8FIA,6VHH


Conserved Protein Domain Family
Tox-GHH
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pfam15636: Tox-GHH (This model is not part of the current CDD release)
GHH signature containing HNH/Endo VII superfamily nuclease toxin
A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteristic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Links
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Statistics
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PSSM-Id: 521927
Aligned: 26 rows
Threshold Bit Score: 84.6104
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8FIA_A        1850 QERHRILKHAHKRAVERAWELEKQLVAAGFQGRGDWTEEEKEELVQHGDVDGWNGIDI---H--SIHKYPQLADDPGNVA 1924 fruit fly
7_pfamImport     1 EERARVREEARKRAVEGAWEKEKRRVEAGDAGSRAWSEVEKQQLLSGGRVQGYDGYYS---L--PIEQQPELSDCPSNIH 75  
XP_022536739  2634 EERTRVLEGARLRAVTGAWLLEQRRVRDGEGGARVWTNKEKDELLSDGHVSGYEGFYV---L--PVEQHPELADSPFNIQ 2708
10_pfamImport    1 KERARVLEQAHQRAMARAWAREQQQVQEGRDGGRAWTESEKQQLLAVGKVPAYEGYYV---L--PVEQYPELADSSTNVQ 75  
XP_011713986  2615 EEKARILEQARQRALARAWAREQQRVRDGEEGARLWTEGEKRQLLSAGKVQGYDGYYV---L--SVEQYPELADSANNIQ 2689
G5EGQ6        2607 eiVKKIVEELKTRENIAVWRAERKRAEAGEKTWRQWSDRETRELTSKGSVSGYDIEMK------PAHQ-SGLLASVHSWK 2679 Caenorhabdit...
WP_015892702    71 LEWNRRLAKRRDAGVKEFWKQEKRRIKNGEPTTRNWTQEQKDAILS-NQVPTFNGKPItghHaySVSKYPHLANRGEIIY 149  Brevibacillu...
6VHH_A        1838 EEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYV---L--PVEQYPELADSSSNIQ 1912 human
XP_026696550  2692 EEKEQVLREAQRRAENEAWEFERQKIQSGI--RTRWTEAEKQEIRSRHRLSSYQLRPT---W--DPERYPELADSGRNMR 2764 vase tunicate
XP_029699366  2706 EEKARILEMARQRAVTQAWARERQRLRDGEEGSRTWTEGEKQQLLGSGKVQGYDGYYV---V--SVDQYPELADSVNNIH 2780 torafugu

8FIA_A        1925 FQR 1927 fruit fly
7_pfamImport    76 FMT 78  
XP_022536739  2709 Lir 2711
10_pfamImport   76 FLK 78  
XP_011713986  2690 FLR 2692
G5EGQ6        2680 FRK 2682 Caenorhabditis elegans
WP_015892702   150 PVT 152  Brevibacillus brevis
6VHH_A        1913 FLR 1915 human
XP_026696550  2765 FVK 2767 vase tunicate
XP_029699366  2781 FMR 2783 torafugu
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