Conserved Protein Domain Family
ARHGEF5_35

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pfam15441: ARHGEF5_35 (This model is not part of the current CDD release)
RhoGEF 5/35 N-terminal disordered region
This entry includes Rho guanine nucleotide exchange factor 5 and Rho guanine nucleotide exchange factor 35. However, this region is disordered and the RhoGEF function resides in a different domain pfam00621.
Statistics
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PSSM-Id: 521846
Aligned: 13 rows
Threshold Bit Score: 540.956
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003475594    1 METEEPEHEVSTSTAGIKEFGVVPETIMRSRQIPALEPEVQD-QGPSFNWTEEHRLLETQPKELRDMSDCETESVSFFPT 79  
4_pfamImport    1 MEAEERQHGASTPIPAVEEFRIIPEAIMRSSQIPTMELEAQEdQDPSYKWAQGHRLLLTQPRGLQDMTDSVEEGLPSFSE 80  
2_pfamImport    1 MDAEEPQYGTSTPIPAKEEFSVTPEALMRSSQIPALGPEAQEgQDLCNNWDEGQRLSATQPSELRDVSDYAAETVPSFPK 80  
3_pfamImport    1 MEAEEPEHEASTSTPAIKDFEVVPEAVMRSSQIPVLEPEVQD-QGPAYKWTEGHRLLEMQAKELRYMNDYAAGSLLFFPK 79  
EGV94019        1 MEAGEPDHGASAPISAVEEVQAIPEAIMRSSQIPALEPEAQEgQDPSYKWADGHRPLMNHPKELRDMSDHTPDSMGFFLK 80  
XP_038964580    1 MEAEEPEHGACTPVPDIEELGAIPEGIMRSSQIPALDPEAQEgQDPSYKWTDGHRSLMDQSKVLRDVSDHTPNSVAIFFK 80  
E9Q7D5          1 MEAEEPEYGVSTEVPDIEELKTIPEGIMRSSQIPALDPEAQEdRDPSYKWTDGHRPVMNQSKVLRDMGDHTPNSMAIFFK 80   house mouse
5_pfamImport    1 MEAEEPQHGPSTPNPAIVEFSIIPEALMRSSQIPAVESEGQEnQDLYSTWTEGGRPLVTQQRELSNVHDYAAERMPSFPK 80  
NP_001103545    1 MEAEEPQHGASTPIPARAEFPVIWAPPMRSSKTPALEPAAEEgEDPRCQWAEGCTLLETQQRHVRDANDRAAERMTSLLN 80  
XP_044919047    1 MEAEEPQHGVSTPIPALAELSVTPEALRRSRQTAALGPEAQEgWEPSSAWAEGRGLSETQRGASRDVKSCATKSVTSFPK 80  
1_pfamImport    1 MEAEEPQHGALTPIPALAELSIIPEPLRRSSQTATLGPEAQEgWEPSSTWAEGRGLLEPQQGGLKDVKSCATESMTSFPE 80  
XP_012661752    1 MEAEEPPHGV-FPIPAIAEFSTVPEVPMGSSQIPALEPEAQEgEDLSHPWREECRPFETQQRESGDVTDYAVTSMASFPK 79  
A5YM69          1 MEAEEAQHGASPPISAIEEFSIIPEAPMRSSQVSALGLEAQEdEDPSYKWREEHRLSATQQSELRDVCDYAIETMPSFPK 80   human
XP_003475594   80 gECALFPQISQVDLLAEVH-DTPEYQESKCQILADSGARTVDPPEPAAFPVQGERLD-TACLS------RVEVELLPELT 151 
4_pfamImport   81 -ESSADVETNQESLVAEAY-DTPGHQEAVLQSLADRGPMIPAPPELWTCPVQGEQLD-KLSISsel-gcRIEVEFQPDLT 156 
2_pfamImport   81 -ESSVEVDSDQETFVAEVS-NTPELQEPMAQSLADEQARIPAPSELQYHPIQSECPG-MVPISsdl-gsRVEKEFQPELT 156 
3_pfamImport   80 -RGSVGAETSQEVLVAEAC-DTPEHQKSEPQTLADSRARTLAPPEHGVYLVQDEWLDtTVPMAtel-gsRVEVEFPPNLT 156 
EGV94019       81 -EVSSDVEANQEILVAEAC-DTVDQREPVSQNLKDRLSRTIAVPELLACAVQEEWLD----ISsnv-nsRVEIELQPELM 153 
XP_038964580   81 -KDSSAMATSQEILLAEAR-DTADQQEAVTQSLQDRLSTTVAAPELLGCAVQEEWLD----IPskl-dsRVEAELQPELM 153 
E9Q7D5         81 -KESSDMETSQEILLAEAC-NTPDQQEAVIQSLKDRLSRTIAAPELLACAVQEEWLD----IPskl-dnRVGAELQSELM 153  house mouse
5_pfamImport   81 -EGSADKEINRERFVSEAW-DSPDVLETMSQNLAERQSRTLGPEEVGAYLVQGKCLD-MIPISiep-dsRAEVEFQPQFT 156 
NP_001103545   81 -EASPEVETDQETLMAEACdDTPSCQEAGPWSLEDRQARTPASLDFLTCPDQGDCLD-TASVSrdl-dtSVEVDFKPELT 157 
XP_044919047   81 -EAPAGAETTQEDSVGEMG-DTPELQELVPHSPTGGGARTPAPSQLGACLVQGEHLD-MAPGSgel-ggGVEMEFRLEPT 156 
1_pfamImport   81 -EAPAGVETDQEDTVGDTW-DTPERQEPVPQSLADGRARTPAHAERGACPFQGEHLD-TVPVSrer-ggGVEMELRPELT 156 
XP_012661752   80 -EGPTHVGTKWETLVTEAC-DSPEQPKAVPQSPADRQARTIFPPEPCACPLQGEHLD-VVSISsdl-dsRVEVEFLPEFT 155 
A5YM69         81 -EGSADVEPNQESLVAEAC-DTPEHWEAVPQSLAGRQARTLAPPELWACPIQSEHLD-MAPFSsdlgseEEEVEFWPGLT 157  human
XP_003475594  152 SLILGMEQTneKEKEEACPApSAQTGCWPPC-EVHPIETSQT-KDSATGAGSQGEElqlkdaQKSQGQEGVLHPEEAQEL 229 
4_pfamImport  157 SLTLGSREA--KEKEATSPDtLAQTVLWLPC-EEHPAEMSQT-RGSRGGTVSQKEE------RESQGGEELLQPQETRGP 226 
2_pfamImport  157 SLTLEFEQA--EEKGQTSPG-SSQTMFWPLC-KEPTTETNQA-EGSESRIIPQGEKlqleevQESRGQEEPLHPQGAQGL 231 
3_pfamImport  157 SSILGTEQA--DEQEEASPVaSAQTGFWSLC-KIHPIETNQT-KASAAGTISQGEElqlekaPESQGQERLLHPQEAQGL 232 
EGV94019      154 SLALAISKA--K-EEERSPGpSLPRGFWPPC-TKHPGET----EGHGSDQLKQGKQlqledtQEKQGQ-GLLQPQEAQGL 224 
XP_038964580  154 SLTLAVSKE--KEEEESSPDtSTP-GFWPPS-KIHPGETDQT-EGSGMELLRQGKQlqleatQENRGQQGLLQPQEAQGL 228 
E9Q7D5        154 SLTLAVSKE--KEEEETSPDtSIPRGSWPPC-KTHPGETEQT-QGSGSELLRQGKQlqleatQENQGQEGFLQSQEAQGL 229  house mouse
5_pfamImport  157 SFI--SGQA--EEKEETFPDpSAQIGSWPPC-EEHLVETSQT-EDSESGSFRQGKElqsmdmQGSPGREGLLHLWDAQGI 230 
NP_001103545  158 SLILETGQA--EGKEETSSNaYARTRHRPSCdDEHPAETSRPlEDSECGPARQ----------ESPG---LVCLQGTEGL 222 
XP_044919047  157 SSTGETGHA--EEK-GAFPDaSAQPRFGPSC-EQCPEETHQP-GDS----VRHGEEpqltaaREGPGSGGPECLLAAEGL 227 
1_pfamImport  157 SLPGGTGHA--EEE-EVSPDtSAQPRSGPPC-EEHPAEPELP-GDS----VKQGEElraagaEESPGRGGLMCLLDAWGL 227 
XP_012661752  156 TPMLGSEQA--EEKEETTLDtFTPTRYSPSC-KEHPTETSET-KDPEDGTVGQ-EEllfravQGSWRPEELWHPQEAQGL 230 
A5YM69        158 SLTLGSGQA--EEEEETSSDnSGQTRYYSPC-EEHPAETNQN-EGAESGTIRQGEElpseelQESQG---LLHPQEVQVL 230  human
XP_003475594  230 GEQKQQQGGPQGEGTVgEGVCSDGLWQEQEQIAAPPNDPEGEQRPQQEQLRDGTVLGRQgEGEN----GELEGLNC-ECV 304 
4_pfamImport  227 EEQGQHEMESQGKGVLgEDACSGGLWEEQEQMVEQANGKEWVHGPKQEQVQDGVWLGGR-ERERl--sGELEVLNCgEQG 303 
2_pfamImport  232 EDLGQQTVESQGTETL-QNVSSDGLWEEQEQMVEQVTGNEEEERQKKEQVQEDGILGRQgETERl--vEELEGLNCgEQD 308 
3_pfamImport  233 EQQEQQEREFQREGTVrEGVCSDGLWWEPEQMVELTEDKEGEQRPKQEQIQDDVLGRQGgERl----sGELAGLKY-EWV 307 
EGV94019      225 EEQEGQEVEVEEEGTLrENICTDGLPGEQEEEEEGVNGSEEEQ--KEEQVQNHVMLGGQrESSEl--sGELEGLDSrEWG 300 
XP_038964580  229 EEQEGQEVEIQEEGTLrEDICFGGLLGEQKEVEEDFNDNKEEQ--KQEQIQSYMLLGGQwESEGl--sGELEGLNYnERS 304 
E9Q7D5        230 EEQEGQEVEIQEEGTLnEGICFGGLLGEQEEVEEGFNGNEEEQ--KQGQIQSYMLLGGQwENEGl--sGELEGLNYsERG 305  house mouse
5_pfamImport  231 ETQKQWEVEFQEEGMQgEDICPDGICGEQEQMVEQVDGKDGKQNPQQEQVLGDVLLTQQeERDRp--nGDLEGLNYsEWG 308 
NP_001103545  223 EEGGPQg----------EAAGSAGLSGAPEQMGEQVKGAEEEGRQKQQQMQNDMVLEDPgEREGwccgEELGGLSYgEW- 291 
XP_044919047  228 GEQGPADAGFQEE----AAVGEGGRSGEQEQKGEQGDRTKGEQRPKQQQRQGDPMPARQgERTGl--cGDSEGLHCpEQ- 300 
1_pfamImport  228 EEQGLAEAAFREE----AAAGGDGRLGGQEQGGEQADGT-GEQEQKQEQRRGRAMCAKHgERTGl--sGELEGLRCsEQ- 299 
XP_012661752  231 EGQGQQKVGLQGEGALsGDNCDDGLWGQQTQRVEQTDGEEGVQRREQNQAQDDGPPRRMgEREWl--pRGLEGPKDgAWG 308 
A5YM69        231 EEQGQQEAGFRGEGTLrEDVCADGLLGE-EQMIEQVNDEKGEQKQKQEQVQ-DVMLGRQgERMGl--tGEPEGLNDgEWE 306  human
XP_003475594  305 PENTERKAQHQGGPEEELQKDWVFQGPEEYWMTSQSTENQSLAEKSEKLPRKQvDEGVR---GEMRPMEgqeee-vvlrG 380 
4_pfamImport  304 QEGRERKAQGQGDLEERGQKKRELRGPEESRVDSQYMENLSLVGKSEEVPGKQ-DQSPK---GKVMAAE----------E 369 
2_pfamImport  309 EEHREKNAEHQKGPEQAEQAKRELSGPEKRRVSSQDMECQSLVGRSEEITRQQeGEGLM---GKVMSVEgqeeeealsdE 385 
3_pfamImport  308 PENREREAGGERGLEEEEQKESELRGPEECWVNSQHAENQSLAEKSEELTLKQvDQGLR---GKMRPMEvqeee-agssK 383 
EGV94019      301 QEDRRGR-----DPEEEGQ-DRGCRAVEGRRGAAQSAENQRLVEKSEGVSGKQeNHGGT---GKAVPAEdqeev-vasgE 370 
XP_038964580  305 QEERERRVCGQRDSKEEGQ-DQELREVEERRVGTQCAENQMLEEISENVRRRQeDHDQA---GQAMHVGdqkev-vdsgD 379 
E9Q7D5        306 QENRERRVWVLRDSEEEGQ-DQESREVEERRVATQYTENQRLVEKSEIVKRKQrDHDQT---GKVMPVRdqkev-vdsgD 380  house mouse
5_pfamImport  309 LEESVRRAPGQEDPKHRGQRKKESHGPEGSRIDSRCMQNQSLVEDSEKVTGKQ-DQGLQ---RYVMSMQg--------qD 376 
NP_001103545  292 ----DWRTWSHGDPEQGEQKGRELTGPEENEVGAQDGENQSSASKSEKGSGKPeDPGAQ---WEAKAAEgqeee-vgslE 363 
XP_044919047  301 ----EMKTQGWGDPPQGEEGKREFGGPQESSVDAQNEERQSLVGRSGKGTGRQeGQGLQ---RKVMFAQr--------qE 365 
1_pfamImport  300 ----GMEPRRQPGLQQGEEGNRETGGPEEGSGAAQNEEKWSVVGKSGQVTGRPeGRGLRglrGKVASVEgreaeavgsgE 375 
XP_012661752  309 QEDVKGSEQGQEGQKQGEPSRRDSKELEESRGDSCSEQCQSWVEQSEEVTGKQrAQGLK---GDVLPVDg--------sE 377 
A5YM69        307 QEDMERKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQeDHGIK---EKGVPVSgq-------eA 376  human
XP_003475594  381 EEPDNPDGHGLGVVEEGQKaeeeeeYHGPSTLAGAAPEVPFSCDSFPEVSCPVTQIPGTQLesr--ageLFPRALASTPE 458 
4_pfamImport  370 EEPGSWAGGGLGAVGDERS------THCPSPLALVAPEDHSPGDLLADAFCPMTQIPQTEA--------LSPKALTSASE 435 
2_pfamImport  386 QEPGNWDGSLQGAVGEERSeee-eeHHGPPTLVLVPSEISSPFDFFPDGSYPMTQVPGTQMepr--aveLSPIVLTPLLE 462 
3_pfamImport  384 EEPGNWDRHGLGVVEEEQRaeeeeeCHGPSTLAPVAPEVPS-CDLFPEVSCPMTQIPGTQSesesgageLFPRALTPTLE 462 
EGV94019      371 G----------GQAAEEGRteqdkhC---PPVVLVAPEVLSSGTLFPGVSCPVADIPGVQRepv--pqeLIPQVLTPAPE 435 
XP_038964580  380 REQGTWDSGGQAAEERSRTgednkpC---LPMTSIAPGVLSPGTLFPAIPSSVDDMSQIQRepv--peeLTTQAPTPAPE 454 
E9Q7D5        381 RVQGNGDSGGQTAVEGSRPgedskpS---LPVASVDPEVLSPGTLFPGISSSVADIPQIQKepv--ceeLSPQA--PALE 453  house mouse
5_pfamImport  377 GEVRSWD---------DRLqgegeaLHGPSTPVVLSAEISSPGDVFPDASCFMTQTAGVQTdsr--aedLSPIAMTPTLE 445 
NP_001103545  364 EEPGGGEGDTPSRGGEESCieq-geREGPTALALVAPEVSPPRDLSLEASSPLSRIPGTQTepg--aevPSPIAPSPAPE 440 
XP_044919047  366 EEPGNWDGDPLRREAGERSteegeaRDGPSTQAPVASEVSSPCDLFLDTCHPKTSVPGTPRepr--aeePLPVAPAPARE 443 
1_pfamImport  376 EEPENWDGDPLRGEGREGPteegeaRDGPSTLALVASEVSSPCDLFPDTCYPMTGTPGPREepr--aeePSPVALPPPLE 453 
XP_012661752  378 EEPGGWGRGSLARVGEEGGmeeekeHHGLSTLALVTAELSSPHDLFPDALYPRMQSPGTQAepr--aeeLSPLALPPTLE 455 
A5YM69        377 KEPESWDGGRLGAVGRARSreeeneHHGPSMPALIAPEDSPHCDLFPGASYLVTQIPGTQTesr--aeeLSPAALSPLLE 454  human
XP_003475594  459 PTRWYPQPTSQPDTFPAGESLNNN 482 
4_pfamImport  436 PRRDLPQLTSLPGPSPTAASLDSR 459 
2_pfamImport  463 PIECSHQPVSLPDCFPKVESPDNE 486 
3_pfamImport  463 PTGWPSQPISPPDSFPSGESLNNK 486 
EGV94019      436 PIEWSLQPISPPDSFATEEPLDDR 459 
XP_038964580  455 PTEWSHQHISPPASFATEEALDNR 478 
E9Q7D5        454 PTEWSHQPISPPASFAPEESLDNR 477  house mouse
5_pfamImport  446 PPGWPQHPISLPASFPPGQSLDNK 469 
NP_001103545  441 PTGCSHQPFSLPGSCPAEESLDPE 464 
XP_044919047  444 SGQWSSQPVSLPGSFPAGESPDQE 467 
1_pfamImport  454 SGGWSGRPASLPGSFPAGGSPAQE 477 
XP_012661752  456 HIECSHQLVSLRSSFPTGESLDNE 479 
A5YM69        455 PIRCSHQPISLLGSFLTEESPDKE 478  human
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