Conserved Protein Domain Family
ECM11
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pfam15463: ECM11 (This model is not part of the current CDD release)
Extracellular mutant protein 11
ECM11 is a family of largely fungal proteins. ECM11 interacts with Cdc6, an essential protein involved in the initiation of DNA replication, and is a nuclear protein involved in maintaining chromatin structure. It was previously identified as a protein involved in yeast cell wall biogenesis and organisation, but is also found to be required in meiosis where its function is related to DNA replication and crossing-over.
Links
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Statistics
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PSSM-Id: 521859
Aligned: 60 rows
Threshold Bit Score: 83.8185
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EEA20975     421 DYPDEVLQYMDFSELEKEP-----------FDHSPGSssplkhqrstpkkpkalppppspsspPPPPP---PP--DTSTS 484
CCU75949      66 DYDDEALQRMTYAELEAQT-----------WEEAAPRk-------------------------PFVYP---RElrAPGTP 106
XP_008081607 283 DYTDEELKKKLFVDLKNED-----------WGAGMPKyq-----------------------iPKFFP---DDlrGPSIS 325
Q6BI00       110 QPEPAEFDTDNHMGILAATk----------FETNRAP----------------------------------LScsVEDET 145 Debaryomyces ha...
Q6C2L2       171 pvqQSATAASLFSELPVHI-----------QEVPPYVg------------------------cEKDLSvaeFSdkVDMAR 215 Yarrowia lipoly...
Q6CWU4       160 NVNEIPKNPGKYEKLNLRL-----------NETDGT---------------------------------------ESAKY 189 Kluyveromyces l...
XP_002555235 159 SARVLSSDPGPYKPVVSAL-----------HEVNPNV--------------------------------------ETREY 189
Q6FMQ5       191 DSLKPAEDPGPFKKQTRLL-----------YEVQND-----------------------------------MT--IDDDN 222 [Candida] glabrata
XP_056087067 174 KSQEAIENPGSYQKIKNYL-----------FD-KPDL-----------------------------LE---TClqDYSSM 209
XP_001645531 175 DSENNEERTLKYEDIRCESpggyeicdkllYELNDNE-----------------------------------------EF 213

EEA20975     485 PSEKLAY-IMT-AlpNPTA---RH----NYISSMPITDWELLGDELIDQMGEMLKMIKDSRQARRKTTALFEAEIRRRHD 555
CCU75949     107 LETKINY-YLA-A--TPPTpgaAAkaaeAFFEQLSSPEWDEAGEIFMDKFSALMRQLQAKRREKRRVAEAYEREVKQRER 182
XP_008081607 326 VEQKVDG-FRDeEitDEKHmmrSDreqeSFFEHLSDEDWKAAGEYIRKKTEEAMNNMQETRKKKREITAKYEKIYEEREK 404
Q6BI00       146 FDEALKT-YAL-----------QN----ELSLGMTFQEWAAKGLENADAQRRLIERLVVNRLVLLQRFHYLNDTINDYAS 209 Debaryomyces ha...
Q6C2L2       216 VKETLIDtVVPhAqfQELA---RV----ERFNNISFDDWQAEGTRLAEVAASLINRLVELRKARIVGYKEIQETVDRHAA 288 Yarrowia lipoly...
Q6CWU4       190 YDEV----FSE-A--EWKQ---EC----IDLATYDISQWILKGQDILKEQHALMCRMVQARIKLSHRFQVISDIINERAE 255 Kluyveromyces l...
XP_002555235 190 YCEVFQE-VQN-N--TERS---AC----VDFAKMDLKSWISAGQVLQQEHAAILGRLVEARMRLNSKFKVITDLINDRAA 258
Q6FMQ5       223 MTEIFPG-LEK-E--EEKT---YC----RQSSLWSLDQWIEEGENILRAHQEIFIKIIKKRIELSYNFNSLITVLIDRAE 291 [Candida] glabrata
XP_056087067 210 LPADIAE--------DDQE---FF----VSVADSTLEEWTNKGQEILDQQYQLYQEVIKKRIELSFKFKGVISVVNDRAD 274
XP_001645531 214 AESHMDEiFKN-LqpNEEE---FY----RDAAKWSLPEWIGFGQKMIDEYTQHVGELVEQRIQLSYKFEIITKAINERAE 285

EEA20975     556 QTITEAGELDRKFVEMKEGGLGVL 579
CCU75949     183 SIRHRTLRLEQKLQKMRASGESML 206
XP_008081607 405 LIQHKAALIQAQLAQVQNQGSSMf 428
Q6BI00       210 SLETARGDFDDKVKRIHVLTNEFL 233 Debaryomyces hansenii
Q6C2L2       289 KLESHGQETESQMSGFQAKASEIL 312 Yarrowia lipolytica
Q6CWU4       256 LLIQQGEILDAKLTKVQDLGKEIL 279 Kluyveromyces lactis
XP_002555235 259 ALNAQGGILDQKLRRIQDLGKEIL 282
Q6FMQ5       292 ALCKHGNVIDSKLEKVKKLGNEIL 315 [Candida] glabrata
XP_056087067 275 ALEEQGQKLEEKIRKIKSLANEIL 298
XP_001645531 286 ALNKRGKLLDTKLNKIKDLGKEIL 309
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