Conserved Protein Domain Family
NYAP_C

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pfam15452: NYAP_C (This model is not part of the current CDD release)
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
NYAP_C is a C-terminal family of eukaryotic proteins that are substrates of tyrosine kinase in the brain. When first identified, the family members were referred to as unconventional myosin XVI, or Myr 8. However, proteins have now been identified as being integrally involved in neuronal function and morphogenesis. The family is involved in both the activation of phosphoinositide 3-kinase (PI3K) and the recruitment of the downstream effector WAVE complex to the close vicinity of PI3K; it also appears to regulate the brain size and neurite outgrowth in mice.
Statistics
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PSSM-Id: 521853
Aligned: 7 rows
Threshold Bit Score: 309.555
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001373995  469 RSSPSV--PHSTARNTLQ-E-GGKMVNASVNTygssQSGSrsrtptSPLEELTSLf----TSGRSLLRK-SSSGRRSKEP 539 
3_pfamImport    1 SQTPSLqqPSSLTGVGEG-SiKSNGGSSSLHS----KVGF------MPWDDCASLaa-deGSYWPMQRK-LSFSHGSRET 67  
2_pfamImport    1 RSSSSV--PHSLIKNTSQ-E-GAKLANSSSSThgsmQNVSrsrtptSPLDELTSLf----TSGRSLLRK-SSSGRKSKEP 71  
1_pfamImport    1 PQLPILqhSEG----------GAKGGTSTTQAhqqaKAGF------LPWDSSSSLgi-deQAYWPMHRK-LSFSHSSRDT 62  
EHB13478      944 NKGCGVgaPSPMVKIQLQ-EqGTDGGAFASIScahvIASAg-----TPEEEEEEMgattfGAGWALQRKvLYGGRKAKEL 1017
4_pfamImport    1 KSCSAV--PEPTVKTQVQ-DrGA----FASIScsraITNSdsrgvsSPSEEGLy------GLGWALQRK-LSCSRKPKDS 66  
XP_047301157  467 RSSPSV--PHSTPR-PVSqD-GAKMVNAAVNTygaaPGGSrsrtptSPLEELTSLf----SSGRSLLRK-SSSGRRSKEP 537  human
XP_001373995  540 AEKP--TDELKIRSHSTEPLPKLENKERghhG----ASSSREPIKAQEWDG-----------TPGPPVA--SSRLGRSSV 600 
3_pfamImport   68 ETLHvsEDEGRAWNGSADALLRVDKEDL---GmgsrGGHSGIPVHFSSATSralglsesvagVDSSPGFraLPRVGLPLP 144 
2_pfamImport   72 AEKSrnSSEAKSRSHSTEPLPRHESKERgghQ----PPPKEQP-KAHEWDG-----------VSGQSAAaqSNRLGRTSV 135 
1_pfamImport   63 EKE-----DARVWNGSTDALLRRDRDDVgvrG----GGHSGIPVRASGRIGhses----lagADGPPGFraLPRAGLPLP 129 
EHB13478     1018 DKV---EDGARAWNGSSEGPGKMEREDR---G----PVASAIPVRSQGAEGllari----------hhdrgGSRTALPIP 1077
4_pfamImport   67 DKP---TEGSQGWSDQPEGRSSTEREEKaapG----ALASGIPIRTQGPEG---------------GSSkgPGRTGLPVA 124 
XP_047301157  538 AEKS--TEELKVRSHSTEPLPKLDNKERghhG----ASSSREPVKAQEWDG-----------TPGTPVV--TSRLGRCSV 598  human
XP_001373995  601 SPTLLAGnSSS-EPKVSCRLGRSAST-SGV--------PPPSVT-PLRQAsdLQQS------------------------ 645 
3_pfamImport  145 CQTFPAC-RNGgEYSEVGRLGRSSSA-AGVrqvgggdvQRQSSL-PVREA--LNQPavav-------------------- 199 
2_pfamImport  136 SPTLMLGsGVS-ESKAVCKLGRSAST-SGV--------PPASVN-PLRQGgeVQQS------------------------ 180 
1_pfamImport  130 CQTFPAC-RNG----ELGRLGRSSST-SGVrqag-gdvQRQSSL-PAREA--LSQLqalsqapcspsltrpqmqaqqqaq 199 
EHB13478     1078 CQTFPAChRNG-DFTGGYRLGRSAST-SGVrqaa-lhtPRPCSQ-P-RDA--LSQThpal-------------------- 1130
4_pfamImport  125 CQTFPAChRNG-AKQSFYNLNKSKCTkKKTrkndqmetARACSLaPPASA----QT------------------------ 175 
XP_047301157  599 SPTLLAGnHSS-EPKVSCKLGRSAST-SGV--------PPPSVT-PLRQSsdLQQS------------------------ 643  human
XP_001373995  646 ------------------------QVACMQW---------LHGDHTMLEMIEKKRCLCKEIKARQKTEKGLCKQDSMPIL 692 
3_pfamImport  200 --------------------paarPAGAATQ---------SQRDGKLLEVIERKRCLCKEIKAHRRPDKSLCKQDSMPIL 250 
2_pfamImport  181 ------------------------QVTQMQW---------VYGDNTMMDMIEKKRCLCKEIKARQKTDKGLCKQDSMPIL 227 
1_pfamImport  200 fqlqqlhqhhlqlqfqqlaqlaaqAQPPASGggspgsggpVQRDGKLLEVIERKRCLCKEIKAHRRPDKSLCKQDSMPIL 279 
EHB13478     1131 --------------------plplPLPPPPA---------RERDGKLLEVIERKRCVCKEIKARHRPDRGLCKQESMPIL 1181
4_pfamImport  176 ---------------------------PQSS---------KERDGKLLEVIERKRFVCKEIKARRRPERGLCKQDSLPIL 219 
XP_047301157  644 ------------------------QVACMQW---------FHGDHTMLEMIEKKRCLCKEIKARQKTEKGLCKQDSMPIL 690  human
XP_001373995  693 PSWKKNTGTKKYSPPPYSKQQTVFWDTAI 721 
3_pfamImport  251 PSWRRTPEPRKTGTPPCQRPQAVVWDTAI 279 
2_pfamImport  228 PSWRKNNGTKKDSPPPYSTQTTVFWDTAI 256 
1_pfamImport  280 PSWRKTPEPRKTGTPPCQRPQAVVWDTAI 308 
EHB13478     1182 PSWRRGPEPRKSGTPPCRRQHTVLWDTAI 1210
4_pfamImport  220 PSWRKSTDTRKSGTPPCRRQQTVLWDTAI 248 
XP_047301157  691 PSWKKNAGAKKYSPPPYSKQQTVFWDTAI 719  human
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