Conserved Protein Domain Family
Tox-HNH-HHH
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pfam15637: Tox-HNH-HHH 
HNH/Endo VII superfamily nuclease toxin with a HHH motif
A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with characteristic conserved s[GD]xxR and HHH motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, type 7 or Photorhabdus virulence cassette (PVC)-type secretion system.
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Statistics
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PSSM-Id: 495235
Aligned: 5 rows
Threshold Bit Score: 168.424
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_007201345 546 PRLTVEMPYVGKGQKNTNAE-GWLRDKDFYWKEMLKKYPEAFSKSNRQKIELGFSPINNTKFRKHFPQYdlKELYNDTLI 624 Fictibacillus m...
EHQ59284      51 PRLMVEMNYKGKGASGTNSA-GWERNSKKFFKELLKRNPEFWSEKNTSEIRRGRAPEVDEHFVKYFPQY--MDYLEDPLR 127
GAP40240      32 DDLLVSMRYNGDYHSSSNSQ-GWDRNSSYYFENLLHNHPEYFSKKNMIRINNNQSPKVDSQFVKNFPQY--KGYENELLV 108
Q82QU7       252 PAEGVDMPWVGRGKGISSSElGYLRDSKYFWPRFQQSYGSAISLANAQLIASGQAPRVDATWIEHFPGH--AAYVNDTLE 329 Streptomyces av...
EFC67227     162 PRYSIDTTTFESGKPTANGG---LRDNKQFWQKWEKLNPSSISKNNRWRIEHGLSPTIDNVWIKEFPEH--GGYKGEILI 236

WP_007201345 625 HHHIGGGGQAVAVPSKLHPGLGGI-HN 650 Fictibacillus macauensis
EHQ59284     128 HHHIGEGGQAAALPVTLHPGYGGV-HN 153
GAP40240     109 HHHIGKDGQAVAIPASIHKGSGEI-HR 134
Q82QU7       330 HHHVGQGSRAVPLPSRLHDAYTVF-HP 355 Streptomyces avermitilis
EFC67227     237 HHHVDQGKYAVPVPASTHVGSGGVwHC 263
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