7XHO


Conserved Protein Domain Family
CENP-C_mid

?
pfam15620: CENP-C_mid (This model is not part of the current CDD release)
Centromere assembly component CENP-C middle DNMT3B-binding region
CENP-C is a component of the centromere assembly complex in eukaryotes. CENP-C recruits the DNA methyltransferases DNMT3B, in order to establish the necessary epigenetic DNA-methylation essential for maintenance of chromatin structure and genomic stability. This middle region of CENP-C is the binding-domain for DNMT3B. Binding of CENP-C and DNMT3B to DNA occurs at both centromeric and peri-centromeric satellite repeats. CENP-C and DNMT3B regulate the histone code in these regions.
Statistics
?
PSSM-Id: 521920
Aligned: 16 rows
Threshold Bit Score: 327.171
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
7XHO_C       296 TKLIEDEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKHHNILPKTLANDKHSHKPHPVETSQP 375  human
1_pfamImport   1 HMNLEDEFIIDESD-SFASQSWITIPRKAVPGKQSTVSPTESTARLQSKKSREKHHSVTPTTLTNDKHSGKAHPLEKSQP 79  
XP_003482452 296 TKLLEDEFIIDESDKSFANQSWITIPRKSGPLIHGTVSPAESTA-LQRKKSREKCDSVSSTALTSDKHSSKAHPVEKSQP 374 
2_pfamImport   1 VKLLEDEFIIDESDISFGNQSLIKIPRNVKPPKQRTISPVESTVVLQGKKSREKHHNV---TLTSDKNSHKAHPVEKPQP 77  
3_pfamImport   1 TKLIEDEFVIDESDRSFAIQSWITIPRKAGPVKQGTVSPAETTALLQGKESREKHSHVSPKTLASDKASCKAQPLEKSQP 80  
NP_001004098 283 MKLLEDEFIIDGPDRSFSSQPWVVIPRKGHHM----PFP-ENIAVPQGKKSREKPHRLSEKTLVSNTQTDKTGPVEEAQL 357 
XP_008266024 296 PKLLEDEFIIDESNRSFASHSWISIPRKVGPLKQRSVPPTESTAVPQVKKSKERHHSISPTTSTHDNHLDGSHPVEKSLP 375 
XP_013001290 293 TKLLEDEFIIDKSDRSFTNQSWITIPRKGRSWNQHTVSSTGSAAILQGKKARE-HQSVSPVTLTGDKYLHKTHPEEKSEP 371 
EHB03331     212 TKLLEDEFIIDKSDRSFASQSWITIPRKSRPLKQHTVSSVESTAVLQCEKPRE-HQSVLPVTLTSDKHLHKAHPEEKSEP 290 
XP_005331772 295 MKLLEDEFVIDESDKSFASGSWITIPRKGGSLKQPTISPDESTAVLQGKKSREKHRSVSPNTLRSDQHLHKAHPEQKFQP 374 
7XHO_C       376 SDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSK--RTIKQKQRRKFMAKPAEEQLDVGQSKDENIHT--SHITQ 451  human
1_pfamImport  80 SDQRKLGRNCALADEMEN--RSTKTEMYSKNAEKSSGNK--RTTTQKQKKKLKVNE-----DMKQGKDKNINM--SPIAK 148 
XP_003482452 375 FEQNILGGSCASTDEMENNCKSAKYEMYSENGKKSSGNK--RTIKQKQGTQFKANVVEEQVDMEHTKDKNINI--SHIAQ 450 
2_pfamImport  78 FEGKKLGKSCASASEMENNCKSTKDALYSENAEKPSENK--GTIKQNRRRKVKAKVVEEHLDMEQPKDKNINT--SFTVQ 153 
3_pfamImport  81 SGQERLGTSC-----MENDSRSTKREIHSQD-KKSSGSK--KAIEQKQTRKLKVNVVEEQLHMEQSDDENLNT--SHIAQ 150 
NP_001004098 358 SVEEKLGTTL--TNEVENDCRSTENKTHSENAKKPSARK--RTVKQKQRRPSKPNVAQE-LSMGQNETENRNM--SKIGQ 430 
XP_008266024 376 CDDKKQSMSCALTDEVDNNSRSTKCETHSKNKGKSSGNK--KTVKQKKKKKYKANVVEEQLHMGQSKEENINAhkKHIAP 453 
XP_013001290 372 SCEQKRSINCTVIDKLENSHRSIK--MYSEKAERKKGKRknKTAKQEQKKKFKTNVVEEQLDTGQSEEEN--I--SDITQ 445 
EHB03331     291 LNEKKPSTSCTLTDELESNCRSIK--MYSEKAEKPSGNK--RTTKKKQKRKLKTSVVEEQPDTGQTKDEN--M--SHIAQ 362 
XP_005331772 375 CDEKKVDTSSSLTDELENNDRSTKYEISSENVKKPSENK--RPIKQNQRRKFKANVVKEQLDLEQSKDKNVNM--SHSAE 450 
7XHO_C       452 defqrnsdrnmeehe-emgndcvskkqmppvGSKKSS--T------RKDKEeSKKKRFSSES-KNKLVPEEVTSTVTKSR 521  human
1_pfamImport 149 dksqrnsdrsmkack-ekrnvhiskkrvppvANGKRSga-----nqGKNRE-CEKENFSNGSrKNSLVLEEVTLTVTRSQ 221 
XP_003482452 451 dklqrnsgqnmeere--eigvqiskkemppmGSKRGStnIpytmnkKKDKE-CKRKCFSDGSkKNRILPEELTSTVTRSR 527 
2_pfamImport 154 gklqrnsdkntevceemrndhispkqiffilGKKKSRthVpikenqKKVKEkLKNKRFSNQPkKESLVPEEVTLTVTKSR 233 
3_pfamImport 151 nkfqrnslksmeece-kmrndhvskkqmppvESKKSSs--------RKHEEeSKKKRFSTES-KNKVIPEEVTLTVTRSR 220 
NP_001004098 431 dklqinskrnmedhe-evrneptpkkpvpalGNKKEKdsT------QANKEkSRKKCFSRES-KRKSVPKEVTLASRRGR 502 
XP_008266024 454 klqrsssrnmkdce---emrndhiskmvpsvGSKQKKstK------KQDKQeSIKKHSPSES-KNNLVPEKVT--VLRSR 521 
XP_013001290 446 dkiprnsertiedce-kmrndhsatkgmppvENMKTKcrT------KKDRKeSRKKHFSSESkRKKLEPEETTSFVTRSH 518 
EHB03331     363 dklprnsdritegce-emrnghnakkemppvENMKTKcsT------KKDKKeSRKKHFSSESkRKKLVPEEMTLTITRSH 435 
XP_005331772 451 dklqknlhrngedce-gtrndnifktptlpvGDKKINrgT------KNNKEeSRKKHFSSESkKNKLVPEEVTITVMRSH 523 
7XHO_C       522 RISRRPSDWWVVKSEESPVYSN-SSVRNELP 551  human
1_pfamImport 222 RISRRPSDWWMVKSDQTDVELS-TSVRNELP 251 
XP_003482452 528 RISRCPSDWWVVKSEQSLFYSN-SSTRNELS 557 
2_pfamImport 234 RISKPPSNWWEVKSDQSPVGSNsSLIKNELS 264 
3_pfamImport 221 RISRCPSNWWVVKSEQRPANSN-SSIRNELS 250 
NP_001004098 503 RTSQHPSEWWLVKPSEGSVDGN-SSKENESS 532 
XP_008266024 522 RISRRPSDWWVVKSQESPAYSDySSIRNELS 552 
XP_013001290 519 RVSRRPSDWWVVHSKESPVHSN--SPRNDVS 547 
EHB03331     436 RVSRRPSDWWMINAEESPVHSN--SVRNDIL 464 
XP_005331772 524 RLSRRPSDWWVVKSDESPVHSN-SSIKNELS 553 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap