Conserved Protein Domain Family
Med26_M

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pfam15694: Med26_M (This model is not part of the current CDD release)
Mediator complex subunit 26 middle domain
Med26_M is the middle domain of subunit 26 of Mediator. Med19 and Med26 act synergistically to mediate the interaction between REST (a Kruppel-type zinc finger transcription factor that binds to a 21-bp RE1 silencing element present in over 900 human genes) and Mediator.
Statistics
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PSSM-Id: 521959
Aligned: 15 rows
Threshold Bit Score: 199.694
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006639856 175 STPPPTNGIGGS-PEPFPSPL---DPSGLPGPDRSRTEHLENDKHN-KIPVNAVRPHTSSPGLAKPPSTSSLLKTAVMQQ 249
XP_040509742 179 SSPPPTNGIGGS-PESFPSPV---DVNLHAGPESSRTELSENDKHN-KIPVNAVKPHTSSPGLVKPSSTSSLLKTAVLQQ 253
XP_031803831 177 SSPLPTNGIGGS-PENFPSPL---DVNLHTGPESSRTEHSENDKHS-KIPVNAVKPHTSSPGLVKPSSTSSQLKTTVLQH 251
XP_028906501 177 SSPLPTNGIGGS-PESFPSPP---EAGTLPGPEGSWTDLGENDKHS-KIPVNAVRPHTSSPGPGKPSSTCSQGKAAGLQP 251
2_pfamImport   1 SSLSPSIEIGGS-PESFPGPL----GAGLLGPESSCSKQVRNDKQGiMIPINSVRSHTSSPGLGKPSRPCVQSKAAVQQQ 75 
XP_016790894 177 SSPLPTNGISGS-PESFASSL---DGSGHAGPEGSRLERDENDKHSgKIPVNAVRPHTSSPGLGKPPGPCLQPKASVLQQ 252
NP_001016996 178 SSPPPTNGIGGSpPENLPSPL---DGGL----QSNRLEPAENDKHG-KIPVNAVRPHTNSPGLVKHPSTSSLLKAVVLQQ 249
XP_003437811 171 VSTPPTNGIAGS-PDALP------DQEVVPSPDRSRVEHLDNDKMN-RIPVNAVKPRPSSPGVAKLPSTSSLIKVAVMQQ 242
1_pfamImport   1 SVSPPTNGIAGS-PETLL------DQEVVTSPDRSRIDNLENDKVN-RIPINAVKPRPSSPGAAKPLSTSSLIKVAVMQQ 72 
XP_005989963 178 SSPPPTNGIGGS-PENFPSPLgvtTVNAHTTSEKSRPENHENDKHS-KIPVNAVKPHTSSPGLVKPPSTSSLLKTAVLQQ 255 coelacanth
XP_006639856 250 HAK--MDEvsggggggGSGQPQPRSPRCASFSPRSIKEE-TMAKRPTTYAPKGT-LSSPSQSSRFLDvaARVQSP----L 321
XP_040509742 254 HDK--LEE--------TTGSHQPKSPRCSSFSPRNVRHD-TFARQHTTYSPKDS-MPSPSQRSQFLDt-AQVPSP----P 316
XP_031803831 252 HEK--PEE--------PTGQHQPKSPRC-SFSPSNLRHE-PFVRQHPTYAPKGS-LPSPSQRSHFLDa-TQASSPssraP 317
XP_028906501 252 LDK--PEE--------AAGPHQPKSPLC-SFSPRNARPE-TSVRQHSTCAPKGS-VPSPSRRPQVLDpsRAVSSP----- 313
2_pfamImport  76 LER--ADQ--------TSGPPHPKGPPRSSFSPRNSRHKgSFARQRSPYSPKGS-VPSPLPRPQSLDv-TQVPSP----L 139
XP_016790894 253 LDR--VDE--------TPGPPHPKGPPRCSFSPRNSRHEgSFARQQSLYAPKGS-VPSPSPRPQALDa-TQVPSP----L 316
NP_001016996 250 HSG--GLE--------DVLSHQPRSPRCSSFSPRGTRAE-LATRQHTTYAPKGS-APSPSQRLPGVD--SAHQSP----- 310
XP_003437811 243 QAR--LDEg-------GGGYYQARSPRGLTTSPRSTKQD-TMTKRSSAYAPKGTpVPSPSSRD----------SP----L 298
1_pfamImport  73 QAR--LDEg-------GGGGYQARSPRSVTSSPRSAKQD-SVSKRSSAFAAKGTpIPSPSSRD----------SP----L 128
XP_005989963 256 HEKlaLEA--------SVGHCPPRSPRCVSYSPRNLKQE-AAAKRPTTCAPKGA-VSSPSVSSQVLDi-APIPSP----L 320 coelacanth
XP_006639856 322 P-LPQPLTPPVQVSHTDGPQPPGPESSRHWHGPA-DADLRLQHSTGTLelpPHSSPHGSRTALHHSECTVPHgLGLPSE- 398
XP_040509742 317 PsLMQPSTPPMPAKRLEFSQQSVSEVSQHWQEQQvPSDSQHRHTAGTL---PQHTSPSCKTSSHPGESLMSH-IGFSQD- 391
XP_031803831 318 S-LMQPSTPPVPAKRPEASHQTGVETSQHWQEHT-SSESHQRHLGT-----LQHVSPGCKVSSPPGETLMPR-VGFSPE- 388
XP_028906501 314 -------PPPVATKRLEAGQQPGPEASQPWQEHL-SSESHHRHPAGTP---LQPPAPGCKVSLPPGEPPMLR-IGFSPDa 381
2_pfamImport 140 P-LAQPCTHPV--RRPE--LLPSAESPVHWLEQP---EGHQRL-----------AGPVCKAGLSPAESILPR-AGFSPD- 198
XP_016790894 317 P-LAQPSTPPV--RRLE--LLPSAESPVRWLEQP---ESHQRL-----------AGPGCKAGLSPAEPLLSR-AGFSPD- 375
NP_001016996 311 ---LHPSTPPATAKRLESPRQDRISSPHKPVEQLpSTDCHQVLPRTSQqhtPRSSLVDSQT---------PR-TGFSPE- 376
XP_003437811 299 S-FSHTVSSPA-SSYADKLPHSSNRSSMHWASSS-EASSLCPSQDISAtleSPSVSP---SPSLSQQNSEPHrQMSEGAm 372
1_pfamImport 129 P-FSHSVSSPGPMSYADKVTHSFHRSSVPPAASS-DIPSHCPTQDFSAaleSPSVSP---SPLLPQLNSDPHrSTFEGTt 203
XP_005989963 321 P-LAQPSTPPILAKRPEAPLQLESDESQLSMGQV-ATESHQHNVVGTAl--QQLPLHGSRVSPHRDPTTTQHsLGFASD- 395 coelacanth
XP_006639856 399 AAKLDSDG-AASSSESKRKKKYRPRDYTVNLDGQpAMEESTKP 440
XP_040509742 392 ASKMDSDD-AASGSDSKKKKRYRPRDYTVNLDGH-VTEGGVKP 432
XP_031803831 389 ASKMDSDDnAASGSDSKKKKRYRSRDYTVNLDGQ-VLEGGVKP 430
XP_028906501 382 ASKMDSDD-AASGSDSKKKKRYRPKDYTVNLEGQ-VVEGGVKP 422
2_pfamImport 199 SSRADSDAaSSGGS-GRKRKRSQPRDYTVNLGGQ-VAEAGVKP 239
XP_016790894 376 SSKADSDAaSSGGSDSKKKKRYRPRDYTVNLDGQ-VAEAGVKP 417
NP_001016996 377 SSKVDSDD-ATSGSDNRKRKKSRLR---TEFEGH-SADGTGKP 414
XP_003437811 373 VVSDDADGtTVPNSEHKRRK-YRSRDYSVNLDGQ-KMEDTTKP 413
1_pfamImport 204 AVSDDADGtAVQNSEHKRRK-YRPRDFSVNLDGQ-KVEDSTKP 244
XP_005989963 396 SSKVDSDD-AASASDNKKKKKYRPRDYTVNLDGQ-LIEGSVKP 436 coelacanth
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