This entry represents the C-terminal domain of chromatin assembly factor 1 subunit B (CAF1B) from animals. CAF1B forms the CAF-1 complex alongside CAF1A and CAF1C, which plays important roles in DNA synthesis and repair and participates in the progression of various malignancies. CAF1B interacts with the two Anti-Silencing Factor (ASF1) paralogues ASF1a and ASF1b in order to contribute in DNA replication and repair-coupled chromatin assembly. This domain has been suggested to interact with ASF1 in order to facilitate the transfer of histones H3-H4 to CAF-1 through an interacting motif called B domain. This domain also has what is known as a PEST box, a region enriched in P, E, S, T and D residues, which has been correlated to short in vivo half-lives.
Jiyao W et al.(2023). "The conserved domain database in 2023.",