Conserved Protein Domain Family
LYRIC

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pfam15686: LYRIC (This model is not part of the current CDD release)
Lysine-rich CEACAM1 co-isolated protein family
LYRIC is a family of proteins found in eukaryotes. It is a type-1b membrane protein with a single transmembrane domain and localises to the endoplasmic reticulum and the nuclear envelope. It is also found in the nucleolus, suggesting functional relationships between these two cellular compartments. It is found to be colocalised with tight junction proteins ZO-1 and occludin in polarised epithelial cells, suggesting that LYRIC is part of the tight junction complex. LYRIC has been shown to promote tumour cell migration and invasion by activating the transcription factor NF-kappaB.
Statistics
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PSSM-Id: 521952
Aligned: 10 rows
Threshold Bit Score: 344.992
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005464971   4 WQDAAARQVILLTDRVNELLSRGLELLRSELGVDFGLKPELIPPWMILL-LAGTGLLLMVAL---WASVCRGLFKKRpvm 79 
6_pfamImport   1 FQVFTLEKAEQLSGRLREVLSGGQAYILARFGVDMGLEPDLYSAWIVLS-ATALVLLLLLAVs--WAAVRGGPLLGK--- 74 
7_pfamImport   1 WQDAASQQVKLLTNRLNELLSKSLGLLRSELGVDLGLKPELIPPWVILL-AACTGLVLMVVL---WASVCRAIFKKRgav 76 
2_pfamImport   1 WQEAASEQFNLLTKRLNELLSKGLGLLRSELGVDLGLKPELIPPWVILL-AACTGLVLMVAL---WASTCRSLFKKRpae 76 
XP_017207032   5 WQEIASQHVEQITGYVRESLSTGLVYLKSELGIDLGLNPDLCAPWLLLL-TAWAGLVLLLVL---WVSVCRG-FSKRlag 79 
Q9Z1W6         6 WQDELAQQAEEGSARLRELLSVGLGFLRTELGLDLGLEPKRYPSWVILVgTGALGLLLLFLLgygWAAACAGARKKr--- 82  Norway rat
1_pfamImport   1 LRGAALEKAELLSGHLKELVSTGQQYVRDRFGVDLGLNPDVYPTWVILS-TATVGLLLLLRLs--WAAACGGRFAGKkrg 77 
XP_056679267   9 WQDVLAQQAEEGSAPLRELLSAGLYLLRTELGLDLGLEPHSYPAWVILLgTAAVGLLLLLLLglgWAAACAGARQRRr-- 86  gray short-tail...
XP_015138435   6 wqeaaaqqaeetaaRVRDVLSGGLGLLRAELGLELGLDPQGLPTWLALAlPAALGLALLGLF---LAAACGGGLRKKaar 82  chicken
XP_006001076   5 WQDAAAQQAEVVSARLRELMSSGLGLLRTELGLDLGLDPERYPSWAILL-VAVLGLLVVGLV---WAATCAGr------- 73  coelacanth
XP_005464971  80 SHADDGIELK---------------RTVGKPV-KSEEPKKK--KKKAEK--KSqpngraiaePQ-EEAIASEEIVP-HHQ 137
6_pfamImport  75 TPTTRVDPRScvp----------dkAGPAKPV-GAEEPKKRnkKKTAEKvqTA---------SAsYDVTVAQSKQT-PNA 133
7_pfamImport  77 RPEDDGIEIK---------------RTVSKPI-KSEEPKKKk-KKVFVWnqKTqsngravaePQ-EEAIVSEELVP-HHQ 137
2_pfamImport  77 NAADDGIAEK---------------RDSGKPV-KSEEPKKKk-KKSTEK--KAqpngraaaePQ-EEAIAAEETVPhQQQ 136
XP_017207032  80 TETGDSAEN----------------TGPAQPVkKADEPKRRnrKKNAEK--KAqrng-lavePQ-EEVKTADDQEL---- 135
Q9Z1W6        83 RSPPRKREEVtpptp------apedPAQLKNL-RSEEQKKKnrKKLPEK---Pkpng-rtveIPeDEVVRTPRSIT-AKQ 150 Norway rat
1_pfamImport  78 SPDPRGAGE----------------PGKAQTP-KPEEQKKRnkKKPLDK--NTqsngqpvaaAQ-DAVKVKATVVV-PK- 135
XP_056679267  87 SPPRRREEAStpvpv-----papedGALLKNL-KSEDSRKKnrKRLTEK---PkpngrtvleVPeEEVVTTPRREA-VKQ 156 gray short-tail...
XP_015138435  83 SAPERKGDEAaaltagggpgraagpG--PGLL-KGDEQKKRnkKKLPEK--AArpngrsfldVSeDEVIQPVRKEN-TKQ 156 chicken
XP_006001076  74 KGAGREKEPLsssvaa----vsssrAPAGKNQ-KIDDQKKKakKKSAEK---GkpngrtaveLPeEEAVPVLLKET-LKQ 144 coelacanth
XP_005464971 138 P----------------------------------------PPPEVKPEKVA---------------------------- 149
6_pfamImport 134 SisilslglhaqtmaaaavpltvgssatlsaaisakqpvnlTPPVLKPKKDKteq------------------------- 188
7_pfamImport 138 P----------------------------------------PPSEVKLEKIP---------------------------- 149
2_pfamImport 137 Q----------------------------------------PAAEGKAEKASeitisrvhsdvnpllksplsprcpctme 176
XP_017207032 136 -------------------------------------------AEVRADKG----------------------------- 143
Q9Z1W6       151 P----------------------------------------PETDKKNEKS----------------------------- 161 Norway rat
1_pfamImport 136 -----------------------------------------PAPQVKTQKVPevq------------------------- 149
XP_056679267 157 Qhqhqhqhqhqhqhqqhhqq---qqhqnqhhqqqqqqqqqqLDAEKKNEKL----------------------------- 204 gray short-tail...
XP_015138435 157 P----------------------------------------LDAEKKNEKS----------------------------- 167 chicken
XP_006001076 145 P----------------------------------------LETEKKTEKS----------------------------- 155 coelacanth
XP_005464971 150 ----EVKKSKKKAKQ----AVKETKTVTT-DGKEPEE------------GTWETKVSNKEKReQRKKDKSSSDgSASPGG 208
6_pfamImport 189 -qpvQAKKTKKKVKI----DVKPAQPVTTnDWKEPDEgq---------aGTWETKVSNREKK-KRRKDKISED-SCGPGG 252
7_pfamImport 150 ----EAKKSKKKAKQ----AAKETKPAAG-DGKEPEEeiphsa-qwsfsGTWETKVSNKEKReQRKKDKSSSDgSASPGG 219
2_pfamImport 177 peqlPLKKSKKKAKQ----PVKETKTGTA-TGKEPEE------------GTWETKVSNKEKReQRKKEKGSSDgSASPGG 239
XP_017207032 144 ------KKNKKKTKA----SAKEKKSSTSvDGKEPDEavgnmsvmvnlaGTWETKVSNREKRqQRRKDKAPDDeSGSPVP 213
Q9Z1W6       162 ------KKNKKKSKS----DAKAVQNSSRhDGKEVDE------------GAWETKISHREKRqQRKRDKVLTD----SGS 215 Norway rat
1_pfamImport 150 -aavQVMKNKKKTKTivkpAVKPAQLVSTnDGKETDDa-----------GNWETKVSNREKKqQRRKDRGPED-SGSPGG 216
XP_056679267 205 ------KKNKKKSKS----EVKAVQNSTRhDGKEVDE------------GAWETKVSNREKRqQRKRDKVQPD----TGP 258 gray short-tail...
XP_015138435 168 -------KKKKKSKG----DAKTVPDASRlDGKEADE------------GTWETKISNREKRqQRKRDKVMTD----GGS 220 chicken
XP_006001076 156 ------KGKKKKPKA----EAKQVHDVSAlEGKEFEE------------GAWETKVSNREKR-QRKRDKVLND----VGS 208 coelacanth
XP_005464971 209 ggtpvsvpTEQPKASTAPAS--TN----QKKKKGE-----------STKVKPE-KVEAVVSKV------NSNNAVEV--- 261
6_pfamImport 253 --------PEAPKAQVETPVvtAT----AKKNRGN-----------NVLSQNQ-GPQLSAPSAs----pSRRGEPSVvdd 304
7_pfamImport 220 gdtpvstpPEQPKTTAAPAP--TN----QKKKK-------------------E-CYITIVPQPpqatslKDLKVAAV--- 270
2_pfamImport 240 gdar-aspPEQPKASVAPTP--AS----QKKKKGE-----------TAKVKSE-KIEVVAPQV------TSREVV----- 289
XP_017207032 214 saa--sgaTEQLQTTLEEAEttITsavsTPPVQrvv-------evdPPEIEATfVQDPVIPQVt----pCWEEVLTVn-- 278
Q9Z1W6       216 ldstipgiENTITVTTEQLTt-ASfpvgSKKNKGDshlnvqvsnfkSGKGDST-LQ------Vs----sGLNENITVn-- 281 Norway rat
1_pfamImport 217 --------LQAPKGNVETp--aATarvnTKKNRGNtgikaskfnsrT----------LCTCTVs----sARREEPSVn-- 270
XP_056679267 259 ldpavsgiESGYTVTTEQLIt-ASfpvgSRKNKGDsllnvqgsnfkSGKGDLT-LQ-------------GLNENPTVn-- 321 gray short-tail...
XP_015138435 221 gesnlqgtESTATVSIEQLMppPSlpvgLRKNKGDtll-----nvqVSSSKPS-KGESSVPQVs----pGLNESHTVn-- 288 chicken
XP_006001076 209 gdanlhgtDATTVASAEQPTamATvsivPRKTKGEpvhtnqltgvkSGTGDSV-SQ-------------GWIEAPDVn-- 272 coelacanth
XP_005464971 262 --SSAVPDVPVKIPAQTVAPKTASCT---------TSREpplWKTGINE---------------------------AWTV 303
6_pfamImport 305 ddGGGWTSVSAKKTEQKGSGRKPVHAapqp-svpqKQQS---WTQETQAaa------------------------aGRSS 356
7_pfamImport 271 --SACITEVPVKVPTHKISGKSEPWKa--------NREes-lWGGDIDE---------------------------SWTV 312
2_pfamImport 290 --AATVTEKALKAP----APKAGPWTt--------ASEPallWRPDVDE---------------------------SWTV 328
XP_017207032 279 --GSGWSDLGLQLPSHMTSVQTESWTsmtv-pterQTSEpsvWPQDMEG---------------------------SWTI 328
Q9Z1W6       282 --GGGWSEKSVKLSSQLSAGEE-KWNsvppasagkRKTEqsaWTQDPGDtna---------------------ngkDW-- 335 Norway rat
1_pfamImport 271 --GGGWTDASRQTG-----------SgvpaathyrAAPRpqtWGQETPGttsgqnqp------------vtqrnrrTWSG 325
XP_056679267 322 --GGGWNEKSIKIPSQISA---ASWSgnv----drRVNN------STEQns------------------------aPFSS 362 gray short-tail...
XP_015138435 289 --GGSWNEKPVKISSQIGVGEE-KWTpvssatagkRKTEtsaWAQDAADangngkdwgvslvsrpwkerslftpidAW-K 364 chicken
XP_006001076 273 --GGAWTDVPMKIPSQISGGEEKKWTpmqatsaanRNQEtttWRPDTGDtng---------------------pakDWSA 329 coelacanth
XP_005464971 304 SKrGMPTTQVNLMSLPSLGI------------------------------GTAE-P----KPVNDLPWISQPRL---DDE 345
6_pfamImport 357 TD-ARGKTGPKTVSFSVLGC------------------------------NATEtP----SNSAELQWASQKEAngaNDD 401
7_pfamImport 313 IEaGMPTAERKLVSLAGLNA------------------------------E----------PVRDLPWIGQPRV---DDE 349
2_pfamImport 329 IErGMATT--SPVSLSGLGV------------------------------GTTE-------PASSLPWLSPPRV---DDE 366
XP_017207032 329 VDrPNI-----PVTFSGL------------------------------------------PAVPDLSWSAPPAVp-vDDE 360
Q9Z1W6       336 ---GRNWSDRSI--FSGIGS------------------------------TAEPvSq---STTSDYQWDGSRNQphiDDE 377 Norway rat
1_pfamImport 326 ID-GRKKADINPVTFSMLGP------------------------------NATAvSletiSNSM--EWAKPPDV---DNE 369
XP_056679267 363 LA-------LNT---TVSGS------------------------------TTEVsQ----STASDFQWDVSRNQphiDDE 398 gray short-tail...
XP_015138435 365 VDaRINTSEQNSTSFSSFGLtpgv-----------------------sgtNSESvSq---AGTSDFPWDLSHTQppvDDE 418 chicken
XP_006001076 330 PLvRKTWGEHTL--FPSIGTwpgvdgrvkttgqntasfstlglnssvsgsSSEPvPq---SSTTDLQWDS--VLtpiDDE 402 coelacanth
XP_005464971 346 WSG--LNG-GSVDTSSDWNAPSEAWGNYe-ePTL---EPPPAQEQP-LPEPA 389
6_pfamImport 402 WSG--FARaAPADPSSDWYAPVEHWGNY---EGVaamAAPPRKAEP-AAAKV 447
7_pfamImport 350 WSG--LNG-SSVDPSSDWNAPAEVWGNYe-dPTS---AAPPLPQKL-LPEPT 393
2_pfamImport 367 WSGpsFTGgTSVDPSSDWNAPSEAWGNYe-ePAA---EPPPAAEPP-APEPA 413
XP_017207032 361 WSG--IKS-SSADPSCDWNAPSEEWGNYieqQPV---SAAPL-EQP-GPEVL 404
Q9Z1W6       378 WSG--LNGlSSADPSSDWNAPAEEWGNWvdeDR----ASLLKSQEP-ISNDQ 422 Norway rat
1_pfamImport 370 WSG--YNGkAAADHSCDWNAPEEHWGNYe-ePPVlvtPAPPLKEPP-VPNKV 417
XP_056679267 399 WSG--LNGlSSTDPSSDWNAPAEEWGNWvdeEK----ASFLKSQEL-AHDEK 443 gray short-tailed opossum
XP_015138435 419 WSG--LNGlSSADPSSDWNAPAEEWGNWvdeEKV---ASVPQPEEAlSDVQK 465 chicken
XP_006001076 403 WSG--ANGlPPADPSSDWNAPAEEWGNWveeEA----AQPPQPEEP-VSEVQ 447 coelacanth
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