Conserved Protein Domain Family
TMEM132_C
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pfam15706: TMEM132_C (This model is not part of the current CDD release)
TMEM132 C-terminal
TMEM132 family of proteins includes TMEM132A-E, which are transmembrane proteins that regulate neuronal structure and function. In mammalian cells, they may regulate NAP1 in the WAVE regulatory complex (WRC) to finely modulate actin nucleation, cellular cytoskeletal and morphological changes. TMEM132D member has been associated with panic disorders, anxiety and major depressive disorders. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. This entry represents the C-terminal region of these proteins which includes the transmembrane helix.
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Statistics
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PSSM-Id: 521965
Aligned: 34 rows
Threshold Bit Score: 79.649
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_009028175         523 SKFHQTNSNNNNNGy--SQHP-PSLHASALTPLEIGMYTLLAVFCLAVFIFIINCAFFMAKHRRkndsnsprknla---s 596 
8_pfamImport           1 PRGEAQTDAPGARPprvLEGD-LSRAFGALWELEVGVYALAGVCCLALVALLLRCSSRSLCAPA---------------- 63  
XP_014324482         940 egdkPENESPKTKTpkvIESD-LIRTFKALSDLEIGMYSLIGVSCIAIMAFLLNCASYRLCFRK---------------- 1002
10_pfamImport          1 HNHEPTVQARQHHGs-nNGGGvIASRQHILTPLEIGMYVLLAAFCFAIVVFVVSCVVYASKFKA---------------- 63  
XP_002431877         881 NNHEPTVQARQHHSaliPHSNfHVRNSNRMTPLEIGMYVLLAAFCFAIVVFVVSCVVYASKFKAqvgetvd--------- 951 
XP_002075390         921 HRSNIQAVHKSHFGg-kGHGN------GNMSSMELGMYVLLTAFCFAIIVFVISCVVYASKFRPaliesgldplsav--g 991 
WGS:AAPP:GF20383-PB  887 HRGSIQAVHKNHHGv-kGAAG-----TGTMSSMELGMYVLLTAFCFAIIVFVISCVVYASKFRPamiesgldplsvgkgn 960 
EDW37907             882 GSSSIQASHKNHFNgkgG--------TGTMSSMELGMYVLLTAFCFAIIVFVISCVVYASKFRPaliesgld-------- 945 
XP_009025744         745 NNNVQLTSNNNNNNn------nAYQKIRNITPLETAMFVAVVIFCVIVVGLLIHWVVGTACKRRtl-------------- 804 
XP_027388651         818 EARKEEAEAREEEEe-eGEEE-MVPAPQRVTDLELGMYALLGIFCLAILIFLVNGVVFVLRYQR---------------- 879 

XP_009028175         597 nrklssgipkrKDGTVAAtTAAVga------aaNCSPDWVWIGRE 635 
8_pfamImport          64 -----------QKSPVQ--PGLAag------pePHKHDWVWLGSG 89  
XP_014324482        1003 -----------QKTPIQTaPPPTad------pkDHKHDWVWMGSN 1030
10_pfamImport         64 -----------DNGPVVG---GIaqeihppqqtQNAHDWVWLGRS 94  
XP_002431877         952 -----vsssddNNGANIGvSNGNsgykglpqstTNVHDWVWLGRA 991 
XP_002075390         992 kgngngsiggfRDVRLKE---ST----------TNAHDWVWLGRS 1023
WGS:AAPP:GF20383-PB  961 gsggsggsggfRDVRLKE---ST----------TNAHDWVWLGRS 992 
EDW37907             946 ---plsmgkgsGGGGGGGiSGGGfrdvrlkestTNAHDWVWLGRS 987 
XP_009025744         805 ---------kvKDSAGVGsGGVC----------GVENDWVWIGHK 830 
XP_027388651         880 -----------KEPPDGAtDPAS----------PQPHNWVWLGTD 903
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