pfam15705: TMEM132_N (This model is not part of the current CDD release)
TMEM132 N-terminal
This entry represents the N-terminal Ig-like domain found in TMEM132 family of proteins which includes TMEM132A-E, transmembrane proteins that regulate neuronal structure and function. In mammalian cells, they may regulate NAP1 in the WAVE regulatory complex (WRC) to finely modulate actin nucleation, cellular cytoskeletal and morphological changes. TMEM132D member has been associated with panic disorders, anxiety and major depressive disorders. This entry represents five of the seven beta-sheets as the last two are contributed by more distant residues in the sequence (i.e residues 647-677 in TMEM132A).
Jiyao W et al.(2023). "The conserved domain database in 2023.",