6VKL


Conserved Protein Domain Family
Sec5

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pfam15469: Sec5 (This model is not part of the current CDD release)
Exocyst complex component Sec5
This entry represents the Sec5 component of the exocyst complex which is an octomeric complex that mediates the tethering of post-Golgi secretory vesicles to the plasma membrane during exocytosis.
Statistics
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PSSM-Id: 521864
Aligned: 42 rows
Threshold Bit Score: 343.95
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6VKL_B         80 RDPLNg------QEMSKELq----HLPnds----mrlNYLVNSKQFNVKAFLRDMHKQDSFNDLNNSLDRLDSDIQDQ-S 144  Saccharomyces...
XP_002629701  134 RDALGlvp--sqKRIDQVMls---rDFpdc-------sgnLRMENFSPQWYLLENHADATIEDLRTAIKNMELAKQND-A 200 
EEC09031       81 EDPLGisd-esvRRFPEEElr---qLFpeg-------sgnLLSENFNPTWYLLENYNSTSFSDLKAGLMSLKRKVGQL-Q 148 
XP_011265081  126 EDPLGlsvegndKKFPEDElt---eLFgdg-------sgdLTSEKFHPGWFLLQHHHATTLEDLKAGLAYLRRKVNSQ-K 194 
XP_001965095  126 EDPLGlsiegneQKIPEDLr----dLFpda-------cgdLSQENFSPAWFLLENHLATSFEDLKAGLSYLKRKVESQ-K 193 
XP_001843214  126 EDPLGlsiegndKKFPEDLr----dIFpdg-------sgdLSQENFLPGWFLLENHHATSFEDLKAGLSYLRRRVESQ-K 193 
EFA11086      125 EDPLGlsvegndKKFPEDDlm---tYFpdk-------sgdIASGNFSPGWFLLENHHATSFNDLQAGLNFLRRKVEGQ-K 193 
XP_002890429  183 IDPLKlgi-idnKTLRLITessesLSKaekvdnalreKLVYISDHFDPKLFISRIHQETSAADLESGALALKSDLKGR-N 260 
Q96KP1        132 ANPLGiei--ekSKFSQKDle---mLFhgm-------sadFTSENFSAAWYLIENHSNTSFEQLKMAVTNLKRQANKK-S 198  human
XP_002127048  129 TDPLGlnseelgHKTQAYMql--adLFgkg-------spdPTDQNFEPSWFLLERHCNTSFSKLKEGHAYMKRKANRNtN 199  vase tunicate
6VKL_B        145 IHLKQLVGKNFTKYVKIKNKLDQIYKEFDEKTneknqcdspkenqinVESLNKKVDEVIRTTTFKLKPLMDNYQKILNYQ 224  Saccharomyces...
XP_002629701  201 KRSEEMHKANLYSLINCVDTLANLHQALE--Kgqnad------hfaaLGNISKLIKDSKLKAESVFADVLKRKDDADATR 272 
EEC09031      149 EGPSSFLKSNVNAIVICLDVLHELQKAMEKDKqemg--------sdltEKLSEAVLRSKEEAENIFESILARKDQADSTR 220 
XP_011265081  195 EGQLSFLKANVGAVMEQLDTIMSLKDQFEADMksyg--------sdptEKLEKAIRQSMSEANKLFDDVLARRDRADATR 266 
XP_001965095  194 EGQLSFLKSNAGSVIDQLDTLMNIRDKLQEDVklhg--------neplNILEASIENSITESQKIFTDVLVRKEKADSTR 265 
XP_001843214  194 EGQLSFLKSNAGSVMDQLDTLMALRDRVAQDTklyg--------kdqvKDLEVAIQKSIDASHELFKDVLSRKEKADATR 265 
EFA11086      194 EGQLSFLKANIGSVMDQIDTLVNLKEKIEGDVakfg--------teptLKLEKSIKESEREGRKLFDDVLARRDRAEKTR 265 
XP_002890429  261 LQRKQLVKDNFDCFVSCKTTIDDIESKLKRIEddpd--------gsgTTHLFNCMKSVTSRANRAFEPLFERQAQAEKIR 332 
Q96KP1        199 EGSLAYVKGGLSTFFEAQDALSAIHQKLEADGtekve-------gsmtQKLENVLNRASNTADTLFQEVLGRKDKADSTR 271  human
XP_002127048  200 NAPLNHVKDSLPVFFEVHETLSGIHHKMQRDEggrkn-------gnltDKLESTLNEASENANKLFDTVLSCKDRADSIR 272  vase tunicate
6VKL_B        225 ATKKFIELNKFYFNLPKSLKRCLTNNDFNEFIIEYSKGLTLRRRfnqssdaSQSLVIKRIWTQIENLLVTYKDLIWNSLI 304  Saccharomyces...
XP_002629701  273 NALGVIVRFKFIFFLSSKIEESMKKGEYITILNDYTRAKSLYAD-------TDVPLFRELMTEIDAKMEVFKEEMKRKLI 345 
EEC09031      221 NALSILQKFRFLFNLPVTIEKNIQKGDYDVVINDYNRAKSVFQD-------TEVAVFRRVFQDVEQRVQRFRNALMDSLK 293 
XP_011265081  267 NALAVMQRYKFLFCMPINIERNIKRGNYDLVINDYARVKNLFKN-------TEVDVFRKVLEEIDDRINNFKVLLRKRLE 339 
XP_001965095  266 SVLFALSRHKFLFCLPNSVDRRAKAGEYDIVVNDYSRAKNLFGK-------TEIPIFRKVLEEVDQRILSIRKQLHEKVV 338 
XP_001843214  266 AALSALSRHKFLFCLPNSVEKSAARNEFDIVVNDYARVKNLFGK-------TEVPIFKKVLEEVDLKILGIRQQLHGKIK 338 
EFA11086      266 NALNVLARFRFLFCLPCVIDRNIKKGEYDIVINDYIRVKNLFNK-------TDVPIFKSALNEVDKRIADLKKKLLTDLQ 338 
XP_002890429  333 SVQGMLQRFRTLFNLPSIIRSSISKGEYDLAVREYKKAKSIALP-------SHVNLLKRVLEEVEKVMQEFKGTLYRSME 405 
Q96KP1        272 NALNVLQRFKFLFNLPLNIERNIQKGDYDVVINDYEKAKSLFGK-------TEVQVFKKYYAEVETRIEALRELLLDKLL 344  human
XP_002127048  273 NTLNVLQRFKFLFNLPLNIEKNIQRGDYGVVINDYEKAKSLFSE-------TDVDVFKKVFAEVEKRIEKFREQLKQEVQ 345  vase tunicate
6VKL_B        305 NSnfniDqpqeTILSLFSKLLNLENfinnnqresesgnknttsssNE------------NPILRWMSIKMNGFQNELNEL 372  Saccharomyces...
XP_002629701  346 DT----PlsyeeQSKLIKYLKILDP--------------------ES------------DPTWDCITSYYVWLEKNLWEL 389 
EEC09031      294 QL----PmpveeQKRLIRYLISLEV--------------------PG------------SPAWDAVRHNYNWLLNSVETC 337 
XP_011265081  340 EM----SfsleeRKKIIRNLVNLDA--------------------EG------------DPAWDAIVSHANYLEKCIVNV 383 
XP_001965095  339 KM----PqsveqQKKLIKALTSLEL--------------------QQsgtpigdklrniDPAWDAIEARAKYLEATFRQT 394 
XP_001843214  339 EM----PqgveqQKKLVKALISLEA--------------------QQagtsvasrlkieDPAWDAIEARAKYLEDTFLKS 394 
EFA11086      339 TM----PitveqQKRLIRYLVNLDC--------------------TE------------DPAWRAIESRSAYINKNIKQI 382 
XP_002890429  406 DP----KidftSLENTVRLLLELEP--------------------ES------------DPVWHYLNVQNHRIHGLLEKC 449 
Q96KP1        345 ET----PstlhdQKRYIRYLSDLHA--------------------SG------------DPAWQCIGAQHKWILQLMHSC 388  human
XP_002127048  346 EL----PsplhrQKKLIRYLLGLGE--------------------SG------------DPGWECLVHQHGWIQESMIKC 389  vase tunicate
6VKL_B        373 SGHMISKIIHSQRL---------------------------ILQNNTNQDKSQGCVELSYYLkinqlfqiisdtgkdseg 425  Saccharomyces...
XP_002629701  390 QEKFLEKAKIEDVEsqq------------------------------------rfHQNPA-------------------- 413 
EEC09031      338 KQKHLSVCKSLHVYlsv--------------------------------------------------------------- 354 
XP_011265081  384 VPEHLDAVNYEDTSktc--------------------------------------------------------------- 400 
XP_001965095  395 FEQHANKDAGPQEKsks--------------------------------------------------------------- 411 
XP_001843214  395 YDQYTGKEGTPESKsrn--------------------------------------------------------------- 411 
EFA11086      383 YGEHNVEKPDPRSKsns--------------------------------------------------------------- 399 
XP_002890429  450 TFDHEARMESLRNQvheralsdakwrqiqqngvqlsddmssMEDNQVQVDQPSEE------------------------- 504 
Q96KP1        389 KEGYVKDLKGNPGLhsp------------------------------------mlDLDNDTRpsv--------------- 417  human
XP_002127048  390 KDRHIKT------------------------------------AFKCTENLDEAGKVQ---------------------- 411  vase tunicate
6VKL_B        426 lkstvepnkvntisgTSYLNLNCQPSSQGLTDSPTIIEMWLLILKYINDL-WKICDQFIEFWEHIEKFLDGTYQNS---- 500  Saccharomyces...
XP_002629701  414 ----------------SSHFTK-----------------SNELQNFVTTLvELLLSKLPSFWKLANTY------------ 448 
EEC09031      355 ----------------------akGDEDERKRSEESHPDLPRQVLFVEEVtALFQKHLCDFWKLGLSYFAGDFLV----- 407 
XP_011265081  401 --------------------ksISLNIKHLRLEKTNGNNPPTQISCIETIcDIVVEQLPDLWRLGQSYFTGQLHV----- 455 
XP_001965095  412 --------------------------------rdRDSSQAPSRVNFCEELcDIAASQLPDLWRLGQLYFTGELRG----- 454 
XP_001843214  412 -----------------------------------dpNATPVRVQFCEEMtEIAASQFPDLWRLGQAYFTGELRG----- 451 
EFA11086      400 ----------------------tsKYSKYNPPPQNDLNTVPANVNFIDEIcLSISETFPDLWKIGQAYFSGELRV----- 452 
XP_002890429  505 ---------------------------------SAGREKDALRGRYIKILtAVIVYHLPTFWKTALSVFTGKFAKSsqvn 551 
Q96KP1        418 ------------lghLSQTASLKRGSSFQSGRDDTWRYKTPHRVAFVEKLtKLVLSQLPNFWKLWISYVNGSLFSEta-- 483  human
XP_002127048  412 -------------------VCH----------------------QYLEELtSIATSQIPEHWNLWQHYSTGVILSEtg-- 448  vase tunicate
6VKL_B        501 ------IinekrkeniligdsniiESYQKSLILKEEQINEVRLKGEEFITSVSQNLISFFTssqsslpsslkdstgditr 574  Saccharomyces...
XP_002629701  449 -------------------------HASSGSPNAIQRLEDINEMLTKLINVSSWLV---LN------------------- 481 
EEC09031      408 --------------------------EDASVNDRERDEKELREMVASLVGQLSWEV---RV------------------- 439 
XP_011265081  456 -------------------------------AVDVEKQGHFKNLVLSSMQRAMEAIKSICShdvd--------------- 489 
XP_001965095  455 --------------------------------PHDPKPGDFKRIILNAIEKYCVYL---RV------------------- 480 
XP_001843214  452 --------------------------------AGQPKPGNFKRIILTVIEQFCSYL---KA------------------- 477 
EFA11086      453 -------------------------------KIEPGRHVEFKHIVMTIMESFCKSI---RS------------------- 479 
XP_002890429  552 dtsaskA-----------------EEKAEEARYSSHSLEEIAGMIRNTISVYEAKVQSTFH------------------- 595 
Q96KP1        484 ----ekS-----------------GQIERS-KNVRQRQNDFKKMIQEVMHSLVKLT---RG------------------- 519  human
XP_002127048  449 ----ekS-----------------SDVENLKEMASKHSKQMKGLLRDTVILFVNLL---RA------------------- 485  vase tunicate
6VKL_B        575 snkdSgSPLDYGFIp------------------------------pNCNGLSCLRylpkivepilKFSTELAQLNITTN- 623  Saccharomyces...
XP_002629701  482 -----------ALItkalpdsvlnqysnq--fakwppvsadisrsnLQQSLKTTR----------SLIASLLENQFNLS- 537 
EEC09031      440 -----------ALLppthhslakqahrvs---awpghktneklgpwLPQCLRSIR----------QCYLSLLKLDIPEE- 494 
XP_011265081  490 -------------------------------------------akwLLHILRCVR----------QMYASLIHLDLPSE- 515 
XP_001965095  481 -----------AILiaadqralrqssgln--wpigsasathqflpwIPQCLRYTR----------IAYATLITLDLPSE- 536 
XP_001843214  478 -----------ALLpagnqrtllvstmkglptwpasnlslnylitwLPHCLRYVR----------VSYATLIRLDLPGE- 535 
EFA11086      480 -----------SLIpntldkadksalg------swtipeleevapfLPEILRCVR----------STYIALIKLDLPSE- 531 
XP_002890429  596 ----D-FDESYILHp------------------------------yMSDTIKEVS----------KACQAFEAKESAPHs 630 
Q96KP1        520 -----------ALLplsirdgeakqyg-------gwevkcelsgqwLAHAIQTVR----------LTHESLTALEIPND- 570  human
XP_002127048  486 -----------AFLpatlhvdddedlhere-sygvwpsevplpatvLYDCVRAAR----------QCLIELSSLTLPHG- 542  vase tunicate
6VKL_B        624 GITICRNTLSTIINRCVGAISSTKLRDISNFYQLENWQVYETV---TfssksqdssknltfEYGVTQFPEIVTSFQEVSI 700  Saccharomyces...
XP_002629701  538 HIAPLVELCMTVRLKLVSDFVECGIERIALLAHRINWKQDILDr--A--------------QQTKTILPDYYENEICECL 601 
EEC09031      495 NTSLVQRLIFDLRVHSMTCLFGQAAEDVRNLLKSEVWRLEKDDr-----------------CGGTTQLPLMFENRVVETL 557 
XP_011265081  516 ALDIFGAFILNLRIQCLIALFKQGADNIIALNREETWQIEYLNe-----------------DGGVTKLPYLFEETVVKIS 578 
XP_001965095  537 ALDIIQKLIDEVRLFCFSIIFKRATDRCKKLGSQETWEMGVEE------------------YPGATLLPGALEALLIETL 598 
XP_001843214  536 ALDIVLKFIDELRLYCLSTILKKANEKVKKLHEKETWEFPVAD------------------FAGATGLPSKLEEILTEAI 597 
EFA11086      532 ALDIVSSLLLDLRIHCMSTLFKQAAEQIKQLN--ENWKIDFSGn-----------------HVGITELPIKFERIIQDVI 592 
XP_002890429  631 AVMALRKVKVEITKIYIQRLCSWMRASTEEISKEETWIPVSILernRs-------------PYSISYLPLAFRSIIVSGM 697 
Q96KP1        571 LLQTIQDLILDLRVRCVMATLQHTAEEIKRLAEKEDWIVDN---------------------EGLTSLPCQFEQCIVCSL 629  human
XP_002127048  543 TLQSLNDVIHDLRVLSLSTFLQEATDDIRGLRMKETWEVSN---------------------KGVTALPSQFHNITVALV 601  vase tunicate
6VKL_B        701 KTTRDLLFAYEKLPIINGISVvSYPSKQLLTGIEIQQIISMEAVL-EAILKNaakd------------------------ 755  Saccharomyces...
XP_002629701  602 SRTRDALSTTGYPGEACLFSR--DRFRDTIIDLFVHLITSIKICF-DRLFTRqrpqalvld------------------- 659 
EEC09031      558 QLVRENILQSG-PREMEVFEQ--INVQGTIKQYAQAVLQAFVETL-EKCALSpdrlspiidaigsnveilp-pgqraksf 632 
XP_011265081  579 RHARETVIACG-PREGPLFNN--PTHQLLYHNTVKMLFTSFTRCL-EQLAFSgcedndetsvsqlig---------spsg 645 
XP_001965095  599 DEVQSVCMQTE-SREGNLLEP-QSDGQREVSQRLQEFLSAFSGVI-EELAFHshdeetpthnvsqllgf-----pnaqqp 670 
XP_001843214  598 DDAQVICLTPE-IRETSLLEP-QSDGQREMSKRIQELLGTFCGVI-ETLALQrsdedpqqapmlsqligfpaallqqqis 674 
EFA11086      593 QIVKESVLSTE-QRETPLLEN--PTAHKELDKQIEAVLVSFHNVLnNLSSDEscdddedtspvvsqlig------tping 663 
XP_002890429  698 EQINMMILSLKGEAARSEDMF--AHIEEILISVRLAFLNCFLDFA-AHLEQIgadlsqrtskreswqngy----sndhqe 770 
Q96KP1        630 QSLKGVLECK--PGEASVFQQ--PKTQEEVCQLSINIMQVFIYCL-EQLSTKpdadidtthlsvdvs----------spd 694  human
XP_002127048  602 SVVRDVLESL--PGEEPVFAR--VAVQSRVTQDFTRLFTTFSSCL-ERCVFIeesesdssk------------------- 657  vase tunicate
6VKL_B        756 --------kdnPRNSHTILTLTNLQYFRECAFPNILQYFDDAFE---WNLA--SKNLELFS--LLSKMESSIFGNYLSDL 820  Saccharomyces...
XP_002629701  660 --ekpkkggqeITTKKLLIAVGDIEFIIAKTLNNVGKKMQECGV---KHVD--QIQEKSRA--KLSAFRTKMINDCIAMM 730 
EEC09031      633 kqkredslttpPLEKRLLIVLSNCSFTSRVVIPRLQESFERHGY---PDMS--LVIQTTLS--RLAELDRKLFQKLLEAK 705 
XP_011265081  646 yksktnkhkgpTWEQCLLISLSNIRYTLNIVLPRIEDALKTQGY---PELS--TAVGWNSDwtQMETLDSAVLEAYLERR 720 
XP_001965095  671 dsvaggagatvTWEQRMLCCLANFAYCNKSFFPKIGDIFVLYGY---PLPT--LAIETARY--TVNQLFTNLLEEYVEHK 743 
XP_001843214  675 ggtdkswgssiTWEQRMLCCLSNCIYCNKVFFPKLAGLFTKHNY---PVPS--IAIENSRS--TVNTLFSSLLDMYVEHK 747 
EFA11086      664 yrtnytnnnmpIWEHRLLITLSNCLYAKNVVFDTILRKFKESGF---PAPE--TPVKNAKD--KLDVLEKTILEKYLEQK 736 
XP_002890429  771 eqsinapesvvDPHRQLLMILSNIGYCKDELASELYNKYKYTWLqsrRNDEdiSDLQDLIM--SFSGLGEKVLEHYTFAK 848 
Q96KP1        695 lfgsihedfsltSEQRLLIVLSNCCYLERHTFLNIAEHFEKHNF---QGIE--KITQVSMA--SLKELDQRLFENYIELK 767  human
XP_002127048  658 ----vpqeslpplEQRLVIGISNLSYTKQNLLHPLIDHFRQLHF---PNIE--VTEKTCDS--EFSKLDEKFFEAYVEHR 726  vase tunicate
6VKL_B        821 KINLRDTLEEKF--HEINWPMYTS-NSfRVGDYIIEALMILIVVHSECFRIGPQLIHKILIETQIFIARYLFEAFKPYv- 896  Saccharomyces...
XP_002629701  731 GSAFQPLIASATy-------eYLPdDD-DISDYAKEMILCSVLQQAELELYAPQLAVECLQHTVSTALDALLTHFSRLn- 801 
EEC09031      706 CDPIVGAIEPNMyaGAFDWKKCAE-PM-GVSSYIKEALMSMIEVHAEVYTISPPLVSRIMTPLAQNVAEE-ISRLYECt- 781 
XP_011265081  721 CDPLVGTIEPSMylGGLEWDFDIE-PT-HLKPYAQEILANLIAVHAEVRRVAPALLQRILSHIIETIAEE-LARLMSCv- 796 
XP_001965095  744 GDPLVGTIEPSMylGRFQWDHEME-IG-QLRPYAHECCDNLVGVYSEIYSISPALLRPILESIVQTISEE-LARLMSCv- 819 
XP_001843214  748 SDPLVGTIEPSMyiGRFQWDQVGP-SD-KLSPYAHECCDNLVSVYSEIFSISPVLLRPVLEPIVQTVAEE-LARLMTCv- 823 
EFA11086      737 SDPLVGTIEPSMylGRFDWDIEIT-PN-NIRPYAKECINNVIHVHSEVNSISSSLLESVLPQVVLTIAEE-LYRLMSCv- 812 
XP_002890429  849 ANLIRTAATNYLldSGIQWGAAPP-VK-GIRDAAVELLHTLVAVHAEVFAGAKPLLDKILGTLVEGLIDTFLSLLEENrs 926 
Q96KP1        768 ADPIVGSLEPGIyaGYFDWKDCLP-PT-GVRNYLKEALVNIIAVHAEVFTISKELVPRVLSKVIEAVSEE-LSRLMQCv- 843  human
XP_002127048  727 VEPLTGALEPGMyaGSFDWNECLR-PE-GVRPYIKTALMSIITIHAEVYSINPDLVPRFLIQVIQMTSEE-VLRLIQCi- 802  vase tunicate
6VKL_B        897 ---gNLSNDGSLQIIVDLEFFQKVMGPLLEKDTEATLRACLQNCFqndt------nrlQKCINEIN-------------- 953  Saccharomyces...
XP_002629701  802 ---qDTSPLIVTQIVIDLTGLEEALSSYATLAIRVQINSYRAGLvgrfd------------------------------- 847 
EEC09031      782 ---eKFTKHGNMQATLDLRALEEAVDSYRTQNTGKFFMICRSRLDpfsstk----------------------------- 829 
XP_011265081  797 ---tQFRPAGIIQARTDITLLRNALQAYSTTRAKSFFEEALDAIPqpvntv----------------------------- 844 
XP_001965095  820 ---qRFSFTGAIQAHVDIRLLRDALEGYVNETAKNYFMEALEAINpplnae----------------------------- 867 
XP_001843214  824 ---qKFNVNGALQAKVDINVIRDAVRVYSNDTAKSFFVEALEAIPqvaes------------------------------ 870 
EFA11086      813 ---qKFSKGGAQQARADISALQIFFDHYSTPKARSYFQEALDIIPplense----------------------------- 860 
XP_002890429  927 ddlsSIDANGFCQLMLELEYFETILNPYLTVDATESLKSLQGAVLekatesisetvenNLGGHQRKptrssedaisddkq 1006
Q96KP1        844 ---sSFSKNGALQARLEICALRDTVAVYLTPESKSSFKQALEALPqlssga----------------------------- 891  human
XP_002127048  803 ---rKIGTNGSMQARLDIEALQQATAAFESTQSSTNFVEALDSIPdmssaa----------------------------- 850  vase tunicate
6VKL_B        954 -----------------PIVSANLKRTAIQFAAF 970  Saccharomyces cerevisiae S288C
XP_002629701  848 ------------nlrlqQCLKNMRTTMRMALQSL 869 
EEC09031      830 -----------dkelvdELLKRFRNQMRLQLLCF 852 
XP_011265081  845 -----------drmridALLSKVTTCMRLQLSCL 867 
XP_001965095  868 -----------qkrkadEILERVKGNMRLQLLCF 890 
XP_001843214  871 ------------edriqETVRQIKNNMRLQLMCL 892 
EFA11086      861 ------------atvvqDILRQCRARMRIQLLCL 882 
XP_002890429 1007 ssvspddllalaqqctsGMLQLELEKTRLNSACF 1040
Q96KP1        892 -----------dkklleELLNKFKSSMHLQLTCF 914  human
XP_002127048  851 -----------drrfldENINKFKSLLIFQLRCF 873  vase tunicate
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