Conserved Protein Domain Family
CEP76-C2

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pfam15627: CEP76-C2 (This model is not part of the current CDD release)
CEP76 C2 domain
Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the new C2 domain that is contained by ciliary CEP76 proteins.
Statistics
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PSSM-Id: 521925
Aligned: 19 rows
Threshold Bit Score: 120.131
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002997419  89 AleNDRDv-FLYLRLSTGKAFVDQlveleqdtknadqddvgldEKRCPVGSVVTFFRVNVTFQTQRQTSRDIRCCVDPPF 167
XP_001470249  92 S--DGRH--YLLVRVNGGRAFVDN-------------------LDLAPSTVSKRSVVFAAHFGNQRFRSAVKPCSAEPKF 148
Q4D5L5        93 KllPGEY--YLHLRLAGGKAFVDN-------------------LDLTPSFAKDYQMYVAVHFGSQRYRSNLEDVSLDPPF 151 Trypanosoma cruzi
Q384E2        93 KllPGEY--YLHVRLAGGKAFVDN-------------------LDIAPSVAQDYHMYVALQFGPHRYRSVSQDVSVDPPF 151 Trypanosoma brucei
XP_002680837  92 KkdLKKNk-ILHMRLLGGNAFMEY----------------------DDNVKTDEKMICFLNYKDQRFVSQPVSCCCNPIF 148
A0BKF5        85 DriNYRS---VSLRIYKGRAFLDF-------------------I-----EPQNQKLQLYLSFCGQRFASATVDATVEPEF 137 Paramecium tetr...
XP_002948818  68 AelPAGKa-FLHVKLLGGRAFTDYtlr-------------ipgP--------EERLQLSLELFGQRFTTHEVPATAEPAF 125
XP_003382466 103 EakSSKHvqCIYFQVLQGRAFVDHl-----------------tSVTELLSQDTSTFTLHVYFRHQRFQSSAVPCSCEPEF 165
XP_002108247  70 MkiDPSKr-YLYVQMLGGRAFLEHil----------------dEDRSTEKNYNGTLSIHIHFRQQRFQSRPILCACEPDL 132
XP_002130643 104 AavNPTRr-YIYFHVLAGKAFLEH--------------------VNATGGAGCSMFKLHLHFRGQRFSSNPVPVACEPNL 162
XP_002997419 168 DEHFRFRVEKKrtrtartrggasyavDVMAPWEALCLVEEPVQLNLVKV---------TKKLQSRnsngtaqwrelsseL 238
XP_001470249 149 DEEFLFEVDAT---------------GFGFGEADLIEVSTPFHIAVLRE---------DSQLNVAe-------------L 191
Q4D5L5       152 RDEFLIDLDYK---------------SFGSCAADLIEVSTPLHIAVFRE---------ERLLTFSk-------------M 194 Trypanosoma cruzi
Q384E2       152 RDEFLIHLDYK---------------AFGTSALDLIEISTPFNLAVIRE---------DRFLSTAt-------------M 194 Trypanosoma brucei
XP_002680837 149 EEDFIIDLEIEnirnvf----tdqqeDADDGVGALLQISTPIDIIILSV---------DSEGRTK--------------Y 201
A0BKF5       138 NELFLFDLRTEa-------------qKANVDLLTLSKLDHPIELCVIQI---------QNGQRK---------------L 180 Paramecium tetr...
XP_002948818 126 AGEAFFQLPTG---------------PGSVDPLQLLALRQGLHAVVMQLnplapwgsdDQAGQRDr-------------- 176
XP_003382466 166 KEGFLLELPKE-------------------GKDDWITSPELIHIILTRT---------HPNREGTtr-----------eL 206
XP_002108247 133 RDGFLLQLPQHk-------------vSARSDPTSLLSIAEPIHLLLIRN---------EPNGDKT--------------L 176
XP_002130643 163 NEAFLLELHSPdag----------esSAMMNVENMLSICDPVHLVLTKH---------DNDGTSS--------------L 209
XP_002997419 239 LAVYRMDWRRVLCStlQLVH---FPIQLt-----gI---MKEPVGSL---------DIRADLLNCKR 285
XP_001470249 192 LGENIIEWRKVLKS--GYLG---LTVEL-------CgrnAGVPAGIV---------DLQLELVSKKR 237
Q4D5L5       195 VGENIVDWRKVLRT--GYLG---LTVEL-------CgdnPGIPAGIL---------ELQLELLPNKA 240 Trypanosoma cruzi
Q384E2       195 VGENVVDWRKVLRT--GYLG---LTVEL-------CgenPGIPAGII---------ELQIEILPNKA 240 Trypanosoma brucei
XP_002680837 202 IGGHRLEWRRVLKK--GVIL---MTIELgg----gSgieSKVSKGIL---------EIRLELLPRPN 250
A0BKF5       181 FSQKLIEWRFLLCY-----GnisLNIELpttyntkMqneRKNHVGIL---------QIHLELLPKTg 233 Paramecium tetraurelia
XP_002948818 177 ----------------------------------gAgpgKAPTAAAVantpeqvarQLSLELRPAFS 209
XP_003382466 207 VGSYLLDWRSVLASpnNKIN---KSFELi-----gPradGRVSPGVL---------TLQWELFPHER 256
XP_002108247 177 LSSTYLEWRKVLSSshNRWT---TAVELn-----gIgpeAKLSVGLL---------DLKIELIPRSl 226
XP_002130643 210 ISSHSFEWREILTEkcGQVR---KTIEMm-----gVgaeCKVPAGII---------DVSVELVPPVK 259
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