8IQF


Conserved Protein Domain Family
CAF1-p150_N
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pfam15557: CAF1-p150_N (This model is not part of the current CDD release)
CAF1 complex subunit p150, region binding to PCNA
CAF1-p150_N is part of the N-terminus of the CAF1 complex p150 subunit that binds to PCNA - proliferating cell nuclear antigen. The PCNA mediates the connection between CAF-1 and the DNA replication fork. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork.
Links
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Statistics
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PSSM-Id: 521907
Aligned: 7 rows
Threshold Bit Score: 360.028
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8IQF_A          1 MLEELECGAPGARGAATAMDCKDRPAFPVKKLIQARLPFKRLNLVPKGKADDMSDD----QGTSVQSKSPDLEASLDTLE 76   human
XP_003460813    1 MLEEPECAAPGARGSAPAMECKDRPSFPVKKLIQARLPFKRLNVVHKEKATDESDDrm-aQGTSVAENVATLKASLDILE 79  
ELK19408       73 MLEEPECGAPCARGAAAAMDCKDR---PVKKLIQARLPFKPVTLTPKEKTEDGSDDtrssPSAPAQSPGPDVDASLDSLE 149 
1_pfamImport    1 MLEEPECGAPGARGAAAVMDCKDRPAFPVKKLIQARLPFKRLNLAPKEKTEDGADStgssPSAPAQSQVPDVETSLDNLE 80  
Q13111          1 MLEELECGAPGARGAATAMDCKDRPAFPVKKLIQARLPFKRLNLVPKGKADDMSDD----QGTSVQSKSPDLEASLDTLE 76   human
XP_003788927    1 MLEEPECVAPGAREAAVAMDCKDRPAFPVKKLIQARLPFKPLNLVPKEKA----DDvrscQSASVQSTVPDS----DTLE 72  
A6QLA6          1 MLEEPECGAPGARGEAAAMDCKDRPAFPVKKLIQARLPFKRLNLVPKEKIDDGLDDtggsRAGPVQTQLHNLETSLDHLE 80   domestic cattle

8IQF_A         77 nNCHVGSDIDFRPKLVNGKGPLDNFLRNRIETSIGQSTVIIDLTEDSNEQPDSLVDHNKLNSEASPS-REAINGQREDTG 155  human
XP_003460813   80 nDCPVDSEQDFTPKLINGKGPLDSFLSSEVKSGLGQHMVTIDLTEDSNEQPERTVTPGPLSTSASLP-REAVNGLGEEAA 158 
ELK19408      150 sNFHMGSDVDFRPKLVNGKGPLDNLLRNRVKSNIGQSMVVIDLTEESSEPPDDTGAHSKLNSATSPS-AKSVSGVREEAE 228 
1_pfamImport   81 nNFHMGSDIDFRPKLVNGKGPLDNFLKSRVKTSIGETTVIIDLTEDSSDQPDNISAYNKLNSAACPSlEEAVNRVREEAG 160 
Q13111         77 nNCHVGSDIDFRPKLVNGKGPLDNFLRNRIETSIGQSTVIIDLTEDSNEQPDSLVDHNKLNSEASPS-REAINGQREDTG 155  human
XP_003788927   73 nNCLIGSDVDFRQKLVNGKSPLDNCVGSSIKTSIGQSSVIIDLTEDSDEQPDSPTHHSRLNPEASPP-REAVNGDREEAA 151 
A6QLA6         81 -NCHMGSDIDFRPKLVNGKGPLDNFLRSQVETSIGQAVVIIDLTEDSSNPPDNMVGHNKLNSAASSA-QKNINGVPDKAG 158  domestic cattle

8IQF_A        156 dQQGLLKAIQNDKLAFPGETLSDIPCKTEEEGV--GCGGAGRRGdsqecsprsCPELTSGPRMCPRKEQDSWS 226  human
XP_003460813  159 -EKGPLKVIHSDKLGLPEETLSDIPCQTEEELG--GSGGPDGQG---------CPTLPSCASVCPQVGRDAWS 219 
ELK19408      229 gERGLPKASPKDKPAFPEKTLSDLR-NTEEEGP--SSGGAGRSGdvqkgsphsCPALTDGPRTCSEKDRDGWS 298 
1_pfamImport  161 dEGGLPKA----------KTLLDIPCKTEEEGT--GSGGTERRGdaqe-asqsCPKLTDGPRTCSEKDQDSWS 220 
Q13111        156 dQQGLLKAIQNDKLAFPGETLSDIPCKTEEEGV--GCGGAGRRGdsqecsprsCPELTSGPRMCPRKEQDSWS 226  human
XP_003788927  152 dQ----QAIQSHKLTFLEETLSDIPCKTEEDGVvfEGRGAERSGnslecsprsCPKLTCGLRSCLEKEWYSWS 220 
A6QLA6        159 dDRGLPKARQKDELASPEEALSEVPCKTEAGGA--DSGGADRRGltqrgspqnCPKLTGDLSMWSEKDRDGWS 229  domestic cattle
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