Conserved Protein Domain Family
EH_Signature
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pfam15611: EH_Signature 
EH_Signature domain
This domain with a strongly conserved glutamate at the N-terminus and a histidine at the C-terminus, is found in a SWI2/SNF2 four gene operon. Its strict-neighbourhood association with SWI2/SNF2 ATPase strongly suggests a function in conjunction with it. The other genes in the operon are a OmpA protein and a TM protein. This has a DNA related function along with the TerY-P triad.
Links
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Statistics
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PSSM-Id: 495216
Aligned: 19 rows
Threshold Bit Score: 156.552
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_013838040   23 WQRVAAEA-------KHIARNAGSGRRA-----EALHGPVRRLLeeRRtdelltrmgdrvfarvvVALWAEEPRLAQRSM 90  Isoptericola v...
WP_012567513   24 LPDMPESG-------RLVTALAGANAAPappgdDMLAAVRRRLLeaARgpggvaaaaprdlcdapWLMWGGLDPLAGLNG 96  Rhodospirillum...
WP_012938609   29 PVELEKWL-------KKTVSDSGRRPALdpvtmEELYTKVKVQErgKK----------------------------VQLD 73  Acidaminococcu...
CDA50130       17 lPQIETVL-------RKLREKADKMIQVdpldlQVLVKKTERMYqgSQ--------------------------EEFTRR 63 
WP_013580918   32 LRPLDAAV-------TKMKAQAASTRPPdpariEKLIARFHAEKqnLD-----------------RFEPREIRLLAWNNQ 87  Granulicella t...
WP_014395903   25 QQQVEEGM-------QQLFLRVETAQQRaddrePDRLARMRQTLdvAAv------------------------------- 66  Corallococcus ...
WP_011771647   16 VAMMEAAFsidncsnESIFENLVLPQVPprdvkQLIQLVMSSQSekISllewfs-----ifdnenYFKQLSGEALINTQK 90  Psychromonas i...
WP_014428003   35 EKPVREA--------ERIFQGYAKAQPRqedsyAAARAFLRGQRldAW-------------------------------- 74  Rubrivivax gel...
WP_013293076   27 slQMQHEL-------SMMKDWVKGASRReevplATIEAALLFYQknSY------------------------------LK 69  Gallionella ca...
jgi:Pnap_4265  25 sDDIDKVL-------LALEKQVKSGGRNdepkdLQIEAVRRFWK-------------------------------TGHVE 66 

WP_013838040   91 TPELVRAVVerpe--------------------------------grpvGHPTAITLASL---------FL------EHY 123 Isoptericola v...
WP_012567513   97 LLEAVLDVC-----------------------------------------NRRNRARRTLie------aWI------RNF 123 Rhodospirillum...
WP_012938609   74 LRREVPFLPvlltrekkekprfye----------vllqdilkviqegipRSARRNTFRNLvf------aYF------TVY 131 Acidaminococcu...
CDA50130       64 EIRNLPFVIfspelsmpv-----------------------akfalrqvDLDKTSCFRRLlf------aYF------RGY 108
WP_013580918   88 MLLNARFRSqlae---------------------------------rvrSRAVKPNLLILsq------vYF------GSW 122 Granulicella t...
WP_014395903   67 ------------------------------------------------lKKLHARDFASLtrrerravpGLwrevgpKDM 98  Corallococcus ...
WP_011771647   91 ALWKCILEIpkvtnialwrmclyfdkqyhmmpllimdafqkhdrqirllDKQRGLVLKALseqkaskiaYFslqignKPE 170 Psychromonas i...
WP_014428003   75 ---QRDLVAsavaqpireagdetalg------sqrfdtllgeyqaeaerGDLWRLTWHGLly------sYFqydisaAGG 139 Rubrivivax gel...
WP_013293076   70 GLRQARLICygctqrlnsyclieer--------dafnklltyvdgyksrRRTFRKLYRGLls------sYFsydpdsADM 135 Gallionella ca...
jgi:Pnap_4265  67 TLREARLVAfglavtpwddrrslmed------krlfgsaldavdawqgaPRQYRKCFQGLvr------sYFdyd-gmGRS 133

WP_013838040  124 DRLDDwha----------------glfEAVASTVDVAAHRthprahrdlvevlrdlrryvv-----erdgprafarhlit 182 Isoptericola v...
WP_012567513  124 SYDMP------------------------RIAEAGNGIRRlitaarrprlepwrdadawcrl--fdaadgprtlarwivl 177 Rhodospirillum...
WP_012938609  132 GQPYK----------------------GERMQKCISLFLQkdpellksvlylrnrkq------------llkpnghkllt 177 Acidaminococcu...
CDA50130      109 EPKES------------------------KTEWIRTVLWKqmqrndrmgrsihflqdfp----------qllakdgvsqm 154
WP_013580918  123 GTHAE----------------------HELFEQMLRILADqqagftpllqrykekatsi---------fsasadvflsrq 171 Granulicella t...
WP_014395903   99 AWFLTlspdslprlvrqrlrdwsssedAASQREWAKLVGQrpleksavrwalpmsveealgpdgpgtlakhw-------- 170 Corallococcus ...
WP_011771647  171 DFLAClglpn------------qislvVKAQEELENVLVEvw-------------------------------------- 200 Psychromonas i...
WP_014428003  140 TAAQT------------------------GWEKLRAFLERtwplidrqvgaglvpdwvhvlrkegavlsrspvdkyargy 195 Rubrivivax gel...
WP_013293076  136 RGGVS-------------------------RDALSLFLSDhlatfvigdftpdwlaalakyp---dllgenpgqavessl 187 Gallionella ca...
jgi:Pnap_4265 134 TPDVG----------------------KVNWRQLRDYLNSnaasirdaslnpdwvsctlsnt---glfteepcaaygpdl 188

WP_013838040  183 sgatpeKDRDARALCGDNSGRYAQVLRNTFYLELIA----GADhSAEGHSFLADATARATALRRD--------------E 244 Isoptericola v...
WP_012567513  178 tdepvdTLLGRACLDDPMRASSGYARTIQAEVLSLVpdhlAGPaGAQRVARVADFLAPGDSLRFDe------------pE 245 Rhodospirillum...
WP_012938609  178 reiqkqRSFRKALEEFCWPVNLWYGSFSQWAVKDFF----QLE-EEDDWDELFGVLKEICEDKAC--------------G 238 Acidaminococcu...
CDA50130      155 aeffsegNLRDALKTLSFPPTLSGSNFVKAAIVKAF----QMDiGLDAKQVLLENLTKDQVY-----------------K 213
WP_013580918  172 isveqaSLTETLALWGVPTTTPLASAVLTAYVNHIL----TEI-SSGRVGQLDDLLATLQLPLVQm------------sT 234 Granulicella t...
WP_014395903  171 --lahplvdvvemlknsglkpgnsyaghviarylLR----RLQsRQDVAEGLKFLVDEPLGRSWMphnntddvavsaplE 244 Corallococcus ...
WP_011771647  201 -----------------------kPELCDNYVKIIK----QYS-YLQADTAVTKLLSLN--------------------- 231 Psychromonas i...
WP_014428003  196 lrgdsaAVDQLAEDLGIPPSSWFWHALVLGAVKRAT----ADS-DAEFQRLVPQLIQLIKTR-----------------P 253 Rubrivivax gel...
WP_013293076  188 lqgdysMLEEIRERLGVDGGSWLVRRLVMSPFVAIG----RMP-DAEFKDHLASLLLLLNDY-----------------P 245 Gallionella ca...
jgi:Pnap_4265 189 lagnsdLVGDIRKLLGISDGSWFTRELIIAQIRQAT----QLG-DQAFHAAVSGLLRLLGGN-----------------E 246

WP_013838040  245 DDRRFGIAVLSALCDKSD--TAVPST---EWVDAVLA---IGGDPRHEQSstwRDWWAHVD---EPLRARAVRWMSGADL 313 Isoptericola v...
WP_012567513  246 SRGQIVRSLMAPWLTGRSglEEPTRA---AVQKFLLA---RLGDPRTRPG-----QWVRAG---EDAVALMETWLSRAAL 311 Rhodospirillum...
WP_012938609  239 NMVPYAAEKMIYLTDRFG--DGNREK---EVRILLFQ---ALGDPRDPGA---SLNWVDVE---ERAREIFLSWLKKNDL 304 Acidaminococcu...
CDA50130      214 GLVPQVVGPVIINVDEEG--SDSAKN---WLMQLIFR---YMGDPRGNDT-----AWLYVE---EEAKEIFLHWLVKNDF 277
WP_013580918  235 FQAGAGTLILSPHADK----NDSFRK---RIEAFVLDs-pRLGDPRLPHN---LPKWNGVD---AAALRKFRTWRATKDL 300 Granulicella t...
WP_014395903  245 ARVAVVAATLACWGNGQV--ASDVRG---RIEERLIArdsVFGDPRLTTL---SKAWQAVRvlgEAAFDEFLAALIQQDL 316 Corallococcus ...
WP_011771647  232 --------------------KEKALNespVLLDHLKE---KYG-PSSASS-----RWGMLS---LQAQHQLRAVIGAGWF 279 Psychromonas i...
WP_014428003  254 GFRDEALEYILVRYHACR--AAPQDE---LLRDFVCAp-aVWRNPKLKAAg-yATAWNRVP---EPVWQMVLGWVNERNL 323 Rubrivivax gel...
WP_013293076  246 LYASAALPLLLERYVQCK--DRPMHA---QMRDYAVG---LWGNPWRAQQ-----QWLCS----DKARVMLAHWLKRQLL 308 Gallionella ca...
jgi:Pnap_4265 247 VLRDRGLQILLDRYALIP--QPPQHP---SLRDYAVT---CWGNPWLPSN---QDRWGGVQ---TAARQMVSNWLKLEFI 312

WP_013838040  314 RAFLRAVRVYgdet------qneSLQRMFPRRERFLMGLYEtgRVQATRLILGNDVRRTM--RRvTNINLVDAPRFDd-- 383 Isoptericola v...
WP_012567513  312 GAFFDLVGEQ-------------NHDPDWRYREAFWSACMEagGIDDAWLALGRTVRRSA-----------PALHHLkga 367 Rhodospirillum...
WP_012938609  305 NLFFTIISKTvrq--------vaTSENMWKYRKNFWEKYLD--AMYYTRVFLGPDAERIA--WRmELAKQGMGFGRLng- 371 Acidaminococcu...
CDA50130      278 AVFFHIIAST--------------ADAKWKYRQDFWSAYMD--EIRASRIIIGQKAKLMLndRPkEEKSKLMAYDYLe-- 339
WP_013580918  301 VFFFRSVLPE---------------GRDPHGRKDFWLRYVD--QVVDSVVALCPTDLQRL--HT-SLSLERVHHCRIq-- 358 Granulicella t...
WP_014395903  317 EFFFERAMHE-------------------QDRRKFWLNYLG--AIRRTTCWLDSVTYDVL--HS-KFATLPVEQQAAfrr 372 Corallococcus ...
WP_011771647  280 AEFKLFIFQLtsqelakalslspKDINQLQKRVTFWSNYQS--RFHSFRVFLPLKTATII--KN-SSLSLPEHTLIEsg- 353 Psychromonas i...
WP_014428003  324 KDFFDILAAR---------------NQADEGRLAFWSQYLK--QITWTRLVFG-ADTMAL--QR-RSPEVRNLIAREega 382 Rubrivivax gel...
WP_013293076  309 SEFFSLLSND---------------DKALSRRFNFWDLYSE--DLTGMYFALG---KDAY--VQ-GNMRLYKFRHLAkgl 365 Gallionella ca...
jgi:Pnap_4265 313 ELFFTKLAQD---------------GLSDTRRVKFWAKYVP--AIEEIHFALG---PHAM--YS-RERDFVELRDKLkgl 369

WP_013838040  384 --------MNTDTAIVFVDCG----DFHLVEGSH-KFK-LHLYlgrpgpKLTDPRRRAYTRDELIHVIPDAHKRRHPLGE 449 Isoptericola v...
WP_012567513  368 ygelvgpgFHGDQTVLLLRVR----DTVFCEWSH-AGK-LRAWpa---eGEDAPRLHRASY-------------TRPDLT 425 Rhodospirillum...
WP_012938609  372 -------sGDSMRSLLMFSIG----DYVFIEASH-NGK-LRIWk----rGKEPLPFYQAKYTYKGFSYSDVTQASNVEKD 434 Acidaminococcu...
CDA50130      340 -------gKSSDTSLLVFTIG----QYTFIEVSY-NGK-LRIY------SREKSPIQIFAQGHRTIPYSHLINSDTEKEF 400
WP_013580918  359 --------ENQSISCFLMRFKganeDFIVAEFSN-VGKaRIFY-----------------------YGRFLERIGDINRS 406 Granulicella t...
WP_014395903  373 a----krlPQGDVSAFELSFE----RYVVVEFSR-TGNaTYIY------------------------------EHGESTQ 413 Corallococcus ...
WP_011771647  354 -------wDLKETELCFLEFD----NHIVVEYLRgNASgLKLY------------------DKSEISISKLLTNEKLKVS 404 Psychromonas i...
WP_014428003  383 y---arldGKSEVDAFMMQIG----SYLIVEFSK-KPNaCYAYk----vDELPFEPYAKHYDGGTTDLAYGYRGEK--AA 448 Rubrivivax gel...
WP_013293076  366 ia--klteEKHGVHTCIMQFS----HHHVVEFNR-EKNiAYFY------------------DVRQGTPSFYFAKGWVDIG 420 Gallionella ca...
jgi:Pnap_4265 370 iv--plqdNIAANNAFIMTMG----DLVAVEFSG-ASNaFYGY--------------------------NVKNRMPFDLT 416

WP_013838040  450 Rahd-----------------awtHDQG----GAWLRKALDF 470 Isoptericola variabilis
WP_012567513  426 ApclpfppnkrhwargssdgnglsHVGSe--sSRWQGSVARL 465 Rhodospirillum centenum
WP_012938609  435 Fv----------------------HSSSe--tGSWQRKVNEW 452 Acidaminococcus fermentans
CDA50130      401 V-----------------------HTNPrgsgPNWQPKVRNW 419
WP_013580918  407 Efrlrelkse------eglaisfsHM------NNWQSKVRST 436 Granulicella tundricola
WP_014395903  414 Vlkravvehash--fkhrgatrliHT------PGWQLRFEQA 447 Corallococcus coralloides
WP_011771647  405 Klaeie--------------fkkeHDHL----FCWQNSCENM 428 Psychromonas ingrahamii
WP_014428003  449 Ri---------------------vHT------PGWQARAAEE 463 Rubrivivax gelatinosus
WP_013293076  421 Aisvtaiekga---diartskplrHEDTk--lSTWEACFAAE 457 Gallionella capsiferriformans
jgi:Pnap_4265 417 Qpvrtpvngqns-lknssralylrHQDNvlgfNGWEGRFQDE 457
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