8BBK


Conserved Protein Domain Family
AROS
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pfam15684: AROS (This model is not part of the current CDD release)
Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1
AROS is a family of chordate proteins active in the nucleolus. It has a stretch of polylysines at the N-terminus and in the middle regions and it localises to the nucleus and especially the nucleolus in high concentrations. It binds to the 40S ribosomal protein RPS19, which is implicated in erythropoiesis. AROS is an active regulator of Sirtuin (SIRT1), an NAD+-dependent deacetylase protein that plays a role in cell survival and hormonal signalling, and AROS regulates the activity of SIRT1 by enhancing SIRT1-mediated de-acetylation of p53 and thus regulates growth of the cell.
Links
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Statistics
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PSSM-Id: 521951
Aligned: 22 rows
Threshold Bit Score: 68.5901
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8BBK_G        28 PRGAPVKR--PRKTKAI--------QAQKL-------RNSAKGKVPKSALDEYRKR--ECRDHLRVNLKFL---TRT-RS 84  human
XP_006006936  45 AGGSDRTEliGTNKKGArkqlearrRLKE--------RPTVKDKVTKSAIEEFHKR--QPTDHLDQNLQYM---LGT-KF 110
EFA00824      28 NNTKDVFNliPDELKITkni---srKGRKE-------KTGVLSTSKKLTVLEAKKTfkSKDEILKENLKKLkeiKNVcTI 97 
Q17C35        31 KRKSDDSDimPRHHKMVryv---gkKGHKE-------AKDVLRRSESLTVMEARKRiqNRKDNTEDNVRKLlllSSA--- 97  yellow fever mo...
EDS34261      39 DAPLATPDlmPQHHKIIkyv---gkRGKKE-------ARELLRRPESLTVGEARKRlqNRRNHTEENVQKLlllSSA--- 105
XP_016841385  29 TKSSGALDliPVNHRIIskn---kkKG----------STVLLKRSSKITVYDAKKQleTKSDPTEENVKRLlllSGN--- 92 
EFN82406      10 SLYTGTFEliPPRHRFTtee---ekAA----------VIRMLGRSNRLTPQEAKKRlaAQKDRTEENVQRLlslKTN--- 73 
XP_011064123  32 IRYKGALDliPTKHRIIskn---dkTD----------LDTILGRSSKTTVYETQKRlaTLKDPTDENVQRLllfSSN--- 95 
Q8C6B9        28 ASGTPAkr---------------trRARAKasqalklRNSAKGKAPKSALAEYQKR--QCRDHLKANLKFM---TSM-RS 86  house mouse
XP_003419799  28 PSGARVkr-----------------arKAKatqarklRNSAKGKVPKSALAEFQKR--ECQDHLKTNLKFM---TCA-RS 84 

8BBK_G        85 TVAESVSQQILRQNRGRKACDRPVAKT-----KKKKa-eGTVFTEEDFQKFQQEY 133 human
XP_006006936 111 MTDSSVTEQVLAQNRGRRAQDRLEEKP-----KAKGe--KSVFTEKDFQKFQREY 158
EFA00824      98 ELDKETTEKIIQRAVTRRPVKEK---------KKRKkaqTTVFTEEDFKKFEEEY 143
Q17C35        98 DIGEEAGAKLVKRAQTGRYVVKADEFL-----DKKEs-kESVFDEEDFKKFEQEL 146 yellow fever mosquito
EDS34261     106 EIGREASAKMIKRAQTGRYVVKADEFL-----EKKKkepASAFTEEDFDNFAKEL 155
XP_016841385  93 RLDSDTSEKLLSRASKKLIHKKKE--------EKPVeeeRTVFTEEDFKKFEAEY 139
EFN82406      74 QLNSNMSNKLLQRAVKNRIKKQ----------EKPKeseKTAFTEEDFKKFEQEH 118
XP_011064123  96 RINAETANNLLQRAVGKKYIQQ----------EKLKkseETAFTEEDFKNFEQEY 140
Q8C6B9        87 TVPESVTQQILQQNQGRKACDRLVAKTknkkkKKKKa-eGTVFTEEDFQKFQREY 140 house mouse
XP_003419799  85 TVAEAVTQQILLQNQGRKACDRPVHKT-----KKKKv-eGTVFTEEDFQKFQQEY 133
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