Conserved Protein Domain Family
Pilt

?
pfam15453: Pilt (This model is not part of the current CDD release)
Protein incorporated later into Tight Junctions
Pilt is a family of eukaryotic tight junction-proteins that binds to guanylate-kinase. Pilt is a component of TJs (Tight junctions) rather than AJs (Adhesin junctions). The protein is incorporated into TJs after TJ strands are formed, thereby suggesting the name Pilt for 'protein incorporated later into TJs'. Pilt binds to the guanylate-kinase region of hDlg otherwise known as Disk large homologue.
Statistics
?
PSSM-Id: 521854
Aligned: 6 rows
Threshold Bit Score: 413.594
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_049337160 294 GPGHARQSSSAASDQQhvNGMCRGQASPDGPSA--Ed-mAPSFEKLNPYPAPPPPHPLYPGRKVIEFSSDDKVKIPKNSP 370
1_pfamImport   1 VDMTGPPPECQEAAQQ--NGSCRSQDSLDGQSGgeEggvATSFDKLNPYPAPPHPHPLYAGRKVIEFSSDDKVKLPKNSP 78 
XP_008123581 277 SPGQPGNEVSGGTRQQ--NGNCKSQACLES-----D---VPTFEKLSPYPTPPPPHPMYPGRKVIEF-SEDKVRIPKNSP 345
XP_005043387 277 SAGQMGKEGGDAGKQQ--NGGCKPQSSVESVPE--E---VPAFEKLSPYPTPSPPHPMYPGRKVIEF-SEDKVRIPKNSP 348
XP_064411490 284 DKEGTEQVPAEGGKQH--NGLCGRQNVTESPPD--E---GLAFETLNPYPTPTPPHPMYPGRKVIEF-SDDKVKIPKNSP 355 coelacanth
XP_011601491 276 egG-GREINQEAEQLQ--NGSLCSHSSLEEEVG--G---VSAFEKLNPYPPPPPPNPLYPGRKVIEFSSDDKVKIPKNSP 347 torafugu
XP_049337160 371 LPNCTYATRQAISLSLVQNDEEage-rqRTVPNSPAVS------DGGWrsgtssssggghasLPRTPQQ--TDVTDPLSS 441
1_pfamImport  79 LPNCTYATRQAISLSLVQSDDE------RTTPASPAPS------GGGF--------------LHRTPLSqrDIGSEPQSG 132
XP_008123581 346 LPNCTYATRQAISLSLVQGEDEsce-rqRTLPSSPASE------GQRSass---------csYQPSPK----ANRAPGSS 405
XP_005043387 349 LPNCTYATRQAISLSLVQSEDEscd-rhRTLPSSPASE------GRRSass---------csCQQSPK----AARAHGSS 408
XP_064411490 356 LPNCTYATRQAISLSLVQGEEDggqdrhRTVPNSPVSEgrrslqA-----------------PSGRPY------SRGSST 412 coelacanth
XP_011601491 348 LPNCTYATRQAISLSLVQNDDE------RHVPGSPAPS------S-----------------HKRTPPpqgdaaseplSS 398 torafugu
XP_049337160 442 Q---------------SSPFSSPPQPPSAFASSGSSEEDLLANWQRMFVEKMAPSSEGTLiNRTSFSSETVKELHRSRNS 506
1_pfamImport 133 Q---------------SSPFSSPPQALSVLASSGSSEEDLLANWQRMFVEKVAPASDLAL-HRTSFSSHTAQELQRRRPA 196
XP_008123581 406 Q---------------SSPFSSPPQVPSTFASSASSEEDLLANWQRMFVEKAPPTTERVLvNRTSFSRDTAQELQKRF-- 468
XP_005043387 409 Q---------------SSPFSSPPQIPSAFASSASSEEDLLANWQRMFVDKAPPTSERVLmNRTAFSRDTAPELQKRF-- 471
XP_064411490 413 KldasrgseneprslqSSPFSSPPQVPSTFASSASSEEDLLSNWQRMFVEKVAPSSETSFiHRTSFSHDTAQDLQKTL-- 490 coelacanth
XP_011601491 399 Q---------------SSPFSSPPQAPSVLASSGSSEEDLLANWQRMFVEKMAPSCDGSVvHRTSFSSRTAQELQRRRLA 463 torafugu
XP_049337160 507 KSGRGAADhgMMRGAYSDGEEGSSAQSWTASRESSLDTDTssvadLRSKRGHygg----dfSQEEGEhllmGTDnEDGAS 582
1_pfamImport 197 AGGGASSE--RNRAAYSDGEEGSSARSWTPSRGSSKGGGA-----LRGRRPS---------PEEGGE----AAD-EQGGR 255
XP_008123581 469 --SRSMQElgRAASAYSDGEESVQSCSWTVSRDSSVDTDSte---sRARQSHlssdygtdfSQEEARkllqEAG-SEGLA 542
XP_005043387 472 --SRSMQElgRAASAYSDGEESAQSCSWTVSRDSSVDTDSte---sRARRSHfssdygtdfSQDEAQklllES--SGGTA 544
XP_064411490 491 --SRSMQElgKAAPAYSDREDCARSCGWTPSRGSSLDADNvd--sLAASKSHyvae--rppPEDTASqpllQTC-EMGEA 563 coelacanth
XP_011601491 464 PGGVA-PSsdCHRAAYSDGEEGSSVRSWTPSRGSSLDTDTdv-epRPSRRGHfg------cgEEGGErllmNLE-DEGDR 534 torafugu
XP_049337160 583 GDTMVMVESSPasakrqefvedvGSASSLTEE----------RDVLPQDFPVVGSRVLagledytDKPPsqrqhhhhQSG 652
1_pfamImport 256 QHGGPPWQQPR------------PIPPSSAEE----------RDVLSRDLPVISPRLL-------DLDPal----aaAAP 302
XP_008123581 543 DPAI----SSPgkhkd---yvdlDSPGSPSEE----------QGMLLQGSKENNQDVVleqstevGKSK----------P 595
XP_005043387 545 ESES----PSAekhkd---yvdlGLPESPAEE----------REMLLQGNKESSQGGVqeesgegRVKP----------A 597
XP_064411490 564 AAASVMAKASPlakrk--dyvdmDSPGSSAEE----------REVLLQE-----SRSVgltaedaAESP----------P 616 coelacanth
XP_011601491 535 edaAVALATSPd------------------EIhvkeeeeeeeRDVLPHELPLISPRLL-------DFDA--------TLG 581 torafugu
XP_049337160 653 SSRPHKSPKRMGVHHLHRKDSLTRAQEHGNLL 684
1_pfamImport 303 SKRRQKSPKRMGVHHLHRKDSLTRAQEQGTLL 334
XP_008123581 596 PGRPHRSPKRMGVHHLHRKDSLTQAQEQGNLL 627
XP_005043387 598 FSRPHRSPKRMGVHHLHRKDSLTQAQEQGNLL 629
XP_064411490 617 SSRPHRSPKRMGVHHLHRKDSLTRAQEHGNLL 648 coelacanth
XP_011601491 582 LQRPQRSPKRMGVHHLHRKDSLTRAQEQGTLL 613 torafugu
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap