Conserved Protein Domain Family
Mif2_N

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pfam15624: Mif2_N (This model is not part of the current CDD release)
Kinetochore CENP-C fungal homologue, Mif2, N-terminal
Mif2_N is a family of fungal proteins homologous to mammalian CENP-C. On depletion of CENP-C proper formation of both centromeres and kinetochores is prevented. The N-terminal of CENP-C is necessary for recruitment of some but not all components of the Mis12 complex of the kinetochore.
Statistics
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PSSM-Id: 521923
Aligned: 34 rows
Threshold Bit Score: 107.809
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014174982  19 IYTLGERG----------RKTGVTLRDTGVRDEHGMEPMESIFSSPAKSspgdaldasGDEQVEEDGGEEDDDDGGE-VD 87 
XP_016763737  20 YFDVGKVG----------RKTGITLQDTGIRDEHGLEPVSGIFSSPISP-------------------EQNGDRTLTsET 70 
XP_007676027  39 YFDVGKVG----------RKTGLVLPDKGVRDEYGLEPVSGIFSSPIAS-----------------PARAFSDTNAS-SD 90 
XP_003855651  20 YFDVGKVG----------RKTGITLQDTGIRDEHGLEPVSGIFSSPGEP------------------SRHNGDRTLTsEG 71 
XP_009161772  16 YSAIGKLG----------RRTGVTLEQRPL-DANGMEEISGMFSSPRKQsplk--kmtTMENVDETSPSPEAHEESV-NR 81 
XP_002845430  15 YSNVGKAG----------RRTGITLKE-GKRDEHGMEEIEGMFSSPEKSp--------VRTNGFA-----NDGLMNS-EE 69 
XP_002543678  15 FGNVGVAG----------RRTGVTLEK-GKLDEHGMEEIDGMFSSPEKSpa------rHNTNGFA-----NDTILHS-ED 71 
GAD97329      14 YSNVGKAG----------RRTGITLKE-GRRDEHGMEEIEGMFSSPEKSp--------IGLNGFAHD---NESDNDS-DG 70 
Q5B2W5        14 YSNVGKAGrpsgtqltvnRRTGITLAE-GKRDEHGMEEVDGIFSSPEKSp--------LGDNGLDTSESIG-------SD 77  Aspergillus nid...
XP_002485013  14 YSNVGKQG----------RRTGITLKE-GRRDEHGMEELDGVFSSPERSp--------VRMNGLNTG---NDTVMGS-EG 70 
XP_014174982  88 MDL-TTVAGPGPAALLNGQN--TAARLAMRQARSPAasR-SLFGSPAVRAGLNNkgvaaaagdqkpkhgalrqnqllrpP 163
XP_016763737  71 MEV-QDSSAPDVTTTLGHRK---TPRLP-PARQSPL--KrTSIGGSPKRMSSVRpqsrpa--------------iseepA 129
XP_007676027  91 IPM-QESSGPDVSETLHMRK---TPKLPLPRAATPK--H-TKI-GSPKRGSTGRqqphttgr---------plqpldenA 153
XP_003855651  72 MDL-QEGSTPDVTKTLTRRR---TPHLPPPRQTTPR--H-TNI-GSPKRMSSARpgsrhi--------------pdedeG 129
XP_009161772  82 TNL-NPTPLRTPASRGSTRR---RSVLP-PRSTSPK--K-TGISGTARKSDGVDifstskhals-----ddledrentpE 148
XP_002845430  70 METgGSSSIPDPSDVLSARRggRNAYLPPPRSRSPM--K-TLMSGSPRRTPGLRsspl-----------------pqseF 129
XP_002543678  72 METgGSSSIPEPADMFSSRRaaRNSYVLPPRSRSPI--K-THLSGSPRRTPGIRsspip----------------hsdqI 132
GAD97329      71 MSI-DDGSAPGPGDFLAGASg-RSSYFPPPVARSPM--K-TGLTGSPRRTPALRsspip---------------rndqpS 130
Q5B2W5        78 MSM-DEGNGPGPADFLSGTNgtRTPRFPPPVPRSPS--K-SGITGSPRRTPGLRssqsp---------------qrhlpS 138 Aspergillus nid...
XP_002485013  71 MSI-DEEDGPGPTDFLSRSAtrRSPFFPPPIARSPR--K-SGLSGSPRRTPALRsspiv---------------qidnvS 131
XP_014174982 164 SSPD-AANAppsspvKPVKRRLDF 186
XP_016763737 130 SSPRgHSE-------PAVNRKLQf 146
XP_007676027 154 ASPVrNLSRt----qPPANRMLDf 173
XP_003855651 130 SSPSgNA--------PPANRRLNF 145
XP_009161772 149 PTPSr----------NEQSRRItt 162
XP_002845430 130 SSPTsAR--------VAAKRTINi 145
XP_002543678 133 SSPSsR---------TVAKRSLDl 147
GAD97329     131 SSPStG-------------RQLNn 141
Q5B2W5       139 SSPSdG-------------RSVRR 149 Aspergillus nidulans
XP_002485013 132 SSPTsARQrrgrvgedettsarqp 155
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