8PPR


Conserved Protein Domain Family
Zwint

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pfam15556: Zwint (This model is not part of the current CDD release)
ZW10 interactor
ZW10 interactor (also known as Zwint-1) is part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. It recruits ZW10 to unattached kinetochores at prometaphase. It is essential for stable binding of a Mad1-Mad2 complex to unattached kinetochores. It can be phosphoryltated by Aurora B (AurB) kinase.
Statistics
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PSSM-Id: 521906
Aligned: 7 rows
Threshold Bit Score: 312.666
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8PPR_Z        29 QEEAELPAKILVEFVVDSQkKDKLLCSQLQVADFLQNILAQEDTAKGLDPLASEDTSRQKAIAAKEQWKELKATYREHVE 108 human
3_pfamImport   1 QEEAEVPGQILAEFVMDFR-KDKLLCSHLQVVDFLQNFLAQEDIVQGLDPLASEDRSRQKATAAKEQWKELKATYQEHVE 79 
4_pfamImport   1 QEESELPAQILAEFMMDSQkKDRLLCSQLQVVDFLQNFLAQENPTQGLDPLASEDLSRQKAIAAKEQWKELKATYRQHVE 80 
2_pfamImport   1 QEEAEVPAQILAEFVTDSRkKDKLLCSQLQVVDFLQNFLAQEDTAQGLDPLASEDTSRQKAIAAKEQWKELKATYQEHVE 80 
XP_011229745  29 QEEAELPAQILAEFVMDSRkKDKLLCSQLQVVDFLQNFLAQEDVVQELDPLASEDISRQKALAAKEQWKELKATYQEYVE 108
XP_006937774  29 QEEAELPAQLLAEFVMDSRkKDKLLCSQLQVVDFLQNFLAREDTAQGPEPLASEDASRQKAVAAKEQWKELKATYQEHVE 108
Q2TBH8        29 QEEAELPAQILAEFVMDSRkKDKLLCSQLQVVDFLQNFLVQEGTAQDQNPLASEDTSRQKALEAKEQWKELKATYQEHVE 108 domestic cattle
8PPR_Z       109 AIKIGLTKALTQMEEAQRKRTQLREAFEQLQAKKQMAMEKRRAVQNQWQLQQEKHLQHLAEVSAEVRERKTGTQQELDRV 188 human
3_pfamImport  80 AISRALIQALPKMEEAQRKQAQLQEALEQIQAKKQVAMEKCRTAQKQWKLQQEKHLQHLAEVSAEMRQRQAGTQQKLEQL 159
4_pfamImport  81 AIKSVLTQALTREEEVHRKRTQLQEAHEQLKAKKQMAAEKFRAAQKQRQLQQEKHLQHLGEVSTEVKKRQSETQQELERL 160
2_pfamImport  81 AITSALTQVLPKVEEAQRKRAQLQEALEQLQAKKQVAAEKLRVAQKQWQLQQEKHLQHLAEVSAEVRERQTGMKQELERL 160
XP_011229745 109 AITGALTQALPMMEEAQRKRVQLQGALEQLQAKKQVAMERLRTAQKQWQLQQEKHLQHLAEASAEVRQRQRGTQQELERL 188
XP_006937774 109 AITRALSLALPRMEEAQRKRAQLQEALEQLQAKKQAAMEKLRTAQEQWRLRQEKRLQQLAEASAEVRLRQTGAQQELQRL 188
Q2TBH8       109 VITNSLTEALPKVEEAQIKQAQLQEALKQLQAKKQMAMEKLRIAQKQWQLEQEKHLQNLAEASSEVRERQTGAQQELQRL 188 domestic cattle
8PPR_Z       189 FQKLGNLKQQAEQERDKLQRYQTFLQLLYTLQGKLLFPEAEAEAE---NLPDDK----PQQPTRPQEQSTGDTMGRdpgv 261 human
3_pfamImport 160 YQELGTLKQQAGQERDKLQRHQTFLQLLYTLQGKLQPPETEAELPqdlDLPEDKkssgSQLLTQSREQTRGDTMGRdgsv 239
4_pfamImport 161 KKELDILKQQAGREQDKLQKYQTFLQLQCTLQGKPLFPEAEIEAE---ELPEDK----TQLPTQPQEQNTGDR-EKdcav 232
2_pfamImport 161 YQELGTLKQEAGQEREKLQRHQTFLQLLYTLQGKLLLPEAEAELPqerDLPEPK----SQQVTQSWELNTGDTMERvgdv 236
XP_011229745 189 SQELGSLQQQAGQKQDTLQRHQTFLQLLHTLQGQLPFPEAETELPqrlDLPEDK----------PQKQNPGDTIGKdrsg 258
XP_006937774 189 HQELGALRQQAGQERDRLQRHQTFLQLLHTLQGQLPFPEAETEPPrklDPAEDE----------PQQRNTGDAVGRdrag 258
Q2TBH8       189 YQELGTLKQQAGQEKDKLQRHQTFLQLLYTLQGKQLFNEAEAEIPqelDLPKDK----LQQVTQPQEQNTQDTMGR---- 260 domestic cattle
8PPR_Z       262 sfKAVG-LQPAGDVNLP 277 human
3_pfamImport 240 teEASNlLQEQGSVCTP 256
4_pfamImport 233 slKVVG-RQPAGDVSLP 248
2_pfamImport 237 ssKASG-PPPIADASLP 252
XP_011229745 259 psKGDG-PQPAGDASSP 274
XP_006937774 259 psEADG-PPPAVDAGSP 274
Q2TBH8       261 --EADN-PQPVGDAGLP 274 domestic cattle
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