Conserved Protein Domain Family
THRAP3_BCLAF1

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pfam15440: THRAP3_BCLAF1 (This model is not part of the current CDD release)
THRAP3/BCLAF1 family
This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).
Statistics
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PSSM-Id: 521845
Aligned: 24 rows
Threshold Bit Score: 299.788
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014352806 125 PRSRSRSPKRRSV-TPRSRSCSRNSDRSSSGrs------rsSSSGSSshhSRSGS-SKRRSVKQHNAAQKEARASLPPAQ 196 
XP_008112728 108 DRSRSRSPKRRSRsSQRSRSRSRRSYRSSrsp-------rsSSSRSSspySKSPVsSKRRGSSEKQAKKTEAATLQESPL 180 
XP_006007788 107 GRSRSRTPKRRSVsSPRSRSRSHHSDRSSvsr-------gsSSSRSSscySQSPVpSKLRSSLEKQPKKTEGVLSEDKAS 179 
XP_028936208 123 GRSRSRSPKRRSP-SPRSRSHSRNSDKSSSDrsr-----rsSSSRSSsnhSRVES-SKRRSGKDKKSSSKDARSSQATGD 195 
Q569Z6       123 GRSRSRSPKRRSP-SPRSRSHSRNSDKSSSDrsr-----rsSSSRSSsnhSRVES-SKRKSTKEKKSSSKDSRPSQAAGD 195  house mouse
1_pfamImport   1 GRSRSRSPKRRSG-TPRSRSRSR-----RSGssk---------rnAAkelKESGR-PDSAAKEAQRAGSRDEEAAGAAGG 64  
6_pfamImport   1 GRSRSRSPKRRSG-TPRSRSRSRYSDRSSSGrsrrtrgsssSDSRSSsthSRSGS-SKSAAKEAQRAGSRDEEAAGAAGG 78  
XP_011479419 141 GRSRSRTPKKRSP----SRSRSRYSDRSSSGpsr----hsrRSSYSSrshSSSPR-HRSSKGRRSSKDVKDKRTEGSAEK 211 
XP_011483948 110 QQNRSGSP---------PQGQSHRTDRSFSPlsr-----hsHHSSSSt-hSSPPK-ARQATGLASQTSEDVKDGELTSKQ 173 
XP_056651132 123 GRSRSRSPKRRSP-SPRSRSHSRNSDKSSSDrsr-----rsSSSRSSsnhSRVES-SKRKSVKEKKSSSKDNRPSQAAGD 195  gray short-tai...
XP_014352806 197 VSQGAESKAKppadatsndskdpeaiskpwkgltaydsspkhpssvvhsvnasglnSPP-HPsPiqk------------- 262 
XP_008112728 181 KNKSQEEEKSafehdpseplddfnks--------------aaasgdiwpglsaydnSPRsPHsP---------------- 230 
XP_006007788 180 GSRQQEEKKDlgkfepdqsklhdefskv-----------stlggdswpglsayndnSPRsHQsP---------------- 232 
XP_028936208 196 -NQGDDTKEQsfsgaaaqdakpsegskpwp-------eataygagsgsrasasaelSPR-ERsPalk------------- 253 
Q569Z6       196 -NQGDEAKEQtfsggtsqdikgsesskpw--------pdattygagsasrasvsdlSPR-ERsPalk------------- 252  house mouse
1_pfamImport  65 egapdrasgs-------------------------------------wqglidydtSPK-RTsPavrsaiivsqgtahps 106 
6_pfamImport  79 egapdrasgs-------------------------------------wqglidydtSPK-RTsPavrsaiivsqgtahps 120 
XP_011479419 212 pgqvgeggniek---------------------------------asggkwidfdaSPK-RGsP---------------- 241 
XP_011483948 174 VQKGGEEDEEpeehvelleenpt--------------------egagsgksdgnwqSPK-KNs----------------- 215 
XP_056651132 196 -NQGDDSKEQpfpggtsqdakpsesskpw--------peattygagsasraavselSPR-ERsPalk------------- 252  gray short-tai...
XP_014352806 263 spLQSVAVKRSPPQKSPQSHSPAGPSSLRQSPVPPiPpl-------------rtVPRQSPQA---HSPKRSSPAERSPV- 325 
XP_008112728 231 -----------S-IASPPSQSSSCSDAHLLSTVHSaKdtpqhs------hsiqhSPERSGSGslgNGSSRYSPSQNSPLh 292 
XP_006007788 233 -----------SPVPTPTSHSSSRSDVALQSIAHSaSgsskigaptqrshsiqrSPERAGS-----NTSRYSPSQDSPLh 296 
XP_028936208 254 spLQSVVVRRRSPRPGPG-----------QKPSPPlSgtsqlgsalqsgpgfqaGSHQGPFD---HGAGGLSPTRKSPV- 318 
Q569Z6       253 spLQSVVVRRRSPRPSPV-----------PKPSPPlSnasqmgssmsggagyqsGAHQGQFD---HGSGSLSPSKKSPV- 317  house mouse
1_pfamImport 107 psLQSVAVKR----PSPAVKG--------GSPSPSrSsaaaqskslgnapwqssGP---------------APTSKSPP- 158 
6_pfamImport 121 psLQSVAVKR----PSPAVKG--------GSPSPSvTppgraagppqrararrsRAQLQSFLalgSFRRTMSGQEKNPLr 188 
XP_011479419 242 -----DRKKEGTPSTSEGRGGGASMWKSVGSPSPP---------------------------------------PKSPA- 276 
XP_011483948 216 --LGPSSVGQKSPSPGQTINTKISNDTSNGAPV--------------------------------WQSSGGTCSTRKPS- 260 
XP_056651132 253 spLQSVVVRRRSPRPSPV-----------QKSSPPlStpsqmgsalqsstgfqaGAHQGQFD---HGAGGLSPSKKSPV- 317  gray short-tai...
XP_014352806 326 ----RKSPPIISTSYN-NAQKE--------ESRAGESTSplVSSYLKRYLEEQKNKATTQDRENGREKDqk-akNEEREK 391 
XP_008112728 293 hipsRRSPAKAVASQNaTREETrvrs-fypEAGEPESSK--GAKFLKRYTD-EESRVYLLDRSNVREKDaqkerGPEKGR 368 
XP_006007788 297 hmssRKSPVKSVTGQSlSREEArgrssfysDTEEKELPK--SGKYLKRYTDEEETGAYLLDKSNVKEKDgqkdrGLDKGR 374 
XP_028936208 319 ----CKSPPALSSVYG-SSQKE-------------EGAApgGAAYSKRYLDEQKA-------ENGKDKEqk-ltGVDKEK 372 
Q569Z6       318 ----GKSPPATGSAYG-SSQKE-------------ESAAsgGAAYSKRYLEEQKT-------ENGKDKEqk-qtNADKEK 371  house mouse
1_pfamImport 159 ----QQSPTAVFSGFG-FFSKD--------DVRAGEkp-ssVSTAFKKFLEEHKNKIQVAEWENGREKEqk-maELERDK 223 
6_pfamImport 189 flqpLKSKL----------SKI-------------------------RFLEEHKNKIQVAEWENGREKEqk-maELERDK 232 
XP_011479419 277 ----KSGQSATFSGFG-FFSKD--------DAKPADNSA--ISAAFKKFLAENKSKKQAAEKESSREKEal-aaDREQEK 340 
XP_011483948 261 ----REGLNPMLSSFD-FFSTE--------EFQDEDKKA--ISIAFRKFLEEQSKKANTTA-EISPKTEae-dgGLEKGN 323 
XP_056651132 318 ----GKSPPAIGSTYGsSSQKE-------------EASApgGAAYSKRYLEEQKS-------ENGKDKEqk-ltNVDKEK 372  gray short-tai...
XP_014352806 392 VKERSGVSEMGV--PFFKSDYLAPKNESESLYRGIPSPRRYRYSNELEKsmSAEFQE--EALHSMDMQ--------ESEk 459 
XP_008112728 369 TEGEREWEDQDAleYYMDKDSGKQKFI-DSEGEDAEETEDYR---QFRKsvLADQGKg-fSASHRNAE--------EEG- 434 
XP_006007788 375 VEQDSEWEDQEAleYFEQKDSDKLPFLGDSEGEGGEKPDTYR---QFKVssQVEQVKsyLAETRWNDD--------DEG- 442 
XP_028936208 373 MKEKGSFSELGLgdAKMKSEPFAPKPDAEKPFRSSQSPKRYKLRDDFEKk-LAEFH-------KEEMD--------EQDk 436 
Q569Z6       372 LKEKGGFSDa---dVKMKSDPFAPKTDSEKPFRGSQSPKRYKLRDDFEKk-MADFH-------KEELD--------EHDk 432  house mouse
1_pfamImport 224 GNGKAGSFDKGAaySGLKPDYYSKNEE-----------EKYGYDDEFELgsAAEFLKgpQFGSAEAGE--------DQEk 284 
6_pfamImport 233 GNVASSLT-------------------------------------TIAKtkRRKFLKgpQFGSAEAGE--------DQEk 267 
XP_011479419 341 SSKSAEIFSV-----------------SSSAYADSKDDKSLPFFDPEEE----EFLK--SQGLKERVIp-------DDA- 389 
XP_011483948 324 MNGKTSAM-------------------VSDCASGKCKEKTKG-----EVs-LKSFLKtpPFLSTEGEE--------EDEi 370 
XP_056651132 373 IKEKGSFSELGLgdPKVKPDPFAPKADAEKPFRGSQSPKRYKLRDDFEKk-MAEFHKeeMDESDKEKAkgrkesefEDE- 450  gray short-tai...
XP_014352806 460 khrvkgl--kdskledePKCKSKVIvpSTAKNQDTYEERLSKWEE---LAYFPSAKEkSWEDE--------DMEDEVYPG 526 
XP_008112728 435 -----------------SKYKSKISmkVNRESEGFREDKNYKLKEpasYVVERPNIPkDKHKEd-----------EKISE 486 
XP_006007788 443 -----------------NKFKTKIVlkGDRDYDRFGEDRAFKLKGs-gFGADRPSTSkEKYREd-----------DKFLE 493 
XP_028936208 437 kdkakgr--kesefddePKFMSKVLa-GSSKNQE--EDRPGKWEG---LVYLPGGKEkPRKTE--------EPEEDSYAE 500 
Q569Z6       433 dkskgrk---epefddePKFMSKVIa-GASKNQE--EEKSGKWES------LHTGKEkQRKAE--------EMEDEPFTE 492  house mouse
1_pfamImport 285 rhkvrnq--keremedePKHKSKITi---TANRDMFDERFNKWDE---LAYFPSAKEkLRKEEdageddidDVEEELY-- 354 
6_pfamImport 268 rhkvrnq--keremedePKHKSKITi---TANRDMFDERFNKWDE---LAYFPSAKEkLRKEEdageddidDVEEELY-- 337 
XP_011479419 390 -----------------D--AQRTP-----TARDIF----GKWGDepsISTSYSSKEkARREAadp---sdAMEDEMYQV 438 
XP_011483948 371 lhrpslkflfkdlhngdESCKPKIS------AQKLFGEAFRKQQN--------AAYSqFTNGEf------dSREEERWVE 430 
XP_056651132 451 -----------------PKFMSKVIa-GTSKGQE--DERPGKWEG---LVYMPGGKEkQRKAE--------ELEDDTYGD 499  gray short-tai...
XP_014352806 527 R--AKREE--------VKRAElGGyrgpipdknprsgsy-------kvvherspsppprrSAEGKEre-kmATKEENPpi 588 
XP_008112728 487 Rt-MKKETqspeqvksEKLKElFDys--------------------------------ppLHKNPDsreksTFREESPlr 533 
XP_006007788 494 RimIKREPvspeqvksEKLSErFDcs--------------------------------plLQKTLDlrekaASREENLpk 541 
XP_028936208 501 R--AKKEErs-----tGKRAEg-Ghrgfvpeknfrvt----------aykavqekgssppPRKASDsrekpGARGDSLpl 562 
Q569Z6       493 R--SRKEErg-----gSKRSEs-Ghrgfvpeknfrvt----------aykavqeksssppPRKTSEsrdklGSKGDFssg 554  house mouse
1_pfamImport 355 R--SRKQEraaaaaaaAKKAEaSGyrgfspdkapkasrk-------kekqgqspspparkSSENREre-mfNVRRDDSpp 424 
6_pfamImport 338 R--SRKQEraadkapkasrkk--------------------------ekqgqspspparkSSENREre-mfNVRRDDSpp 388 
XP_011479419 439 RklSKKEEkskkkekkEKEKQ--R------------------------------------RSASPQmkerpLFPGAFPps 480 
XP_011483948 431 R----KQDkaaaisavLAKRElTEkfedlspemsfk------------kkmmagspsvlaSAAVSSnremfMIREQDPa- 493 
XP_056651132 500 R--PKKEEra-----aTKRTEaTThrgfvpeknfrvtaykalpekssspppppprkatatTPATAApgdklGPARAESlp 572  gray short-tai...
XP_014352806 589 s-ktTFSVYRGSEINVRMDALEDDFG-SS---VAHERRLSRDLVHGNKKDLGFRSIFQHIQSSQSRRSPSELFAQHIVTI 663 
XP_008112728 534 i-kmIASDSHRPEVKLKMAPVPLDDSnRPa-sLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHVVSL 611 
XP_006007788 542 i-kmVPSESYRPDVKLKMPPVSFDDPvRPgtsLTSDRLLASALVHSGKKEQGFRSIFDHIKLPQMYKSSAESFIQHIVSL 620 
XP_028936208 563 g-ksSFSITREAQVNVRMDSFDEDLA-RPsglLAQERKLCRDLVHSNKKEQEFRSIFQHIQSAQSQRSPSELFAQHIVTI 640 
Q569Z6       555 --ksSFSITREAQVNVRMDSFDEDLA-RPsglLAQERKLCRDLVHSNKKEQEFRSIFQHIQSAQSQRSPSELFAQHIVTI 631  house mouse
1_pfamImport 425 rstpAYSGKRSAEVSVRMDPFHEDYA-SSsgvLANERRFSRDLVHPSKKDQEFRSIFQHIQSTQLRRSPSELFAQHIVTI 503 
6_pfamImport 389 rstpAYSGKRSAEVSVRMDPFHEDYA-SSsgvLANERRFSRDLVHPSKKDQEFRSIFQHIQSTQLRRSPSELFAQHIVTI 467 
XP_011479419 481 d-psPVRPLSASREDFEL-KFSSLEE-LPsssLSKDRLIPRDLPNSSKKDPEFRSIFQHVQSAQLRRSPSELFAQHIVSI 557 
XP_011483948 494 ---pVSSQKPEAKFHVRMGFLGDSLM-SSsdiLAEERQLSQDLVLSSKKDPEFRSIFQHVQTAQSQRSPSELFAQHIVTI 569 
XP_056651132 573 lgksSFSITREAQVNVRMDSFDEDLA-RPsglLAQERKLSRDLVHSNKKDQEFRSIFQHIQSAQSQRSPSELFAQHIVTI 651  gray short-tai...
XP_014352806 664 VHHVKEHHFESPEMTLSERFTMYQRRAMEQGAARSKKSPEFHRRIDISPSAFRKHPFLQDEMKGSREsssykgegKYKeD 743 
XP_008112728 612 VHHVKEQYFKSAAMTLSERFTAYQKS--PEEHSTRQKSPEIHRRIDISPSALRKHTRLAGEERAFKEetqk-gdkKLKcD 688 
XP_006007788 621 VHHVKEHYFKSTGMTLNERFTVYQKA--TEGQVPRQKSPEIHRRIDISPSALRKHTRLTDEDRLFKEesqkqgdkKLRcD 698 
XP_028936208 641 VHHVKEHHFGSSGMTLNERFTKYLKRGTEQDAAKNKKSPEIHRRIDISPSTFRKHGLAHEEMKSPREpgyk-aegKFKdD 719 
Q569Z6       632 VHHVKEHHFGSSGMTLHERFTKYLKRGNEQEAAKNKKSPEIHRRIDISPSTFRKHGLTHEELKSPREpgyk-aegKYKdD 710  house mouse
1_pfamImport 504 VHHIKAQHFESSGMTLNERFAMYQRRAA--EMMKPRKSPEIHRRIDVSPSAFRKHSHLFEEMKSSREssskdegkKMKtD 581 
6_pfamImport 468 VHHIKAQHFESSGMTLNERFAMYQRRAA--EMMKPRKSPEIHRRIDVSPSAFRKHSHLFEEMKSSREssskdegkKMKtD 545 
XP_011479419 558 VHYIKAQHFPSSDISLSERFAMYQRKAAEAEMMKPRKSPEIHRRIDVSPSAFKRHPHLFEDLDEssyk---dpgkKFKgD 634 
XP_011483948 570 VHHVKTQHFPSSGLTLNERFTLYQREAAEQEMKKSRKSPEIHRRIDVLPSAFKKPPQLFGGVKSSEEgtyksageKVKgD 649 
XP_056651132 652 VHHVKEHHFGSSGMTLNERFTKYLKRGTEQDAAKNKKSPEIHRRIDISPSTFRKHGLTHDEMKSTREpgyk-aegKYKdD 730  gray short-tai...
XP_014352806 744 PVDLRLDIERRKKY--KERDHKRDGSRESVDSRDSSQSRERsTEKAQR---EHKESKKR-KKQkKIRSR-------SKSS 810 
XP_008112728 689 AADLRHDIDRRRKErsKER-------GDSKGSRESSGSRKQ--EKMPK---DYKDFKPYkDDSkQKREQdrsrsssTSSP 756 
XP_006007788 699 SADLRHDIDRRRKErsRER-------EGSRGSRESSGSRKH--EKSTKdymDYKEYKPYkDESkPKNREg-----dHSRS 764 
XP_028936208 720 PVDLRLDIERRKKH--KERDLKRDKSRESVDSRDSSPSRERsAEKTEK---THKGSKKQ-KKHrRTRDR-------SRSS 786 
Q569Z6       711 PVDLRLDIERRKKH--KERDLKRGKSRESVDSRDSSHSRERsTEKTEK---THKGSKKQ-KKHrRARDR-------SRSS 777  house mouse
1_pfamImport 582 SMDLRLDIERRKKYssKEREHKRDGMRDSGESRGSSLSRERsTEKSSK---HHKKTKKRk----KTRER-------SRSS 647 
6_pfamImport 546 SMDLRLDIERRKKYssKEREHKRDGMRDSGESRGSSLSRERsTEKSSK---HHKKTKKRk----KTRER-------SRSS 611 
XP_011479419 635 VMDLRLDIERRKRFagRERDYKREGGRSPEGSRGP--SREQsTEKSGK---HQKKSKKSk----KKRDR----------- 694 
XP_011483948 650 TMDLRLDIERRKKYscFQNQNQE---RDVGDSADF--SKELcEQNLSK---HSNKLNGQk----RRRSS----------S 707 
XP_056651132 731 PVDLRLDIERRKKH--KERDLKRDKSRESVDSRDSSHSRERsTEKTEK---THKGSKKQ-KKHrRTRDR-------SRSS 797  gray short-tai...
XP_014352806 811 STSSHSSQSYKG 822 
XP_008112728 757 SSSSSSSREEKD 768 
XP_006007788 765 SSSSSASRDDKD 776 
XP_028936208 787 SSTSQSSHSYKA 798 
Q569Z6       778 SSSSQSSHSYKA 789  house mouse
1_pfamImport 648 SESSSSSHSFKG 659 
6_pfamImport 612 SESSSSSHSFKG 623 
XP_011479419 695 -----------S 695 
XP_011483948 708 SSSSSSSKSPKP 719 
XP_056651132 798 SSSSQSSHSYKA 809  gray short-tailed opossum
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