Conserved Protein Domain Family
Barttin

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pfam15462: Barttin 
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
Barttin is a family of mammalian proteins that are chloride ion channel beta-subunits crucial for renal Cl-re-absorption and inner ear K+ secretion. Bartter syndrome is a term covering a heterogeneous group of autosomal recessive salt-losing nephropathies that are caused by disturbed transepithelial sodium chloride re-absorption in the distal nephron. Mutations in the BCD proteins lead to sensorial deafness.
Statistics
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PSSM-Id: 495118
Aligned: 11 rows
Threshold Bit Score: 368.021
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005607080  27 SHDRPQVYGTFYAMGSIMVIGGVIWSMCQCYPKIAFVPADADLQGILSPK-APGLVGNGLAAELK-----SAQPPYTRLW 100
3_pfamImport   1 SHDRPQVYGTFYAMGSVMVIGGVIWSMCQCYPKITFVPADSDFQGILSPK-ALGLLENGLATEKKrsrapAPHAPYVRLF 79 
ELW67986     351 SHDRPQVYGTFYAMGGVMVIGGVIWSMCQCYPKITFVPADSDFQGILPPK-ALGLLESGLHAEMK-----STQPPYVRLW 424
4_pfamImport   1 SHDRPQVYGTFYAMGGIMVIGGVIWSMCQCYPKIAFIPADSDFQGILSPK-ALGLLENGLAAEMK-----SPQPPYARLW 74 
ELK06192      27 SHDRPQIYGTFYAMGSVMVIGGIIWSMCQCYPKITFIPADSDFQGILSPRkSLGLLESGLIAE-K-----SPQPPYIRLR 100
1_pfamImport   1 SHDRPQVYGTFYAMGGVMVIGGVVWSMCQCYPKITFVPADSDFQGIMSPK-ALGLLDNGLAVEMK-----SPQAPYVRLW 74 
2_pfamImport   1 SHDRPQVYGTFYAMGGAMVIGGVLWSMCQCYPKIAFVPADSEFQDTLSPK-ALGLLENKLGTEMK-----SPQPPYVRLW 74 
XP_003495801  27 SHDQPQVYGTFYAMGSIMVIGGVIWSMCQCYPKITFVPADTDFQGILSPK-ALSLLESSLS-EVK-----SPQPPYVRLW 99 
XP_021582544  27 SHDRPQVYGTFYAMGSVMVMGGVIWSMCQCYPKIAFVPADSDFQGILSPK-PLGLLENGLAPEVK-----SPQAPYVRLW 100
EHA99015      27 SHDRPQVYGTFYAMGSVMVVGGVIWSMCQCYPKVTFVPADSDFQGILSAK-A--LLENGLAAEMK-----SPQPPYTRLW 98 
Q8WZ55        27 SHDRPQVYGTFYAMGSVMVIGGIIWSMCQCYPKITFVPADSDFQGILSPK-AMGLLENGLAAEMKs---pSPQPPYVRLW 102 human
XP_005607080 101 EEAAYDQSLPDFSHIQMKIMGCSEDPRPLLAPKQGQPQLGASDAGEG-GPRDTQAWMDAAVVIHRGSDEDGGERSPTQSR 179
3_pfamImport  80 EEAAYDQSLPDFSHIQMKVMGYSEDPRPLLGPQLGQLSLGSSDGGEG-SPQDIQAWTEAAVVVHRGSDENEGERDPTQSR 158
ELW67986     425 EEAAYDQSLPDFSHVEMRVMGCAEDPRPLLAPGQGQPRLEGSDGGEG-GPRGAQAWMEATVVVHRGSDENEGERSPARSR 503
4_pfamImport  75 EEAAYDQSLPDFSHIPMKVMGYSEDPRPLLA------------------------WLEAAVVIHRGSDQDEGERRPSQGR 130
ELK06192     101 EEAAYDQSLPDFGHIQMKVMGYGEDPHPLLAPELGQQQPEASDRGES-GPHDAQAWMEAAVVVHRGSDEDEGERIPPQSR 179
1_pfamImport  75 EEAAYDQSLPDFSRIQMKVMSYSEDPRPLLASEPAQLKPASSDDRGGlGPRDAQSWVEAAVVVHRGSDEKEGGRTPSQSR 154
2_pfamImport  75 EDAAYDQSLPNFSHIQMKVMGYREDPRPLLAPEPGQLQLGASDGGGG-SPVNSQAWVESAVVVHRSSDEDKGERIPAESS 153
XP_003495801 100 EEAAYDQSLPDFTHIQMKVLGYSEDPRPLLAP---EPKTGVSSGGEG-EPHTAQAWMEAAVVVHRGLDEKEGERPGTQSS 175
XP_021582544 101 EEAAYDQSLPDFSHIQMKVLGHSEDPRPLLAP---ETQPRTSDGEAG-GPQDAQAWVEAAVVVHRGLDENEEERHRTQNR 176
EHA99015      99 EEAAYDQSLPDFSHIQMKALGYSEDSRMLLAS---EPGPRPRDTGEG-GPCDAQAWVEAAVVVHRGVDQSEGERTRTQSS 174
Q8WZ55       103 EEAAYDQSLPDFSHIQMKVMSYSEDHRSLLAPEMGQPKLGTSDGGEG-GPGDVQAWMEAAVVIHKGSDESEGERRLTQSW 181 human
XP_005607080 180 PGPPACPQGSAPLASFPDDLDTGSSEGGSPRPSPPEGEQP-------PACRCRLDPFHDFALIDA-PTSED 242
3_pfamImport 159 PGPPTCPQGPAPLASFQEDLDMGSSEDSSPNPSPPDREEPrpptqepKAYWCQLDRYSDFALIDA-PTAED 228
ELW67986     504 LGSPGCSQGPAPLASLQDDLDLGSSDGSSPNPSPPDGEEPrpppqepWACRCPLDHFHDFALIDA-PT-ED 572
4_pfamImport 131 PSPQTCPQGPAPLASFQDDLDVGSSEGKLPLPPPe-----------pWACRCQLDRFHDFALIDA-PTLED 189
ELK06192     180 PGPPACPHGPAPLASFQDDLDVDSSEGDIPNPSPCEAEEPgpqprepWAGRCWLDRFHDFALIDD-PTLED 249
1_pfamImport 155 PGPPACPQGPAPLASFQDDLEVGSSEGSSPRPSPANGEEPppppgepWACRSPPDRFHDFALIDEvPTSED 225
2_pfamImport 154 P--PACPPGPAPLASFQEDLDVGSSKGSSPSPSPPNGEEPrlpppdpWACRCQLDRFHDFALIDS-ATSGD 221
XP_003495801 176 P--PACSQGSAPLASFQDDLDMGSSEGSSPHPSPPNREEPhpq--vpWASMGPLDRFSDFALIDDtPTSED 242
XP_021582544 177 PGSPACPQGPAPLASFQDDLDLGSSEGSSPNPSPPAGKEPhplaqkhQACRGTRDHFYDFALIDD-ASVSE 246
EHA99015     175 PSLTGYHQGPAPLASFQDDLDMGSSEGSSPAPSPPGRAAPwppqqepRASRSPLDDSHDFALIDD-PSTPE 244
Q8WZ55       182 PGPLACPQGPAPLASFQDDLDMDSSEGSSPNASPHDREEAcspqqepQGCRCPLDRFQDFALIDA-PTLED 251 human
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