Conserved Protein Domain Family
LAX

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pfam15681: LAX (This model is not part of the current CDD release)
Lymphocyte activation family X
LAX is a family of proteins is found in chordates. LAX is membrane-associates and expressed in B cells, T cells, and other lymphoid-specific cell types. It down-regulates antigen-receptor signalling in T cells by inhibiting TCR-mediated p38 MAPK activation.
Statistics
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PSSM-Id: 521948
Aligned: 16 rows
Threshold Bit Score: 534.352
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ELK03342      29 DRDDplpphssvypafpylapipnprartpkesifsnlptshgwglalsfphrstDQSIGIFSGLAGLLALLLVIAVVCV 108
XP_020918860  29 DRAK---------------------------------------------------DQNSSIFSGFAGLLSILLVVAVFCV 57 
XP_023359831  14 SGFK---------------------------------------------------DQPRVLFSVVAGLLAIFFVIAFLFI 42 
3_pfamImport   1 DRDK---------------------------------------------------DQSTSIFSVFAGLLATLLVTVVLCI 29 
XP_007644430  29 EGKK---------------------------------------------------GQNSSIFPGFVALPTIFLVIVAACI 57 
Q5FVQ5        28 EGEK---------------------------------------------------GH--LLFPGFVVLVTIFLVVIVTCI 54  Norway rat
Q8BHB3        28 QGEK---------------------------------------------------GQ--IIFPGFVVLLTIILVIIAACI 54  house mouse
XP_021098149  28 EENK---------------------------------------------------DQSSSIFSVFSGLLAILLIITAFCI 56 
XP_013013274  28 EEGK---------------------------------------------------DQSSGILSGFAGLLALLLIITAFCI 56 
XP_051677108  22 EGGQ---------------------------------------------------DQSSGIIFGFAALLALLLVITASCI 50 
ELK03342     109 LRNWNKRKKRQGPYLRVTVMPLPTLPRLRQQAKNIYDSLPQRQEEQGRHQSRSVRIFSTESLFSRNSDSPPSAHMPSQAD 188
XP_020918860  58 LWNWNKWKKRQVPYLQVTVMPLLTLPRPRQRAKNIYDLLPRRQEERGRHPSRSIRVFSTESLLSRTSDSPPSDHMPSGAG 137
XP_023359831  43 LWFWNKRKKQQVSYFRVTVVPLVTLSQSRERGKNIYGFLPQSQARPGRRHSRNIRIFSTESLIPRNSDNPHSEHVFSPPV 122
3_pfamImport  30 LWNWNKRKSCPLPYLRVTAMPLLTLPQCRQRSKNIYDFLPRRQEDPGRCQSRSIRIFSTESLLSRNPDSPTPEHVLSQAG 109
XP_007644430  58 LWNWNKRKKRRVPYFQVA--PSLTLPPPRQRAKNIYDFLPQQQAELGRHQSNG---FSTENLLSRDSDS--PEHEATPAD 130
Q5FVQ5        55 LWSRKKQKKRRVPYLQVT--PSLALPPPRQRAKNIYDFLPRQQTELGRHQLSG---FSTESLLSRASDSPEPE--VPQAS 127 Norway rat
Q8BHB3        55 LWSWKKQKKRPVPYFQVA--PSLTLPPPRHRAKNIYDFLPRQQTELGRHQLSG---FSTESLLSRASDSPEPE--APQAN 127 house mouse
XP_021098149  57 LWNWNRRKKRQVPYLRVTAIPSLTLPQPRQRAKNIYDLLPRRQEELGRHQSRSIRIFSAESLISRTSDI--PEHVPSQAD 134
XP_013013274  57 LWNWNKRKKRQVPYLRVTGMPSLTLPQPRQRAKNIYDFLPRRQEELGRHPSRGIRIFSAESLISRTSDS--PEHVSSQAE 134
XP_051677108  51 LCTWNKRKKRRVPYLRVTGMPSLTLPRPGQRAKNIYDLLPPRQEDLGRCQSRSIRVFSTESLLSRNPDP--PGHVPSQGS 128
ELK03342     189 NALQVHRAHSHAVSCARDIYDNAMEAQMYGNPIPSAHYINVRAAGDSLSISSEDSRDYVNVPIAE----------EVTET 258
XP_020918860 138 DALQLHRTHTLAMGYAVGIYDNAVGSQMCGNLAPSAHYVNVRASRDCSSTSSEDSRDYVNVPTAK----------EIAES 207
XP_023359831 123 HVLQSCRTSAPAIGYEVGIYDNTAISQVCGHLVPEVDYINVGASIERMSTSSEDSQDYVNVPNAK----------EASGN 192
3_pfamImport 110 NALQVHEAHTCDVGFPVGVYDNTMVPQMCKTLTPSAHYINVRASRDDLSISSEDSRDYVNVPRAE----------EMAED 179
XP_007644430 131 GPLQIHRASVHAVEYTVGIYDNGTVPQMCGHLASSD--ISVRTSRNNSSISSEESNDYVNIPTAE----------ETSET 198
Q5FVQ5       128 GSLQKHRASVHAVEYTVGVYDNGTVAQMCGPLASSAHRVCDGTSRNN-SISSKESNDYVNIPTAE----------DTSET 196 Norway rat
Q8BHB3       128 GSLQMHRVSVHTVEYSVNIYDNGTVPQMCRHLASSTHHVCVRTSRSNPSISSKESNDYVNIPTVE----------DTCET 197 house mouse
XP_021098149 135 DTLQRHQAQVHAVDYSVGVYDNATVPRVSGNLAASAHYINVPASQDGSSISSEETNDYVNVPTAE----------ETAEM 204
XP_013013274 135 NILQRHRVYIHTAGYAVGVYDNATVPQTCGNLPPSACYINVTASRDGSSVSSEELNDYVNVPTEE----------ETAEM 204
XP_051677108 129 STLQGHGARIPTVGFAVGIYDNAPVPHVCQTLVPSAHYGNDGAPRQRTSSASEDANDYVNVPAADaaaeppasacSTAEP 208
ELK03342     259 LASTNTLPRNLLVFPSAQELESTEEKNEGCGDAHNSTSFWSPETESNDSLSDEEGSSQTSNDYVNMAGLDLRAIQGEHPW 338
XP_020918860 208 LASTNSPPGNLFGPPSAEELEFTEERDEGCGNASDCTSLGAPGTESGDPLSDGERSSQTSNDYVNMAGLDLEATQGKQPC 287
XP_023359831 193 SGAMKSLSGNLQDPQTSEESVPRAERDGCSRDAEDSTSIWVLGLEDSDYNGDAECSSHSSNDYVNIPAEDNEEDQGRPQW 272
3_pfamImport 180 LGS--SSPRNLFVLPSAQELDFTEKRDVGYGDASGCTRFWSPGTESSDQLSDEDSSSQTSNDYVNMSELDLGATQQEQPW 257
XP_007644430 199 LTSTKSTPENHCGLPSAQKLELAEGGRAGCGAATNHTGLWTPGRERGASLSDGEESSQTSNDYVNMTGLDLDDIQENQPG 278
Q5FVQ5       197 LTCTKSTPESHLGLPSGQRLEFAEGGHAGCGKATDRTGVWAPGLQGSNSLSEGDDSSQSSNDYVNMTGLDLEDIQESRPR 276 Norway rat
Q8BHB3       198 LTRIESTPENHLGLPSALRLEFAEGGHAGCGNATDHDGFWAPGPKCSDSLSDGDDLSQTSNDYVNMTGLDLENIQENRPR 277 house mouse
XP_021098149 205 LTSTNSPPKNVFVLPSAQELECNEEGHKSCGNTSDGTSFGFPRPEGSDPLSDGEGSSQSSHDYVNMTGLDLGDIQEKEPW 284
XP_013013274 205 LTSTSSPAENVFVLPHVQELEFNEEGHESCGNTNDGTSVGSPETEVNDPVSDGEGSSQTSHDYVNMTGLDLGDVQEKEPQ 284
XP_051677108 209 PASSCSAPGCCFAHQSAQGLGFTEESHEDCDGAGDYSTLWCP----ADPLSEADSSSQASDDYVNMARLELSGSQETQLW 284
ELK03342     339 MSCQCCRDYADVP-PADLNRSQQQAEE-VTSSNTDH-VERRADGLGTHVQLAmqSGKFLDLGDYVTYQPPAQNENSQM-- 413
XP_020918860 288 GAFRGCRDYENVP-P-EPNENQQQEEEeVIASNSDH-EEGMTDGSGTHVPPVmqSGSLLALKDCVASQSSAQSENSEMkh 364
XP_023359831 273 MNFQSYRAYDNVL-WKQNNWKKPHAGErLTT-NIGG-MLRWTLSLPFDVQCEesRENSLDFWDYENIEPLAQDGNSQEts 349
3_pfamImport 258 KTFRCCRDYENVP-PADVNRSQQQAEEeVTSLNTDY-VKDRTD--------------ALETEDHVAFQPLLQSGNSQMkh 321
XP_007644430 279 EAFQGCRDYENVPaAADTNGGQLQTREeVTSSHTDH-GEP--------------VWGALSSVYYMAFQPSPQSEDSEVah 343
Q5FVQ5       277 VAFQCCRDYENVP-PVVANGSQLQTVEeVTSSTTDR-GEP--------------AQRTLPSVYHMAFRPSAWSEDGAMip 340 Norway rat
Q8BHB3       278 GAFQCCRDYENVP-WVDTNESQLPTLEeVASSTVDH-REP--------------VWRTLSSVYHMAFQPSAQSEDSAMvh 341 house mouse
XP_021098149 285 VAFQCCRDYVNVP-AEDTNGSQQPEEEe-TSSNTDY-GEDRTDGPGIHIQPV--TRRSLSSRYFVAFQLSLQSENSQMth 359
XP_013013274 285 VDFQSYRDYVNVP-AAAPNGSTQQVEEeEMSSTTDC-GEGGTDGPETRIQPV--TRRSLSSGCYVALWPCIQSGNSQMth 360
XP_051677108 285 AALQRCGDDGNVA-PAQPDGSQQRAGGeATSSSLDGaAAGRAQGPGTHLQPV--SRRLLASGEVVAFQPPAESESCQLqr 361
ELK03342     414 ----TKEDSNDYENM 424
XP_020918860 365 geemSNEDSHDYENV 379
XP_023359831 350 g-etDSEGSDDYINV 363
3_pfamImport 322 geemPSEDDNDYENV 336
XP_007644430 344 eeeqSDEDSNDYENV 358
Q5FVQ5       341 geeaSNGDSSDYENV 355 Norway rat
Q8BHB3       342 reeqSSEDSSDYETV 356 house mouse
XP_021098149 360 geemSEEDSDDYENV 374
XP_013013274 361 geemSDEDSDDYENV 375
XP_051677108 362 e-rtCSEDSSDYENV 375
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