSASERADQDYLSEPGTNVP 226
XP_021564906 159 GQPGEPTQADGSCS--------------EQRVQDPVK--PGSGDSQPEAS----PEVGTGPSTSERASQNHLTEQGTNTP 218
3_pfamImport 158 R---DPMQADGACP--------------EQSSQDPANPLPSRGDAQPKAS----PEGGAGPAAPQMASQDHLLEPGTN-- 214
2_pfamImport 159 MEPGDPMQADGAHP--------------KQSSQSPVKAVSSSGDSQPEDP----PGRGMGWSASQRASQDHPSEQGTD-- 218
Q0VDD7       159 TELGDPTQADSARP--------------EQSSQSPVQAVPGSGDSQPDDP----PDRGTGLSASQRASQDHLSEQGAD-- 218 human
EHB14456     147 --PRAQMPADNPHL--------------EQSGQKPGTPVPGE---------------GTGSCNSEMASQDPVSEQGTSTS 195
XP_020850485 322 NGKNpesk-----nlkSGSLVEMEMNGTPmyenlavGSHSQKeaAQLISNTLMLQQnrplPDRRATHEGDtTQEEVGTst 396
XP_021589581 221 AGGNl-----------GNSRPETEMAWVP-------GDRGQK--GHLPGSDAGGQG----SDRGAPRGGG-AQGRSGA-- 273
XP_023580535 233 -GGNssfqsgflvepqGNGRPGTEKGLAP-------EGPGQK--GPPPSNESEGKE----PHGGAP-------------- 284
4_pfamImport 225 DAGS------------------TEGGRIP-------GDLSQK--GHLPSSGAEKKE----PDQGVPQEEG-VQGGTGT-- 270
5_pfamImport 227 KGGS------------------TEEGWAP-------GNHSQK--GRLPGSDTGEME----PEQGAPQQGG-ARALAGA-- 272
XP_021564906 219 DGGNl-----------GNSRPETERAWTL-------GDLDQK--GHQPGCATEEME----PDRGAPWEGD-APRGTGA-- 271
3_pfamImport 215 -----------------NSGPETEKAWVP-------SSGGQK--GHLLSSDAGGKE----PDGGAPQRGG-AQRGAEA-- 261
2_pfamImport 219 -----------------NSRPETER--AP-------GDHGQK--EHLPSSDSEGKE----PDRGAPQEGG-AQRTAGA-- 263
Q0VDD7       219 -----------------DSKPETDR--VP-------GDGGQK--EHLPSIDSEGEK----PDRGAPQEGG-AQRTAGA-- 263 human
EHB14456     196 DGGNl-----------WSS--GPERSQVP-------NDLAPK--RNHPCSGAEGMK----PARGAPQEGG-AQNGT---- 244
XP_020850485 397 tygligslysnDFSEGQGKREESSSLMIPSDSNLPTAREQNIGKENPWDNATDQGCPDNMPQSNKMNQKAELSHDSQGSR 476
XP_021589581 274 -----------ELPPVPKDEGASRPHTAAPAPAVGLAQELSPATPHLKTWSVGQDLPDPRQIPGGSGGEAGQSHSSPGCT 342
XP_023580535 285 -----------------QEEGEGIPGALGP----DPARRLSPVSQGPEPGSATQGCPSHVQTPSRPvviv---------- 333
4_pfamImport 271 -----------D-----QEKGDSI---------------LGLVTQGSELGSAAQAPPDPLQILSRVGKEAGGSCSSPRHS 319
5_pfamImport 273 -----------DLLEGLQEEGGSL---------------LGP-----EPPSAALVPPRCLQT---LGREAEWSWSCPRCP 318
XP_021564906 272 -----------DLPGGPQEEGDSIPNAPASAPVLAPTQGLGHDTWCLEPGSLVQTPPGPLQTPSGTDREAEVRHSSPGCS 340
3_pfamImport 262 -----------DLPGGSQEEGDGVLSAPASASPSDPARGLGPATWCPEPRFAAQDLPDPWQTPHGTGRVAEQSRSSPGCS 330
2_pfamImport 264 -----------GLPGGPQEEGGNVPCTSASVPTSDPALGLGPTSWCLEPGSVAQGSPDSQQTPSRMGREREGTHSSLECS 332
Q0VDD7       264 -----------GLPGGPQEEGDGVPCTPASAPTSGPAPGLGPASWCLEPGSVAQGSPDPQQTPSRMGREGEGTHSSLGCS 332 human
EHB14456     245 -----------------PEEGGGITNGLVSAPT------LAT-----------------PETPTGAGRQAECSCGGPVCA 284
XP_020850485 477 MLrqeslsysrptdtdskvitdiS--ESKGRAQVSKISQPINGstg-vpSFSNKNSS----VEVLLEGTSYTEKGGEDRE 549
XP_021589581 343 SL---------------------SvdPTEVDQRTPEVAGPGGQ------AFPSRQAPgrgcSAAKLDCAPLAEDTTAGRG 395
XP_023580535 334 --------------------tnwStdPTALPPGALKVARLHRQ------------APnsshSVAL----PCSLVAVGVQG 377
4_pfamImport 320 SLrisv-------------itdvVtdPTKSEQRALELTGPDEKantqapASPSGKAPdgghSGALLTGLPLAGETTESRG 386
5_pfamImport 319 PLgaiv-------------itdvNtdPAEPEHKALRVAVPDREvsarvpASPSGKAPnagrSRALLSCAPLTGVTSGGRG 385
XP_021564906 341 SLgmvv-------------iadlStdPLEPEQRTPEVAGPDGQasagslASPGGKVSdsthRRALSGYTPLVGVTTGGSG 407
3_pfamImport 331 SLgevv-------------sadlSmdPPEVEQRVLEVAGLDEQadarspASPGGKVPdgghRMVLPGCTPLTGDTSRGRG 397
2_pfamImport 333 SLgmdv-------------itdlStdPTELEEKALEVAGPDRQvsamspASPERKATdgghRRALPGCTPLTGETTGGRG 399
Q0VDD7       333 SLgmvv-------------iadlStdPTELEERALEVAGPDGQasaispASPRRKAAdgghRRALPGCTSLTGETTGESG 399 human
EHB14456     285 CLgsav-------------mentStdAPETEQRTLRVAGPDVQpdtqppASPG--------KHTLQGCRSLAEETTGDRG 343
XP_020850485 550 EAKHEGEPSEGirVVCDHLTSIVSATKDLIPETEHKDTIVLALEkesLYPDMEQKQVTTSTDQKevshlPNTRVTspwlm 629
XP_021589581 396 DLGLEGGPQGD--MPSSPLGFLAPASGNQTSTVCAKDSGHLALE---MGPDVGQVPRPSPVQEG-----PGRMCT----- 460
XP_023580535 378 EAGPEDKPPGD--APGPPVAARVPAQENQEPTVVGGDSGPLATE---AGPGVDLKQMLSPGQEE-----PVGVCAll-sp 446
4_pfamImport 387 EEGWEADSPGD--VSRGPAASLVLAHETQEPSVGAGCSSPIASE---IDPVVGQTQVPDLDQEG-----LEG-------- 448
5_pfamImport 386 EAQREDEPPGD--ILGCFAASLPLPHETQEPTLVAGDPSLSALE---MGPDVGQTQVPGPDQEG-----LGG-------- 447
XP_021564906 408 EERWENEPHCD--ASVGPPASLALASGNQEPTIGTGESSCRAPD---MGPGVDSKWVPDPHHK----------------- 465
3_pfamImport 398 EVGQEDKPPGD--ILVGPATSLALVPGNQEPTMGAGDSGHLAPD---TGPGVSQKQVPGPDQE----------------- 455
2_pfamImport 400 EAGQDDNPHND--VPVGPAASLALAPGSRQPMMGAGDSGHPSLD---AGPCVCQKQEPGPAQE----------------- 457
Q0VDD7       400 EAGQDGKPPGD--VLVGPTASLALAPGSGESMMGAGDSGHASPD---TGPCVNQKQEPGPAQE----------------- 457 human
EHB14456     344 EAEPEHEPPSD--TLRNPEAFWAVVLGNQEPTRDAKNPGNPVPD---VGPGVHQ---PGPAAH-----------Vlpsla 404
XP_020850485 630 DLVDENEPGLGIISGrsEQNLglpKESNLSVSTACLFIGEKMRADPAGETESNFNSRKSS-EKIG-LSESGCNSEDhidw 707
XP_021589581 461 QPVDRRAAGLGSQGR--EQVL---KELSLSPGASGLLELRDTVGDPPPETGAPLGSPEPSvEAAG-QPQQPPTSSD---- 530
XP_023580535 447 KPLGGKAAEPGGESRl-DPEP---PGHSLSLRATSPPEHREVVDGPSQ----------------GpEAHTALDPADqavw 506
4_pfamImport 449 ----EKAAELGSQSH--EQDF---GGFSPSLGASVPPLHRETVVGPPLDARAHQGNPDAPaGPAG-QPKH-PDPADqa-- 515
5_pfamImport 448 ----EKAAELGSPSL--KQDL---QGLSLSLRASAAPMYQEAAGGPPQDAGAGRGSPDTPtGPVG-QPWRPTDSSKqaiw 517
XP_021564906 466 ------TAKSGSQTL--EQDL---EGLSLSLQASGLPEHRETVDGLPQETQVRQSSADTLaDLAG-QPGH-PRSVQqatw 532
3_pfamImport 456 ------AAELGSWSH--EQDP---KGPSVSLQASGPLEHKEAADGP-RETRARQDSPDTPvDPGAlQPDHPPHPADqatw 523
2_pfamImport 458 ------AAESGSQNL--EQDL---KGLGLTPQASVLLEHKEATDGPLQEPGTQQGGPDTTlDLAG-QRDHLPHSADqatw 525
Q0VDD7       458 ------EAELGGQNL--ERDL---EGFRVSPQASVVLEHREIADDPLQEPGAQQGIPDTTsELAG-QRDHLPHSADqgtw 525 human
EHB14456     405 QLGDRQVAESGSQCL--EGGC---TGLSLALCALCPPEHRAATNGPLWEARAQQGSLEAPtDPPG-PLQHSLDSLSqagw 478
XP_020850485 708 geslaLELDFLPDSQIRDALDDLNFGFPSEQASPVENGLVPSLPGKNPHPDEEqvpskaPRalkstsSHSKQQHRDE-MA 786
XP_021589581 531 -----LEVGFLPDSQIREALEGASFEAPPEQVSPAGSESGLCWPDPSPRARGD------LV------MMAQVQPRPG-VG 592
XP_023580535 507 gcsspMELDFLPDSQIQDALDAPDFEAPPGQASPMGSKPSSCWPGTSPPATGA------P--------VTVVQPRTHdLG 572
4_pfamImport 516 ----aLELDFLPDSQIQDALEALNLEAPPEQRFPAGSGVGPCWPGTSLSTEGG------P--------LIESQPSAH-KG 576
5_pfamImport 518 egspaMELDFLPDSQIQDALEAPGFEAPPEQLFPAGGELDPCRPGTGPRADRG------S--------CAEAQPRTR-VG 582
XP_021564906 533 vdpsaVELDFLLDSQMRDALDASDFEASTEQLFPAGSRLGLCWAGPSPRDNGD------LA------TVAQGQSRAH-VG 599
3_pfamImport 524 ggslaVELDFLPDSQIQEALDASDFESPPEQLFPARSRLGPGRPGPSPCTNGD------PT------EMAKAQPRTS-VG 590
2_pfamImport 526 adssaVELDFLPDSQIQDALDASDFEAPPEQLFPSGSKPGPCWPGPSPHASED------PV------AVARAQPRTF-VG 592
Q0VDD7       526 adslaVELDFLLDSQIQDALDASDFEAPPEQLFPSGNKPGPCWPGPSSHANGD------PV------AVAKAQPRTF-VG 592 human
EHB14456     479 pesltMELDFLPDSQLRDALDAPDLEAPLEQDASTENESGLCWPCPSLSAGGGnr---vP--------VVEAQPS---GG 544
XP_020850485 787 ESICDPPr---EDATAIVCGLTVELSNLNRLIMSTHRDLESFRRLKH-RKGKAAGKQPpyqFPYPAKGvtHCSHSVKK-- 860
XP_021589581 593 VQAPEAPr--mEDATGTVQGLVVELSNLNRLIMSAHRDLEAFRRLHS-RKAKPPGKAP---SLYPPKG--SLSRGEQA-- 662
XP_023580535 573 NKAFEAPr--lEDATDTVCGLIMELSNLNRLIMSTHRDLEAFKRLSY-WKAKPAGKAP---VPYAPKGaaNLPRGEQP-- 644
4_pfamImport 577 IKPREATr--mEDATDTMRGLIIELSNLNRLIMNAHRDLEAFKRLNY-RKAKPAGKAP---MPYTSKGagALPRGEQP-- 648
5_pfamImport 583 IKTCEATg--iEDATDTVRGLVMELSNLNRLIMSAHRDLETFKRLNYyRKAKPAGKAP---TPYTKGGwgPLPRGEQS-- 655
XP_021564906 600 TQASEASr--mEDATGVVCGLVVELSNLNRLIMSTHRDLEAFKRLSY-RKAKPAGKGP---APHPPKGtgTVPRGEQP-- 671
3_pfamImport 591 IQALEASg--mEDATDVVRGLVVELSNLNRLIMSAHRDLEVFKRLGY-RKAKLAGKAP---LPYSSKGagNVPRGEQP-- 662
2_pfamImport 593 IQACEAPr--mEDATNVVRGLIVELSNLNRMIMGTHRDLEAFKRLNY-WKTKPGGKAP---CLTLQRGlgMSLEGTNPgg 666
Q0VDD7       593 IQASEASr--mEDATNVVRGLIVELSNLNRLIMGTHRDLEAFKRLNY-RKTKLGGKAP---LPYPSKGpgNIPRGDPP-- 664 human
EHB14456     545 RPACSLPslriEDASDTVHGLIVELSNLNRLIMSAHRDLEAFKRLSS-RKAR-----P---LPWPPKGagAVSRGEQP-- 613
XP_020850485 861 -WKEK 864
XP_021589581 663 -WRDL 666
XP_023580535 645 -WRDV 648
4_pfamImport 649 -WRDL 652
5_pfamImport 656 -WRDL 659
XP_021564906 672 -WRGL 675
3_pfamImport 663 -WRDL 666
2_pfamImport 667 sCRRL 671
Q0VDD7       665 -WREL 668 human
EHB14456     614 -WRDL 617
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