Conserved Protein Domain Family
Dendrin

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pfam15498: Dendrin 
Nephrin and CD2AP-binding protein, Dendrin
Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.
Statistics
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PSSM-Id: 495149
Aligned: 5 rows
Threshold Bit Score: 805.704
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004053111  55 MDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGG 134
3_pfamImport   1 MDFQASHWAPGSQSRTCRPRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGG 80 
1_pfamImport   1 WTSRSSHWARGPRSRTCRPRPGSPEPSPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGG 80 
2_pfamImport   1 MDPTGGPWVQEPSSHRYGLDKKPPERLLRRAWVPRVLQEATNWGTGHPPEIRPREQEKRKAASQEREAKETERKRRKGGG 80 
Q80TS7        55 MDIQASYWARGPQSRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGG 134 house mouse
XP_004053111 135 AR------------RSPPGR------PRPEPRNAPRAAQLAGIPAPLRPERLAPVGRAPRPSAQPQSDPG-SAWAGPWGG 195
3_pfamImport  81 PR------------RSPLGQ------SRQEPRNALRAAHPAGLSAPPRPERFGQVGRAPRPPAQPQSDPG-AVWAGSWAG 141
1_pfamImport  81 AR------------RSPPGQ------PRPEPRNAPRAVQPAGLSGPSRRERLGPAGRAARPSAPPHSETG-AAWAGPWGG 141
2_pfamImport  81 VRswsppglyrsepRSPLGRarggggSRQEPGNVPKTAQPKVRQFPWLPGHLGPAGRPPRPAAQSLRVPGtAARAGLRVG 160
Q80TS7       135 AR------------RSPLGQ------PRPEPRNALRAAQPTGFPVFSRPERFGQVGRAPRPSVLPQGDPG-VAWAGPWGG 195 house mouse
XP_004053111 196 RRPGPPSYEAHLLLRGSAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPGNSQVPTSSAPAAT---PARTEGGRTKKR 272
3_pfamImport 142 RRPGPPSYEAHLLLRGAAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPERSQGPTSSAPAPT---PARTEGGRAKKR 218
1_pfamImport 142 RRPGPPSYEAHLLLRGAAATAPRRRWDRPPPYVAPPSYEGPHRTLGTKRSPERSQASAASAPAPT---PARTEGGSARKR 218
2_pfamImport 161 RPSGPPSYEAHLLLRGAAGPIPRKRWDRPPPYVAPPSYDGPHRTLGAKRPPQLPGLPAPLAPAPTlegKEREE--RPKKR 238
Q80TS7       196 RRPGPPSYEAHLLLRGSAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPELSRAPTSSAPVPA---TTRTEGGRTKKR 272 house mouse
XP_004053111 273 LDPRIYRDVLGAWGLRQGQGLLGGSPGCGAARARPEPGKGVVEKSLGLAAADLNSGSDSHPQAKA-TGSAGTEIAPAGSA 351
3_pfamImport 219 LDPRIYRDVLGAWGLRQGRGLLGGSPGCAAAKPRLEFSKGGAEKSPGLATAALNSGSDSHFQADV-PSSPGTEIALAGPV 297
1_pfamImport 219 LDPRIYRDVLGAWGLRQGRGLLGGSPGCGAVRARPASGKGAAERGPVLPAAGLHGGSDRRFQATAvAGSPGSGTAPARPA 298
2_pfamImport 239 LDPRIYRDVLGAWGIRQGRGALGGFPACGGLG----LGGKTSDKVSGVFLGGLNSNCSES------CSQPGAN-QIARAA 307
Q80TS7       273 LDPRIYRDVLGAWGLRQGRGLLGGAPGCTAARARPESCKGAIEKSSGLVAAGLNSAGDSHSQGKT-TGGPGTDAALSRSA 351 house mouse
XP_004053111 352 TAAPCAPRPAPRSRHHLKGSREGKEG-REQIWFPKCWIPSPKKQPPRHSQTLPRPWAPGGTGWRESLGLGEG--AGPETL 428
3_pfamImport 298 PATTSPPRTAPRFRHQLQGSREGKEG-RERIWLPKCWIPSPKKQPPRHSQTLPRPWAPGGTGWRESLGQREG--VGPEAL 374
1_pfamImport 299 AAPSSPPRPAPRSRHQLEGSREGKEGrREQVWLPRCWMLSPKKQPSRQSQTLPRPWAPGGTGWRESPGHGDG--PGPA-- 374
2_pfamImport 308 TLTSGTSQTTARTQVPLRDVSEGERA-GEQSWSRETGGPSPGDQVAQHSQTLPRPWAPGSPREKESPGEGDGyqRSPKLP 386
Q80TS7       352 --ISSPPRPVPRSRQHLRGSRKGKEG-SEQIWLPTCWLASPKKPPVRHSQTLPRPWAPGGTGWKESLGQREG--AEHETL 426 house mouse
XP_004053111 429 EGWKGTRRAHTLPRSSQGLSRGEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGVTRVVGDSPSQSKP-GKEEGEGVTVF 507
3_pfamImport 375 EDWKETRRPHTLPRSSRGLARGEGVFVIDATCVVIRSQYVPTPRTQQVQLLPSGESRVVGDGPRQPNG-SKEEGERASVF 453
1_pfamImport 375 -----ARRAHTLPRCSRRPAGGEGVFVIDATCVVIRSQYVPTPRAQQVQLLPSEMVRVVGDAPSPPKP-GPQQGEGASGS 448
2_pfamImport 387 TDWKETHRAHTVPRSPHSSAGENGVFVIDATCVVIRAQFVPTPQIQHVQLLSSPGPRNGGNSLAFQKP-GKEEGEEEQAF 465
Q80TS7       427 EVWKVTRRAHTLPRISRGPAGREGIFVIDATCVVIKSQYVPTPRTQQGQLVPSGESCSVSDSLSQPKPcHEEEGEGAAAN 506 house mouse
XP_004053111 508 PSPCQKRLSSSRLLHQPGGGR--GGEA-----EGGRPGDSSL-EERTFRILGLPAPEVNLRDAP----TQPGSPEHQALG 575
3_pfamImport 454 SSACQKLLLSSRVLHQPSGEP--RCEA-----EGGKAEDSSHgGARGPHLWDSRAGEVHVPCAA----AQPASPEHAASG 522
1_pfamImport 449 PFRVPRPQLVS-LSHRPGEGSegEGEA-----EGGKPGDSSSlEERASRILGLPVGEVNLRGAP----AQSGRPEHPALG 518
2_pfamImport 466 TSPCQKLLQNSRLFDQLSKGF---SDAwgegvEAGIPEDPSL-KERASRILGLPIRELDLGVSPnkcnSDPGGPNE---- 537
Q80TS7       507 PSVCQKRLLSSRVLNQPSEGR--ECEA-----EVGQQGDSSL-EERSSSGLGFPVGEVNPRDAP----TQPGSQEHPTLG 574 house mouse
XP_004053111 576 PAASGAQGRAEGSE-VAMVQRRAGRGWARTPGPYAGALREAVSRIRRHTAPDSDTDEA-EELSVHSGSSDGSDTEAPGAS 653
3_pfamImport 523 AAAPADAGSVRGSK-VTAAPRRAGGGWARTPGPYAGALREAVSRIRRHTAPDSDSDEGeEELSVHSGSSDGSDTEAPGAS 601
1_pfamImport 519 PAAPAGAGCARGSG-GAAGPRRAGGGWARAPGPYAGALREAVSRIRRHTAPDSDSDEA-EELSAHSGSSDGSDTEAPRAS 596
2_pfamImport 538 -TAARCADVARDSEpAPRVLRPAGRGWARDPGPYAGALREAVSRIRRHTAPDSDSDEA-PECGARSCSSEGSDTEASGTS 615
Q80TS7       575 PAAPVCAGSLKGSE-AAGVPRRAGGGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA-EDLSVHSGSSDGSDTDAPGAS 652 house mouse
XP_004053111 654 WRNERTLPGVGNSSPEEDGKTAELSdsvgEILDVISQTEEVLFGVRDIRGTQQANRK 710
3_pfamImport 602 WWSERTPPETGGTSPGEGGKTADIR----ETLDAISQPEQALFPTRDTNGTPQGHRK 654
1_pfamImport 597 WRNEMTQPAAGNPGPQEGGKRTEMSdsfrELLGAVSQTEEALFGARDPAETPQADRE 653
2_pfamImport 616 RQPEQSLPGTSGDQGEAGRRAGELRdcirEILDVICQTEEALFRAEGSAQGKQGGGH 672
Q80TS7       653 WRNERTLPALGNTRPREGGKTAGLSdsirEIVDVISQTEEG-FIREDTRKTPQGNRE 708 house mouse
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