Conserved Protein Domain Family
DUF4639

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pfam15479: DUF4639 
Domain of unknown function (DUF4639)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 161 and 601 amino acids in length.
Statistics
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PSSM-Id: 495132
Aligned: 11 rows
Threshold Bit Score: 860.672
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_021584817  12 ERQAR-DRGMTRSKAEKARPPTVTVPQVEIVPGRLNEAEWIALTAIEEGEDVVGDILADLLARVMDSAFQVYLTQQCIPF 90 
Q9DAQ4         6 SRQAR-DRGVTRSKAEKARPPTQPVPQVDIVPGRLNEAEWIAFMSLEEGEDVVGDILADLMTRVMECAFKVYLTQQCVPF 84  house mouse
XP_016835523   6 SRQVR-DRGVTRSKAEKARPPTQPVPQVDIVPGRLNEAEWIAFMSLEEGEDVVGDILADLLTRVMECAFKVYLTQQCVPF 84 
EHB01721      26 ERQAR-DRGTTRSKVEKARPPTVPVPHVDIVPGRLSEAEWIALLALEEGEDVVGDILADLLARVMDSAFQVYLTQQCIPF 104
XP_008252936   9 ERQAR-DRGVTRSKAEKARPPTVPVPQVDIVPGRLNEAEWIALTAVEEGEDVVGDILADLLARVMDSAFKVYLTQQCVPF 87 
3_pfamImport   1 ERQMRgDRGVTRSKAEKARPPTVPVPQVDIVPGRLNESEWMALTALEEGEDVVGDILADLLARVMDSAFQVYLAQQCIPF 80 
ELW64008       7 ERQVR-DRGVTRSKAEKVRPPTVPVPQVDIVPGRLNEAEWMALMALEEGEDVVGDILADLLARVMDSAFKVYLTQQCIPF 85 
2_pfamImport   1 ERQAR-DRGVTRSKAEKARPPTVPVPQVDIVPGRLNEAEWMALAAIEEGEDVVGDIIADLLARVMDSAFRVYLTQQCIPF 79 
XP_011226068   9 ERQIR-DRGVTRSKAEKARPPAVQVPQVDIVPGRLTEAEWMALMALEEGEDVVGDILADLLSRVMDSAFKVYLTQQCVPF 87 
1_pfamImport   1 PRQVR-DRGMTRSKAEKVRPPTVPVPQVDIVPGRLTEAEWIAFTALEEGEDVVGDILADLVARVIDSAFKVYLTQQCIPF 79 
4_pfamImport   1 ERQAR-DRGMTRSKAEKVRPPTVPVPQVDIVPGRLTEAEWMALSVLEEGEEVVGDILADLLARVMDSAFKVYLTQQCIPF 79 
XP_021584817  91 TISQAREAMLQITEWRFLARDEGESAVAEDPTWGEDEEPLACTTDAWAQGSVPVLHTPASEVL-----EENCQVEDLENL 165
Q9DAQ4        85 TISQAREAMLQITEWRFLARDEGESAVAEDPTWGEDEEPLACTTDSWAQGSVPVLHTPAPVCV-----EEQFHNEEPGNP 159 house mouse
XP_016835523  85 TISQAREAMLQITEWRFLARDEGESAVAEDPTWGEDEEPLACTTDAWAQGSVPVLHAPAPVGV-----EEHFQGEEPGNS 159
EHB01721     105 TVSQAKEAMLQIVEWRFLARDEGDAAVAEDPTWGEDKEPLACVTDTWAQGSVPVVHAPACESLedfedEDEDKDEDPGSR 184
XP_008252936  88 TISQAREAMLQIAEWRFLARDEGESAVAQDPTWGEDEEPLPCTTDAWAQGSVPVLHGRLSEGQ-----EETFQSEDTESQ 162
3_pfamImport  81 TISQAREAMLQITEWRFLAHDEGESAVAEDPTWGEDEEPSPCTTDSWAQGSVPVLRAPTLEGP-----QENLQGEGPRNL 155
ELW64008      86 TISQAREAMLQITEWRFLARDEGESAVAKDPTWGEDEEPLACTTDSWAQGSVPVLHTPAAEGM-----DETLQDED---- 156
2_pfamImport  80 TISQAREAMLQITEWRFLARDEGESAVADDPTWGEDEEPLACITDAWAQGSVPVLHAPASVGP-----EETLQ-EDRGSV 153
XP_011226068  88 TVSQAREAMLQITEWRFLARDEGESAVAEDPTWGEDEEPFACTTDAWAQGSVPVLHAPAFMGP-----EDTFQGEDQGRV 162
1_pfamImport  80 TISQAREAMLQITEWRFLARDEGESAVAEDPTWGEDEEPLACTTDAWAQGSVPVLHARASMGL-----EETFQGEDQDSV 154
4_pfamImport  80 TISQAREAMLQITEWRFLARDEGETAVAEDPTWGEDEEPSACTTDAWAQGSVPVLHAPTSVGL-----EETFPGEDRGSV 154
XP_021584817 166 DRIPLRRSWpGRASQELTESREHS---LSVTLGPQPNPELFQEAELGDTLE--EPDRGARShssl---vgflNG----SV 233
Q9DAQ4       160 DQFLLGSSW-DKESQKPTQPSEPSa-ePKVTPRPTATLEAFEEAEPGDALE--VPHGQEGS-----------HMlavpSK 224 house mouse
XP_016835523 160 DRFLLGSPWlDRDSQEPTASSQPSa-eTRVIPGLTPTLEEFQEAEPQDDFE--EPDGQEQSdvlvtslkepsHIltgpSK 236
EHB01721     185 GRILLGRSWlARGSQERFp-------eLRVTPGPPATPELFQKAGAGGALQ--EPDGQARSlfla----gslNE----NL 247
XP_008252936 163 DQSPLGRLWlDRHSQGQTGSWEPSp-eLRATSGRPLTPEPFPEAGPGDVLE--EAD----Shlss---aeslHS----FQ 228
3_pfamImport 156 DQMPLGRSRmSRGSQELRQPWEPSq-eVRINPSTPPMPDVFQEAGPRDPLE--EPDplit---------kslNK----SF 219
ELW64008     157 ---PLGKPWiERDSQEEAESQe-----LRVTPGPVPTAELFQEAEPGGSFE--EPVDQMRDppss---agslSA----CF 219
2_pfamImport 154 DRSPLKRSWvGRGSQEQMESLERS---------PEPGAELFQEAGPGEPLE--ELDDQERGavss---aescNA----SF 215
XP_011226068 163 m---------ARGSQEQMESWEHSp-eLQFTPGPPPTPELFQETGSRGPLV--DLDIQARDhqat---vrslNV----SR 223
1_pfamImport 155 DQIPLGGSWtDSGSQEPMESWe-----LTVTPDSPPTPELLQETGPRSPLE--KLGDQSRSdqtdlfavgssNS----SS 223
4_pfamImport 155 DQITLGRSWmDTGSQEPMEPWDRClpeQRVVPGPSSTLELLKETGPRGPLEelELDGQARGhlss---vgclTV----SS 227
XP_021584817 234 Q---PSLEVELAESPRPFLELSQVALPRASVGSQSpphLRSPLSLEDFYSCISQPDAAGDQLKRKTQAmsPNASGVLVPF 310
Q9DAQ4       225 EslrSTAEGERVYSPQSSLKQPQVVRLQASEKESS---FGSHLSLEDLYLCMPQPDAAGDRLSLQSKG--QLHSSPIGSE 299 house mouse
XP_016835523 237 QsspPS-----AHSPQLSLDLPHVVSLQISEKGSSs--LSSHLSLEDLYNGLPQPDAAGDRLKRESKGtpRAPS--VGSV 307
EHB01721     248 Q---RSGEAEGIQSPHPSLELSQVASPLASAVRGQp--LGSCLSPKDLY---PQPDAAGDRLLNVTEGmsCMASGV--SC 317
XP_008252936 229 L---PWVEVGPREGPHPSLELSQVASPQAPALRPQs---GSLLSLEDLYYCMPDKDAAGDRMELKREElpPVASAAALSV 302
3_pfamImport 220 QenfQSVQVASADSPGP-LELSLVASPKALAKTVQp--FDSQV-LENLCYGLPQVDAAEDQLELKTKGvpRAASGV--PV 293
ELW64008     220 Q---PCAEGAPADSPPTPPELSRLASPQASTPSGQf--LKSQLSLEDLRYCTSQPDAAGDRPELKTAGapYVASGVSASG 294
2_pfamImport 216 H---PSEEMASAGSPEPSEEEFLEAGSQTPEETGQp--LSNQLSLGDLYYCAPQPDEAGDRAELEKEGvsPIASGTLLSC 290
XP_011226068 224 Q---PSVELAPDGSPHPSLELSQVASTQTLARRAQp--RGSQSLLEDLHYCTSQPHVAGDGLKCKKEDvpRISSGVSGAG 298
1_pfamImport 224 Q---LSMEMVPAGSTHASLELSLVASPQASVERAQp--ISSQFSLEDLYNCTPQPHAAGDRLELREEKvpLIPSRVLVSD 298
4_pfamImport 228 Q---LSMEMAVAGGPHLSLEPTPVASPKGSVEKAQp--FSSPFSLEDLYYCTPQAQAAGDRMEPKKEEvpFISSSGSVSG 302
XP_021584817 311 SSKGDTSALSASVSsqsQQSvyldsqrRgTLQSRVDRK-AAEVRLDPARLPRHWVRPLAEVLVP------------DSKV 377
Q9DAQ4       300 SHLGALTPAEPSAF---QEP-------E-VLGERPKHK-TTTLRMDSSRLPRHWVRPVAEVLIP------------DLEV 355 house mouse
XP_016835523 308 SLLSALTLERPSWS---QLP-------E-CLDSPQTRK-MPMVRLDPARLPRRWVRPVAEVLIP------------ETET 363
EHB01721     318 LSRGGPPSLSPSASlqsYQPgr----lG-EPHYRAGCK-ATTAHLDPEQLPRHWVRPLAETVIPdsdacpletyllDSDA 391
XP_008252936 303 GSEDRPTQLGPSVPfrwQQPgrwharlN-PPRSRMDRR-ATRRRLDSARFPRHWVQPLATVLIP------------SSER 368
3_pfamImport 294 PTVGSPTRFSPSASvqpQWPlsldvqlS-MPPYRAR---KAATRLDPARFPRQWVRPLAEVLIP------------DSEA 357
ELW64008     295 TSLGDPTQISPSASfqsQQPggwnawpR-TPHPRPGRK-PTVARLDPARLPRHWVRPLAEILIP-------------DDA 359
2_pfamImport 291 PSVDSPTRLSPSASlwsQQP-------------RAGGKvGGTARLDPARLPRHWVRPLAEVLVP------------GTEA 345
XP_011226068 299 LSSGSSTTLSRFASlepRQPrftdalrS-GLPYRMGLK--AGACLDPTRLPRHWVRPLAEVLVP------------DSEA 363
1_pfamImport 299 PSAGGPTTLNPSAGfqpQPPwlaeerpS-ALHSRIGRK-GTTARLDPARLPRPWVRPLSEVLVP------------DSEG 364
4_pfamImport 303 TSAGGLSTLSSSSGfqpQQLwrpdarpS-SLRGRIGPS-AEMERLDPARLPRRWVRPLAEVLVP------------NSEM 368
XP_021584817 378 HPLEAYRKRQRg--KIQA---QVGLQAPGPHVPASL-----AAFFPLQSDVPF-RVVGPEprlqlPTLNLGPPSLSFGSK 446
Q9DAQ4       356 HPLEIYRGRPR---RSQAgtaTSACESQALSSRAPSkphvsSPRFPLQRCATF-RALGPD-----PSLNLAQTSPSFGSN 426 house mouse
XP_016835523 364 RPLEIYRGRPRg-eKSQAgarTPASRSQALGLHAPPklqasPLKFPLPCNAPF-RALGPD-----PTLNLAQSAPTFGSK 436
EHB01721     392 RPLETYLGRRRh-cKTKT---RARPQGPVSGDRVSP-----AAFFPFQPKGP--CALGPD-----AALNLAPLLPSSRAK 455
XP_008252936 369 YSMEAYCGHQQs-kKTKA---QAVPQFPGPGDCTSP-----AMFFSLHPGTPF-RPLGRGrrlkfPTSNLGPLESSSGSK 438
3_pfamImport 358 HPLETYRGHQHsseKTQT---PAEPQSPIPGASVFQ-----AAFFPFRSGVPF-RALGPGpkvqsSTLNLNLPSPTFGSK 428
ELW64008     360 GPLESYRWRPQs-gKTEG---RDTSLGSDAAAPVSP-----EAFVPLRLGVPSqRSLVNGsglqfHTVNLGLPSPPFRSK 430
2_pfamImport 346 CLLEAYRGRRRn--KTDA---RATPQAREHGHRVSP-----AAFVPLRPGVPF-HALDSRlglqfPSLR----SPVLVSK 410
XP_011226068 364 RHLEAYRGRRRv-aKTKApqpSARPLASGPGVRVSP-----TVFFSLPPSTPF-HALGRSpglqsPTLSLGLPSPGFGSK 436
1_pfamImport 365 RPLEAYRGRQRg-eKTEA---PAGPQASRPSCRVSR-----SEFFPFPPGVPV-RTLGPGlslqfPTLNLGLPSPGFGSK 434
4_pfamImport 369 RPQKAYRGCLQs-rKTEA---PAGPQAPGPDVRVSP-----SVFYPLPPGVPF-RALAPGrrlqfPTLSSGLPSPGFGSK 438
XP_021584817 447 LPFPSPGIHFLDTHPAVVEAAHRSSPSVWPRAKWPSGWEREADLLGNLWAGRTRVPPQGLGLAEKEG-QA-SGWPQTMPQ 524
Q9DAQ4       427 VPFLSPGFRFLPRNPIPPDVASTPTPKLWPLAKWPSGWEREAEQLGELWAGRTRVPPQGQEPVEVTPlEEdSGWPLAAPQ 506 house mouse
XP_016835523 437 LPFLSPGFRFLPTKPGPPEVSSSPSPKLWPRAKWPSGWEREAEQLGELWGGRTRVPPQGQEPAADDA-SDdSGWPLAAPQ 515
EHB01721     456 VPFPSHGAHFLPKHPVLAEVPRSPSPKSWPNTKWPRGWEGRAELLGKLWAGRTRVPPQGLEPADKED-QD-FGWPQIAPR 533
XP_008252936 439 MPFFSPRLHFLAPQPKLPEEARSLSPKPRPSAKWPSGWEWEAELLDELWTGQTRAPSRGLGTIDKEG-QDhDGWPQPA-Q 516
3_pfamImport 429 IPFPSPGLRFLTKRPKLLDVAHIPSPKLWPSAKWPTGWEGEAEMLGDLWAGRTPVSAQGLEPTYREG-QDlQRWPRTTRQ 507
ELW64008     431 IPFPSSGLRFLATHRALPALPHSSSPKQWPSAKWPRGWEAEAEQLCELWAGRTRVPPQGPRPTE-EG-QGaRGRAETPPH 508
2_pfamImport 411 MPFPSPGLRFLTTHPTLPDVARSPSPKLWPSAKWPSGWEGEAELLDELWAGRTRVPPQRLDPGDRKG-QDsRGWPLLAPR 489
XP_011226068 437 LPFPRPGLGFLATHLAFPDLARSPSPKLWPGAKWPSGWEGEAELLGEVWAGRSRVNPQGLDPRDREG-QDpHRWPQMAPR 515
1_pfamImport 435 LPFPSPGLRFLATHRARPDMARSPSPKLWPGAKWPSGWEGEAELLGELWAGRTRVPPQGLDLGDRES-QDpHQYRHPVPQ 513
4_pfamImport 439 LPFPSSRLRFPITHSVLPDVAHSPSPKLWPGAKWPSGWEGEAELLGELWAGRTRIPPQGLDPGYRES-QDpHKWPHPAPQ 517
XP_021584817 525 VLEATSQVFWKPVLVPEAVKLTPGVSMWNRSTQVLLNSAVSQEEVKEGGTSPAv-EQRPIQKGVSKP 590
Q9DAQ4       507 VLEATSQVLWKPMVISETMKLVPGVSMWNRGTQELLNPAVIRKEAEEGTPQAP--EQQPIQTGVSKP 571 house mouse
XP_016835523 516 VLEATSQVLWKPMVLSETMKLVPGVSMWNRGTQELLSPDAILEEAEGGTSNGA--EQQPIQTGVSKP 580
EHB01721     534 ILEASSQVLWKPVVRPEVVRVAPGVSMWNRSTQVLLSSAVP-QEAKEGGTFSSi-DQHAIQTGVPKP 598
XP_008252936 517 VLEATTQVLWKPLLQPEAVKLAPGVTLWEHGTKVLLSSAVSQEENQEDSTSPPteQQHPIQMGAPKP 583
3_pfamImport 508 VLEATSQVLWKPMLLPEAMKLAPGVSMWNPATQVLLSSAVPQQEDKEGGTFPPi-DQHPIQTAPLKP 573
ELW64008     509 VLAPTSQVLWKPLLLPEAVRLTPGVSMWSPNAQVLLSSAVPPQENKDGSCSPS--EQHPIQTSAPRP 573
2_pfamImport 490 VLEATSQVMWKSVLLPDAMKLEPGVSLWNPSTQVLLSASEPQEEDKEGRISPPv-EQHPIQTGAPKP 555
XP_011226068 516 VLEATSQVMWKPMLLPDAMKLAPGVSMWNPSTQVLLRAAVPQQEDKESVTSLPi-EQHPIQTDAPKP 581
1_pfamImport 514 VLEATSQVTWKPVLLPGALKLAPGVSMWNPSTQVLLSSSEPQRNDREGSASP------PIHTGAPKP 574
4_pfamImport 518 VLEATSQVMWKPMLLPEALKLAPGVSMWNPTTQELLSSAEPQQEDKKGSTSP------PIHTGAPEP 578
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