7ENA


Conserved Protein Domain Family
Med26_C
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pfam15693: Med26_C (This model is not part of the current CDD release)
Mediator complex subunit 26 C-terminal
Med26_C is the C-terminal domain of subunit 26 of the Mediator complex in eukaryotes. Med19 and Med26 act synergistically to mediate the interaction between REST (a Kruppel-type zinc finger transcription factor that binds to a 21-bp RE1 silencing element present in over 900 human genes) and Mediator. The C-terminal domain is critical and sufficient for its assembly into Mediator and its interaction with Pol II. The most highly conserved C-terminal amino acids are critical for these interactions because deletion of the last eight amino acids from the Med26 C terminus disrupted binding to Mediator and Pol II.
Links
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Statistics
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PSSM-Id: 521958
Aligned: 18 rows
Threshold Bit Score: 229.544
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7ENA_z       419 RLKERKLTFDPMTRQIKPLTQKEPVRADSPVHMEQq---------sRTELDKQE------------AKASLQSPFEQTNW 477 human
NP_001016996 417 VKKERKLTFDVMTGQIKPLTLKDPVQAESTAPSEQh----------RTETDKQD------------PKLCLPSPFQLTNW 474
6_pfamImport   1 GFKRVETGHHGMMRHIKPPTQKQPARTDGPVHPKQsst-----eldRQEAEAKA---------------PLQSPFRQTEW 60 
5_pfamImport   1 QLKKRKLSFDPVTRQVKTLTQKQPERTDSPVQAERpra-----eleRPEAKAKA-------------KASLPSPFQQRKG 62 
7_pfamImport   1 RLKERRLTFDPVTGQIKPLVHKEPSPAEEGSTPSPgpylhpgefmqRTESPTHQ-------------------PYHQTNW 61 
4_pfamImport   1 RLKERRLTFDPVTGQIKPLVHREPSQTEDASTPDLaes------rqRTESTVQQp-----------AAPILPNPFLQTNW 63 
1_pfamImport   1 RLKERRITFDPVTGQIKPLVHKEPSQSEDVPTPDPaes------rqRAQSVVPQstattsapgpspATGAGPNPFHQTNW 74 
XP_005800941 335 RLKDRRITFDPSTGQIKRTCPKESSEEQEV-----------------SELQLKS------------NQPIPPSPFQQTDW 385
XP_004068014 373 KLKDRSLTFNPLTGQITPTCQKDSLQKEDFTQTHRse-------lqQSE-ELKL------------NALITSNPYRQTDW 432
3_pfamImport   1 RLKDRRLTFDPVTGQIK-SFQKESSQEEGVRQVPRpe-------tqRSE-QPKQ------------TPPVPPSPFQQTDW 59 

7ENA_z       478 KELSRNEII--------QSYLSRQSSLL---SSSGAQTPGAHHFMSEYLKQEESTRQGARQLHVLVPQSPPTDLPGLTRE 546 human
NP_001016996 475 KELSRNEII--------QSYLNRQSSLL---SSSGVQTQSAHYYMSEYLKQEECTKREARKTHVLVPIVLPSDLPGRTRE 543
6_pfamImport  61 TELWHREIIpdiprypgHTSVPRRRITCchrLACRPQGPAPSLPVPEAGREH---LARTKKLQVLLSQDRPIDLPGLTQK 137
5_pfamImport  63 KELSAKEMI--------PSDLHLQISPLpswSSSSLHAPGARPLVPQYLKQEENTRPGAPKQQVLVPQAPHTDLPGLTRE 134
7_pfamImport  62 KELSRNEII--------QSYLNLQSSLL---TSSGVQAPGAHFFMSEYLKREGKESANS-QVHALQTDSSPEDVPGVTRE 129
4_pfamImport  64 KELSRNEII--------QSYLNLQSNVL---TSSGVQAPSAHFFMSQYLKREEQEIKDSRKRHVLQTDGAVEDLPGLSRE 132
1_pfamImport  75 KELSRNEII--------QSYLNLQSNVL---TSSGVQAPSAHFFMSEYLKREEQESKESRTSHVLQTDRLTGDLPGVSRD 143
XP_005800941 386 KELSRSEII--------QSYLTQQSNIL---SSSGAHTPGANLFMSEVCKRADHQKRHTTETSILVSDHHVKELPGVSRE 454
XP_004068014 433 KALSRSEII--------QSYLCQQSNVL---TSSDTHIPGAHFFMTELLKKEEHCTKDTKKCHTLISDDPPKDLPGVSRE 501
3_pfamImport  60 KELSRSDII--------QSYLSQQSNVL---TSSGANTPGAHFFMTEFLKKEEPRSTDFKQTHVLAPEPPVIDLPGVSRE 128

7ENA_z       547 VTQDDLDRIQASQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNILPYVC 598 human
NP_001016996 544 ITSSDTDRIHNQHWPGVNGCHDTQGNWYDWTQCISLDPHGDDGRLNVLPYVC 595
6_pfamImport 138 ITQDNLNRILARQWPGVNGCQDTQGNWYHWTQCIWVDWEDDCRPLSI----- 184
5_pfamImport 135 VTRDDVHRIQACQWPGVNGCQDTQGNWYNWTQCMSVDREDGSGPLTILPYVC 186
7_pfamImport 130 VSAEDLERIHTQHWPGVNGCYDSKGRWYDWTECISLDPHGDENKLNILPYVC 181
4_pfamImport 133 VTDEDLDRVQTQHWPGVNGCHDTEGAWYDWTECISLDPHGDESKLNILPYVC 184
1_pfamImport 144 ITEDDLDRIHKQNWPGVNGCYDTKGAWYDWTECISLDPHRDESKLNILPYVC 195
XP_005800941 455 ISSEDLNRLQRQRWSGVNGCYDTKGNWYDWTECISLDPHGDESRLNILPYVC 506
XP_004068014 502 ICKEDLSRLQTQHWSGVNGCYDTRGNWYDWTECISLDPSDNESKLNILPYVC 553
3_pfamImport 129 VIKEDLTRLHKQHWSGVNGCYDTKGAWYDWTECISLDLHGDESRLNILPYVC 180
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