Conserved Protein Domain Family
SPICE

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pfam15678: SPICE (This model is not part of the current CDD release)
Centriole duplication and mitotic chromosome congression
SPICE is a family of proteins found in chordates. It localises to spindle microtubules in mitosis and to centrioles throughout the cell cycle. Deletion of SPICE compromises the architecture of spindles, the integrity of the spindle pole and the process of aligning chromosomes on the spindle (chromosome congression).
Statistics
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PSSM-Id: 521946
Aligned: 16 rows
Threshold Bit Score: 206.22
Created: 17-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007493755   36 VSDLTVHRATPEDLVRRHELHKSKNRALAHWELQEKALKRKWKKQKQDTPDlLGKRRLAIMKEILSDHYQMQ-DTLERSD 114 
XP_001640231   47 VNDLNVYKASEDEVRHRHEAHKSKNYGLPRKQATNKE-----NSPGYITTPnSAQRKQAILQEILYGRDQFQ-DVLAESD 120 
XP_040023320   35 VNDLSVHKASPAELIHRHEIHKSHNRAAAQWELREKDLQRRLR--RAGSPApLDDASLSIIREVFSDQLLLQ-DVLARSD 111 
7_pfamImport    1 VHDLSVHKPTPAELTHRHEIHKSRNKAVAQWELKEKALKRCAR--QAGSPApLDPASLSIIREVFSDQLLLQ-DVLARSD 77  
XP_023181770   35 VNDLSVHKLSPAELCHRHEIHKSHNKAAAHWELREKALKRRLR--HAGSSPgLDHTSLTIIRDVFSEQPLLH-DALAQSD 111 
XP_008118673   35 IHDLSVLRATPEDIAIRHEMHKSKNRALAHLELQEKSLENTRNKLRPRAPQsVEKKKLDLMRAIISDQYQLH-DVLEGSD 113 
6_pfamImport    1 VHDLTVHRATPEDILRRREIHKSKNKALAHVELQEKALNRKWKKQRQVDADsLEKRKLALMREILSDQHHWQ-DVLERSG 79  
XP_001748050   18 VHDLSEHKLSSAALRRRKEAHASRHANQAKQLLQA---QRRRNLAQPQTPPqPHTPTTGVFRLLKAFRMHGArGVLTHIP 94  
XP_416545      96 VHDLTVHRATPEDILRRHEIHKSKNKALALLELQEKAQRRKWKKQKQLAPDsLEKRKLALMHEILSDQYDLQ-DVLKRSD 174  chicken
XP_064413241   39 VSELSVHRATPEEIVQRHEMHKSKNRSLAQWELRERALRKKLRKQGQGSPDiLEKRKLAIMREVLFDQYQMQ-DVLERSD 117  coelacanth
XP_007493755  115 EMMTVAk-----dLF-----------------GDAPRRRTGYPNVTVAPDse---------------------------- 144 
XP_001640231  121 RTMSVVk-----dLF-----------------GDDPKKYMGFPNITVPPQvls--------------------------- 151 
XP_040023320  112 RAMAVVk-----dLF-----------------GDAPRRQTGHPSVTMAPNcd---------------------------- 141 
7_pfamImport   78 RAMAVVk-----dLF-----------------GDAPQRQIGHPSVTMAPNcd---------------------------- 107 
XP_023181770  112 RALAVVk-----dLF-----------------GDAPRRQTGHPSVTVAPNcd---------------------------- 141 
XP_008118673  114 QAMAVVk-----dLF-----------------GDAPHWHLGFPNVTVAPDhd---------------------------- 143 
6_pfamImport   80 QVIAVAk-----dLL-----------------EAAPRTRTGFPNVTMAPNcd---------------------------- 109 
XP_001748050   95 SLLSSPrdacdrcLFpraalprrrfvlppnhaGQAPLRRTLRPGLEAFEDddndvhghddddddldygaednyvytadll 174 
XP_416545     175 QVMAVVk-----dLV-----------------GNAPRTRTGFPNVTMAPNcd---------------------------- 204  chicken
XP_064413241  118 RAMAVVk-----dLF-----------------GDAPHRHAGFPNVTMAPDse---------------------------- 147  coelacanth
XP_007493755  145 ------igSSPGPVVSKRDPLTE-SILTESSIDPQ--ALNEVee-geGEETINSQSEES--ENELDss--lNFQSNTRTD 210 
XP_001640231  152 -----entERNGPIAEVPEAQTQlTQLSESVMQTT--ALNEIse----dEGNSSGTEPSpqSNQNQaaqrmTFQPRLDLQ 220 
XP_040023320  142 ------sdSGL-PVLQRPDPPTQlSLLSQSLMDPQ--ALNELea----------sEEDY---SDEDpg--pTGRSDYDVI 197 
7_pfamImport  108 ------sdTEL-PVLERPDPPTHlSFLSQSMMDQE--ALNDLev----------sKENRrv---------eNTSSDSHVI 159 
XP_023181770  142 ------sdSEL-PVLQRPDPPTQlSLLSQSIMDQE--ALNEVev----------sREDV---RDEDls--sSSGSRF--I 195 
XP_008118673  144 ------veSSEDLIVQKCDLPTQlSILSESVMDPQ--ALNEke---eCSFVCNTNSEGGvy---------lNTRSNIDTK 203 
6_pfamImport  110 ------leSSQGPIVQKSHPPSQlSILSESVMDSQ--ALHEEee--------eALAEDG-----HHdv--lGFKSRINSD 166 
XP_001748050  175 qsphnrrpRGGQPVLAARAYRTVvPGTANSSFEEThaAHNDTaaqrqYGYHAPGGASASpsERAVDwehyaQVVSDARER 254 
XP_416545     205 ------leSSQGPIVQKWEPPTQlSILSESVMDSQ--ALNEGge---eEALSIFQSENG-----QHes--lNFKSSISCD 266  chicken
XP_064413241  148 ------mdTSVGPIAQKRDSLTQlSILSESVMDSQ--ALNEd-----VENSQSECSEDG--EEEVDas--mNFKSSVDMN 210  coelacanth
XP_007493755  211 RLLQRLNEENSE-FISKLCTSMRQKIATSQ--KITPPSTPTVAI-P--------------SLEH----RALNATNAVKRI 268 
XP_001640231  221 KFKEFVSQEQND-----------------SgqPSYEVKNPISASrSqgippgkvlqpavqAEDHssflSGTSGNTILAGA 283 
XP_040023320  198 RRNNVQKMKAQS-RGRLVQRQK---VNSKQagRDNDPVTPCTSGrA--------------SAQ-----AALNATMAVQRL 254 
7_pfamImport  160 HRVTGRKSKSQS-GSGVLRQQKMHHSNFHHadSDDGPVTPCASRkP--------------PNQN-----ALNATVAVQRV 219 
XP_023181770  196 RRTNIRKTKTQT-RA--TQKQKGHRLRSHAgdKENIPVTPIRSGrA--------------PDP-----TALNATAAVKRF 253 
XP_008118673  204 RVLNLLKEDNS--VANCQPEASKQHISTVSteEVDILLTPAASF-Q--------------SLEH----TALNATHVVKKV 262 
6_pfamImport  167 RLLRLLRKGNSL-VNSPLWVEKDMRKSTLSq-ESNVPCTPTTVS-P--------------SLDH----SALNATSVIKRT 225 
XP_001748050  255 R-----AEQESQlLSSLERVQAWAEKSADQiqEPNSPSRLTSATlQ---------------QQQaelaAQTQAQDAAKAL 314 
XP_416545     267 RLLHILREENSS-ANSELWAERDLRKTTVS---QEIPLTPTIAS-S--------------SLEH----SALNASSVVKRI 323  chicken
XP_064413241  211 RFRCLLNEKDNS---------FSQSRTKPPplAGNLPKTPKTPVrP--------------STAEp--sSALNATTVVRRV 265  coelacanth
XP_007493755  269 QSRLPPDEPAGn------VNSHYEVGQVLnpNSRKQKQQLAKVKKKSDLSVPSKAKKNVSFNNITTSDTSRGDGSSLDVL 342 
XP_001640231  284 PNFMFPAQQSS-------GEPTAIAE--IpgSEQLEQTGEVKARVKSNEKAPKLKATVKPAQGPKGL-------RCLDDL 347 
XP_040023320  255 RSRRSQSEEGM-------EEPEVLVSQVLnpDVPLNQS-GRISSRTSRGRNGVSQRSALDGSSVASL---SGDQSSLGLL 323 
7_pfamImport  220 RSKHFEEN--E-------EETSSQVSQVLnpEPLLCRS-GRSGSCTRKVRKCVSHGSELDGSTAASL---SGEQSGLGLL 286 
XP_023181770  254 LTKQRPSDQNE-------EEASVLVSQVLnpELPSRQS-GRIRKHTEKTRKGVCRALELDGSSVASL---SGDQSSLGLL 322 
XP_008118673  263 HSRFQNEEQt--------ADTPCTIQQVLnaKVKKQKHTSTKVKKKQTAQTPTGQTRINLNATSASV---NGQNSSLEYL 331 
6_pfamImport  226 HSRLRNEDEEEs------VDSSDTVRQVLnpNSRKQKQIAAKMKRKQAEQNSARQKRGDSPANLIQTDLQRDSKPSLDVL 299 
XP_001748050  315 VAQLVSER----------------VDQL---ETRLRQALQPGTESPRSTQAPASDPLGATT------TLAAGTGPSNGTP 369 
XP_416545     324 HSGHQNQDEEEt------VDSAYTVRQVLnpNSRKEKQISAKMKRKQTAQNSARQRRDDSPAYSIPVDLQRDNKSSLDVL 397  chicken
XP_064413241  266 KSRLGMGDGASaalnglsPENTLVVGQVLnpGPGKKKRTAAKGKKSRRADAPSAKERECYQPSSSTFNLSNGNQSSLEVL 345  coelacanth
XP_007493755  343 KHMIHEVEHEMEEYERWT-GREVKGWK--NSQGLTGFTLSLVSSLCRLV---RYLKESEMQLRKEVDTRQRLEVVLGDHR 416 
XP_001640231  348 KKMVENLEDEIAEYEMET-GRESSGKTn-QTNSFSGYTSALVMAVTKLM---RYLKESEIQRRAEAVIRDQILQGFAEQR 422 
XP_040023320  324 QTMLGQVEADLDTLIPATePASAQSQKtdKAQGLTGFSVALVSTLGRLV---HLLKQREEKAQEEARERRILEEVSREQR 400 
7_pfamImport  287 QAMLGQVEADLDAFCPQM-ASAQSLKQh-KTQSLTGFSVALVSTLGRLV---HLLRQAGEDTQKETEGRRRLEGELKEQR 361 
XP_023181770  323 QDMLGQVKADLDTMSSDIaPEPTGSPEpyERQGLTGFSVSLVSTIGRLV---QLIRKREAEAQEEAEERRRLQEDLKEQR 399 
XP_008118673  332 NQMLHDLEHDIEEYERWM-GHEVQYVH--SREGVSGFTHSLVHALNRML---HCLKQTETKVRQEIINRQQLERELSEHR 405 
6_pfamImport  300 SHMIQEVERELEEYERCT-GREVPKKE--RSEGLSGFTLSLVNALCRLM---RYLREAEMQLHEKEMVRQQQKEMLNEHR 373 
XP_001748050  370 SHNRTDV----------------------PGTQLHGPMLAILEFMDRLVdgtAQLSTTQAQLGAQQERTAERLNSLEHAQ 427 
XP_416545     398 SCMIHEVEHELEEYERCT-GREVKKMQ--KSEGLTGFTLSLVNALCRLM---RYLKESEVQLHEKEMMRQHHEEMLNEHR 471  chicken
XP_064413241  346 HHMIGEVEQEMEEFERQT-GRMVKDQRsqTGQGLTGFTASLLGTLSRLV---RYLKETEVGVRWGQRETERLREQSREQR 421  coelacanth
XP_007493755  417 ELIDA---LTAEILLLREENTALQAKLQQ 442 
XP_001640231  423 TLIDA---LTNDIVQTQEQNMILQEEMHV 448 
XP_040023320  401 GLIDA---LTAETMALREEAAALQSGLQQ 426 
7_pfamImport  362 GLIDA---LTAETMALREEAAAVQ----- 382 
XP_023181770  400 GLMDA---LTAETMTLREEGAAMQAGLlq 425 
XP_008118673  406 VLIDA---LTAEILLMREENFAMQSTFQr 431 
6_pfamImport  374 ELIDA---LTAEVLQVREENITMQKKLQQ 399 
XP_001748050  428 QATDArleQQHEVLTTLEASLRAHGDARE 456 
XP_416545     472 ELIDA---LTAEILLVREENIAIQKKLQQ 497  chicken
XP_064413241  422 QLIDA---LTAEMLSIREELTVAQTRLQQ 447  coelacanth
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