Conserved Protein Domain Family
Retinal
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pfam15449: Retinal (This model is not part of the current CDD release)
Retinal protein
This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.
Links
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Statistics
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PSSM-Id: 521852
Aligned: 15 rows
Threshold Bit Score: 1555.93
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002691539    1 MGCTPSHSDLVNSVAKSGIQFFKKPKAIL---PAHQRASERGSLPLLVQSSTCYDPGGGSSQGQR-------AEEEQPSP 70  
2_pfamImport    1 MGCTPSHTHIVNSVAKSGIQFLKKPKGIL---PGRQGDSERGSIPLLVRSSTCYDSGGDLSCRPT-------LAEAQPKH 70  
XP_006239833    1 MGCTPSHNVIVNSVAKSGIQFFKRPKAIL---PGCQWGSQKCPIPLLIQSSTFCDPGGELHPGAR-------LAEETASS 70  
XP_027298566    1 MGCTPSHSGIVNSVAKSGIQFFKKPKAIL---PGCQRGSPKCPIPLLVQSSTFCDPGEDLHLGQR-------PAEEPASS 70  
XP_005322544    1 MGCTPSHSDIVNNLTKSGVQFFKKPTVIL---PGCHRRSGRGSIPLLVQCSTCYDTWGGLPQGQR-------PAEEQLSS 70  
EHB15890        1 MGCTPSHSDIVNSVAKSGIQFLKKPKEVL---PGHQGSRKKGSAPWLVKSSTCLDAVESLSQGRR-------LAEELPSS 70  
XP_003787613    1 MGCTPSHSDIVNSVAKSGIQFLKKPKAIL---PGRQGASERGSIPLLVKNSSCYDTGGSLRQGRE-------PTGEHPGS 70  
XP_003411903    1 MGCTPSHSDIVNSIAKNGIQFLKKPKVIL---PGRQEDNERCSVPLLLRSPTCPDSGSGQPQGQR-------PAEEQPSS 70  
XP_012395299    1 MGCTPSRSDIV---SRSGIQFWRKPKAIL---SVHQACCERLSIPLLVQNSTYYGNGEAAPGGWRq------QAREHPDP 68  
5_pfamImport    1 MGCTPSHSEIVNTLARNGFKALNKPKGVLridPADKG------IPLLVKGSSCYNIDEFHQYKIQrnsslseTEEKLSEQ 74  

XP_002691539   71 RwTQTVADSlcQPTRDPTAGKAKDMERLIPETKTSPSQLNKSQSCMATDIPFKRQSSHGSQGAafsgeESEESITQETSK 150 
2_pfamImport   71 R-TQTTAQG--QFMRDPASGNRKDKAELIPGGQSSPAQLNKAQSHVARDGSFQTPACHGMQGG-----DNERSATQETTE 142 
XP_006239833   71 RkLPDMTEGlcQL----------------PESQT--FHMNKSQSRMATDISFRTEGSHRTQEVefsgkEGKENTPRETSE 132 
XP_027298566   71 KkLQTMAEGlcQLTK--------DMKGLIPESQI--LQLNKSQSHAAMDMSFRTGGYHTTQEAdfagqEREENISQETSK 140 
XP_005322544   71 RkSQTTAEGlgQPLG--------DMEGLISETRTSPSWLNKPQSHT----PFQTKGTHGTQGAafpreESMESTTQETSR 138 
EHB15890       71 KrTQTAAEGlcQLLG--------GMEGLMPETQT---------SHVAEDIPFNTPGSHGTHGAafpgkESVQSTTQETSR 133 
XP_003787613   71 RrSQTKAKGlcQLMGDPASCKRKDVEGRSPENKTSPSQLNKSHSRTAKGVPLKTQGSHRSQGAacsgeESEE-----TSK 145 
XP_003411903   71 KwNQTTTEGlcQLTGNPASGKRKDMEGWILEAKTSPSQLTKSQSHTAKDILFKTQNSHRSQGTpfsveLSEASNTQETST 150 
XP_012395299   69 KrNQNMVKSlhLFPGNPSPGRRRDA---TLDDEVALSETMDSQKHLTKDTHLESQNSSRGDfc---wdENKEQSAREFSK 142 
5_pfamImport   75 DkSDYLQFSskSHSDPHISREDNLTERKATGAEV-MSKLIESQKHIIEAVQIRKQSSCESEASasicdDKNESNAKQILK 153 

XP_002691539  151 WAKRPKCHRSSKQGHYRQT----ILPAHESEDKVDFPDPLVKAHQRTYTYLHACLSKYEAVLSITHQATQTHELLQPMVS 226 
2_pfamImport  143 WEKKLKCHGSSKQGPGCQP----IPPAPGWAGKVDFPEPLVKAHQHAYAYLHHSLSKYEAIVCLVQRATQTRELLQPLLG 218 
XP_006239833  133 RGREPKCHPSDSQDHCCQT-------VPEPKGKVDFPESLVKAHQHAYAYLHTSLSRYEAIVHLVQQASQTWELLQSMLS 205 
XP_027298566  141 WDKKPMCHQSDNQDQCYQT-------TPESKGKVDFPEPLVKAHQHAYAYLHTSLSRYEAILQLVQQASHTRELLEPMLS 213 
XP_005322544  139 WERKPKCYCSSKQGHCSQT----ILPTPESEGKVDFPEPLVKAHQHAYTYLHASLSKYEAILHLVQQASQTQGLLQPMLS 214 
EHB15890      134 ------------PGHCCQT----IPPAPGSAGKVDFPEHLVKAHQHAYTYLHSSLSKYEVILCLIHQATQTRELLQPMLH 197 
XP_003787613  146 WERKPESHRSSKQCHCCQT----PLPALGSEGKVDFPEPLVQAHQRTYAYLHSSLSKYEAILCIMRQATQTRELLQPMLS 221 
XP_003411903  151 QERKPKCHRLGEQGHRSQT----VLPPHGSAGRVDFPEPLVKAHHDTYTYLHSSLSEYEAILRIVHQAAQTQELLQPMVS 226 
XP_012395299  143 KGIVPTAHILGKDSCYCQAq---DFLAYGPEDKVNFPEALVKAHHKAYAFLHPSLSRYEAILGIAYEAAQTQQYLQQMVG 219 
5_pfamImport  154 KGRKPKNHKLAKQGRPSKTkkksILSPCEIEKKVDFPELLVKAHQNAYAYLNPNLSKYEAILHMANQAAQTQLFLQQMVS 233 

XP_002691539  227 FLMLCFDEVNQLLGEISKDGDKLLQEVRKDLAWPLKKGEPQEQPDLLQQLLQYTVSKLQELSSTVALLTSSLLEGSGSYL 306 
2_pfamImport  219 FLLRCFEEVSQLLGEIAKGGEELLQEVREDLAWPLGKGEPREQPDLLQQLLQYTVGRLQALHGTVASLTGSSLEGCHHSL 298 
XP_006239833  206 FLLLGFEEASQLLGEISKDGEVLLREVRGDLAWPVRKGEPWEHPDLLQQLLQYTVNKLQVVHSTVAALTGSFLEGSSSYL 285 
XP_027298566  214 FLLLCFEEVSQLLGEISKDGEVLLQEVRGDLAWPSGKGEPWEQPDLLQQLLQYTVNKLQVFHSTVAALTGSLLEGSSSYL 293 
XP_005322544  215 FLLLCFEEVGQLLGEISKDGEVLLQEVREDLAWPLKKGEPQEQPDLLQQLLQYTVSKLQVLHGMVAALTGSFLESSSSYF 294 
EHB15890      198 FLLLCFEEVTQLLGEISRDGEVLLQELRDDLAWPSRKGKPQEQPDLLQQLLQYTVSKLQVLHGMVASLTGSFLEGSSGYF 277 
XP_003787613  222 FLLLCSEEVSQLLGEISKDGEVLLQEVKEDLAWPSRKGEPWEQPDLLQQLLQYTVSKLQALNGTVAALTGSCLEGSSSYL 301 
XP_003411903  227 FLLLCFDEVNQLMGKISKDGEALLQEVRADLAWPLKEGEPQEQPDLLEQLLQYTISKLQGLRGTVDSLTCSLLEGSSSYF 306 
XP_012395299  220 FLLWRFDEINKLLRDMANDGEVLLQEAGAHLAWPAKKEDAPWQPDLLQQLLQYTANRMQVLHDTVTTLTSSSLQDSSSYL 299 
5_pfamImport  234 FLMLRFDEINQLLEEIANDGENLLKDVGRYLAWPSGKDDLKEHPDLLQQLLQYTINKMQLVSGTLASVTSDALQETCSYL 313 

XP_002691539  307 NAAAAHLGNKLSTKRGADEHLLRALGHLESLASSHSDPEAWDLPLCSEDSGIGADNESVQL---ADKLGKQASWDLVPEA 383 
2_pfamImport  299 HSTASHLETKLSTKRGVEERLLRALGQLESLAGGRGDPGLQGLPLCSEDSGIGGDSESVHS---VDKLGRQGSWDLTPEP 375 
XP_006239833  286 RATAGHLEGKLSTKRGIDECLLRALGQLESLTSGSSDPGLLGPPLCSEDSGIGADNESVHS---VEKLGKQASWDFAAEL 362 
XP_027298566  294 NSTASHLEGKLSTKRGIDECLLRALGQLESLTTGHGDPGLLGPPLCSEDSGIGADNESVQS---MEKLGRQTSWEFTAEP 370 
XP_005322544  295 HSTASRLENQLSTKRSVDERLLRALRQLESLASGHGDPGLQDLPLCSEDSGIGADNESVKS---MDKLGKQASWNVVPEA 371 
EHB15890      278 YSTATHLGNKLSTKRGVEERLLRALVQLESLASGHGDPGLQDLPLCSEDSGIGAD-ESVQS---LDKLGKQASWDFTPEP 353 
XP_003787613  302 HSAASHLENKLSLKRSMDERLLRALGQLESLASSHSDPGVQGPPLCSEDSGIGADNESLQS---VDKLAKQNSWDCVPEP 378 
XP_003411903  307 HSTASRLEKKLSIKRGMDEHLLRVLGQLENLASGHGDPGVQGLPLFSEDSGIGAENESGQS---LDKLGKQTSWDFVLEP 383 
XP_012395299  300 HSAAQHLDKKLETKRELDQCLLKAIGLLKGCVAGPGTPKVDDRPLYSEDSGIGADNESLHS---VDKLGKQSSWDSLEEP 376 
5_pfamImport  314 QSAASNLEGKLKAKQSYDERLFRAVRLLEASTMGSSQSHSDDRTLCSEDSGIGVDSESLKDfspFSQLGAQASCES---- 389 

XP_002691539  384 AEWRPAISPTVEARLSGHTWQQSPFRMGLDGPQDCPLSRPLTAKVHPAVQGGSGSPWSSVA-GPENTASRPWGLGQSAPC 462 
2_pfamImport  376 AEWKSRILPQTEARLPGQAWQQNPCWVGSDRPQDCPLSTPTRAKIQPAAQREASSPAPCST-SLGKSSPRHLEPGKSRLG 454 
XP_006239833  363 GEWKPGTAAQGEARPSGHAWQKGPYWTGPDRPQDCPLSGPRIAKVQPAVQDEARSSNTSST-SPEAVTSRPPEAAKSIPW 441 
XP_027298566  371 GEWKLGTAPQVEARLAGHAWQKGPYWTGSERHQGCPLSRPRIAKIQPAPQANARHSSASST-DPEAVTSRLPEAAKSILQ 449 
XP_005322544  372 TELKPGISPQTEARQSGRAWQQSAFWMGSDRPQDCP--RPPIAKVHPTSQGKVRSPGPHST-GPETLTSRPSEASKSAWC 448 
EHB15890      354 IEWKLGTSPQMEASLSELAWQQSPFWMGPDRAPGCPLSRAPMSKVQPATQGEARRPCFSST-GPETTTSRPLAVSRSMPQ 432 
XP_003787613  379 TEWKPGTPPPVETRPPGQAWQHGPSWLGSDRPQDCPLSRPPLAKVQPAAQGEARGPSPSHL-APGNVTSRPLEPGKSTPS 457 
XP_003411903  384 IEQKPVISPQVEARPSGYAWQPSPFWMGSDRPQDCPLSRPPTAKFQPAAKGEAGIQCSSNT-DPESISSGPFWPGKSTPH 462 
XP_012395299  377 TERKPWVSSHRETKAD--AWLHYPSALGPSRPQDGALER---QRAQPAALGN---PSQSDE-ALANSHSRSLQLEKRSSH 447 
5_pfamImport  390 --CARGLLSQNHTKTMEHM-HSGTMSPGTATSHGCALEWHFKDTFYSSVRSREETSCQGGVpGGTSTAAKYASLSKRHSS 466 

XP_002691539  463 GPPGMGTSGEAHLS-KGSRCMdAPSFSEGEDSSs--EEEEDEGSCT----SPCTWRKNASHPRPRSSPASAESPFQP-HP 534 
2_pfamImport  455 KPPRGEGPAEAHPS-KGWEWT-APALSEPEDSS---PEEEEEVGGT----IPCTWQEKAPPSRPRSSPASPKSPFQP-HC 524 
XP_006239833  442 DSLGTEIPVQTQLSrRSSGLMgSPYLSGDEDSS---PEEEDELGST----DLHPEPQKALPSRPQSSPDPRESLFQP-YS 513 
XP_027298566  450 DSLGVETPVQTHFS-QSSGLVdAPSLSEDEDSS---PEEEDEVSST----DLQAEHQKAS-SRPRSSPATWESLFQP-YS 519 
XP_005322544  449 DSLGTGIPVEVQLP-KSSRSGeVLPLSESENSSp--DEEEDEVSNM----SPCAGLENVSPARPQTSPADWESSFQS-HT 520 
EHB15890      433 DSLGTTASTKAHLP-KSSRLMaTPCLSESEDSSp--EEEDNKVSRM----SLCTGQERAPRSRPQSSPADRESPFQP-RS 504 
XP_003787613  458 DAFRTGVPAEAHVS-TSSGLMhTVSLSEAEDSS---SEEEDEISSL----NLCAWQQKGPHSRPQSSPANRESPFQS-RP 528 
XP_003411903  463 DSLGIGVPVEACLS-KGSSSMdSPSLSEDEDSSp-dKEEEDEVSSV----SLCAWQDTALFPRPQSSPASRESTFQP-HS 535 
XP_012395299  448 K--------KGEHS-KDCGLTvPLLLTDEEDGNseeEEEEEEEDSEegtpSLSHSQRETWFLRPTTSPALTEIMLWP-HF 517 
5_pfamImport  467 NSFQSDSTQEGEHF----ESTdFPS--DDDEESt--LGEDDDNT------SLSEMGKDALPKRPQSSPAVTDNTQRQsST 532 

XP_002691539  535 RRLRSPQAREMVLKMKEAISEKIKFVPVPSEHQDWM-EEEE-RTTVPPRPSTASGSRRTPSRQRRSQSEGCLKSHTEDTT 612 
2_pfamImport  525 RRLRSPQAQEMILKMKEAISERIKFVPVPSAHQDWA-EEEDeATAVPPRPNTVSGSRRAPERQRRSQSDACLKNPMEDPT 603 
XP_006239833  514 TKLRSPQAQEMILKMKEAISERIKFVPVPSRPQDWA-EEEEgRSVVPPRPRSVSGCRRAPERQRRSQSEGCLKSHVEDPT 592 
XP_027298566  520 KKLRSPQAQEMILKMKEAISERIKFVPVPFGPQDWAeEEEEgRTMVPLRPSTASGSRKAPERQRRSQSEGCLKSHVEDPT 599 
XP_005322544  521 RKLRSPQAQEMILKMKKAISERIKFVPAPLAHQDWS-EEEEgRTVVPRRPSTVSGSRRTPERQQRSQSETCLKSHVEDPT 599 
EHB15890      505 RKLRGPQAQEMVLKMKEAISERIKFVPVPCGHQDWA-EEEEgGTMVLPRPSTVSVSRRAPERRRRTQSEGCLKSHAEDPT 583 
XP_003787613  529 RRLKSPQAREMILKMKESISERIKFVPVPSSHQDWT-EEEEgRPVVPVRPNTVSGGRRAPGRQRRSQSESCIQSQVEDPT 607 
XP_003411903  536 RRFRNPQAQEMILKMKEAISERIKFVPVPSGPQDWA-EEDDrRTMVPPRPSTVSGSRKAPVRQRRSQSEVSLKSHTEDPT 614 
XP_012395299  518 KRIKSPQAHEMILKMKNAISERIKFVPIQPVHKEWM-EDEEkKIILHDRPSTASEGRTWSEGPKRSKSEESLKNYTEDPT 596 
5_pfamImport  533 KRTENVETEEIILKMKDAISEKIKFVPAKSGRKEWV-EDESgTAVLTARPSTAMGRQKASGKQRRSRSEESLRSQAEDPT 611 

XP_002691539  613 LQELQRVQRDLSQRLEAFYSLGTRWQ--------GQSQEPVMQPRAATLRPDNRCWVVPSS-AISKLKSSFTKNFSILPS 683 
2_pfamImport  604 LQELRRIQWDLGQRLEAFYALGAEQQ--------GHSKGRVLPPRAAVLRPGDSCRVSPST-TSSKLKASLTKNFSILPS 674 
XP_006239833  593 LQELRRVQTDLSKRLEVFYALGATQQ--------GQSREQCLPPRTSLLWPPTNCRVSPSS-AISKFKASLTQNFSILPN 663 
XP_027298566  600 LQELRRVQTDLSRRLEVFYALGGTRQ--------GQNKERLLPSRASVLWPPSNCRVSPSS-AISKFKASLTQNFSILPN 670 
XP_005322544  600 LQELRRVQKDLSQRLEAFYAQGPKRQ--------GQRKEQIVRSRGAAIWPNSNCRVSPSNsTISKLKASLTKNFSILPS 671 
EHB15890      584 LQELRRVQRDLSQRLEVFYALGAKRQ--------GQNKEQILLPRAAALWPTSNCRVSCSS-TISKLKASLTKDFSILPN 654 
XP_003787613  608 LQELRSVQRDLSQRLEAFYALGAKGQgqsqgqshGQSQEQTQQPR--ALWPNSS-KVRPSS-TTSKLRASLTKNFSILPS 683 
XP_003411903  615 LQELRRVQRDLSQRLEAFYALGAQRQ--------QHSTEQILKPRAAGLWPENNCRATPSN-TISKLKASLTKNFSILPS 685 
XP_012395299  597 LLELQRVQKDLSQRLEMFYDFRRKRK--------TQNKEE--HPRTAVLCLDSRRGPTQGS-SISKLKASLAKNLSILPS 665 
5_pfamImport  612 LLELQRTQKELNKRLEMFYG---KVD--------TDNNQEPRKPRSTRHLQDKQITSRSSS----KLKACLSKNFSILPN 676 

XP_002691539  684 QDKSILQKCCSRPEGEQPGQGKAEGLPSIIP------PGERAHEAPAVRDQTIRSCPTRTSVKKLIETFSPTESLRTLGD 757 
2_pfamImport  675 QDKSIVQRCSPHPEADQPWQRKAEKLPNATG------SSERDHEAPGPRDWNARGCASRTSVKKLIETFSATESLRPPGD 748 
XP_006239833  664 QDKSIFQRGSPCFDSDQPCQGKAEKLPSAIF------CGKKNSRAPGDNERDIRACPTRTSVKKLIETFSPTESPRMPRD 737 
XP_027298566  671 QDKSILQRGSPLSECDKPCQEKAEKLPNAIF------CGEKNSGGPGDTDWDVRGCPTRTSVKKLIETFSPNESLRMPRD 744 
XP_005322544  672 QDKSILQKCGPLSEGEQPWQKRAELLPNAIP------PGEKD-ETPRAKDCSVRGSPTRTSVKKLIETFSPTESVKTLGD 744 
EHB15890      655 QDKNIGQRCHPHPEGEQLRQENTEKLPSTIP------SGEDG-EASRAKDCIVGGCPTRTSVKKLIETFSPAESMRTPGD 727 
XP_003787613  684 QDKSILQKCNPQPEGEQPWPGKAEKLPSATQ------SDEDI-EAPRAPD---RGCPTRTSVKKLIEAFSPIESVRTEGD 753 
XP_003411903  686 QDKSILQKGSPHPKGEQPWQRTAEQHANTTP------SSEKGSEVPGTEDHHIRGHPTRTSVKKLIETFSPTDHLRTLGD 759 
XP_012395299  666 QEKIVWQKPDSNSKCEQPSKGKAEVLSKTTSpvqeheSWERKKEVPETQGWNGEGCSPQPSVKKLIETFSPAEEMVNP-- 743 
5_pfamImport  677 QDKVPLYMVDQNPASQLDEKRCKKPVRATVPaq--etSGSKDDKTSGAQTLSGSSCAPRQSVKKLIETFSPTDDLEKATP 754 

XP_002691539  758 SQDSGPSPCPKKWGVPSMPPRFPIYRGLAPLYPKPRISPAVGGESLRMGPGWRPLAPTFPPLLTAEATKSEDLNWETEEN 837 
2_pfamImport  749 SKSPGSSPFLRKWGVPIMPPRFPIYRGLAPLYPKPQISPAAGRDSLGVGMAWRPLAPALPPLPPAEEPNSEDVSWEGEGD 828 
XP_006239833  738 CRNLGTSPCLRKWGVPAMPPRFPIYRGLAPLYPKPQISPAVGRDPLKLGMSWRPSAP-FPSLPPAEASEGEDIGGEMEED 816 
XP_027298566  745 SRNLGSSPCLRKWGIPAMPPRFPIYRGLAPLYPKPQISPAAGREPLKVGMGWRPSAP-FPSLPPAEACKREDINCEALED 823 
XP_005322544  745 SRNSGSSPCLRKWGVPIMPPRLPIYRGLAPMYTKPQISPTGSRECLKVDTGWRPVAPIFPPLPTAETFKNEDIRCEVEGD 824 
EHB15890      728 SKNSGSSPCLRRWGIPPMPPRFPIFRGLAPLYPKPQISPVAG-SYLNADMGWRPLAPVILPLPAAEASESEDTHFGTEGD 806 
XP_003787613  754 SKNSGSSPCLRRWGVPIMPPRFPIYRGLAPLYPKPQISPALGREPPRVGTGWRPIAPIFPPMLTAEAPRSTDISYKMEGD 833 
XP_003411903  760 SKDSEPSPCLRKWGVPIMQPRFPIYRGLAPLCPKLHISPAAGRDALNVGTGWRPFTPIFPPAFTAEASRSKDVNGETDED 839 
XP_012395299  744 -RPSGEVNGIKKFGFPITPPRFPIYRGLAPLYPKHQLFPGTAGESPKLGSSWRPFAPIFTPLPTVAQVSRNAPNGETEED 822 
5_pfamImport  755 LRPLGPIKCIRKFGLPVIPPTIPFQRGLVPLNIKHRISPVEDTSLSNTSGACSNFSNAFPPIPSAELSKD--TKEEPEVD 832 

XP_002691539  838 PEDLPPPPLEILMDQSFTSLEPPESNKPAESPLEGTHVPGLGGTGSA-RRTWASPRLRVSMSPTDLLPSKSTATLTRARS 916 
2_pfamImport  829 PEPLPPPPLEILMDTSFASLEPPGSAVPAGSSPTEPRGTGLGRACPP-GGTCTSPKLRASMGPRDVLPSKSTVSPSRPRS 907 
XP_006239833  817 LQNLPPPPLEILMDKSFTALEHPEC------SLEETLLPELQEARRP-KRTWASPKLKASMSPMDLLPSKGNGSSPRLQG 889 
XP_027298566  824 LENLPPPPLEILMDKSFTALELPASSQPACSSVEEKLVPGLQENSPP-RKTWASPKLRASMRPLDLLPSKGTGSSLRLHG 902 
XP_005322544  825 PEHLPPPPLEVLMDNSFTSLENPESRKSTGSSPEGSPVPGLGRAGPT-RRTWASPKLRASMSPIDLLPSKSTASPTRLCS 903 
EHB15890      807 SEHLPPPPLEILMDKSFTSLEPPESSNPAGSSPEGTPVPGLGGSGST-RGTWVSSKLRASVSPIDLLPSKCTASPTKLCS 885 
XP_003787613  834 QEHLPPPPLEVMMDKSFTSLESPESSKSAESSPEGTPVPGLGGAGTArRRTWASPKLRASMSPVDLLPSKGTASPPRSRS 913 
XP_003411903  840 PEHLPPPPLEILMDKSFTSLELPESSAPAGSSPKGTGMPGLEGVGPP-RRTWASPKLRASMSPIDLLPSKGTASPTRPRS 918 
XP_012395299  823 LEDFPPPPPEILMDNSFNSLLNPGDPEPGGGSPAEVP----SKLPPP-RKTSASQRLKASLNPIDLLPSKNIPNPIPPSG 897 
5_pfamImport  833 TENLPPPPPEMLMDTSFELSEPEETARIGENSSEDAKKPAKTESHAT-KRAQVSPKMKASLQSIDLLPSKSI-SPSAVAN 910 

XP_002691539  917 TEPGNSKGSCNTGKL-ALDFNHPPAASGNPEVQSSrAQSQVRADRASGLSKPPRKVIHWLHSSHTS----GQNRISE--- 988 
2_pfamImport  908 TGPAGSKVSCSPRRP-ALDLHHPPAPKPNPEGASG-AQSHAQAEKAASLAKHPQKASAWHRSSPTS----GQNRTSE--- 978 
XP_006239833  890 TRPGSTSNVGNSRKL-TLDLNSQQTANPSPEAEGG-AQIQAPPENTAGLSKHHQKAIPRHHANPTS----GQSRALE--- 960 
XP_027298566  903 TGPGIIRNVGNSRKL-TLDLNSQQAVNLSPEAEGG-AHIHAQAENAASPSEHHQKALPWHHTNATS----GQSRTLE--- 973 
XP_005322544  904 TGPGSSKNGSNPRKP-VQDPNLPSAASPNPEAEGG-AHSQAQAEKATSFSKHHRKAVPWHHASPTS----GQSRTSE--- 974 
EHB15890      886 TGLGSTKRGSNPRML-ALDPSLPPAASPDSEQEGR-AQSQAQAAKATGPSKQPRKAVAWHHTSLPS----GQSRTSE--- 956 
XP_003787613  914 TGPAISKSS--PRKP-ALDLSHPPATSQNPEAEGS-AQGQGQAEKAPSLNQQPRRAVPWHHSSHTS----WQNRTSD--- 982 
XP_003411903  919 TGPGSIKSGCNPRKF-ALDLNHPLATSQSPETEDR-AESQAQAEKATSLGKHPWKAITWHHSRHTS----GQNGTLE--- 989 
XP_012395299  898 KGSGDTKAERRGRNL-YLELIHVPRTGHSQERSAV-APRRPEVEEATSLSKQPHKVIPLPQLGSTA----GLKGNKE--- 968 
5_pfamImport  911 KVPRSSGPKDEKLQIySLELN--PTNTHIPSQEEIlA---TQRKEAADLYKQTHKIIPLQNPSGVSkphdNSSESKEpsp 985 

XP_002691539  989 PSLSRPMRGPHSPEAPRQTQGRSPVLVRKASPTRAHW-TPRVDKRHSGLPSTHRS-------AQpSAPCVHGSPSPPL-- 1058
2_pfamImport  979 PSLARPPRGPRSAEAPRPGRERSPAVVRKTSPPRAHW-APQADKKHRSLPASHRP-------AQ-SPPAAHSSPSPPLsp 1049
XP_006239833  961 PSLARFSRDPHSPEASRKGPERSPPGVRKASPPRAQW-ASQGGRRLQSLPSTHGP-------SQpGLRAVLSSPSPPL-- 1030
XP_027298566  974 PSLVRPSRGPHSPEASRKGPERSPPGVRKASPTRAQW-ASQGDRRLQSLPSSRGL-------SQsGLPAVLSSPSPPL-- 1043
XP_005322544  975 PSLARLTRGPHSPEASRQSRERSPPVVRKSSPTRAHW-APQVDRKQRGLPSSPGP-------AQpS--TVLSSSSPPLsp 1044
EHB15890      957 PSLARSTRGTHSTQASRLSRERSPPVIRKTSPTKAHW-VPQADKRQHSPPSSQGP-------AQpSLPTAVSSPSPPLsp 1028
XP_003787613  983 LSLARPTQGPRSPEAPRQSRERSSPTARKASPTKAHW-VPPADKTPPSLPSSHRP-------AQpSSPTVQGSPSPPLsp 1054
XP_003411903  990 PSQARPTRGPHSPEASRQSQERSPLVLKKASPPRVHW-APRAEKRHPSLPSSYRP-------AQpILPPVHRSPSPPFst 1061
XP_012395299  969 GSTGRPSQ----PEGPRQGQEKGPSLVRKVSPTRLHW-SHRTERRNLSPPASHRPtg---lpTQpTLPQVQRQASPPFsp 1040
5_pfamImport  986 PATSVPYQKHGSPDSLRRN-EKGSSFNRRVSPARTPPsSPPTEKQLFSPPVHHRRalqafnsQQlSSPTMQRKPSPPTsp 1064

XP_002691539 1059 ---SPPV--SPRGLSLPTV----KKRASP-------PLQHKLH--SPPsaspl---aqhkISSPPPQRTEAGSLASGP-- 1115
2_pfamImport 1050 aapSPPV--SPRVLSPPPT----KRRTSP-------LPPHKLP--SPP------------PASPPTQHPEANSPSSAP-- 1100
XP_006239833 1031 ---------SPRTLSPPAT----RKPTSP-------PCQYPQS--NPA------------PGSPPVQRTETNTPSSAS-- 1074
XP_027298566 1044 ---------SPRTLSPPAA----RTPTSP-------PCGHMQP--NPA------------QGSCPVQQTETNTPSSAS-- 1087
XP_005322544 1045 aapSPTA--SLGILSPPNT----KKRTSS-------PPQHKLP--SPPlgspp---aqpkVSS-PAQHTEASPPSSVP-- 1103
EHB15890     1029 gaaSPPEdnSPAPAGCPTS----AAQFQPhwsllgiPAQPKQPplSSWfrlpcgqqfqeeVKPQPQGDTEENQPPGLSfr 1104
XP_003787613 1055 gvpSPPM--SPRVLSPPTG----KKRASP-------QRQHKAS--SP-----------------PTQCPEASSPSSLP-- 1100
XP_003411903 1062 gapSPPV--SPRVLSPPTP----KKRTSP-------LPQHKQP--SPP------------LVSPPTQSREASSPSSGP-- 1112
XP_012395299 1041 -ktSPPA--RARTPSPPTSpptlRKSTSP-------LPHPKHP--SSPvevpqsppapqeLSSPLVSHREVSPPSSGS-- 1106
5_pfamImport 1065 rapSPPR-----GPSPPLQ----KKLPSP-------PAQRKLL--SPPaehkqssptphrLPGSPVYRREASPTPFLT-- 1124

XP_002691539 1116 ------------------SPSPPASPSQGPKETQDSEDS----RAATA--SGNTRSIFCPATSSLFEAKLPFSTVHPltp 1171
2_pfamImport 1101 ------------------SPSPPGSPSQGHKERGDSEGS----QAATAeaPGNARSIFCPATSSLFEARSPLSTAHL--- 1155
XP_006239833 1075 ------------------SSSPSVSPSRGSKDSSHSEDS----EGTTNkaSRGTCSVLFPATA-FCEAKSSFSTSHPqtl 1131
XP_027298566 1088 ------------------SSSPSVSPSQWSKENSHSEDG----EATTAkaPRNTCSIFCPAASSPFEAKSSFSIPHPrtl 1145
XP_005322544 1104 ------------------SPSPPGSPSQGCKETRDSEGN----QAPAAkaSRNTCSIFCPATSSLFEAKSPSLTAHLqts 1161
EHB15890     1105 fmrnlggeqqdlghgkeqDSACPLVPTR---------------PNHSRwaGGHTARTAQPDKPDM-ERQRPGAKGEPlgf 1168
XP_003787613 1101 ------------------SPSSPVSLSQGHKETRDSEDS----RADTAqvSGNTCSIFCPAASSLFETRLPLSTAQSltp 1158
XP_003411903 1113 ------------------SPSTPVSPSQECKEARDSEDC----PSAMVkvSGNTCSIFYPATSSLFEAKVPLSRPHPlts 1170
XP_012395299 1107 ------------------TSTPPTSPSQEPKEQSSWGDR----DPAPAkvAPNTCSIFYPASPSLFEAKSPSSPKAShp- 1163
5_pfamImport 1125 ------------------ASSPPTSPSCSYKGSKAGLDAgdeyQPASSkkGSNVRSIFCPATSSLFEARPPPAPSKPtv- 1185

XP_002691539 1172 sslppeaGGPLETPTGGwrgssgprmrTDSQRGTTLCALNPQPFIRRTASD--PRPGVRLHLPVPGATSSACESQHG-QS 1248
2_pfamImport 1156 -------LAPPSLPPGC----------SGSQRRMALCALNPQPFIRRPAAH--RQPGLQLQLPGSSPTGTPWDSQLS-QS 1215
XP_006239833 1132 ----pepGGLLRTPAGGwrgsagprlrADSQKRTVLNALDALPFVRRTASDrqRQQGDPLQLPSSDWESHPCQNSS---S 1204
XP_027298566 1146 ----pehGGPLRNPTGGwrgnsgprlrADSQRRTALCALNPLPFVRRTASDrqRQQGDPLLLPSSSWDSHPCQSS----S 1217
XP_005322544 1162 tslppepGGALGTPAGCwrssleprlkADSQRRMALCALNPLPFVKRTAPA--CHPGVRIQLPGSSSTGSSWEPQLDqSS 1239
EHB15890     1169 v---relGrntqk----------peewGGSQEEE---QHT------RVRSDlvLSPRS---------------------S 1205
XP_003787613 1159 ----peaGGPLRSPAGGwrsssgprlrADSQRRGALCALNPLPFVRRTASD--RRPGARLPLPASGLTGTSCDSQLS-QS 1231
XP_003411903 1171 pslppeaGGSLGMPTGCwrsssgprrrVESQRRVALCALNPQPFIRRTASD--HRQGTRLQLPVSGCTGTASESQLS-HR 1247
XP_012395299 1164 -----esGEHPEMAAEAkrtavsprpwGEPQRRMALCALNPQPFIRRTASD--HRPRVRLRLPGSASVGTTSELCS---Q 1233
5_pfamImport 1186 -----evTKQTEASPPSqksslllqqpADRTRKLSLSAANPQPFVRRSFSD--RRPGVRFYLPAP--VTAGSEPALN--Q 1254

XP_002691539 1249 SGSEESP-KDTEPWKSPCGLELKGN-SRGVPSPELCVLGHGLQ 1289
2_pfamImport 1216 SSGEESPkQDAEPWGGPCGPELQGGgSRRASPPELCVLGHGLQ 1258
XP_006239833 1205 SSSEENAkQELPPWNNSRVPELQSSsTKWTSPLELCVLGHGLQ 1247
XP_027298566 1218 SSSEESPkQESPSWNNSRAPEFQGSgTKWASPLELCVLGHGLQ 1260
XP_005322544 1240 SSSEDSPkLNASTWSSPCAPEPQGGsSRCASPPELCVLGHGLQ 1282
EHB15890     1206 SSSEDSPkQDVAPWSSPHVPELQGGgGSWASPPELYVLGHRLQ 1248
XP_003787613 1232 SSSEESLgKDTEPWSNPSAPELQGS-SRHAPPPELCVLGHGMQ 1273
XP_003411903 1248 SSSEESPrKGNEAWSSSYSPELK---QRRVSPPELCILGHGLQ 1287
XP_012395299 1234 ISSEESSpKEAAAWNSLCSPDTKGS-SKWASQPELYVVGRGLQ 1275
5_pfamImport 1255 ASAEESPgKAGDCWSNPCAPEIKES-NRSTSHPELYIVGQGLQ 1296
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