Conserved Protein Domain Family
SGIII
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pfam15467: SGIII (This model is not part of the current CDD release)
Secretogranin-3
Secretogranin_3 is a family of vertebrate proteins that is one of the granin family. Granins are rich in acidic amino acids, exhibit aggregation at low pH, and possess a high capacity for calcium binding. Because granins are restricted in their localisation to secretory granules of neuroendocrine cells, two interesting characteristics of their sorting mechanisms have been observed. These are, first, that they aggregate on low pH/high calcium concentrations and second that two of them carry an N-terminal disulfide loop, mutations in which lead to mis-sorting. Thus, granins are thought to be essential for the sorting of secretory proteins at the trans-Golgi network. Chromogranin A (CgA) binds to SGIII in secretory granules of endocrine cells. SGIII directly binds to cholesterol components of the secretory granule membrane and targets CgA to secretory granules in pituitary and pancreatic endocrine cells. Mutations in the SGIII gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion.
Links
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Statistics
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PSSM-Id: 521862
Aligned: 10 rows
Threshold Bit Score: 708.467
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_011486780  23 VYAFPTPsaSTDADKSVYNQQLTEERPVQQQI--AEADSVKaalQSAGGQHPAASKESd--QDSDDFTMLKSLADGQK-S 97 
2_pfamImport   1 ISAFPTPt-ASSDDKTVYNRELTEERPLQDQI--AEADSVKaavQSAESKRLAASKDTeseQDLHDLTVLKSLADGQK-S 76 
XP_005799798  23 TSAFPTPt-ASADDKTVYNRQLTEERPLQEQI--AEADSVKaavQSAESKQPATSKDAe-sEQGDDFTMLKSLADGQK-S 97 
A3KQQ9        19 INAFPTP--AGPDDK--YNRELTEEKPLEQQI--AEADSIR---KTESKPTPPAEEETn--SEDDDITFLKALAEKSK-E 86  zebrafish
XP_015198349  22 LNAFPTP--DVTSDKAVYNRQLSEERPLQEQI--AEADSVS---KSVAKDNQSASTEPtidPDNDDFSLLRSLAETSK-D 93 
F7E728        18 VQGFPNP--GIKQDKAVHNRELSEERPLEEQI--AEADTVS---RGTSKENQEMLKND---SFADELGLLMSVAEKEGdV 87  tropical clawed...
XP_008116704  19 GHSFPKPe-GARSDKAIHNRELSVERPLEEQIaeAEADKMK---KATSKENKPEFRNY---SFAEDLNLLKSAVEKER-- 89 
Q8WXD2        17 IQAFPKP--GGSQDKSLHNRELSAERPLNEQIaeAEEDKIK---KTYPPENKPGQSNY---SFVDNLNLLKAITEKEKiE 88  human
XP_064421797   1 ------migfstlDKAVYDRELSVERPLQEQi--AEADWAS---KTVNTESKADSKNI---SDADNFNLHKNLKENKRnE 66  coelacanth
XP_011608318  21 vSAFPTPt-PSTDDKTVYNRQLTEERPIQEQI--AEADSVKaaiQLAEVKPPASSKDT---QDLDDLTVLKSLADGQK-P 93  torafugu

XP_011486780  98 KEPSVVPVKK-DDQYVPDESDSTKSRRLADDYDSTKKGMDY----DDPESFRQVDGTPLTAEDIVQKIANKIYEEDDRGV 172
2_pfamImport  77 KGTSEGPPEK-EDQYVPDESDSTKSRRLAEDYDSTKNRMDDgkyqDDPESFRQIDGTPLTAEDIVQKIANKIYEEDDRGV 155
XP_005799798  98 KEAPEGPVKKgDHQYVPDESDSTKSRRLADDYDSTKNGMDY----DDPESFRQVDGTPLTAEDIVQKIANKIYEEDDRGV 173
A3KQQ9        87 SNNETPISDSaNERLGADDTDSTKNRRLADDYDSTKNGMDYky-qDDPESFRQLDGTPLTAQDIVQKIANKIYEEDDRGV 165 zebrafish
XP_015198349  94 LGSKTPSSKSiNTHYFPDDADSTKNRRLVDDYDSTKNGMDYry-qDDPDGLHQLDGTPLTAEDIVQKIATRIYEEDDRGV 172
F7E728        88 KRSGSVRSSVgGHRGTLDDADSTKNLKPAEYFDSTKSMLDYky-eDDPDGLHQLDGTPLTAEDIVRKIATRIYEENDRGV 166 tropical clawed...
XP_008116704  90 KEKASVRSSLyDQQLALDDADSTKSRRLVDDYDSTKSGLDYky-qDDPDGLHQLDGTPLTAEDIVQKIATRIYEENDRGV 168
Q8WXD2        89 KERQSIRSSPlDNKLNVEDVDSTKNRKLIDDYDSTKSGLDHkf-qDDPDGLHQLDGTPLTAEDIVHKIAARIYEENDRAV 167 human
XP_064421797  67 KKSGST-NKSfNDQSFFDDTDSTKNRRLVDDYDSTKSGSSYks-qDDPDGLRQLDGTPLTAEDIVEKIATRIYEENDRGV 144 coelacanth
XP_011608318  94 KDGADLPLKKeEEQYAPDISDSTKSRRLVEDYDSTKNGMDD----DDSETFRQVDGTPLTAEDIVQKIANKIYEEDDRGV 169 torafugu

XP_011486780 173 FDRIVSKLLKLGLITESQADTLEYQVAEALQDLITKNAKNNEIDDIESIDQAAGGEQE---DQDSDTGTWE--------- 240
2_pfamImport 156 FDRIVLKLLKLGLITDSQADTLEYQVAEALQDLITKNARDNEIEDVDSNGQETNGEEDrgsDADKDKDNSKgnfghpqdt 235
XP_005799798 174 FDRIVSKLLKLGLITENQADTLEYQVAEALQDLITKNAKNNEVEDMD---QESRGEQD---DLGPDTDAWE--------- 238
A3KQQ9       166 FDRIVSKLLKLGLITDSQAETLEYEVAEALQDLITKNAKDNMIGDRSVDYPVSAAK-----DTQDEED------------ 228 zebrafish
XP_015198349 173 FDRIVSKLLNLGLITESQADTLEYEVAEALQQLIANQVKNNEIEDTSMDYPASSTE-----DPGEKQEKSV--------- 238
F7E728       167 FDKIVSKLLNLGLITESQAYTLEDEVAEVLQQLIANEAKNREKEAGDLDYAAVRSDVY---DDDKQEGKME--------- 234 tropical clawed...
XP_008116704 169 FDKIVSKLLNLGLITESQAYTLEDEVAEVLQQLIANEAKDREKAAEGLDYLPSKTDMN---TNQNLEEKMV--------- 236
Q8WXD2       168 FDKIVSKLLNLGLITESQAHTLEDEVAEVLQKLISKEANNYE---EDPNKPTSWTE-N---QAGKIPEKVT--------- 231 human
XP_064421797 145 FDKIVSKLLSLGLITESQAYTLEDEVAEALQQLITNEAKNNERESESFDNHPIRTGGD---LKEKQEEKML--------- 212 coelacanth
XP_011608318 170 FDRIVTKLLKLGLITDTQADTLEYQVAEALQDLITKNAKNNEIMDIESNDRDAREEQD---DQGSDTNMDA--------- 237 torafugu

XP_011486780 241 -PPKRRY-----------------------------NEKeedaaeaddedved-evereaeedvneaGDTWE--KGTEDG 287
2_pfamImport 236 wKPPRRS-----------------------------DTA----------------------------AKTWD--KDTQDG 256
XP_005799798 239 -TPRRRY-----------------------------DEEdhdevannddei----adevdrdveedmDNSWD--KEKEEG 282
A3KQQ9       229 -RPSPRF-----------------------------DEEdeveneggddangdepqeeesrddtvrsDDSWDavSDGNDR 278 zebrafish
XP_015198349 239 -SEKASR-----------------------------RYEdqhvse----------------dvddtvDNTWAppNEADQR 272
F7E728       235 -TRNKNE-----------------------------DREssetk------------------nedsfSSK-------ERR 259 tropical clawed...
XP_008116704 237 -PKAPEQ-----------------------------Ddt---------------------------lDNTWAssNILERR 259
Q8WXD2       232 -PMAAIQ-----------------------------DGLakgen-------------------detvSNTLTltNGLERR 262 human
XP_064421797 213 -LEKPHK-----------------------------DGQselmne----------------diddtlGNSWTfpNSMERR 246 coelacanth
XP_011608318 238 -WEPPRGrynedeeqegdgeeedddeeveddverdvEDNerd-----------------------taGNSWD--KDTEEG 291 torafugu

XP_011486780 288 NEVSPEDGLQDLQYFPNFYRLLKSLNLEKDTQERETLITIMKTLIDFVKMMVKYGTITPEEGVSYLENLDAMIAMQTKNK 367
2_pfamImport 257 NEVSPEDGLQDLQYFPNFYRLLRSLDSDQDAQERETLITIMKTLIDFVKMMVKYGTITPEEGVSYLENLDAMIAMQTKNK 336
XP_005799798 283 NEVNPEDGLQDLQYFPNFYRLLKSLDSEQDAQERETLITIMKTLIDFVKMMVKYGTITPEEGVSYLENLDAMIAMQTKNK 362
A3KQQ9       279 NELNPEDGLQDLQFFPNFYRLLKSLDSEQDKEERETLITIMKTLIDFVKMMVKYGTITPEEGVTYLENLDAMIALQTKNK 358 zebrafish
XP_015198349 273 NELSPEDSLQDLQYFPNFYNLLKSLNSEQDAKEKETLITIMKTLIDFVKMMVKYGTITPEEGVSYLENLDAMIALQTKNK 352
F7E728       260 NELSPEEDFDDLQYFPNFNRLIKSLNSENDAKEKKTLITIMKTLIDFVKMMVKYGTITPEEGVNYLENLDAMIAVQAKNK 339 tropical clawed...
XP_008116704 260 NELPPEDNFEDLQYFPNFYELLKSLNSEKEAKEKETLITIMKTLIDFVKMMVKYGTITPEEGVSYLENLDAMIALQTRKK 339
Q8WXD2       263 TKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNK 342 human
XP_064421797 247 NDLSPEDDFEDLQYFPNFYNLLKSLNSEADKKEKKTLITIMKTLIDFVKTMVKYGTITPEEGVSYLENVDAMIALQTKSK 326 coelacanth
XP_011608318 292 NEVNGGDGLKDLQYFPNFYHLLRSLDSDQDTQERETLITIMKTLIDFVKMMVKYGTITPEEGVSYLENLDAMIAMQTKNK 371 torafugu

XP_011486780 368 LGKALGLP-DVTAPSE--KDWDDDDNTKAEAAKMQKEYENLKDSTKEEQPPT--ETNQP----GKSEAYLEAIRKNIEWL 438
2_pfamImport 337 LGKALGLP-DFTGPNE--KDLDEEDNTKAEAAKMQKEYENLKDSTKEEQQPTt-ETNHP----GKSETYLEAIRKNIEWL 408
XP_005799798 363 LGKSLVVP-DISGLTG--KNFDEDDNTKSETAKMQKEYENLKDSTKEEQTST--ETNQP----GKSESYLEAIRKNIEWL 433
A3KQQ9       359 LGKSLVPL-SITPPTG--KAADDDDNTKTEAAKMQKEYESLKDSTKDVQTAA--EISHP----GKSESYLEAIRKNIEWL 429 zebrafish
XP_015198349 353 LGKSLVTS-DIRAPTD--KTSEEEDNTKEEVAKMEKEYESLKDSTKEEQAVP--ESGSS----GKTETYLEAIRKNIEWL 423
F7E728       340 LGKSFG---SHKSILSedKNVDESDSTKQEAAKMEKEYEALKDSTKPEPKDAe-DKDKPk---GKAETYLEAIRKNIEWL 412 tropical clawed...
XP_008116704 340 LEKP-----GTKAKLLsdKSTEESDSTKAAAAKMEKEYETLKDSTKIEEQNTe-NDEEPk---GKAEAYLEAIRKNIEWL 410
Q8WXD2       343 LEKNATDNiSKLFPAPseKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPggKTDEPk---GKTEAYLEAIRKNIEWL 419 human
XP_064421797 327 LGKPLAYP-TDKEPAe--WSNEETDSTKEEADLMEKDSESLKDSTKKEGQKIsvKDEEPkgslGKSESYLEAIRKNIEWL 403 coelacanth
XP_011608318 372 LGKSLGST-DFMGPNG--RNVDEDDNTKAEAAKMQKEYENLKDSTKVEQPSTa--TNQP----GKSETYLEAIRKNIEWL 442 torafugu

XP_011486780 439 KKHNKEDGK--EDYDLSKLKDFMDQQLDSYIDKGIIAKEEGDTIKRIYSSL 487
2_pfamImport 409 KKHNKDEGK--EDYDLSKLKDFMDQQVDAYIQKGIMAKDEGETIKRIYSSL 457
XP_005799798 434 KKHNKDEGK--NDYDLSKLKDFMDQQVDSYIEKGIIAKDEGDTIKRIYSSL 482
A3KQQ9       430 KKHNKEGNK--EDYDLSKLRDFMDQQVDSYIDKGILEKDEGDVIKRIYGSL 478 zebrafish
XP_015198349 424 KKHNKQGNK--EDYDLSKLRDFMDQQVDSYIDKGILEKDEGEIIKRIYSSL 472
F7E728       413 KEHNKEGNKgvSDNDLSKLKDFINQQADSYVEKGILDKEEANVIKRIYSSL 463 tropical clawed frog
XP_008116704 411 KKHNTQGNK--EDYDLSKLRDFIDQQADAYVDKGILDKEEADVIKRIYGSL 459
Q8WXD2       420 KKHDKKGNK--EDYDLSKMRDFINKQADAYVEKGILDKEEAEAIKRIYSSL 468 human
XP_064421797 404 KKHNKQGNK--EDYDLSKLRDFIDQQADTYVEKGILEKEEADVIKRIYSSL 452 coelacanth
XP_011608318 443 KKHNKEESK--DDYDLSKLKDFMDQQVDAYIEKGIIAKDEGDTIKRIYSSL 491 torafugu
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