Conserved Protein Domain Family
DUF4659

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pfam15558: DUF4659 (This model is not part of the current CDD release)
Domain of unknown function (DUF4659)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.
Statistics
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PSSM-Id: 521908
Aligned: 19 rows
Threshold Bit Score: 254.213
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGV92516     173 EISSRDQKILALVLSRLKKAQKMRELQQQAAVAWEELKRSDKKVHMTLERERRLLLQQSQEQWQGQKEQHKSRRdheqlr 252
XP_002111183 227 GVPEKDRKIIELMLNRHREEEESDRVRRLANLNWEQQRLALDEKMAMNLNRKKEEIRESNRARLAAQEQQKAKV------ 300
XP_006011788 266 EVPERDRKIAALMLAKHQEENILSEQRHMAYLQWDSERKRNELRKEREEREKQRALLQCHKMWESRVEKRRWKM------ 339
XP_015206663 338 EVPERDRKIAALMLAKHQEEDIMSRTRYVAHLQWDSERRLEEMRREREEWEKQRAVLQCQRMWHAQVAMRQRRL------ 411
XP_008116349 328 EVPERDRKIAALMIAKRQEESLLSAQRYSAHLQWDTQRRRAEQRKEQEEREKHRALVQGQRMWESRLEKHRRRR------ 401
XP_030130308 257 EVPERDKKIAALMIAKHQEASLLREQRQAAHLQWDSQRRLAEQRKEREEKEKQRALLQGQRMWESQVEKRRGRL------ 330
4_pfamImport   1 TVPEKDRKIAALMLVKHEEEQSQQQRRLQAELRRDEARRRESLRKERVERARRQERCCRLERWQLELEARRRRV------ 74 
2_pfamImport   1 TVSERDQKIAALMLVKHEEEQARLKLSQQEEWERQEARRQEAAQQVQAEIKRRKKLKQSTKRWNEELEARMRLR------ 74 
XP_006012811 221 TIPEKDRKIAALMLAKHEEEKLRQEQKLKADHLWAELKRRDELFKLKAEKKKRWNQCKNVERWQRELKMRKSKI------ 294
XP_002717431 245 VMSSRDQKIVALVLTRLKKAQRMRELQQQAAVAWEELKLSDQKVQVTLERERQLLLQRSQEQW-QEKEPRKTRP------ 317
EGV92516     253 qGYEQQg-ERRDRQEKStiqaqaESQSRWPEQPDNPENGDLDKLDRVHAQAEHLKQCQMQRLQEQERVLQSLRDLNRLQM 331
XP_002111183 301 -DYENEvqRKFKIEKIQ------EKDAKLAAITSAKQKLLEQQIQLKILQDQSKKKNQEYNLKVEEEYRNAKAIQNHLRN 373
XP_006011788 340 -TQEKR--DTASFKQQQt----mTQEEKWREQAEKQERARKEKLEKARQEEQQKKLHQEQNLKIKEEEKKVTLEQEGQML 412
XP_015206663 412 -SQEQQ--QATIQKMLHv----aESEERWKELAEMQEHSRQEKLRQAAQEQKQKKCLQEQNLKALEEERQAMLEQEQLLL 484
XP_008116349 402 -SSEQE--EAALQKQRQs----lMVEEKWQAHLERQEGLRKAKLEKAAQEDKRKKRHQEHNLKAQEEGKKEAVEREVQLL 474
XP_030130308 331 -NQEQE--EAALMRQKQl----lVCEERWREQAEKQERLRRERLERAIKEDKQKKLHQELNLKAKEEVKKEHQEREEQLL 403
4_pfamImport  75 -EQEER--QLASLREQSa----iLHEDRWRLLAEEQEARRQEKMEMAQQEANGKKRCQEQLLKEKELEEQALREKQGREA 147
2_pfamImport  75 -ERREK--EKAEQLKQEv----lLQEDQWRRLKEEVEVYRREKMEDAQKEAEERKRYQEKLLREKEEAGKKERERERQVA 147
XP_006012811 295 -QMEEK--VLADHRSRDl----tLNEEKWKRLAEEQENRRKENLKREKYEAEIKKLQKEQQLKEKEAINQAAKEQLNQTL 367
XP_002717431 318 -GREPHg-RRRSSPGKNa----pPAESRWRAPPEDQENQRQEKPDGARALAEQRKQSQVQRLREQERQAQRLREQSGLQL 391
EGV92516     332 QKKLEVTCHKRQQHlPEESQKKVPENNLsSSIINFQARKVLMDCQAKAEELLRKLSLEQSSQSSQDVQEDLAKERHREQQ 411
XP_002111183 374 LRIEENARINRQIR-SREDQLRIGANNL-KSELEHDKKKYDNEMKTREDQHYLQNSIELKHLRADTNYKRQQQIKAEEMR 451
XP_006011788 413 QEKLTSAEQKKLER-ELQQQQERKSLSK-ADQLKHQALLKELAKQTQMEKKMLRKSLEQNLSKAQENYEQLVEKRNQELK 490
XP_015206663 485 REKLTMAELKKQER-EHQFQKERRGLNR-AEKMRHGALIKEIAGREVEEREMARKSMELRLSRSIENYEQIQERRHQKLK 562
XP_008116349 475 QDKLTLAAQKKLRK-EQLLQKEKQLLNQ-AEKRKHEAILKELAKQEVEEKAMLRASVEGSLNKAQENYEQLVERRNRELR 552
XP_030130308 404 QEKLSTAAQKRLKK-EVQLQKEKRLFNQ-AEKLKHEALLKELAKQEAEEKEMLKASLKMSLTKAQENYEQLVEKRNQELR 481
4_pfamImport 148 QERIIRAGRSKMLK-ERREKRKIQLENQ-QKRVKHLLLKREVESQIQAEELLKRIALEQKLLKSSNNYHRVLEARLQELK 225
2_pfamImport 148 AEKEEKALRSKMLK-EKGERKRLQEENH-KELLRHILLKHQVELQGEEEEAQRRSTLEKKLQHSCQRRAKSVEARLEELR 225
XP_006012811 368 HEKILWATQGKTLK-EMKERRKIQMNNK-QEKLKHLTLKKEVDNQSKAEELMKRLTTEQRFLKSQEKYYLIIEERDKKLK 445
XP_002717431 392 QRRLEEASHKRHLH-AAEGQKKVQQTNL-SSLVNYQARKVLLDCQVKAEELLRKLSLEQSCQRSQEVQQCLIKERYRELR 469
EGV92516     412 GKAQKEAEQFQRVRWRTEEAEErRRQERQRVLAELAEQKIRQARCHEHKTSKDRVQHLQELSVLRERNNHILKLKAEKEE 491
XP_002111183 452 AEIMKMQKQFRKQQETAKLMTE-EHDEWLKHLQLEEDLKLEKAETIAALVKEEKRFRAKEQREARQAGQKLNMKKIKKQE 530
XP_006011788 491 ERAKKEELQIQRARLAAEKKER-EHREHLEALAKLAEKKLQHAAQVAEETAQQKARRAVQSRLEKEKLQRLNKQKVEQDE 569
XP_015206663 563 GKARKEEQQIQKARQVVERKEQ-QQKEHIEALAREAERRAQQATQVAEERAKERAFKAVQSRLEKEKIQRMNRQRVEELE 641
XP_008116349 553 ERAKREDQQIQRAKLAAEKREK-EQKEHLKALAKVSERKLQHATQVAEEVVQQKARKVVQSRLEKEKVQKVNKKKVEQCE 631
XP_030130308 482 EKARREDMQIQRAKLAAEKKEK-EQKEHLEALARETERKLQHAAQVAEEAVQEKARKVVLSRLEKEKVQKMNKQKVEQYE 560
4_pfamImport 226 ERSLREEEHLLRAQSRAEKHLR-ERQKHKEALAQVMDRRMRQALEVAGTLVQRRAELARQANTEKDKSHRLLYEKVQEEQ 304
2_pfamImport 226 ERAAREEEMSQRVQLRAELQSV-QQLTHKQILVQLSQRRMERAALHASAQHRRRAQQTQQHNRHRQLCHQRLREELQREE 304
XP_006012811 446 EKAAKEDQQLLTARNRAERYNQ-GQMQHKNALIYITDRKIKQANNAQVQNVLEKVERIKKLNAEKEKTHHLMKQKVEEET 524
XP_002717431 470 EKARKEAEQLQQVRWRAGEAEE-QTKARKRVLVELADQKIRQARSHAHRTARDKAQHLRELNALREKNHLVLKLRAEKEE 548
EGV92516     492 KCHIEGIKEAIKKKEQRVEQMTRWKDPIFQEFQKVPSASKTDR----------CFDYVAaeTQLPAHHLS 551
XP_002111183 531 ELKQRYTTAQAMSKDRKRQQIAAAKEENLSKLRDTARATSLMRykvkemtaksSIGILL--ESLGTDQHH 598
XP_006011788 570 NFRRKELLMSIEKKLERSEQIFKEKKTVLENARSIARASFHVRekvreetnvrTFNKMAleAELHANLDK 639
XP_015206663 642 QHRRQELLLSIEKKLEKSEQIFREKRAVLESARSVARASFHVRdrvreetnmrTFDKMAleAKLKASLNE 711
XP_008116349 632 DIRRRELLLSIEKKLERSEQICKEKKNILENARSVARASFHVRekvreemnirTFDKMAfeAEMQATLVK 701
XP_030130308 561 DLRRREILLSIERKLERSEQIFKEKKTVLENARSVARASFHVRervreetnmrTFDKMAfeAELHAQLSK 630
4_pfamImport 305 ETLQQQLKADIAVKDRRSEQLLRDKEAAVEESRKVARASFQMRekvreqihsrSFDQMAleAQLRASLSR 374
2_pfamImport 305 EAARRVRESRISTKERKRERLRRQREQIQEEAQRLARASFHMRervrqqthsrTFDQMAleAQLTASLNR 374
XP_006012811 525 EWHRQGIQEIIREKDKKSEQILKEKEATIEESRKTARASFQMRekirdhinnrSFDQMAldAQLIASFHA 594
XP_002717431 549 KSHVEGIKEAIKKKEQRMEQISRGKQLASQDFPKGSGAP--RGsdsre-lqdsRFDRLApeAQLRVGSQR 615
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