Conserved Protein Domain Family
DUF4650

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pfam15509: DUF4650 (This model is not part of the current CDD release)
Domain of unknown function (DUF4650)
This family of vertebrate proteins lies to the C-terminus of Ubiquitin-specific peptidase-like protein family peptidase_C98, pfam15499. It might be acting as the exosite for the peptidase.
Statistics
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PSSM-Id: 521888
Aligned: 19 rows
Threshold Bit Score: 464.966
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002691857  574 SLPNLKGSVDSGILPLTLEEV--------QSNSEGFL-LEHKPVA------ENAGVVEANTLQSEE-------------- 624 
3_pfamImport    1 SLSSPCGLVDNNLLTLTLEEI--------QVNSDGFL-LEKRPVG------ENEGIFETNTLQLQE-------------- 51  
4_pfamImport    1 LLSGLEDLVDNDVITLTLTEI--------HVDSEGNP-IENQPVIdqp-liREKAVVDMDTLQKQE-------------- 56  
8_pfamImport    1 LLADPGGVIDSQILPLALEGI--------QVNSEDFL-LENGPVA------GNE-VARTDAAQSQE-------------- 50  
1_pfamImport    1 FLPEPKDWVANKVLPLTLKETvqetasvvQVNSQSFPnLENKPVA------ENTGIVETRALPSQD-------------- 60  
NP_001273753  544 VLSGAKGMVDS-ILPSALEETiqetasvsQVDSKDCL-LEDKPVA------GSAALVRVLAFQPQDsp------------ 603 
XP_003496695  572 VLSGTKGLVEAas--------------vfQVDFKDCL-LEDKPVA------ESAELVRALSLQPQD-------------- 616 
XP_016277352  577 LLSGLEDLVDNDIITLTLTEI--------HVDSEGNP-IENQPVIedqsviRDKAVAEMDTLQKEE-------------- 633 
XP_008106138  561 LLWGLENLADDDVITLTLVSV--------PLDSEGKP-LEESHI-------EESLLANAGTPQLQDvgqvnmlpftseen 624 
5_pfamImport    1 VHHGSENLADGDLVTLMLEEV--------PVDSEDKS-VPNGRMV------GNNFLDGWGTPEQEE-------------- 51  
XP_002691857  625 -----PLIALLV-APFEDKLTHNQ-PDLSFSSQLLT--MPSVQVSTEDTAVTQPVN-DTQAGGLIQQVKPVDTEgav--- 691 
3_pfamImport   52 -----SLTNSFVlAPCTEKLIKDQaVDVRFPSQVINadVPSVQPNTEDIVITQPVN-NGHATDLTQGVESIEIE------ 119 
4_pfamImport   57 -----SVLASSQsAPYEEILVQPQtLPASILTQNASidLKSDQLNPENTSGTVCINnTVHVTALPQGEKPLQIQetkvkf 131 
8_pfamImport   51 -----SLMASFVsAPRKEKLSQDQfADSSFPSRTVNadTQSAQRNTEGMVVATAVT-DTRAADPTQGVKSAHVEgav--- 121 
1_pfamImport   61 -----SLTASSVsDPCKEKQVQDQcVGLGFPSQVVNtnMPSVQPNTGDSGSSKSVS-DSHAAVLTQGVEATEME------ 128 
NP_001273753  604 ----gSSGSSLVsSLCEGKLVAPC-VDSSFPSQAVStdLQAVLSQAGDTVVPNPVT-DAPVPVLVQELKSLATE------ 671 
XP_003496695  617 -----SLMTSLLsNPYEGKLVTPP---------VVStdPEAVPSQAGDTVIPNSVT-DAPVPVPVQELKSMVAE------ 675 
XP_016277352  634 -----LVLASSQtAPYRETPVQSQaLPTSILNQNGSidLKSDQLTPENTSDIISMNnPVQVIALQQGEKPLQIKerkvkf 708 
XP_008106138  625 ishneSILPEHRtVPLHQELPGNEsNLFIMPTVLLSnsS------------------NLQTALPVQEAEPeanl------ 680 
5_pfamImport   52 -----PAFSLSTpYAGEFAGTSLAmNNKSMLYENSSicLPLEELNSVSITAPVPKKhDADS------------------- 107 
XP_002691857  692 ---aleRNASLKQFLVAETEKLNPEQh--VTSQVS-------------DWKEKETT-AFSQTVT----AKPLQNPp---l 745 
3_pfamImport  120 ------RSPQFRQFLSPETEKLKSEH---VTSQVS-------------NLKKKEAA-THSPGIA----ARSVQNQppkal 172 
4_pfamImport  132 sppaleKGAVSSPILSPTVEKLISKQs--VLSQMS-------------NLKTANNIaRDSQGAV----LDSTHNS----- 187 
8_pfamImport  122 ---apeKSVPFKQLLSPETEKLKPEQc--VTLEIR-------------NLKKKETSlKKKKTLTfsqmAKPVPDPp---l 180 
1_pfamImport  129 ------TSAQFKQSFPQKLEELKSEQh--TTSQLS-------------NLEEKKPA-AEPQTFT----VKSLQSQc---l 179 
NP_001273753  672 ------KDSQT-QLLPLKTEKLDPEQp--GKSQAS-------------NLRKRETT-ASSKTVA----ARSAQNQp---r 721 
XP_003496695  676 ------KDTQI-QLLPLSAERLKPAQp--AKSQAS-------------NVRKRETA-ASSKTVM----ASSLQTQp---q 725 
XP_016277352  709 spitleKDAVSSPVLSTKVENFLSKSn--VLSQES-------------NVKVANNAaGDPQNIV----LGSTNNS----- 764 
XP_008106138  681 ---vpvKDSGL---VNAKNEATKTKSnntCQRAPN-------------TLEKKRKI-TGHCHVP----ASSNSSQs---p 733 
5_pfamImport  108 ------SDSLPSQ-LNERTNLANRENglnSELLLNkllaventiqnppDLKDASKT-VVNSQVG----SSSGVSNsvqss 175 
XP_002691857  746 KENQKKPFVGSWVKGLLSKGVSFMPSCVSAHNRN---------TVTDLQPSVKG--ASNFGGFQTKGS-RQKASQASRKA 813 
3_pfamImport  173 KENQKKPFVGSWVKGLLSKGASFMPPCVSAHTRN---------TITDLQPSVKG--ASNFGGFKTKGI-NQKANQVSRKA 240 
4_pfamImport  188 SQSQKKKFVGSWVKGLLNKGVSFMPSCASANERKvh-----lqKTTDLNSLVKR--ANNFRGFKPKGItNQTSPQAPKKM 260 
8_pfamImport  181 EAARKKPFVGSWVQGLLSKGASFMPPCVSAHSRS---------AVADLQPSVKG--ASNFGGFKTTGK-RQKANQASRRA 248 
1_pfamImport  180 KENQKKPFVGSWVKGLLSRGASFMPLCVSACNRD---------TV--LHSVVTR--ANSVDGFKGKGR-NQKGKQVSKKS 245 
NP_001273753  722 KEDQKRAFVGSWVKGLLSRGGAFMPTCVLSQSR----------AVSDLQPSVKG--ASNFDGFKTKSI-SRRSKRMSRKA 788 
XP_003496695  726 KDDQKKAFVGSWVKGLLSRGGSFMPPCVLAQNR----------AVTDLQPSVKG--ANNFDGFKTKNV-NRKAKRMSRKA 792 
XP_016277352  765 SQSQKKKFVGSWVKGLLNKGVSFMPSCASANERKvh-----lqKTTDLNSLVKR--ANNFRGFKPKGItNQTSPQTPKKT 837 
XP_008106138  734 PKNGMKS--ANWVKTLLGRCPS-VPKSASVFIKE---------ETSSKKPTLSGrhALHFRGFETKFS--RKLAK----- 794 
5_pfamImport  176 YKDRKGGFVGSWVKK-LSKSTSFMPSSSSALKNErncktpsvqRISEVWLPMKG--ASNFGGFQSRGT--KKTTETPKLL 250 
XP_002691857  814 HRRA------------------AKPPLLSN----SPPShqsptSTASPPRADGTGDSEVWKRC---ESASCGAYLNHNSH 868 
3_pfamImport  241 RKCA------------------SKPPPVSN----PPPN-----GTAAHLRPSGSADSDVLKQS---ESAPHGAHLSHSSH 290 
4_pfamImport  261 SRSVc-----------------NSLPVLNS----SPSNvsttlLPDEVQEGTKVLTKSLHKNV---QSLSNGLSSKHSFN 316 
8_pfamImport  249 RGCA------------------SKPPPASG----PPASpp-wpGGAALPHAVVSASPRVVARC---DSASLGAPLGHGSH 302 
1_pfamImport  246 RRHAgkplpvqspppacplagtAAPPPASK----TAAPapppaHTAAPP--ARIAAPASSAAS---EGLKKCENTSYRAH 316 
NP_001273753  789 KHME------------------ELSPRNSS----PPLS-----WTAALTQAAENATSALLRE----QEGSRPAPLRHRSP 837 
XP_003496695  793 SKHV------------------DEPTAGSC----SPPSg----STATLPHAGGNATSILLKG----QESSRATPLSNNLH 842 
XP_016277352  838 SRSAc-----------------NSLPVPNS----SPSNistplMSGKVLEDTKTLTKSLHKNF---QPLSSEISPKHNFN 893 
XP_008106138  795 ----------------------QDSPPTNL----LPPSatslsHPTIKKHAAVGSDGTVTNKSgswVTLNKQIQPNQNCN 848 
5_pfamImport  251 APQS------------------NNAHPLSNfkgfSQSTylptaNHTTIAGPTWTKSERTLGTP---GKVTQFPSPGYNSG 309 
XP_002691857  869 GNENGVSSPNHgdtiEGQIHKLRLKLLKKLKAKKKKLASL----MSSPQN--------------GTLPSEPSEQVSHCGS 930 
3_pfamImport  291 GNESGISSASHgnsvDGQIHRLRLKLLKKLKAKKKKLAAL----MSSPQN--------------GTLPGENLENASHCGS 352 
4_pfamImport  317 GNENHISSGTR----ESQTHKLRLKLLKKLKAKKQKLATL----QALQIN--------------GKSPKKNTKLLPQDAS 374 
8_pfamImport  303 RDDIDVSSTNPgnsvEGQIHKLRLKLLKKLKAKKKKLAAL----MSSPQN--------------GKLPGENVEHVSHCGS 364 
1_pfamImport  317 LSHSPLSSAKHgdsvEGQIHKLRLKLLKKLKAKKKKLATL----KSSPQN--------------GTLASEHLEQVSQCES 378 
NP_001273753  838 GNESAISPASRgdaaEDQVHKLRLKLLKKLKAKKKKLAAL----ISSPHRepslsdhsepashcGTPASDQSEPVSHCGS 913 
XP_003496695  843 SSESVISPASCgdaaEDQVHKLRLKLLKKLKAKKKKLAAL----MSSPNR--------------GTSVSDHSEPVSHCGS 904 
XP_016277352  894 GNENHISSGTY----ESQTHKLRLKLLKKLKAKKQKLASL----QALQIN--------------GKPPKKSKKHLAPAGS 951 
XP_008106138  849 ENKKTISLKNgk-lvVDQTQQLRFELLQQLKAKKEKLASLdklaKSQVR---------------KKRSKKTEKNQSQPGS 912 
5_pfamImport  310 KAEESDS---------DKTKKLRLKLLKKLNAKKKRLASLdrlaVEQRKR--------------EKHVSGDISTPSQTES 366 
XP_002691857  931 PNDSESIEGLLQELQRQIDIADNKSGCATVPGVSPYGGQTHEEILAELLSP-ATVVSTELSENGEADFRYLEMGDSHIPA 1009
3_pfamImport  353 PNDCESIEDLLNELQYQIDNADTKSGCTTIAGASQCSGQTQEEILAELLSP-TAVVSAEPAEHGEADFRYLEMGDNRIPA 431 
4_pfamImport  375 QNECESLQGLLMELEDHISATDNKPKDTTHSNIALHNSPTHEEFLAELLSStTTVASSELPRERENDCEYLEMVHNHNMT 454 
8_pfamImport  365 PNDGESIEDLLKELQYQIDLADNKCGGATVPGVAPYGTQAHEDILAELLSP-AA-VSAVLSEPGEADLRYLEVGENRVPA 442 
1_pfamImport  379 PNDCDSLEDLLNELQFQIDIADKQPGCTPVSDVSSYSGQTHEDILAELLSP-TNTVSTELSDNGDVDFGYLEMGDNCIPA 457 
NP_001273753  914 PNDCESIEDLLKELQHQIDLADSKSGCTSAPDATSNNSQSHEEILAELLSP-TA--MSEPSESGELELRYLEMGDS-TPA 989 
XP_003496695  905 PNDCESIEDLLNELQYQIDLADNKSGCTTAPDGTSCNSQSHEEILAELLSP-PA--LSEPSASVESELRYLEVGDS-TP- 979 
XP_016277352  952 QNECESLQGLLRELQDHIDATDNTPNGTTHSGISLNSSPTHEEFLAELLSS-STVVSSEPPRDREDDYEYLEMVDNHNTI 1030
XP_008106138  913 QKEGDSLQRLLNDLQRQIDVEDSKSVNSPATTVSQCSSSSYDDILSELLSPaTTVASLELPH--EEECRYLEMGGGS--- 987 
5_pfamImport  367 QNDSELLQSFLRELQYQIDVTGHQSDLNANTVPGCTGHDNTDEILAELLSPtSTVTSLEAPK-SEDECMYMEMVHSSVAT 445 
XP_002691857 1010 PVPNELNSIAHNTHLRQEHNYCSP-KKNQSELQPDSLTNNAFIRTLNLESPMKTDIFDEFFSASALNSLANDTLDLPHFD 1088
3_pfamImport  432 PVADALNTTPQDTHLRQDHNYCSPtKKHQGEVQTDSLTSHSCVRTLNLETCMKTDIFDEFFSTSALNSLADDPLDLPHFD 511 
4_pfamImport  455 PIPSDFVSGFSSSYPSKDHNYYSPvKQSQYEVQIDSLTNNSCAKTLNLENPLKTDILDEFFSTSVLSSSADDIEYLPHFD 534 
8_pfamImport  443 PVPSELSSVPRHARLGQDHDSRSPaKDNQCGVQPAPLTGHACSRTPSWESPVKPDVFDDLFSTSALNSLAHDTLDLPYFD 522 
1_pfamImport  458 PVPSELNDIPQNTHLRQDHNYCSPsKKNQCEVQPDLATSNACIKTLSLESPVKTDIFDEFFSTSALNPLVNDTLDLPHFD 537 
NP_001273753  990 QAPSEFSVVSQNTCLKQDHDYCSP-EKGQREVDLHSVMDSACIRTLNLGSPMKTDIFDDFFSTSALNSLTNDTLDIPHFD 1068
XP_003496695  980 -APTEFNAVSQSICLGQDHNYCSP-KKNQCEAEVQSLTDSACIRALNLGSPMKTDIFDDFFPTSALNSLANDTLDIPHFD 1057
XP_016277352 1031 PTPSDFVCDLSSANPSKDHNY-SPaKQSQYEVEVDSLMNNSCDKTLSLENPLKTDIFDEFFSTSVLNSSANDIEYLPHFD 1109
XP_008106138  988 PISSISNENPDEI-IGHDHNYHTPeKQNGVEDQTDLLAVRSPLKKLEFGNPEKQDFLDDLFPSSMLNSIMADVEDLHNFD 1066
5_pfamImport  446 TVPYESTSVPQAAVTSEDHNYYSPvKDTNLELD---AINKHSVKKLSFESPTRDDILEDLFSISAPSSMSGDM-DLPHFD 521 
XP_002691857 1089 EYLFE 1093
3_pfamImport  512 EYLFE 516 
4_pfamImport  535 EYMFD 539 
8_pfamImport  523 EYLXX 527 
1_pfamImport  538 EYLFE 542 
NP_001273753 1069 DSLFE 1073
XP_003496695 1058 EYLFE 1062
XP_016277352 1110 DYMFD 1114
XP_008106138 1067 ETLLT 1071
5_pfamImport  522 ETLFE 526 
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