7XHO


Conserved Protein Domain Family
CENP_C_N

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pfam15622: CENP_C_N 
Kinetochore assembly subunit CENP-C N-terminal
CENP-C is a vertebrate family that forms a core component of the centromeric chromatin. On depletion of CENP-C proper formation of both centromeres and kinetochores is prevented. The N-terminal of CENP-C is necessary for recruitment of some but not all components of the Mis12 complex of the kinetochore.
Statistics
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PSSM-Id: 495224
Aligned: 13 rows
Threshold Bit Score: 352.641
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7XHO_C          7 DHLKNGYRRRFC------RPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVPNSTR-KIKDTCIQSPSKE-- 77   human
1_pfamImport    1 DHLKNDYRRRFC------RPSRAPDINMQVGQNILEILQDCFEEESPANDFSGNSTKSVVYLTP-KTKDLCVKSPSKEaq 73  
3_pfamImport    1 DHLKNGYRRRFC------RPCRAPDINPEQGQNILEILQNYFEEKSFVNDFSSDSTKSQLYSTP-KVENIYIQSSSQK-- 71  
NP_001004098    7 DHLKN-YHRRFC------RPSRAPNIPTKQGQNMLEILQDCFEEQ--------NSTESLSCSTP-KEKDIYVQSTGKEr- 69  
XP_008266024    7 DHLKNDYRRRFC------RPSRARNINKEQGQNMLEFLQDCFEERSLANDFSTNSTKSVLCSTP-KVKDSCFQSPGKE-- 77  
XP_005331772    7 DHLKNGYRRRFC------RPFRVPDINTGQGKNMLEILQDCFEEKSLTNDFSINSTKSVRYSTP-RVKDNSIHSSSKE-- 77  
XP_007496443    7 DHLKISYRTRFC------CTSRLPVTDLWQGQNLLENIQDCFEEKSYDTGFSTNPGSPTLCSTPcKLRNDSYSSPNKE-- 78  
XP_013001290    7 DHLKNDYRRRFC------RPSRAPGINTEQSQNMLEILQNCFEEKSLTD--VTNSPESVLYSTL-KIKNSFIQSPSKD-- 75  
ELK08694       32 DHLKNGYRRRFC------RSSRPPDINMGQGQNILVILQDCFEEKSLANDFSTNSTKSVLYSTP-KIKDTCLPSPSREaq 104 
XP_003482452    7 DHLKNGYRRRFC------RPSRAPDINTEPNQNILEILLDCFEEKSLPSDFSTNSTKSGLNSTP-KIKDNYIQSPREEiq 79  
2_pfamImport    1 DEMK-------CyiflsfHLIRAPDINVEQGKNILEILQDCFEEK--------NSTKSVPCSTP-KIKDTCIQSPSKEh- 63  
XP_006931147    7 DHLKNDYRRRFC------RPSRAPDINTKQGQNILEILQDCFEEKSLTNDFSTNSTKSVLYSTP-KMEDICIQSSSKEaq 79  
Q03188          7 DHLKNGYRRRFC------RPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVPNSTR-KIKDTCIQSPSKE-- 77   human
7XHO_C         78 CQKSHP----KSVPVSSKKKEASLQFVVEPS--------------------------------EATNRSVQAHEVHQKIL 121  human
1_pfamImport   74 CQKSHP----KSIPVSSRKKEASLQFLVEPSeaanrsawlvsgvvpclgskpvnqatevehvnLTTTSPVQAHEVHQEIL 149 
3_pfamImport   72 CQNSQP----KSIPVSSRKKEASLQFIVEPS--------------------------------EAASRSDQQYRFNLIIS 115 
NP_001004098   70 -QASHS----ESVPISSRRKEASLQVPAKPS--------------------------------DPADEPVQANEVHQKIL 112 
XP_008266024   78 IQKSCP----KSVPVSSKKKEDFLPCFEEPS--------------------------------KTSNRSVQAYEVHQKSL 121 
XP_005331772   78 --KSHS----KSVPVSSRKKEAPLQDIIEPN--------------------------------ETAHKSVQGHEVLQKIL 119 
XP_007496443   79 CQISPS----KTDCVSSVKKKAKTSVLSHQTim----------------------------lqSQGNNSVLPPEIPQKLS 126 
XP_013001290   76 CQISFPvssrKSLPFSSRKK-ASLQGVIEPS--------------------------------EAASRSVQVHEINQKVP 122 
ELK08694      105 CQKSHP----KSVPVSSRKKETSLQLTVEPN--------------------------------EAVSKSVHTHEVHQKTL 148 
XP_003482452   80 CQKA-P----ESDPVSSKKKQASMQLIVEPG--------------------------------EAVNTSVQAHEVHHKIL 122 
2_pfamImport   64 -QKSRP----KLLPASSRKKEG---FIVEPN--------------------------------EEISKSVQAPEVHQKTP 103 
XP_006931147   80 CQKSHP----KSVPVSSRKKEASRQFTVEPR--------------------------------EVVNRSVQDHEVHQQIL 123 
Q03188         78 CQKSHP----KSVPVSSKKKEASLQFVVEPS--------------------------------EATNRSVQAHEVHQKIL 121  human
7XHO_C        122 ATD-VSSKNTPDSKKISS--RNINDHHSEADEEFYLSVGSPSVLLDAKTS--VSQNVIPSSAQKRETYTFENSVNMLPSS 196  human
1_pfamImport  150 ATD-VGAKNTPDSRKMSS--KKVKDHHNEVSEEFYMSVGSASVLSDAKTS--VSKNAVASVVEKRETHSLKNSISMLSSG 224 
3_pfamImport  116 VYP-IAFARIPE--PILS--HNGDSRHSYSKQFFSISLFCLSIFVLFLIL--YKASTLPTEAQ---VPSCXNSLNTLSSS 185 
NP_001004098  113 STD-VVSKSTPDSTKTSS--KGVKGHHGASDE-LYLPGGSPVVLLGARVS--GSQKAISSGGQKR--VTSRRSADMQSSN 184 
XP_008266024  122 ATD-VGSRNTPDSKKISS--RKLDDYESESDEEFYLSVGSPSVVLSAKTS--TSQNAIPSVAQKRETYIFENSENMLSSS 196 
XP_005331772  120 ATD-IVSRNTPDLKKKSS--KKPSDHPSEAEEEFYLSVGSPAVLLDAKTS--VSQNTSSSLAQKRETYTFGNSLNMLSSS 194 
XP_007496443  127 QADlVDLKNTPNLKYASSgaEEFNKIPNEVVEEFYLTVGSPGLLAKETEIlpLPKQATPT-AHDRWNHKFGNSVNQQPSL 205 
XP_013001290  123 EAD-VGSKSTPDLGKKSD--KKTNGLCAETDEEFYISVGSPSVLLHGKPS--ESQNAISS-AQKRETHT---SGNILSSG 193 
ELK08694      149 ATD-VGSKNTPDSRKMSN--KKLKDHHNEADEEFYLSVGSPSVLLDPKTS--VSQNAISSIAQKRETYTFENSVNMLSSS 223 
XP_003482452  123 APE-VHSEHTSDLRKMSG--KKLKDHHKEADEEFYLSIGSPS-DLDAKAT--LLQKAVPSVAQKRETYTSENSVNTMSSS 196 
2_pfamImport  104 ATD-VGSENTTDLKNVSS--RKQNDHHNEVDEEFYISVGSSSVVLDAKAS--LSQNAIPSIAQKKETYTSENSLNVLSSS 178 
XP_006931147  124 ATD-VGSKNTPDSRKMSS--EKLKRHHGGVDEEFYLSVGSPFVLLDAKTC--VSQSAVSSIAQNRKTYTSEKSVNTLSSS 198 
Q03188        122 ATD-VSSKNTPDSKKISS--RNINDHHSEADEEFYLSVGSPSVLLDAKTS--VSQNVIPSSAQKRETYTFENSVNMLPSS 196  human
7XHO_C        197 TEVSVKTKKRLNFDDkvMLKKI--------EIDNKVSDEEDKTSEG-QERKPSGSSQNRIRDSEYEIQRQAKKSFSTLFL 267  human
1_pfamImport  225 TESSHKTKKRLNFDD--VLKKV--------AIESKVSEIEDKVSEGpQEKKPSGASQKRIQDSEYEIQPEAKKSFSTLFL 294 
3_pfamImport  186 AEISLKTKKRLNFEDkvILKAL--------EVESKVEQCN--VSERqQERKPAETSQKRIQDPEREIQAHAKKTFSTMFL 255 
NP_001004098  185 TDIPFKTRKRLNFEDkvISNTA--------EIESSASQVEDSISEE-QEGTSSETSQKR-DDLSSEIQPQSKKSFSELYL 254 
XP_008266024  197 TEISLKTKKRLNFEDkdILKNI--------EIENEVSEVEDKISER-QERKQSETSQKRIQSLELEIQPQATKRFSTLFL 267 
XP_005331772  195 TEISLKTKKRLNFEDkdIFKKV--------EIENKVSEVENKIPEGqQERKPSETFQKSVQDLEHEIQPQTKKSFSTLFL 266 
XP_007496443  206 PTSSLKTKKSLNYEDitVWSAV------------KTAEKDIKLSERrQKRIQSE-SEKGSQDTKQKIQQRAKTNFSTLLL 272 
XP_013001290  194 TEISLKIRKRLNFEDkdTFRKV--------ERETDKSKVENKIL-GqEEKKVSETSSKRLQDTEYEIKSQAKKSFSTLFL 264 
ELK08694      224 TEISLKTKKRLNFEDkdISKKVdkdiskkaEIENKVSDIQDEVSGRpQERKLAEASQKRIQGSEYEIQSQAKKSFSTLFL 303 
XP_003482452  197 TESSRKTKKRLNFGDkdVLKKV--------EIVNNTSEIGDKVSEGpQEKKQSGTSEKRIQGSEYEDQPQTRKSFSTLFL 268 
2_pfamImport  179 TEISCKTKKRLNFED--ISKKV---------------EIEDKVLEGpQGKKASGTPQKRTQDSEYEIQPKAKKSFSILFL 241 
XP_006931147  199 TEISLKTRKRLNFEDknISKKV--------EIPNELSETEDKVSEEpQERKSSRTSQKRVQDSEYEVQPQTKKSFSALFL 270 
Q03188        197 TEVSVKTKKRLNFDDkvMLKKI--------EIDNKVSDEEDKTSEG-QERKPSGSSQNRIRDSEYEIQRQAKKSFSTLFL 267  human
7XHO_C        268 ETVKRKSESSPIVRHAATAPPHSCP 292  human
1_pfamImport  295 ETVKGKSESSPIVRHIATTPPHSSV 319 
3_pfamImport  256 ETVNRKSESSSIVRHLATVAPHLSP 280 
NP_001004098  255 ETVNRKSKCSSVVRHTAAVPSPPYP 279 
XP_008266024  268 ETVTRKSESSPIVRHTATASPHLSP 292 
XP_005331772  267 ETVRRKSEFSPIVKHIVTAPPHSSS 291 
XP_007496443  273 EAAKGNCRNSSVHRHV-------SP 290 
XP_013001290  265 ETIKRNNESSSVVRHTSTAPSHSSP 289 
ELK08694      304 ETLKRKSESSPVVRHIATAPLHSSP 328 
XP_003482452  269 ETVKRKNESSSVVRHT-TAPPHLSP 292 
2_pfamImport  242 ETVKRKTESSPVIRHVATDPPHSSP 266 
XP_006931147  271 ETVKRKSESSPVVRHIATAPPHSSP 295 
Q03188        268 ETVKRKSESSPIVRHAATAPPHSCP 292  human
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